Abstract：
:Preoperative diagnosis of papillary thyroid carcinoma (PTC) comprises numerous diagnostic procedures which are mostly applicable in tertiary institutions. Normal thyroid function depends on the presence of many trace elements and copper (Cu) and zinc (Zn) are some of those. The study is based on retrospective review of 118 patients with preoperatively diagnosed benign thyroid disease (BTD) and 12 with PTC, who underwent thyroid surgery at the Center for Endocrine Surgery Clinical Center of Serbia, Belgrade, between 2010 and 2012. The objective was to evaluate concentrations of Cu and Zn in serum as possible prediction markers for PTC in patients who underwent surgery for preoperatively diagnosed BTD. Concentrations of Cu and Zn ions in serum were measured using atomic absorption spectrophotometer. Data were analyzed using methods of descriptive statistics, Anova and t-test (p < 0.05 was considered statistically significant). Definitive pathohistological findings revealed PTC in 23 (19.5%) and papillary microcarcinoma-mPTC in 13 (11.0%) of BTD patients. The concentrations of Cu ions in serum of PTC patients as well as in serum of patients with mPTC were significantly higher than in serum of BTD patients (p < 0.05). The concentrations of Zn ions and Cu/Zn ratio in serum of PTC and mPTC patients were not significantly higher than in serum of BTD patients. The concentration of Cu ions in serum of patients before thyroid surgery can be useful, easy available, and a low-cost tool in prediction of preoperatively undiagnosed PTC in patients with BTD.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Dragutinović VV,Tatić SB,Nikolić-Mandić SD,Tripković TM,Dunđerović DM,Paunović IRdoi
10.1007/s12011-014-0071-zsubject
Has Abstractpub_date
2014-09-01 00:00:00pages
311-5issue
3eissn
0163-4984issn
1559-0720journal_volume
160pub_type
临床试验,杂志文章abstract：:The levels of iron, zinc, and copper in the tissues of the pregnant rat, on d 12, 19, and 21 after impregnation have been determined and compared with controls. Iron levels decreased considerably in late pregnancy as a result of increased fetal requirements, thus diminishing iron stores in rat tissues, but maintaining...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917464
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journal_title：Biological trace element research
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journal_title：Biological trace element research
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doi：10.1007/BF02992682
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917184
更新日期：1989-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s12011-014-0022-8
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更新日期：2000-02-01 00:00:00
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journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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更新日期：2005-07-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
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journal_title：Biological trace element research
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journal_title：Biological trace element research
pub_type： 杂志文章
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