Abstract:
:Two organoselenium compounds: xylitol selenious ester (xylitol-Se) and sucrose selenious ester (sucrose-Se) were synthesized, and their molecular structures were characterized in this study. In MTT assay, xylitol-Se and sucrose-Se showed cytostatic effects on human hepatocellular carcinoma cells SMMC-7221 in a dose-dependent manner, whereas they had no negative influences on the proliferation of human normal hepatic cells HL-7702 in the concentration range from 0.15 to 1.2 ppm Se. Morphological observation, agarose gel electrophoresis, and caspase-3 assay indicated that xylitol-Se and sucrose-Se induced mitochondrial apoptosis to SMMC-7221 cells, which is supported by the depletion of mitochondrial membrane potential and suppression of caspase-3 activity, indicating their ability of inducing apoptosis to cancer cells and great potentials as anticancer drugs.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Guo P,Wang Q,Liu J,Liu L,Zhao P,Cao Y,Liu Y,Qi C,Liu Ydoi
10.1007/s12011-013-9715-7subject
Has Abstractpub_date
2013-08-01 00:00:00pages
304-11issue
2eissn
0163-4984issn
1559-0720journal_volume
154pub_type
杂志文章abstract::The effect of aging on the status of macrominerals and trace elements in tissues was studied using two strains (SAMP1 and SAMR1) of senescence accelerated mouse. Two-month-old, 6-mo-old, and 10-mo-old female SAMP1 and SAMR1 mice were fed a commercial diet. Iron, zinc, copper, calcium, magnesium, phosphorus, sulfur, so...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:80:1:53
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02795685
更新日期:1987-12-01 00:00:00
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更新日期:2020-09-05 00:00:00
abstract::Patients with chronic kidney disease (CKD) have an increased incidence of cancer. It is well known that long periods of hemodialysis (HD) treatment are linked to DNA damage due to oxidative stress. In this study, we examined the effect of selenium (Se) supplementation to CKD patients on HD on the prevention of oxidati...
journal_title:Biological trace element research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12011-010-8776-0
更新日期:2011-09-01 00:00:00
abstract::To elucidate compositional changes of the cardiac walls with development and aging, the authors investigated changes of elements in the atrial and ventricular walls of monkeys. The left and right atrial walls, left and right ventricular walls, and interatrial and interventricular septa were resected from the subjects....
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:110:3:233
更新日期:2006-06-01 00:00:00
abstract::Continuation of prolonged treatment against arsenicosis with conventional chelating therapy is a global challenge. The present study was intended to evaluate the defensive effect of arjunolic acid against arsenic-induced oxidative stress and female reproductive dysfunction. Wistar strain adult female rats were given s...
journal_title:Biological trace element research
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doi:10.1007/s12011-017-1077-0
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9461-2
更新日期:2012-12-01 00:00:00
abstract::Selenium selenate was administered to streptozotocin-induced diabetic rats to assess its effects on the detrusor muscle. Thirty-two rats were divided into four groups of eight subjects each. The study animals were made diabetic by means of a single intravenous injection of streptozotocin (STZ). The responsiveness of t...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:93:1-3:171
更新日期:2003-07-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02950788
更新日期:1994-02-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8264-y
更新日期:2009-05-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-8994-0
更新日期:2011-12-01 00:00:00
abstract::Selenium is increasingly recognized as a versatile anticarcinogenic agent. Its protective functions cannot be solely attributed to the action of glutathione peroxidase. Instead, selenium appears to operate by several mechanisms, depending on dosage and chemical form of selenium and the nature of the carcinogenic stres...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/BF02783992
更新日期:1992-04-01 00:00:00
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journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/s12011-016-0711-6
更新日期:2016-12-01 00:00:00
abstract::Thirty rats were divided randomly into five groups and fed with different feeds. They were killed after 2 mo. Right thighs of these rats were taken as samples. Bone mineral densities of these samples were measured by the double-energy x-ray bone mineral densitometer, and trace elements contents of the samples were ana...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784252
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journal_title:Biological trace element research
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journal_title:Biological trace element research
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1411-1
更新日期:2019-04-01 00:00:00
abstract::Deficiency in the intake of trace elements, such as copper (Cu), iron (Fe), selenium (Se), and zinc (Zn), is very common in the general population of most developing countries. A preliminary study in India and Pakistan showing the plasma levels of Zn and Fe indicates that approx 50% of the subjects who participated ha...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02789092
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02990343
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02991414
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journal_title:Biological trace element research
pub_type: 杂志文章
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01801-8
更新日期:2020-04-01 00:00:00
abstract::Relative stability of mineral elements in tissues is necessary for health. High static magnetic fields (HiSMFs) have been widely used in biomedical research and industry. However, the bioeffect of HiSMFs on animals is still unclear. In this study, we investigated the effects of HiSMF exposure on the levels of Mg, Fe, ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02469-1
更新日期:2021-01-07 00:00:00
abstract::Metallic tin powder injected into Lewis rats caused marked enlargement of draining lymph nodes with prominent hyperplasia of plasma cells. A low level of dietary protein (8%) or deficiency of choline interfered with the cellular proliferation and reduced the size of the nodes by nearly one-third compared to a normal p...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:85:1:71
更新日期:2002-01-01 00:00:00
abstract::Elemental concentrations in head hair and blood (whole-blood, erythrocytes and plasma) of 28 Nigerian subjects were determined using instrumental neutron activation analysis (INAA) and proton-induced X-ray emission (PIXE) techniques. Correlations found between different elements in hair and blood are reported. Hair le...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/BF02917347
更新日期:1994-10-01 00:00:00
abstract::The intervention effect of fucoxanthin, which is reportedly a powerful antioxidant, on cadmium-induced thyroid damage in mice was evaluated. Animals (N = 120) were divided into control group (given pure water, N = 20) and CdCl2-exposed group (given CdCl2 orally at a dose of 30 mg/kg body weight (bw)/day for 30 days, N...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02291-9
更新日期:2020-07-21 00:00:00
abstract::Selenoprotein T (SelT) is associated with the regulation of calcium homeostasis and neuroendocrine secretion. SelT can also change cell adhesion and is involved in redox regulation and cell fixation. However, the structure and function of chicken SelT and its response to selenium (Se) remains unclear. In the present s...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0049-x
更新日期:2014-08-01 00:00:00
abstract::Injectable trace minerals (ITMs) could provide a potential alternative way of trace mineral delivery for sick animals. Therefore, evaluation of ameliorative potentials of ITMs (copper, manganese, selenium, and zinc) on the circulating Th1/Th2 cytokine misbalance in Theileria annulata-infected calves was aimed. Forty-t...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02263-z
更新日期:2020-06-22 00:00:00
abstract::Information on cadmium (Cd) uptake and transport is essential to understand better the physiology of Cd tolerance in plants. In this study, Cd uptake, translocation, and tolerance were investigated in AHA1 (Arabidopsis plasma membrane H(+)-ATPase gene) overexpressed plants. Exposed to 10 µM CdCl(2), AHA1OX showed a hi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8657-6
更新日期:2011-02-01 00:00:00
abstract::A study was conducted to validate the effects of nano form of zinc (NZn) on nutrient digestibility, zinc retention, organ and serum zinc profile, and hepatic metallothionein gene expression in Wistar albino rats (WAR). Nano zinc (NZn) was synthesized through chemical method, by using 0.45 M zinc nitrate [Zn(NO3)2.6H2O...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1517-5
更新日期:2019-07-01 00:00:00