Nuclear microscopy in the life sciences at the National University of Singapore. A review.

Abstract:

:The nuclear microscope is now gaining popularity in the field of life sciences. In particular, the combination of proton-induced X-ray emission to measure the elemental concentrations of inorganic elements, Rutherford backscattering spectrometry to characterize the organic matrix, and scanning transmission ion microscopy to provide information on the density and structure of the sample represents a powerful set of techniques that can be applied simultaneously to the specimen under investigation. These techniques are extremely useful for measuring any imbalances in trace elements in localized regions of biological tissue and, as such, can provide unique information on many diseases. In this article, we describe the nuclear microscope and its related ion-beam techniques, and we review the biomedical work carried out using the nuclear microscope in the National University of Singapore.

journal_name

Biol Trace Elem Res

authors

Ren MQ,Thong PS,Makjanic J,Ponraj D,Watt F

doi

10.1007/BF02784192

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

65-76

eissn

0163-4984

issn

1559-0720

journal_volume

71-72

pub_type

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