Abstract:
:The nuclear microscope is now gaining popularity in the field of life sciences. In particular, the combination of proton-induced X-ray emission to measure the elemental concentrations of inorganic elements, Rutherford backscattering spectrometry to characterize the organic matrix, and scanning transmission ion microscopy to provide information on the density and structure of the sample represents a powerful set of techniques that can be applied simultaneously to the specimen under investigation. These techniques are extremely useful for measuring any imbalances in trace elements in localized regions of biological tissue and, as such, can provide unique information on many diseases. In this article, we describe the nuclear microscope and its related ion-beam techniques, and we review the biomedical work carried out using the nuclear microscope in the National University of Singapore.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Ren MQ,Thong PS,Makjanic J,Ponraj D,Watt Fdoi
10.1007/BF02784192subject
Has Abstractpub_date
1999-01-01 00:00:00pages
65-76eissn
0163-4984issn
1559-0720journal_volume
71-72pub_type
杂志文章,评审abstract::Auxiliary enzymes participate in β-oxidation of unsaturated fatty acids. The objective of the study was to investigate the impact of a moderate zinc deficiency and a high intake of polyunsaturated fat on Δ(3)Δ(2)-enoyl-CoA isomerase (ECI) in the liver and other tissues. Five groups of eight weanling rats each were fed...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9940-8
更新日期:2014-06-01 00:00:00
abstract::Plasma molybdenum concentrations were determined in children, ages two to 12 yr, with and without phenylketonuria (PKU). Mean plasma molybdenum concentrations did not differ significantly between the children with PKU (1.33 +/- 0.5 microgram/L) and without PKU (1.75 +/- 0.8 microgram/L). Plasma molybdenum concentratio...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785307
更新日期:1993-09-01 00:00:00
abstract::The present study was conducted to investigate whether the combined treatment with Se and Zn offers more beneficial effects than that provided by either of them alone in reversing Cd-induced oxidative stress in the kidney of rat. For this purpose, 30 adult male Wistar albino rats, equally divided into control and four...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-009-8324-y
更新日期:2009-08-01 00:00:00
abstract::Selenium and methylmercuric chloride (MMC) interactions regarding cellular uptake and selenium protection on MMC toxicity have been studied. Human K-562 cells were pretreated or simultaneously treated with either selenite (5 or 50 microM) or selenomethionine (10 or 50 microM) together with (3.5 or 5 microM) MMC. Cells...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:80:3:251
更新日期:2001-06-01 00:00:00
abstract::This study was conducted to investigate the effect of zinc chitosan chelate (CS-Zn) on zinc transporter expression and content of tissue zinc in weaned piglets. A total of 90 weaned pigs (Duroc × Landrace × Yorkshire) were randomly allocated to treatment groups with supplementation of 100 mg/kg zinc as ZnSO4, 100 mg/k...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-016-0732-1
更新日期:2016-12-01 00:00:00
abstract::In the affiliation section, Luiz Fabricio Zara's affiliation "Pontifical Catholic University of Goiás (PUC), Goiânia, GO, Brazil" was incorrect. The correct affiliation is College of Planaltina, UnB - University of Brasília, Distrito Federal, Brazil. ...
journal_title:Biological trace element research
pub_type: 杂志文章,已发布勘误
doi:10.1007/s12011-017-1195-8
更新日期:2018-05-01 00:00:00
abstract::Zinc (Zn) is an essential nutrient that is required in humans and animals for many physiological functions, including immune and antioxidant function, growth, and reproduction. The present study was performed to investigate the effects of three Zn levels, including Zn adequate (35.94 mg/kg, as a control), Zn deficienc...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:107:2:153
更新日期:2005-11-01 00:00:00
abstract::Samples of Evernia prunastri, collected in a mountainous zone, were exposed in urban and highly industrialized areas in order to monitor the atmospheric pollution. Amounts of Cr, Mn, Fe, Ni, Cu, Zn, and Pb were determined by EDXRF spectrometry in secondary target excitation mode and in the thin film approach. An incre...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917318
更新日期:1994-10-01 00:00:00
abstract::Iron and copper are essential microminerals that are intimately related. The present study was performed to determine the effect of iron-deficiency anemia (IDA) and treatment with iron on laboratory indicators of copper status. Hemoglobin, mean corpuscular volume erythrocyte Zn protoporphyrin, serum ferritin, serum co...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:112:3:213
更新日期:2006-09-01 00:00:00
abstract::Previous studies revealed that Se was an important regulatory factor for glutathione peroxidase (GPx) genes. However, the relationship between Se concentrations and mRNA expression levels of GPxs were unclear in goats, especially the goats living in natural Se-enriched area. Thus, the aim of this study was to determin...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9830-5
更新日期:2013-12-01 00:00:00
abstract::Instrumental neutron activation (INAA) with k0 standardization has been used to determine the concentration levels of a variety of major and trace elements (Al, As, Br, Cd, Cl, Co, Cr, Cs, Cu, Fe, Hg, K, La, Mg, Mn, Mo, Na, Rb, Sc, Se, and Zn) in rice grains (raw and parboiled) and in rice flour collected from local m...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:103:1:083
更新日期:2005-01-01 00:00:00
abstract::Serum selenium levels were determined cross-sectionally in 57 HIV-infected patients who were classified according to the Centers for Disease Control (CDC) 1993 classification system. Mean serum selenium levels were lower in CDC stage II (58.7 +/- 12.2 micrograms/L; p < 0.01; n = 18) and stage III (47.6 +/- 11.3 microg...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02778982
更新日期:1997-01-01 00:00:00
abstract::Pituitary dwarfism (hGHD) is known to be associated with trace element deficiency, which causes improper functioning of the involved endocrine system. Previously, we reported on the head hair concentrations of zinc, copper, manganese, and iron from a total of 418 normal subjects (154 male and 264 female). In this repo...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:85:2:127
更新日期:2002-02-01 00:00:00
abstract::Tungstate is an oxyanion that has biological similarities to vanadate. In recent years, a number of studies have shown the antidiabetic effects of oral tungstate in animal models of diabetes. However, because of the tissue accumulation and potential toxicity derived from chronic administration of vanadium and tungsten...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1385/BTER:88:2:097
更新日期:2002-08-01 00:00:00
abstract::Body stores of lead, cadmium, and mercury are determined by the levels in the circulation, and their levels in blood may be related to hemoglobin levels and their absorption by soft tissue and bone. We investigated the association of body fat percentage, hemoglobin levels, and nutrient intakes with the blood concentra...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9566-7
更新日期:2013-03-01 00:00:00
abstract::Linolenic acid is an inhibitor of electron transport in chloroplasts of higher plants. It has obvious effects on the structure and function of chloroplasts. In the present paper, we investigated the nano-anatase relieving the inhibition of photoreduction activity and oxygen evolution caused by linolenic acid in spinac...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-8055-x
更新日期:2008-04-01 00:00:00
abstract::This in vitro study was designed to assess the impact of divalent (Fe(2+)) or trivalent (Fe(3+)) iron on the activity and oxidative balance of bovine spermatozoa at specific time intervals (0, 2, 8, 16, and 24 h) during an in vitro culture. Forty-five semen samples were collected from adult breeding bulls and diluted ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0288-5
更新日期:2015-09-01 00:00:00
abstract::During pregnancy, the demand for daily iodine increases by 50-70% which occurs to reach around 250 μg/day. Limited information is available on the association of high-risk pregnancy (HRP) with urinary iodine concentration (UIC) and variables such as socioeconomic factors. To analyze iodine nutritional status and socio...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02028-8
更新日期:2020-10-01 00:00:00
abstract::Serum copper and zinc estimations in humans were made to find their diagnostic and prognostic value in cases of myocardial infarction. Following infarction, there was an increase in serum copper levels from the first 24 h up to the 7th day, with gradual decline that did not reach the normal value up to the 14th day. T...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02990200
更新日期:1991-12-01 00:00:00
abstract::Molybdenum (Mo) is an essential element for human beings and animals; however, high dietary intake of Mo can lead to adverse reactions. Cadmium (Cd) is harmful to health. To investigate the toxicity of Mo combined with Cd in duck kidneys, 240 ducks were randomly divided into six groups and treated with a commercial di...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0348-x
更新日期:2015-11-01 00:00:00
abstract::This study was designed to measure the effect of iron supplementation on antioxidant status in iron-deficient anemia, including the time for hemoglobin normalization and at the time of filling of iron body stores. The extent of plasma lipid peroxidation was evaluated by measuring the levels of malondialdehyde and glut...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:96:1-3:117
更新日期:2003-01-01 00:00:00
abstract::In this study, a method of positive matrix factorization (PMF) combined support vector machines (SVMs) was adopted to identify possible sources and apportion contributions for trace element pollution in surface sediments from the Jinjiang River, Southeastern China. Utilizing diagnostics tools, four significant factors...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9576-5
更新日期:2013-03-01 00:00:00
abstract::To elucidate compositional changes of the rami of the internal iliac artery with aging, the authors investigated age-related changes of the calcium content in the uterine, internal pudendal, umbilical, and obturator arteries by inductively coupled plasma-atomic emission spectrometry. After an ordinary dissection was f...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:101:3:203
更新日期:2004-12-01 00:00:00
abstract::Exposure to mobile phone-induced electromagnetic radiation (EMR) may affect biological systems by increasing free oxygen radicals, apoptosis, and mitochondrial depolarization levels although selenium may modulate the values in cancer. The present study was designed to investigate the effects of 900 MHz radiation on th...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0032-6
更新日期:2014-08-01 00:00:00
abstract::Concentrations of toxic elements (lead, cadmium, mercury, and arsenic) were measured in water, sediment, and four commercial fish species (Cyprinus carpio, Hypophthalmichthys molitrix, Silurus glanis, and Esox lucius) and their tissues (muscle, liver, and kidney) from Saničani Lake, Bosnia and Herzegovina. The concent...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01982-2
更新日期:2020-09-01 00:00:00
abstract::Fluoride (F) concentration in blood serum of healthy dromedary camel population was measured, and its relationship with age and sex was determined. In male animals, the level varied from 0.017 to 0.296 ppm, with mean (± S.E.) value of 0.163 ± 0.013 ppm. In females, the level varied from 0.036 to 0.372 ppm with mean va...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02534-9
更新日期:2021-01-06 00:00:00
abstract::The hypothesis was tested that marginal copper deficiency affects iron status. Copper restriction (1 vs 5 mg Cu/kg diet) significantly lowered iron concentrations and transferrin saturation in plasma and reduced blood hemoglobin, hematocrit, and iron concentrations in tibia and femur, but raised iron concentrations in...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02786240
更新日期:1992-10-01 00:00:00
abstract::The role of zinc (Zn) in hepatic steatosis of patients with HCV-related chronic liver disease (CLD-C) remains uncertain, although persistent HCV infection often evokes hepatic steatosis. The primary purpose of this study was to elucidate the contribution of Zn deficiency to hepatic steatosis in patients with CLD-C. Fi...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/s12011-014-0177-3
更新日期:2015-02-01 00:00:00
abstract::Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is the most common human enzymopathy in the world. Trace elements are important for normal hematopoiesis and can play a role in acute hemolytic anemia induced by G-6-PD deficiency. For this purpose, we studied two groups consisting of 10 male children who are G-6-P...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:99:1-3:041
更新日期:2004-07-01 00:00:00
abstract::Women with gestational diabetes mellitus (GDM) may have lower serum selenium levels than healthy controls, which may be associated with preterm birth. We explored the association of serum selenium levels in early pregnancy with the risk of GDM and preterm birth among Chinese women. We included 398 women with a singlet...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02191-y
更新日期:2021-02-01 00:00:00