Effect of iron supplementation on oxidative stress and antioxidant status in iron-deficiency anemia.

Abstract:

:This study was designed to measure the effect of iron supplementation on antioxidant status in iron-deficient anemia, including the time for hemoglobin normalization and at the time of filling of iron body stores. The extent of plasma lipid peroxidation was evaluated by measuring the levels of malondialdehyde and glutathione peroxidase (GSH-Px), and the activities of superoxide dismutase (SOD) and catalase in 63 patients with iron-deficiency anemia before and after 6 wk of iron supplementation and at the time when body iron stores are saturated. After 6 wk of iron supplementation, a significant decrease of oxidative stress was observed in the treated subjects relative to controls (p<0.05). No significant differences existed between treated patients at 6 wk and at the end of the study. The erythrocyte levels of catalase, SOD, and GSH-Px were significantly lower in treated patients relative to controls (p<0.05). These levels increased after 6 wk of supplementation (p<0.05) and showed no significant differences with those at the end of the study.

journal_name

Biol Trace Elem Res

authors

Kurtoglu E,Ugur A,Baltaci AK,Undar L

doi

10.1385/BTER:96:1-3:117

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

117-23

issue

1-3

eissn

0163-4984

issn

1559-0720

pii

BTER-96-1-3-117

journal_volume

96

pub_type

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