Abstract：
:Synaptosomes are used as an ex vivo model in the investigation of neuronal transmission and neurodegenerative processes. In this study, we aimed to determine the protective effects of boric acid (BA) and curcumin, which have antioxidant and anti-inflammatory properties, on Aβ1-42 induced neurodegenerative damage. Synaptosomes obtained from the rat cerebral cortex were divided into five groups: control, 10 μM Aβ1-42, 10 μM Aβ1-42 + 25 mM BA, 10 μM Aβ1-42 + 10 μM curcumin, and 10 μM Aβ1-42 + 25 mM BA+10 μM curcumin. Synaptosomes treated with Aβ1-42 caused a significant decline in synaptophysin levels and increase in malondialdehyde (MDA) levels, acetylcholinesterase (AChE) activities, DNA fragmentation values, and nitric oxide (NO) levels compared with the control group (P < 0.01). Synaptosomes treated with BA showed a significant reduction in MDA and NO levels against Aβ1-42 exposure (P < 0.01). In addition, curcumin treatment has been found to cause a significant reduction in AChE activities and MDA levels in synaptosomes (P < 0.05). Co-administration of BA and curcumin on synaptosomes exposed to Aβ1-42 resulted in a significant decrease in DNA fragmentation values, MDA levels, and AChE activities. Curcumin and BA + curcumin combination showed an enhancement in synaptophysin levels of Aβ1-42-induced synaptosomes (P < 0.01). The results showed that BA and curcumin had protective effects on rat brain synaptosomes against Aβ1-42 exposure. BA and curcumin treatment can have abilities to prevent the alterations of the cholinergic system and inhibit oxidative stress in the cerebral cortex synapses of Aβ1-42 exposed.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Hacioglu C,Kar F,Kar E,Kara Y,Kanbak Gdoi
10.1007/s12011-020-02511-2subject
Has Abstractpub_date
2020-11-25 00:00:00eissn
0163-4984issn
1559-0720pii
10.1007/s12011-020-02511-2pub_type
杂志文章abstract：:Lung cancer is seriously threatening human health and exposure to trace metals is the most important aetiology for lung cancer. Selected essential/toxic metals (Ca, Mg, Na, K, Fe, Zn, Cu, Sr, Li, Co, Mn, Ni, Cr, Cd and Pb) are measured in the scalp hair and nails of lung cancer patients and controls by atomic absorpti...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9942-6
更新日期：2014-06-01 00:00:00
abstract：:Selenium is a trace element that, although toxic in higher concentrations, is essential for human and animal health. In this study, we looked at microarray-based gene expression patterns from liver and gastrocnemius tissues in mice fed either a selenium-deficient diet or diets containing sodium selenite, selenomethion...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8894-8
更新日期：2011-11-01 00:00:00
abstract：:Urine lead level is one of the most employed measures of lead exposure and risk. The urine samples used in this study were obtained from ten healthy male cyclists. Dispersive liquid-liquid microextraction combined with ultraviolet and visible spectrophotometry was utilized for preconcentration, extraction, and determi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0844-7
更新日期：2017-04-01 00:00:00
abstract：:A survey of mercury (Hg) and selenium (Se) contents was performed in fish collected from lakes located in two National Parks of the northern patagonian Andean range. Two native species, catfish (Diplomystes viedmensis) and creole perch (Percichthys trucha), and three introduced species, brown trout (Salmo trutta), rai...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-8059-6
更新日期：2008-04-01 00:00:00
abstract：:The interaction of the vanadyl (IV) cation with N-acetyl-D-galactosamine, D-galactosamine, and D-glucuronic acid has been investigated by electron absorption spectroscopy at different metal to ligand ratios and pH values. In the case of D-glucuronic acid, a more detailed study was undertaken, using differential IR spe...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02785436
更新日期：1996-02-01 00:00:00
abstract：:The purpose of the present study was to measure the pattern of uptake of(75)Se into proteins in normal rat lenses and into the proteins of lenses with selenite-induced cataract. Ten-day-old suckling rats received a single injection of(75)Se with or without a cataractous dose of cold carrier sodium selenite. Four days ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917506
更新日期：1984-06-01 00:00:00
abstract：:The distribution and chemical species of iodine in various subcellular fractions of human liver were studied by using epithermal neutron activation analysis combined with chemical and biochemical separation techniques, such as gradient centrifugation and gel chromatography. It was found that the total iodine content o...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783916
更新日期：1999-07-01 00:00:00
abstract：:Herein, we assess the antioxidant potential of core-shell yttrium oxide nanoparticles functionalized with ethylene glycol methacrylate phosphate (EGMP). The antioxidant properties of these nanoparticles were investigated in heat stressed models of 21 rats (heat stressed group, group B). Different samples of blood, ser...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02036-8
更新日期：2020-11-01 00:00:00
abstract：:Selenomethionine metabolism and the biochemical basis for its cytotoxicity were analyzed in cultured human and murine lymphoid cells. The metabolic pathways were also addressed, using purified mammalian enzymes and crude tissue extracts. Selenomethionine was found to be effectively metabolized to S-adenosylmethionine ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02990463
更新日期：1991-01-01 00:00:00
abstract：:We investigated the possible correlation between the leptin concentration and the Zn/Cu ratio in the plasma of women with thyroid disorder. Forty women with hypothyroidism (n = 20) or hypothyroidism (n = 20) and 20 euthyroid controls were recruited. The results showed that the women with thyroid disorder (hypothyroidi...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1385/BTER:75:1-3:99
更新日期：2000-07-01 00:00:00
abstract：:Copper is an essential trace element with various biological functions. Excess copper, however, is extremely toxic, leading to many pathological conditions that are consistent with oxidative damage to membranes and molecules. Exposure to high levels of copper results in various changes in the tissues. In liver, hypert...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:96:1-3:209
更新日期：2003-01-01 00:00:00
abstract：:The exposure of toxic elements may directly or indirectly associate with different pathogenesis of heart diseases. In the present study, the association of arsenic (As), cadmium (Cd), cobalt (Co), lead (Pb), and nickel (Ni) in biological samples (whole blood and urine) and mortality from myocardial infarction (MI) pat...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8713-2
更新日期：2011-06-01 00:00:00
abstract：:Copper (Cu) parenteral administration is used in a beef cow-calf operations to prevent or correct Cu deficiency in bovines. At present, Zinc (Zn) salts have been incorporated to complement Cu antioxidant effect. A risk of hepatotoxicity generated by overdose is a negative consequence of injectable Cu application. Cu-Z...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-0965-7
更新日期：2017-10-01 00:00:00
abstract：:Since waterborne minerals appear in ionic form and are readily absorbed by the gastrointestinal tract, drinking water could be a crucial source of mineral intake. However, no comprehensive research has yet determined how trace elements in drinking water relate to body composition. We aimed to assess the relationship b...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-016-0779-z
更新日期：2017-02-01 00:00:00
abstract：:Rare earth elements (REEs) have been widely used to increase accumulation of biomass and secondary metabolites in medicinal plants in China. However, very few studies have investigated how REEs mediate secondary metabolism synthesis in medicinal plants. Lanthanum (La), an important REE, is known to improve the accumul...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9379-8
更新日期：2012-09-01 00:00:00
abstract：:An experiment was conducted in a 3 × 3 (Cu × Zn) factorial experiment based on a completely randomized design to evaluate the effects of dietary copper and zinc on apparent mineral retention and serum biochemical indicators in young male mink on a corn-fish meal based diet. Animals were fed basal diets supplemented wi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0220-4
更新日期：2015-05-01 00:00:00
abstract：:Zinc and fluorides are capable of modifying the process of bone formation and mineralization. Statistically significant differences have been revealed in the content of zinc and fluorides between structures of the femur in chicken. The content of zinc in compact bone remained constant during the first 50 d of life. Lo...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:91:1:67
更新日期：2003-01-01 00:00:00
abstract：:Overall nutritional status has been proved associated with people's health. The overall nutritional status of children in Kashin-Beck disease (KBD) areas has been overlooked for decades. Therefore, it is worth investigating in the current generation to gather evidence and make suggestions for improvement. A cross-sect...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1154-4
更新日期：2018-06-01 00:00:00
abstract：:Samples of Evernia prunastri, collected in a mountainous zone, were exposed in urban and highly industrialized areas in order to monitor the atmospheric pollution. Amounts of Cr, Mn, Fe, Ni, Cu, Zn, and Pb were determined by EDXRF spectrometry in secondary target excitation mode and in the thin film approach. An incre...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917318
更新日期：1994-10-01 00:00:00
abstract：:We investigated the effects of zinc supplementation in case of moderate growth retardation in which GH treatment could not be used. Zamic (ZA, an association containing arginine, L-methionine, and zinc; from Aguettant pharmaceuticals) was compared with arginine aspartate (AA) (5 g) in a crossover randomized trial (6 m...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02789076
更新日期：1995-04-01 00:00:00
abstract：:The toxicological literature is replete with studies attempting to explain the mechanism of action of organophosphorus (OP) insecticides to their anticholinesterase activities, but not much is known about the metabolism and detoxification of these compounds. The goal of this study was to ascertain the toxic effects of...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:74:2:171
更新日期：2000-05-01 00:00:00
abstract：:For this study, we investigate more deeply the effect calcium (Ca) develops on the mechanism underlying fluoride-triggered osteocyte apoptosis. We detected the morphology of osteocytes by HE staining, mitochondrial microstructure by using the transmission electron microscope, and the biochemical indexes related to bon...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02305-6
更新日期：2020-07-25 00:00:00
abstract：:This study was to investigate the alterations of serum copper homeostasis after hypertensive intracerebral hemorrhage (ICH), which is not yet clear. We recruited 85 hypertensive ICH patients and determined their serum levels of total copper (TCu), small molecule copper (SMC), and ceruloplasmin (Cp). Sera from 32 healt...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1227-4
更新日期：2018-09-01 00:00:00
abstract：:The contribution of gamma-ray scattering to the total efficiency for point-source geometries in a gamma spectrometer was measured. Scattering of gamma-rays on the shield and in the sample was considered. For a 25% efficiency detector in a small shield, about a 1% contribution to the total efficiency was measured, wher...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917374
更新日期：1994-10-01 00:00:00
abstract：:Aluminum (Al) has various adverse effects on health of humans and animals. The aim of present study was to demonstrate that Lactobacillus plantarum CCFM639 can alleviate the adverse effects on liver and kidney of mice caused by chronic Al exposure. Animals were assigned into control, CCFM639 only, Al only, Al plus CCF...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0843-8
更新日期：2017-04-01 00:00:00
abstract：:Bioenvironmental trace elements play a vital role in plant, animal, and man metabolism. This study aims to determine trace element concentration in different parts (pods, pericarp, seeds, cotyledon, and taste) of the warm climate plant pigeon pea (Cajanus cajan L. Millsp.). The pigeon pea pods were collected from the ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02256-y
更新日期：2020-06-20 00:00:00
abstract：:Spinal fusion is among the most frequently applied spinal surgical procedures. The goal of the present study was to evaluate whether the local administration of boric acid (BA) improves spinal fusion in an experimental spinal fusion model in rats. Currently, there is no published data that evaluates the possible posit...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0274-y
更新日期：2015-09-01 00:00:00
abstract：:In vivo and in vitro studies were conducted to investigate the chemical forms by ion-exchange chromatography of selenium (Se) present in rat and ovine spermatozoa. After injection with 75Se-selenite, the form of 75Se in rat sperm was selenocysteine, but selenocysteine and selenomethionine (SeMet) were present in ovine...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/bter:76:2:161
更新日期：2000-08-01 00:00:00
abstract：:The origins of the usage of different substances in beauty, skin, body, hair, and nails care products can be found in ancient times. To achieve better quality and enhance their effects, some additives such as preservatives, stabilizers, mineral pigments, dye, and shine were added to these products. Some of these subst...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0477-2
更新日期：2016-04-01 00:00:00
abstract：:This experiment was designed to assess the effect of chronic fenvalerate toxicity on tissue Cu concentration in goats and to explore the pathways responsible for it. A significant decrease in tissue Cu concentration of kidney, heart, and brain while an increase in the liver were recorded in fenvalerate intoxicated goa...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8629-x
更新日期：2010-12-01 00:00:00
