Abstract:
:This study was to investigate the alterations of serum copper homeostasis after hypertensive intracerebral hemorrhage (ICH), which is not yet clear. We recruited 85 hypertensive ICH patients and determined their serum levels of total copper (TCu), small molecule copper (SMC), and ceruloplasmin (Cp). Sera from 32 healthy persons and 12 primary hypertension patients were collected and analyzed as well. Serum TCu levels in ICH patients were tested at three time points (on admission, day 3, and day 7) and found to be higher than that in hypertension patients (p < 0.05). The serum SMC levels in hypertension patients and ICH patients at three time points were higher than that in healthy controls (p < 0.05). Higher serum SMC levels on days 3 and 7 were associated with death in the hospital. Additionally, higher serum SMC levels on the seventh day were associated with poor outcome at discharge. High serum Cp levels on admission, as well as low serum Cp levels on the seventh day, were associated with death in the hospital (p = 0.002 and p = 0.034, respectively). Our findings indicated that declines in serum Cp and increases in serum SMC are correlated with lethal or poor outcome in hypertensive ICH patients, possibly as a result of contributions to secondary injury of brain after hemorrhage due to impairment of iron transport and enhanced oxidative stress.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Han M,Ding S,Zhang Y,Lin Z,Li Kdoi
10.1007/s12011-017-1227-4subject
Has Abstractpub_date
2018-09-01 00:00:00pages
56-62issue
1eissn
0163-4984issn
1559-0720pii
10.1007/s12011-017-1227-4journal_volume
185pub_type
杂志文章abstract::The toxic mechanism of La3+ to Escherichia coli is investigated by detecting the concentration change of La3+ in E. coli cells growing in La3+-containing medium. Stimulatory action and inhibitory effect of La3+ in different concentrations can be attributed to the permeability alteration of the cell. Low concentration ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/bter:114:1:293
更新日期:2006-01-01 00:00:00
abstract::Samples of Evernia prunastri, collected in a mountainous zone, were exposed in urban and highly industrialized areas in order to monitor the atmospheric pollution. Amounts of Cr, Mn, Fe, Ni, Cu, Zn, and Pb were determined by EDXRF spectrometry in secondary target excitation mode and in the thin film approach. An incre...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917318
更新日期:1994-10-01 00:00:00
abstract::It has been demonstrated that zinc exerts its beneficial influence on skin fibroblasts. Propolis, a complex mixture of plant-derived and bees' products, was reported to stimulate cicatrization processes in skin and prevent infections. The aim of this study was to find out how zinc and propolis influence human skin fib...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0019-3
更新日期:2014-07-01 00:00:00
abstract::Endemic waterborne fluorosis is a public health problem in Isparta, a city located in southern Turkey. Fluoride is a cumulative element that increases metabolic turnover of the bone and also affects the homeostasis of bone mineral metabolism. There are number of similarities between the effects of excess parathyroid h...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8847-2
更新日期:2011-10-01 00:00:00
abstract::This study was performed with the aim of investigating the concentration of zinc and copper in the blood of healthy alpacas (Vicugna pacos) kept in central Europe and to compare the concentration of Zn and Cu in plasma and in whole blood. A further objective was to evaluate blood Zn and Cu in relation to different mic...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1043-x
更新日期:2018-02-01 00:00:00
abstract::The authors present a simple and rapid method for assaying ultrafilterable copper (Cu UF) and albumin-bound copper (Cu ALB). It is based on the ultrafiltration of serum in the presence of ethylenediaminetetraacetic acid (EDTA), used to prevent adsorption on the membranes. EDTA at 0.4 g/L has no effect on the equilibri...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917499
更新日期:1988-12-01 00:00:00
abstract::Instrumental epithermal neutron activation analysis was used in determining the halide concentration of camel serum. The halides determined were sodium, chloride, bromide, and iodide. Serum was examined when the camels had free access to drinking water, following 10 d of water restriction and 2 h following rapid rehyd...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02796697
更新日期:1987-04-01 00:00:00
abstract::The selenium levels and the glutathione peroxidase activity GSH-PX of whole blood and of erythrocytes, respectively, were determined in 139 normal Danes and related to sex and smoking habits. No differences were found in relation to sex apart from a higher GSH-PX activity of females when assayed with tertiary butyl hy...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/BF02990131
更新日期:1988-01-01 00:00:00
abstract::Lipid disturbance induced by high-fat diet is a worldwide problem, and it can induce inflammation and oxidative stress in vivo. Zinc is considered as an antioxidant, anti-inflammatory agent. Since matrix metalloprotease 2 (MMP2) and matrix metalloprotease 9 (MMP9)'s expressions are changed under many pathological cond...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0367-7
更新日期:2015-12-01 00:00:00
abstract::Trace elemental content was analysed in edible tissues of Mytilus galloprovincialis collected in five different sampling areas near the mouth of river Tagus estuary in Lisbon. The concentrations of essential elements (S, K, Ca, Fe, Cu, Zn, As, Br and Sr) were determined by energy-dispersive X-ray fluorescence (EDXRF) ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9974-y
更新日期:2014-06-01 00:00:00
abstract::Nutritional profile of minerals and antioxidants in Indian spice extracts was evaluated in order to examine their efficacy in treating various diseases, disorders, and allergies in human health. Extracts of four medicinal plants such as Curcuma longa, Zingiber officinale, Piper nigrum, and Piper longum, regularly cons...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02228-2
更新日期:2021-03-01 00:00:00
abstract::The effect of low copper and high zinc intakes on Cu,Zn-superoxide dismutase (Cu,Zn-SOD) activity and mammary tumorigenesis induced by 9,10-dimethyl-1,2-benzanthracene (DMBA) was investigated. Groups of 40 weanling female Sprague-Dawley rats were fed a modified AIN-76 diet containing the following (/kg diet): 1 mg Cu ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02990343
更新日期:1991-07-01 00:00:00
abstract::Copper is an integral part of many important enzymes involved in a number of vital biological processes. Even though it is essential to life, at elevated tissue concentrations, copper can become toxic to cells. Recent studies have reported oxidative damage due to copper in various tissues. Considering the vulnerabilit...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9320-1
更新日期:2012-06-01 00:00:00
abstract::Analysis of variance, analysis of covariance, correlation coefficient, multiple correlation, and partial correlation coefficient statistical tests were applied to Cs, Cr, Co, Fe, Rb, Sc, Se, and Zn content in human ovaries in order to evaluate statistically the possible relationships between these trace elements at: t...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784090
更新日期:1996-04-01 00:00:00
abstract::Copper is an essential trace element with various biological functions. Excess copper, however, is extremely toxic, leading to many pathological conditions that are consistent with oxidative damage to membranes and molecules. Exposure to high levels of copper results in various changes in the tissues. In liver, hypert...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:96:1-3:209
更新日期:2003-01-01 00:00:00
abstract::Hexavalent chromium (Cr(VI)) is present in the marine environment and is a known carcinogen and reproductive toxicant. Cr(VI) is the form of chromium that is well absorbed through the cell membrane. It is also the most prevalent form in seawater. We measured the total Cr levels in skin biopsies obtained from healthy f...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0311-x
更新日期:2015-07-01 00:00:00
abstract::Negative potassium balance during hypokinesia (decreased number of kilometers taken/day) is not based on the potassium shortage in the diet, but on the impossibility of the body to retain potassium. To assess this hypothesis, we study the effect of potassium loading on athletes during prolonged hypokinesia (HK). Studi...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/BF02783845
更新日期:1999-10-01 00:00:00
abstract::The effects of 10 wk of selenium (Se) supplementation (5 ppm) in drinking water on immune responses and resistance to a myocarditic Coxsackie virus B3 (CB3) infection were studied in female Balb/c mice. Se supplementation reduced CB3-induced mortality: at day 14 postinoculation, survival was 58% in the Se-treated grou...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785277
更新日期:1998-07-01 00:00:00
abstract::Selenium (Se) mainly performs its function through Se-containing proteins. Selenoprotein W (SelW), one member of the selenoprotein family, plays important roles in the normal function of the heart. To investigate the possible relationship between Se and SelW for the regulation of oxidative damage in chicken embryo myo...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0529-7
更新日期:2016-06-01 00:00:00
abstract::Obesity, a chronic inflammatory state, is associated with altered zinc metabolism. ZnT and Zip transporters are involved in the regulation of zinc metabolism. This study examined the relationships among obesity, zinc transporter gene expression, and inflammatory markers in young Korean women. The messenger RNA (mRNA) ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9902-1
更新日期:2014-04-01 00:00:00
abstract::In brain, excess zinc alters the metabolism of amyloid precursor protein, leading to β-amyloid protein deposition, one of the hallmarks of Alzheimer's disease (AD) pathology. Recently, it has been reported that zinc accelerates in vitro tau fibrillization, another hallmark of AD. In the current study, we examined the ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9411-z
更新日期:2012-11-01 00:00:00
abstract::This meta-analysis was conducted aiming to summarize the results obtained from the previous studies so that the effect of opium on blood lead levels (BLLs) can be investigated. Scopus, Embase, PubMed, and Web of Science (ISI) were systematically searched up to June 2020. Heterogeneity of the included studies was evalu...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02504-1
更新日期:2020-11-26 00:00:00
abstract::Adverse effects of mercury on female reproduction are reported; however, its effect on myogenic activity of uterus and mechanism thereof is obscure. Present study was undertaken to unravel the mechanistic pathways of mercuric chloride (HgCl2)-induced myometrial contraction in rats. Isometric tension in myometrial stri...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1379-x
更新日期:2019-02-01 00:00:00
abstract::Zinc and fluorides are capable of modifying the process of bone formation and mineralization. Statistically significant differences have been revealed in the content of zinc and fluorides between structures of the femur in chicken. The content of zinc in compact bone remained constant during the first 50 d of life. Lo...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:91:1:67
更新日期:2003-01-01 00:00:00
abstract::Manganese (Mn) is an essential element for normal development and bodily functions in humans. In the present study, we examined whether Mn supplementation can alter the serum lipid parameters and liver function in Ca-deficient ovariectomized (OVX) rats. Sixty female Sprague-Dawley rats (6 weeks) were divided into five...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8714-1
更新日期:2011-06-01 00:00:00
abstract::In this study, eight kinds of nickel (Ni) compounds were orally administered to Wistar male rats and the distribution of each compound was investigated 24 h after the administration. The Ni compounds used in this experiment were nickel metal [Ni-M], nickel oxide (green) [NiO(G)], nickel oxide (black) [NiO(B)], nickel ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02789001
更新日期:1995-07-01 00:00:00
abstract::Plasma concentrations of a zinc carrier peptide, namely thymulin, were measured according to a bioassay in young donors, healthy elderly, and patients with senile dementia of Alzheimer's type (SDAT). Thymulin is a hormone released by thymic epithelial cells and its biological activity on cells of immune system is depe...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02790147
更新日期:1996-01-01 00:00:00
abstract::Deficiency in the intake of trace elements, such as copper (Cu), iron (Fe), selenium (Se), and zinc (Zn), is very common in the general population of most developing countries. A preliminary study in India and Pakistan showing the plasma levels of Zn and Fe indicates that approx 50% of the subjects who participated ha...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02789092
更新日期:1998-03-01 00:00:00
abstract::Women with preeclampsia have been shown to have elevated blood levels of the metabolite homocysteine, and alterations in blood levels of zinc and copper have also been reported. This study measured plasma levels of zinc, copper, and homocysteine in women with preeclampsia and in women with healthy, normotensive pregna...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:104:2:097
更新日期:2005-05-01 00:00:00
abstract::In this study, a new method was developed for the pre-concentration of trace mercury from seafood samples prior to analysis by spectrophotometry. The method is based on the complexation between 2-hydrazinobenzothiazole (2-HBT)-modified copolymer(s) and Hg(II) in the presence of an ionic surfactant, cetyltrimethylammon...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1614-5
更新日期:2019-09-01 00:00:00