Abstract:
:In this study, eight kinds of nickel (Ni) compounds were orally administered to Wistar male rats and the distribution of each compound was investigated 24 h after the administration. The Ni compounds used in this experiment were nickel metal [Ni-M], nickel oxide (green) [NiO(G)], nickel oxide (black) [NiO(B)], nickel subsulfide [Ni3S2], nickel sulfide [NiS], nickel sulfate [NiSO4], nickel chloride [NiCl2], and nickel nitrate [Ni(NO3)2]. The solubilities of the nickel compounds in saline solution were in the following order; [Ni(NO3)2 > NiCl2 > NiSO4] > [NiS > Ni3S2] > [NiO(B) > Ni-M > NiO(G)]. The Ni level in the visceral organs was higher in the rats given soluble Ni compounds; Ni(NO3)2, NiCl2, NiSO4, than that in the rats receiving other compounds. In the rats to which soluble Ni compounds were administered, 80-90% of the recovered Ni amounts in the examined organs was detected in the kidneys. On the other hand, the Ni concentration in organs administered scarcely soluble Ni compounds; NiO(B), NiO(G), and Ni-M were very low. The estimated absorbed fraction of each Ni compounds was increased with the increase of the solubility. These results suggest that the kinetic behavior of Ni compounds administered orally is closely related with the solubility of Ni compounds, and that the solubility of Ni compounds is one of the important factors for determining the health effect of Ni compounds.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Ishimatsu S,Kawamoto T,Matsuno K,Kodama Ydoi
10.1007/BF02789001subject
Has Abstractpub_date
1995-07-01 00:00:00pages
43-52issue
1eissn
0163-4984issn
1559-0720journal_volume
49pub_type
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更新日期:2003-07-01 00:00:00
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更新日期:2001-03-01 00:00:00
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pub_type: 撤回出版物
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更新日期:2013-01-01 00:00:00
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更新日期:2008-01-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章,随机对照试验
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