Abstract:
:Recent studies have identified a new existence of a genetically programmed and regulated cell death characterized by necrotic cell death morphology, termed necroptosis. Lead (Pb) is a ubiquitously distributed environmental pollutant that is highly toxic to animals and human beings. However, no detailed report has been conducted on the necroptosis in lymphocytes caused by Pb. Selenium (Se), a trace element in the body, has been shown to exert cytoprotective effect in numerous pathological injury caused by heavy metals. Here, lymphocytes isolated from chicken spleen were divided into four groups, control group, Se group, Pb group, and Pb + Se co-treatment group to investigate the potential mechanism in the necroptosis triggered by Pb and in the antagonistic effect of Se on Pb toxicity. Flow cytometry analysis and AO/EB staining showed Pb caused typical necrosis characteristics in the lymphocytes. The expression of RIP1, RIP3, and MLKL was increased, whereas the level of caspase 8 was declined in Pb group, which proved the occurrence of necroptosis. Meanwhile, Pb exposure disrupted the antioxidant enzyme (SOD, GSH-Px, and CAT) balance, promoted the expression of MAPK/NF-κB pathway factors (ERK, JNK, p38, NF-κB, and TNF-α), and activated HSPs (HSP27, HSP40, HSP60, HSP70, and HSP90). However, those Pb-induced changes were significantly alleviated in Se + Pb group. Our study revealed that Pb could trigger lymphocyte necroptosis through MAPK/NF-κB pathway activated by oxidative stress and that Se could antagonize Pb-induced necroptosis in chicken lymphocytes.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Zhang J,Hao X,Xu Sdoi
10.1007/s12011-020-02094-ysubject
Has Abstractpub_date
2020-12-01 00:00:00pages
644-653issue
2eissn
0163-4984issn
1559-0720pii
10.1007/s12011-020-02094-yjournal_volume
198pub_type
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journal_title:Biological trace element research
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journal_title:Biological trace element research
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journal_title:Biological trace element research
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更新日期:2019-07-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Biological trace element research
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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