Abstract:
:Selenomethionine metabolism and the biochemical basis for its cytotoxicity were analyzed in cultured human and murine lymphoid cells. The metabolic pathways were also addressed, using purified mammalian enzymes and crude tissue extracts. Selenomethionine was found to be effectively metabolized to S-adenosylmethionine analog, and that analog was further metabolized in transmethylation reactions and in polyamine synthesis, similarly to the corresponding sulphur metabolites of methionine. Selenomethionine did not block these pathways, nor was there a specific block on the synthesis of DNA, RNA, or proteins when added to the culture medium. Selenomethionine showed cytotoxicity at above 40 microM levels. Yet, low selenomethionine levels (10 microM) could replace methionine and support cell growth in the absence of methionine. Selenomethionine toxicity took place concomitantly with changes in S-adenosylmethionine pools. D-form was less cytotoxic than L-form. Methionine concentration modified the cytotoxicity. Together, this indicates that selenomethionine uptake and enzymic metabolism are involved in the cytotoxicity in a yet unknown way.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Kajander EO,Harvima RJ,Eloranta TO,Martikainen H,Kantola M,Kärenlampi SO,Akerman Kdoi
10.1007/BF02990463subject
Has Abstractpub_date
1991-01-01 00:00:00pages
57-68issue
1eissn
0163-4984issn
1559-0720journal_volume
28pub_type
杂志文章abstract::Neonatal uptake of mercury (Hg) from milk was examined in a pregnant sheep model, where radioactive mercury (Hg203)/silver tooth fillings (amalgam) were newly placed. A crossover experimental design was used in which lactating ewes nursed foster lambs. In a parallel study, the relationship between dental history and b...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785388
更新日期:1997-02-01 00:00:00
abstract::A study was conducted to validate the effects of nano form of zinc (NZn) on nutrient digestibility, zinc retention, organ and serum zinc profile, and hepatic metallothionein gene expression in Wistar albino rats (WAR). Nano zinc (NZn) was synthesized through chemical method, by using 0.45 M zinc nitrate [Zn(NO3)2.6H2O...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1517-5
更新日期:2019-07-01 00:00:00
abstract::This study was designed to investigate the pro-inflammatory cytokines and their involvement in the cytotoxic potential of fluoride (F) in HeLa cells. HeLa cells were cultured with varying F concentrations (1-50 mg/L) for 48 h, and treatment effects were analyzed. The viability of HeLa cells was determined with a color...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-016-0749-5
更新日期:2017-01-01 00:00:00
abstract::The effect of ad libitum ingestion of selenium (Se) in drinking water (0.15 mg SeO2/L) for 3 wk on the brain weight, total brain protein, glutathione (GSH) level, catalase activity, and lipid peroxidation in the brain of protein-undernourished (PU) rats was investigated, in an attempt to determine whether antioxidants...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02685933
更新日期:2007-05-01 00:00:00
abstract::In this study, hair levels of Cu and Zn were determined in healthy male and female individuals (n = 192) ages 3.6-14.5 yr and the correlations with Cu and Zn daily intakes were examined. Determinations of Cu and Zn concentrations were performed by way of atomic absorption spectrometry and X-ray fluorescence. Nutrition...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02950788
更新日期:1994-02-01 00:00:00
abstract::Multielemental detection using Instrumental Neutron Activation Analysis (INAA) and Proton-Induced X-Ray Emission (PIXE) of drinkable water of Florence (Italy) is described. The concentrations of 52 elements were measured. No chemical treatment was performed on the samples, before or after irradiation. On the basis of ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02992691
更新日期:1990-07-01 00:00:00
abstract::The aim of the current study was to assess relationships between multiple metals burden in human seminal plasma and semen quality parameters. Levels of five metals (lead, manganese, copper, arsenic, and selenium) in human seminal plasma were determined by inductively coupled plasma mass spectrometry (ICP-MS), and the ...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/s12011-012-9335-7
更新日期:2012-07-01 00:00:00
abstract::The control of metallothionein (MT) synthesis was investigated in freshly prepared rat hepatocytes in experiments of short-term duration. Viability and metabolic function were maintained in incubations of 6-h duration. MT synthesis was measurable in hepatocytes from fed rats at Zn concentrations down to 1 microM. Zn a...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783778
更新日期:1993-01-01 00:00:00
abstract::This paper reports the synthesis of a new bioactive complex, 8-hydroxyquinolinato-bis-(salicylato) yttrium (III) (HSAY), whose composition and structure were characterized by elemental analysis, IR spectra, thermogravimetric analysis, and X-ray diffraction. The power-time curves of the compounds HSAY, C(7)H(6)O(3), C(...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9297-1
更新日期:2012-06-01 00:00:00
abstract::The effects of Spirulina maxima supplementation on calcium, magnesium, iron, and zinc status were studied in a double-blind placebo-controlled trial of 50 obese subjects with treated hypertension, each randomized to receive 2 g of spirulina or a placebo daily for 3 months. At baseline and after treatment, the calcium,...
journal_title:Biological trace element research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12011-016-0623-5
更新日期:2016-09-01 00:00:00
abstract::The contribution of gamma-ray scattering to the total efficiency for point-source geometries in a gamma spectrometer was measured. Scattering of gamma-rays on the shield and in the sample was considered. For a 25% efficiency detector in a small shield, about a 1% contribution to the total efficiency was measured, wher...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917374
更新日期:1994-10-01 00:00:00
abstract::The humoral immune response was evaluated in male CD-1 mice fed the iron deficient (7 ppm Fe), iron sufficient (120 ppm Fe), and high-iron diets (3000 or 5000 ppm Fe) for 54 d. The IgM and IgG antibody responses against sheep erythrocytes (SRBC) determined by hemolytic plaque assay were suppressed by 65.4 and 51.2%, r...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02790075
更新日期:1994-10-01 00:00:00
abstract::Plasma chromium concentrations have been determined for 150 patients. These were subjected to coronary artery cineangiography and thereby divided into three groups: group CAD (those with coronary artery disease), group HD (those with heart disease, but no CAD) and group N (those with no CAD and no HD). Weighted, avera...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02989260
更新日期:1984-10-01 00:00:00
abstract::The study was conducted to determine the effects of iron glycine chelate (Fe-Gly) on growth, tissue mineral concentrations, fecal mineral excretion, and liver antioxidant enzyme activities in broilers. A total of 360 1-day-old commercial broilers (Ross × Ross) were randomly allotted to six dietary treatments with six ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9418-5
更新日期:2012-11-01 00:00:00
abstract::The effects of cerium oxide nanoparticles on the proliferation, differentiation, and mineralization function of primary osteoblasts in vitro were evaluated. The results showed that the cell biological effects of cerium oxide nanoparticles varied with different diameters. The cytotoxicity of cerium oxide nanoparticles ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9655-2
更新日期:2013-06-01 00:00:00
abstract::Strontium (Sr) ralenate is a new agent used for the prevention and treatment of osteoporosis. As a bone-seeking element, 98% of Sr is deposited in the bone and teeth after oral ingestion. However, the effect of Sr treatment on bone microarchitecture and bone nanomechanical properties remains unclear. In this study, 18...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9158-y
更新日期:2012-01-01 00:00:00
abstract::The effect of aging on the status of macrominerals and trace elements in tissues was studied using two strains (SAMP1 and SAMR1) of senescence accelerated mouse. Two-month-old, 6-mo-old, and 10-mo-old female SAMP1 and SAMR1 mice were fed a commercial diet. Iron, zinc, copper, calcium, magnesium, phosphorus, sulfur, so...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:80:1:53
更新日期:2001-04-01 00:00:00
abstract::Zinc is a nutritionally essential trace element required for many biological functions to be successfully carried out. The aim of the present work was to study the influence of zinc on the intestinal absorption of L-threonine and on the aminopeptidase N activity in rabbit jejunum, after in vitro addition and/or oral a...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784557
更新日期:1996-07-01 00:00:00
abstract::This study aimed to determine the effect of excessive fluoride (F) on the morphological characteristics of the small intestine and the contents of serum cytokines in rats. A total of 48 3-week-old healthy female Sprague-Dawley rats were randomly divided into four groups (n = 12). The control group was given deionized ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1503-y
更新日期:2019-06-01 00:00:00
abstract::Activity of the immunoregulatory peptide thymulin reflects differences in zinc status. This study compared thymulin activity with four other zinc status measures in rats fed zinc at either 5 or 25 ppm. Rats fed the lower zinc showed the following results compared with rats with adequate zinc intake: serum thymulin act...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02159-y
更新日期:2021-02-01 00:00:00
abstract::Chromium picolinate is used in the poultry diet because of its antistress effects in addition to the fact that the requirement for it is increased during stress. This study was conducted to determine if the negative effects of high ambient temperature (34 degrees C) on egg production, egg quality, antioxidant status, ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:101:2:181
更新日期:2004-11-01 00:00:00
abstract::We investigated the effect of exercise on iron metabolism in horses. Four horses were walked on a mechanical walker for 1 wk (pre-exercise). They then performed moderate exercise on a high-speed treadmill in the first week of the exercise and relative high in the second week and high in the third week. Serum iron was ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:107:1:033
更新日期:2005-10-01 00:00:00
abstract::Smoking is one of the major causes of mortality and numerous diseases, both directly and indirectly. The role of smoking as a significant risk factor is already known in several human diseases such as cardiovascular diseases, lung cancer, and chronic obstructive pulmonary disease. We aimed to compare the toxicity of h...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02537-6
更新日期:2021-01-20 00:00:00
abstract::The present study was undertaken to evaluate methylmercury-induced alterations in hepatic enzymes and oxidative stress markers in liver tissue of rainbow trout (Oncorhynchus mykiss) by using a perfusion method, and to explore possible protective effect of vitamin C against these alterations. Forty-eight fish were divi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0241-7
更新日期:2015-05-01 00:00:00
abstract::Plasma concentrations of a zinc carrier peptide, namely thymulin, were measured according to a bioassay in young donors, healthy elderly, and patients with senile dementia of Alzheimer's type (SDAT). Thymulin is a hormone released by thymic epithelial cells and its biological activity on cells of immune system is depe...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02790147
更新日期:1996-01-01 00:00:00
abstract::This study is aimed at investigating the inhibitory effect of cadmium ion on glutathione reductase activity of rabbit brain and liver and the relationship of this effect with dietary selenium. For this purpose, one group of New Zealand rabbits were fed a selenium-deficient diet, another group was fed a selenium-rich d...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/bter:91:2:151
更新日期:2003-02-01 00:00:00
abstract::Intraperitoneal administration of zinc chloride (ZnCl2) to Swiss albino mice in vivo induced a significant (p less than or equal to 0.05) increase in the frequencies of chromosomal aberrations of the bone-marrow cells at all concentrations used following acute (7.5, 10, 15 mg/kg body weight) and chronic (2.0, 3.0 mg/k...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02990346
更新日期:1991-08-01 00:00:00
abstract::Serum selenium levels were determined cross-sectionally in 57 HIV-infected patients who were classified according to the Centers for Disease Control (CDC) 1993 classification system. Mean serum selenium levels were lower in CDC stage II (58.7 +/- 12.2 micrograms/L; p < 0.01; n = 18) and stage III (47.6 +/- 11.3 microg...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02778982
更新日期:1997-01-01 00:00:00
abstract::Previous studies on the endodontic broken stainless steel instruments have mainly focused on retrieval of specimens. However, the systemic consequences of the retained separated instruments need an investigation. The current study aimed to evaluate the correlation between broken stainless steel instruments inside the ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9959-x
更新日期:2014-06-01 00:00:00
abstract::Melipona quadrifasciata anthidioides is a species of stingless bee popularly known in Brazil as "mandaçaia". Products derived from bees for food and therapeutic uses, have stimulated the evaluation of the chemical composition of geopropolis. Concentrations of 24 essential and potentially toxic elements were determined...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02455-7
更新日期:2020-10-23 00:00:00