Microarchitecture and nanomechanical properties of trabecular bone after strontium administration in osteoporotic goats.

Abstract:

:Strontium (Sr) ralenate is a new agent used for the prevention and treatment of osteoporosis. As a bone-seeking element, 98% of Sr is deposited in the bone and teeth after oral ingestion. However, the effect of Sr treatment on bone microarchitecture and bone nanomechanical properties remains unclear. In this study, 18 osteoporotic goats were divided into four groups according to the treatment regimen: control, calcium alone (Ca), calcium and Sr at 24 mg/kg (Ca + 24Sr), and calcium and Sr at 40 mg/kg (Ca + 40Sr). The effects of Sr administration on bone microarchitecture and nanomechanical properties of trabecular bones were analyzed with micro-CT and nanoindentation test, respectively. Serum Sr levels increased six- and tenfold in the Ca + 24Sr and Ca + 40Sr groups, respectively. Similarly, Sr in the bone increased four- and sixfold in these two groups. Sr administration significantly increased trabecular bone volume fraction, trabecular thickness, and double-labeled new bone area. Sr administration, however, did not significantly change the nanomechanical properties of trabecular bone (elastic modulus and hardness). The data suggested that Sr administration increased trabecular bone volume and improved the microarchitecture while maintaining the intrinsic tissue properties in the osteoporotic goat model.

journal_name

Biol Trace Elem Res

authors

Li Z,Peng S,Pan H,Tang B,Lam RW,Lu WW

doi

10.1007/s12011-011-9158-y

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

39-46

issue

1

eissn

0163-4984

issn

1559-0720

journal_volume

145

pub_type

杂志文章
  • Reversible hypomagnesaemia-induced subacute cerebellar syndrome.

    abstract::Magnesium is the second most abundant intracellular cation and is a fundamental cofactor in a multitude of cellular enzymatic reactions. Magnesium deficiency causes diverse clinical features predominantly due to cardio- and neurotoxicity. We describe a case of severe hypomagnesaemia associated with intermittent downbe...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-010-8757-3

    authors: Sedehizadeh S,Keogh M,Wills AJ

    更新日期:2011-08-01 00:00:00

  • The interactions between the chronic exposure to Aluminum and liver regeneration on bile flow and organic anion transport in rats.

    abstract::The chronic exposure to Aluminum (Al) may compromise different liver functions, mainly during the hepatic regeneration. The aim of this study is to investigate the interactions between the chronic i.p. exposure to Al and hepatic regeneration (HR) on bile flow and organic anion transport in experimental animals. For th...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-008-8234-4

    authors: González MA,Bernal CA,Mahieu S,Carrillo MC

    更新日期:2009-02-01 00:00:00

  • Presence of Toxic Heavy Metals in Platelet-Rich Fibrin: a Pilot Study.

    abstract::Platelet-rich fibrin (PRF) is widely used blood-derived biomaterial which is directly applied to the surgical wounds. Depending on its autologous origin, PRF is thought as a safe material. However, it is not known to what extent the blood-derived toxins can be found in the PRF by considering the systemic exposure rate...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-019-01695-6

    authors: Yaprak E,Yolcubal İ

    更新日期:2019-10-01 00:00:00

  • Effects of iron(II) salts and iron(III) complexes on trace element status in children with iron-deficiency anemia.

    abstract::Iron-deficiency anemia (IDA) is the most common nutritional deficiency in childhood throughout the world. Although it has been shown that IRA is associated with elevated plasma copper and depleted zinc levels in children, there are conflicting results on the effect of iron supplementation on the absorption of these el...

    journal_title:Biological trace element research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1385/BTER:94:1:79

    authors: Sözmen EY,Kavakli K,Cetinkaya B,Akçay YD,Yilmaz D,Aydinok Y

    更新日期:2003-07-01 00:00:00

  • Mercury from maternal "silver" tooth fillings in sheep and human breast milk. A source of neonatal exposure.

    abstract::Neonatal uptake of mercury (Hg) from milk was examined in a pregnant sheep model, where radioactive mercury (Hg203)/silver tooth fillings (amalgam) were newly placed. A crossover experimental design was used in which lactating ewes nursed foster lambs. In a parallel study, the relationship between dental history and b...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02785388

    authors: Vimy MJ,Hooper DE,King WW,Lorscheider FL

    更新日期:1997-02-01 00:00:00

  • Selenium-mediated inhibition of mammary carcinogenesis.

    abstract::Using the dimethylbenz(a)anthracene-induced mammary tumor model in rats, our studies indicated that there was a dose-response relationship between dietary selenium supplementation and the inhibition of mammary carcinogenesis. The degree of inhibition was proportional to the level of dietary selenium up to 5 ppm, at wh...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02987217

    authors: Ip C

    更新日期:1983-08-01 00:00:00

  • Effects of taurine on oxidative stress parameters and chromium levels altered by acute hexavalent chromium exposure in mice kidney tissue.

    abstract::The kidney has been regarded as a critical organ of toxicity induced by acute exposure to hexavalent chromium [Cr(VI)] compounds. Reactive intermediates and free radicals generated during reduction process might be responsible for Cr(VI) toxicity. In this study, the effects of pretreatment or posttreatment of taurine ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:102:1-3:209

    authors: Boşgelmez II,Güvendik G

    更新日期:2004-01-01 00:00:00

  • Effect of auxinhormone lanthanide complexes on the growth of wheat coleoptile.

    abstract::Naphthalene-1-acetic acid (HNAA), dichlorophenoxy acetic acid (HDAA), and indole-3-acetic acid (HIAA) are auxinhormones that can affect the growth of plants. The lanthanide complexes of the above auxinhormone LnA3 x 3H2O (Ln = La3+, Ce3+, Sm3+, Er3+, Yb3+; HA = HNAA, HDAA, HIAA; A = NAA-, DAA-, IAA-) were synthesized ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02783322

    authors: Wenmian H,Jian F,Zhengzhi Z

    更新日期:1998-07-01 00:00:00

  • Relationship between serum nickel and homocysteine concentration in hemodialysis patients.

    abstract::Severe hyperhomocysteinemia (HHC) is associated with atherosclerosis. In hemodialysis (HD) patients, one of the main causes of death is cardiovascular disease. In animals, trace elements such as cobalt, copper, iron, and nickel ameliorated vitamin B(12) deficiency-induced HHC. However, correlations between plasma tota...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-008-8139-2

    authors: Katko M,Kiss I,Karpati I,Kadar A,Matyus J,Csongradi E,Posta J,Paragh G,Balla J,Kovacs B,Varga Z

    更新日期:2008-09-01 00:00:00

  • Regional distribution of metallothionein and zinc in the mouse gut: comparison with metallothionien-null mice.

    abstract::Gut Zn homeostatic responses to low, replete, and excess dietary Zn (10, 150, and 400 mg Zn/kg, respectively) were compared in mice with (MT+/+) and without (MT-/-) metallothionein (MT) expression. MT concentrations decreased progressively from stomach (12.9 nmol Cd bound/g) to colon (4.6 nmol Cd bound/g). Small intes...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02778942

    authors: Tran CD,Butler RN,Philcox JC,Rofe AM,Howarth GS,Coyle P

    更新日期:1998-09-01 00:00:00

  • Analyses of impact of metal ion contamination on carp (Cyprinus carpio L.) gill cell suspensions.

    abstract::The decline in fish population because of water contamination is problem. As a result of direct exposure in water, it has been readily accepted that the gills are the main site of water contamination and toxicity (e.g., metal ions). In the present study, we investigated metal ion contamination on the functional capaci...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:100:3:229

    authors: Arabi M

    更新日期:2004-09-01 00:00:00

  • Perinatal Lead Exposure Alters Calsyntenin-2 and Calsyntenin-3 Expression in the Hippocampus and Causes Learning Deficits in Mice Post-weaning.

    abstract::Calsyntenin-2 (Clstn2) and calsyntenin-3 (Clstn3) are the members of the cadherin superfamily and function to regulate the postsynaptic activity. Both proteins are known to play an important role in memory and learning. This study was designed to test the hypothesis that exposure of mothers to Pb in drinking water may...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02241-5

    authors: Li N,Cao S,Yu Z,Qiao M,Cheng Y,Shen Y,Song L,Huang X,Yang G,Zhao Y

    更新日期:2020-06-16 00:00:00

  • The effect of selenium and vitamin E on microvascular permeability of rat organs.

    abstract::The effects of dietary sodium selenite and vitamin E on the microvascular permeability of rat organs such as heart, brain, kidney, liver and eye were investigated by using the Evans blue leakage method. Combined deficiency of selenium and vitamin E caused an increase in the permeability of the heart and eye with respe...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02783332

    authors: Demirel-Yilmaz E,Dinçer D,Yilmaz G,Turan B

    更新日期:1998-07-01 00:00:00

  • Anemia and Iron Status Among Different Body Size Phenotypes in Chinese Adult Population: a Nation-Wide, Health and Nutrition Survey.

    abstract::Previous studies have shown that there is a controversial relationship between iron homeostasis and obesity. This study aims to explore the relationship of anemia and iron status with different body size phenotypes in adult Chinese population. Using information on iron status-related parameters and lifestyle data from...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-017-1213-x

    authors: Li J,Xiao C,Yang H,Zhou Y,Wang R,Cao Y

    更新日期:2018-09-01 00:00:00

  • Associations Between Serum Zinc Levels and Alanine Aminotransferase Elevation in Adults.

    abstract::Recent findings showed that zinc might be linked to alanine aminotransferase (ALT) elevation. This analysis aimed to explore the association between serum zinc levels and ALT elevation in adults. Data on serum zinc and ALT levels from adults aged 20 years and older who participated in the 2011-2016 National Health and...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02318-1

    authors: Hu J,Cai X,Li J,Zheng N,Zhang J

    更新日期:2020-07-31 00:00:00

  • Effect of Dietary Selenium Deficiency on the Cell Apoptosis and the Level of Thyroid Hormones in Chicken.

    abstract::This study assessed the effect of dietary selenium (Se) deficiency on male reproductive function in chicken. A total of 180 Hy-line laying cocks (1 day old; Weiwei) were randomly divided into 2 groups (n = 90) of Se-deficient chickens and control chickens. The control group was fed a basic diet (containing 0.15 mg of ...

    journal_title:Biological trace element research

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s12011-015-0534-x

    authors: Huang Y,Li W,Xu D,Li B,Tian Y,Zan L

    更新日期:2016-06-01 00:00:00

  • Carnosine and Histidine Supplementation Blunt Lead-Induced Reproductive Toxicity through Antioxidative and Mitochondria-Dependent Mechanisms.

    abstract::Lead (Pb)-induced reproductive toxicity is a well-characterized adverse effect associated with this heavy metal. It has been found that Pb exposure is associated with altered spermatogenesis, increased testicular degeneration, and pathological sperm alterations. On the other hand, it has been reported that Pb-induced ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-018-1358-2

    authors: Ommati MM,Jamshidzadeh A,Heidari R,Sun Z,Zamiri MJ,Khodaei F,Mousapour S,Ahmadi F,Javanmard N,Shirazi Yeganeh B

    更新日期:2019-01-01 00:00:00

  • Effects of Supplemental Chromium Source and Concentration on Growth Performance, Carcass Traits, and Meat Quality of Broilers Under Heat Stress Conditions.

    abstract::The objective of this study was to investigate the effects of dietary supplemental chromium (Cr) on growth performance, carcass traits, and meat quality of broilers reared under heat stress. A total of 252 1-d-old Cobb 500 commercial female broilers were randomly allotted by body weight (BW) to one of six replicate ca...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-015-0443-z

    authors: Huang Y,Yang J,Xiao F,Lloyd K,Lin X

    更新日期:2016-03-01 00:00:00

  • Influence of different amounts and sources of selenium supplementation on performance, some blood parameters, and nutrient digestibility in lambs.

    abstract::Two trials were conducted in a 2 × 2 + 1 factorial arrangement based on a completely randomized design to evaluate the effects of different sources of selenium (Se) on performance, blood metabolites, and nutrient digestibility in male lambs on a barley-based diet. The first trial lasted for 70 days and consisted of 30...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-013-9698-4

    authors: Alimohamady R,Aliarabi H,Bahari A,Dezfoulian AH

    更新日期:2013-07-01 00:00:00

  • Plasma levels of trace elements have an implication on interferon treatment of children with chronic hepatitis B infection.

    abstract::This study evaluated the plasma levels of trace elements in children with chronic hepatitis B virus (HBV) infection and assessed whether they can be a factor that affects the response to interferon alpha (IFN-alpha) treatment. The study included 35 cases (ten girls, 25 boys) aged 3-13 years with chronic HBV infection ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-009-8507-6

    authors: Balamtekin N,Kurekci AE,Atay A,Kalman S,Okutan V,Gokcay E,Aydin A,Sener K,Safali M,Ozcan O

    更新日期:2010-06-01 00:00:00

  • Determination of arsenic in scalp hair of children and its correlation with drinking water in exposed areas of Sindh Pakistan.

    abstract::This study was focused on the analysis of arsenic (As) levels in scalp hair of children (age, <10 years) collected from two towns of Khairpur, Pakistan, to evaluate the effects of As-contaminated groundwater. For comparative purposes, scalp hair samples of children were also collected from that area having low levels ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-010-8866-z

    authors: Kazi TG,Baig JA,Shah AQ,Arain MB,Jamali MK,Kandhro GA,Afridi HI,Kolachi NF,Khan S,Wadhwa SK,Shah F

    更新日期:2011-10-01 00:00:00

  • Effect of oral aluminum and aluminum citrate on blood level and short-term tissue distribution of aluminum in the rat.

    abstract::Aluminum (Al) absorption seems to be very low, but many factors can enhance it in animals and humans. In the present study, we investigated the acute effect of Na citrate on Al absorption by monitoring Al levels in blood and several tissues. For this purpose, 18 Wistar male rats were divided into 3 groups: control, Al...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02778873

    authors: Deng Z,Coudray C,Gouzoux L,Mazur A,Rayssiguier Y,Pépin D

    更新日期:1998-08-01 00:00:00

  • Zinc Regulates Lipid Metabolism and MMPs Expression in Lipid Disturbance Rabbits.

    abstract::Lipid disturbance induced by high-fat diet is a worldwide problem, and it can induce inflammation and oxidative stress in vivo. Zinc is considered as an antioxidant, anti-inflammatory agent. Since matrix metalloprotease 2 (MMP2) and matrix metalloprotease 9 (MMP9)'s expressions are changed under many pathological cond...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-015-0367-7

    authors: Xu C,Huang Z,Liu L,Luo C,Lu G,Li Q,Gao X

    更新日期:2015-12-01 00:00:00

  • Correction to: Mercury Exposure: Protein Biomarkers of Mercury Exposure in Jaraqui Fish from the Amazon Region.

    abstract::In the affiliation section, Luiz Fabricio Zara's affiliation "Pontifical Catholic University of Goiás (PUC), Goiânia, GO, Brazil" was incorrect. The correct affiliation is College of Planaltina, UnB - University of Brasília, Distrito Federal, Brazil. ...

    journal_title:Biological trace element research

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s12011-017-1195-8

    authors: Vieira JCS,Braga CP,de Oliveira G,do Carmo Federici Padilha C,de Moraes PM,Zara LF,de Lima Leite A,Buzalaf MAR,de Magalhães Padilha P

    更新日期:2018-05-01 00:00:00

  • Enrichment, Distribution of Vanadium-Containing Protein in Vanadium-Enriched Sea Cucumber Apostichopus japonicus and the Ameliorative Effect on Insulin Resistance.

    abstract::Sea cucumbers are a potential source of natural organic vanadium that may improve insulin resistance. In this work, vanadium was accumulated rapidly in blood, body wall, and intestine by sea cucumber Apostichopus japonicus. Furthermore, water-soluble vanadium-containing proteins, the main form of the organic vanadium,...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-015-0517-y

    authors: Liu Y,Zhou Q,Zhao Y,Wang Y,Wang Y,Wang J,Xu J,Xue C

    更新日期:2016-05-01 00:00:00

  • Ortho-silicic Acid Inhibits RANKL-Induced Osteoclastogenesis and Reverses Ovariectomy-Induced Bone Loss In Vivo.

    abstract::Numerous experiments in vitro and in vivo have shown that an appropriate increase intake of silicon can facilitate the synthesis of collagen and its stabilization and promote the differentiation and mineralization of osteoblasts. In this study, we examined whether ortho-silicic acid restrains the differentiation of os...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02286-6

    authors: Ma W,Wang F,You Y,Wu W,Chi H,Jiao G,Zhang L,Zhou H,Wang H,Chen Y

    更新日期:2020-07-16 00:00:00

  • Correlation analysis between bone mineral density and serum element contents of postmenopausal women in Xi'an urban area.

    abstract::The objective of this paper is to investigate the correlation between serum macro-element and trace element contents and bone mineral density (BMD) as well as the occurrence of osteoporosis. After the epidemiological investigation of 290 postmenopausal women from ages 45 to 65 in the Xi'an urban area, their blood was ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-009-8363-4

    authors: Liu SZ,Yan H,Xu P,Li JP,Zhuang GH,Zhu BF,Lu SM

    更新日期:2009-12-01 00:00:00

  • Effect of calcium, tannic acid, phytic acid and pectin over iron uptake in an in vitro Caco-2 cell model.

    abstract::Calcium, phytic acid, polyphenols and fiber are major inhibitors of iron absorption and they could be found in excess in some diets, thereby altering or modifying the iron nutrition status. The purpose of this study is to evaluate the effect of calcium, tannic acid, phytic acid, and pectin over iron uptake, using an i...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-014-9911-0

    authors: Andrews M,Briones L,Jaramillo A,Pizarro F,Arredondo M

    更新日期:2014-04-01 00:00:00

  • Effects of nano-anatase on ribulose-1, 5-bisphosphate carboxylase/oxygenase mRNA expression in spinach.

    abstract::Being a proven photocatalyst, nano-anatase is capable of undergoing electron transfer reactions under light. In previous studies, we had proven that nano-anatase improved photosynthesis and greatly promoted spinach growth. However, the molecular mechanisms of carbon reaction promoted by nano-anatase are still not clea...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-008-8203-y

    authors: Xuming W,Fengqing G,Linglan M,Jie L,Sitao Y,Ping Y,Fashui H

    更新日期:2008-01-01 00:00:00

  • Simultaneous analysis for multiple heavy metals in contaminated biological samples.

    abstract::In the present study, the conditions of analysis by inductively coupled plasma-atomic emission spectrometry (ICP-AES) were investigated. Twenty-six elements (Mg: 25 ppm; Sc: 10 ppm; Ti: 50 ppm; others: 100 ppm) were used as the elements interfering with selected 24 wavelengths. Consequently, the background values in 1...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:87:1-3:211

    authors: Mochizuki M,Hondo R,Ueda F

    更新日期:2002-07-01 00:00:00