Abstract：
:Numerous experiments in vitro and in vivo have shown that an appropriate increase intake of silicon can facilitate the synthesis of collagen and its stabilization and promote the differentiation and mineralization of osteoblasts. In this study, we examined whether ortho-silicic acid restrains the differentiation of osteoclast through the receptor activator of nuclear factor κB ligand (RANKL)/receptor activator of nuclear factor κB (RANK)/osteoprotegerin (OPG) signaling pathway by investigating its effect in vitro and in vivo. Bone marrow macrophage (BMM) cells were isolated and cultured with or without ortho-silicic acid, and then TRAP staining and immunofluorescence were performed to detect the differentiation of osteoclast. The RANKL-induced osteoclast marker gene and protein expression including c-Fos, nuclear factor of activated T cells cl (NFATcl), tumor necrosis factor receptor-associated factor 6 (TRAF6), nuclear factor kappa B P50 (NF-κB P50), NF-κB P52, RANK, integrin β3, cathepsin K (CTSK), DC-STAMP, and TRAP were quantitatively detected by western blot and RT-PCR. Ovariectomized (OVX) rats were injected with ortho-silicic acid (OVX+Si group) and normal saline (OVX group), and sham-operated rats were injected with normal saline (Sham group). And micro-CT, H&E, and TRAP staining, ELISA, and western blot were performed. Ortho-silicic acid could inhibit the differentiation of osteoclast, and the marker genes and proteins were decreased. The OVX-induced bone loss could be reversed by ortho-silicic acid. Our finding demonstrated that ortho-silicic acid suppresses RANKL-induced osteoclastogenesis and has potential value as a therapeutic agent for OVX-induced bone loss.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Ma W,Wang F,You Y,Wu W,Chi H,Jiao G,Zhang L,Zhou H,Wang H,Chen Ydoi
10.1007/s12011-020-02286-6subject
Has Abstractpub_date
2020-07-16 00:00:00eissn
0163-4984issn
1559-0720pii
10.1007/s12011-020-02286-6pub_type
杂志文章abstract：:China has eliminated iodine deficiency disorders since 2011 via the implementation of universal salt iodisation. Following this, a new revised salt iodisation policy was introduced to reduce iodine content in table salt. Since maternal iodine deficiency can lead to cognitive impairment and cretinism in infants, the ai...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02135-6
更新日期：2021-01-01 00:00:00
abstract：:This study evaluated the effects of supplemental dietary chromium (Cr) on the performance, carcass traits, and some serum parameters of broilers under a heat stress (23.9 to 37 °C cycling) condition. A total of 150 1-day-old broiler chicks (Cobb 500) according to a completely randomized design were assigned into five ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9663-2
更新日期：2013-06-01 00:00:00
abstract：:Platelet-rich fibrin (PRF) is widely used blood-derived biomaterial which is directly applied to the surgical wounds. Depending on its autologous origin, PRF is thought as a safe material. However, it is not known to what extent the blood-derived toxins can be found in the PRF by considering the systemic exposure rate...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01695-6
更新日期：2019-10-01 00:00:00
abstract：:Iodine, an essential micronutrient, is required to produce thyroid hormones. Iodine deficiency disorders (IDD) comprise a range of adverse maternal and fetal outcomes, with the most significant irreversible effect resulting from neurodevelopmental deficits in fetal brain caused by deficient iodine status during early ...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/s12011-018-1606-5
更新日期：2019-03-01 00:00:00
abstract：:The purpose of the study was to determine the concentration of trace elements in serum samples of women who are chronic users of skin-whitening agents as well as the hepatic and renal effects of these agents on these women. The study was conducted among 23 skin-whitening users while 25 women served as the controls. Th...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-8962-8
更新日期：2011-12-01 00:00:00
abstract：:The aim of this study was to assess the effect of sibutramine on mineral status and selected biochemical parameters in obese women. The study was conducted on 24 patients who received 15 mg daily doses of sibutramine for 12 weeks, and on 20 patients who received placebo. At the baseline, after the sixth and twelfth we...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9425-6
更新日期：2012-11-01 00:00:00
abstract：:The study aimed at determination of the mineral composition of slimming herbal teas and estimation of the coverage of their total intake with infusions in women's daily diet. The content of Na+, K+, Ca+2, Mg+2, Zn+2, Cu+2, Fe+2, and Mn+2 was determined in infusions and mineralisates obtained from the slimming herbal t...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0790-4
更新日期：2017-02-01 00:00:00
abstract：:The concentrations of 3,4-dihydroxybenzoic acid, caffeic acid, catechin, chlorogenic acid, epicatechin, gallic acid, p-coumaric acid, quercetin, rutin, ferulic acid, and the major metals in graviola (Annona muricata), atemoya (A. squamosa x A. cherimola), fruta do conde (A. squamosa), biribá (Rollinia mucosa), and the...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-02005-w
更新日期：2020-10-01 00:00:00
abstract：:The thermogenic curves of the metabolism of mitochondria isolated from the liver of chicken Star-Cross 288 and the effect of La3+ on it were studied by using an LKB-2277 BioActivity Monitor, ampoule method, at 37 degrees C. After isolation from the chicken liver tissue, mitochondria still have metabolic activity and c...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/bter:84:1-3:103
更新日期：2001-01-01 00:00:00
abstract：:The levels of iron, zinc, and copper in the tissues of the pregnant rat, on d 12, 19, and 21 after impregnation have been determined and compared with controls. Iron levels decreased considerably in late pregnancy as a result of increased fetal requirements, thus diminishing iron stores in rat tissues, but maintaining...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917464
更新日期：1985-09-01 00:00:00
abstract：:Elemental analysis of archaeological bones, particularly for elements such as fluorine, strontium, and zinc, has been carried out for many years, with the aim of determining their age or relating their composition to diet. Bone samples are commonly dry ashed before analysis to remove organic material and render them m...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02990417
更新日期：1990-06-01 00:00:00
abstract：:Metal nanoparticles synthesized by green methods with the use of microorganisms are currently one of the most closely studied types of nanomaterials. It has accurately been shown that the characteristics of metal nanoparticles generated in the presence of different bacteria vary. For the two isogenic strains of obliga...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01740-4
更新日期：2020-02-01 00:00:00
abstract：:Information on cadmium (Cd) uptake and transport is essential to understand better the physiology of Cd tolerance in plants. In this study, Cd uptake, translocation, and tolerance were investigated in AHA1 (Arabidopsis plasma membrane H(+)-ATPase gene) overexpressed plants. Exposed to 10 µM CdCl(2), AHA1OX showed a hi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8657-6
更新日期：2011-02-01 00:00:00
abstract：:Many studies have shown that zinc deficiency could decrease the response to insulin. In genetically diabetic animals, a low zinc status has been observed contrary to induced diabetic animals. The zinc status of human patients depends on the type of diabetes and the age. Zinc supplementation seems to have beneficial ef...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/BF02784615
更新日期：1992-01-01 00:00:00
abstract：:Breast milk is considered the best source of nutrition for all infants. However, exposure of newborns to toxic metals is of special interest due to their potential harmful effects. Thus, the primary aims of this study were to determine the concentration of toxic heavy metals including lead, mercury, cadmium, and bariu...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1355-5
更新日期：2019-01-01 00:00:00
abstract：:This study evaluated the microbial diversity of rooftop tank-stored drinking water consumed by Japanese quail (Coturnix coturnix japonica) using silver nanoparticles (AgNPs) and acetic acid (AC) and their mixture. Japanese quails (2 weeks old) of two different plumage colors, white and brown, were divided into four gr...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02422-2
更新日期：2020-10-08 00:00:00
abstract：:Quercetin, a plant-derived flavonoid, is frequently used as an antioxidant for efficient anti-oxidative capacity. However, whether quercetin has protective effects on goat sperm and preimplantation embryos against Cd2+-induced oxidative injury is still unclear. So, we researched the influence of quercetin on goat sper...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1255-8
更新日期：2018-10-01 00:00:00
abstract：:In the present study, 15 different commercial tea brands sold in Khyber Pakhtunkhwa were collected from the markets. The samples were analyzed for the concentrations of ten selected heavy metals. The metal concentration showed a random distribution in all samples. The mean concentration of Cd, Cu, Mn, Pb, Zn, and Fe w...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02059-1
更新日期：2020-11-01 00:00:00
abstract：:Se is an important bioelement essential for a healthy immune system. Dietary Se influences both innate and adaptive immune responses. However, the effects of Se deficiency in chicken spleen are still unknown; thus, we designed an experiment to study the role of Se in chicken spleen. A total of 180 one-day-old sea blue...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1396-9
更新日期：2019-02-01 00:00:00
abstract：:Over the last decade, there has been an increased concern about the health risks from exposure to arsenic at low doses, because of their neurotoxic effects on the developing brain. The exact mechanism underlying arsenic-induced neurotoxicity during sensitive periods of brain development remains unclear, although enhan...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1286-1
更新日期：2018-11-01 00:00:00
abstract：:The effects of long-term oral administration of magnesium sulfate and insulin on hyperglycemia were investigated using Akt2 and IRS1 gene expression methods in streptozotocin-induced diabetic rats. Fifty rats were randomly divided into five experimental groups: 1, non-diabetic control (NDC); 2, Mg2+-treated non-diabet...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1555-z
更新日期：2019-08-01 00:00:00
abstract：:Accumulation of lanthanum oxide nanoparticles (La2O3NPs) in the femur bone of rats after 30 days of oral administration was explored. Also, the influence of La2O3NPs on macro and trace elements in the rats' femur bone was assessed. Inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma op...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01907-z
更新日期：2020-07-01 00:00:00
abstract：:Selenium selenate was administered to streptozotocin-induced diabetic rats to assess its effects on the detrusor muscle. Thirty-two rats were divided into four groups of eight subjects each. The study animals were made diabetic by means of a single intravenous injection of streptozotocin (STZ). The responsiveness of t...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:93:1-3:171
更新日期：2003-07-01 00:00:00
abstract：:The combination of excess mycotoxin exposure and selenium deficiency has been widely considered as a cause of Kashin-Beck disease (KBD). The present study aimed to investigate the expression profiles of selenium-related genes in human chondrocytes after exposure to T-2 toxin and deoxynivalenol (DON) and to preliminari...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1560-2
更新日期：2019-08-01 00:00:00
abstract：:The variance of testing was compared between the College of American Pathologists clinical survey and that of a recent review about hair mineral testing. The review suggested that the accuracy of hair mineral testing was unreliable. In general, there was a greater range of variance in the College of American Pathologi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:87:1-3:001
更新日期：2002-07-01 00:00:00
abstract：:The structure and bioactivity of Ginkgo biloba leaves polyprenol (GBP) are similar to that of dolichol which widely exists in human and mammalian organs. GBP possesses potential pharmacological activities against cancer. This study involved oil-in-water type nanoemulsion (NE) loading GBP was prepared by dissolving pol...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1184-y
更新日期：2018-07-01 00:00:00
abstract：:The synthesis, characterization, anti-hyperglycemic activity, oxidative DNA damage capacity, and acute toxicity of chromium(III) malate complex [Cr2(LMA)3] were described. [Cr2(LMA)3] was synthesized in a single-step reaction by chelating chromium(III) with L-malic acid in aqueous solution. Based on elemental analysis...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8916-6
更新日期：2011-11-01 00:00:00
abstract：:The present study was undertaken to evaluate methylmercury-induced alterations in hepatic enzymes and oxidative stress markers in liver tissue of rainbow trout (Oncorhynchus mykiss) by using a perfusion method, and to explore possible protective effect of vitamin C against these alterations. Forty-eight fish were divi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0241-7
更新日期：2015-05-01 00:00:00
abstract：:The AIN-93 reformulation of the AIN-76A rodent diet includes a change in selenium supplement from sodium selenite to sodium selenate to reduce dietary lipid peroxidation. A change to selenate as the standard form of Se in rat diets would render results from previous work using selenite less relevant for comparison wit...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:79:3:257
更新日期：2001-03-01 00:00:00
abstract：:Magnesium (Mg) concentrations in diets have been associated with performance and eggshell quality of laying hens, but the results have been inconclusive. In this experiment, the effects of increasing concentrations of dietary Mg on productive performance and eggshell quality of aged laying hens were evaluated. A total...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9537-z
更新日期：2013-01-01 00:00:00
