Abstract：
:Over the last decade, there has been an increased concern about the health risks from exposure to arsenic at low doses, because of their neurotoxic effects on the developing brain. The exact mechanism underlying arsenic-induced neurotoxicity during sensitive periods of brain development remains unclear, although enhanced oxidative stresses, leading to mitochondrial dysfunctions might be involved. Here, we highlight the generation of reactive oxygen species (ROS) and oxidative stress which leads to mitochondrial dysfunctions and apoptosis in arsenic-induced developmental neurotoxicity. Here, the administration of sodium arsenite at doses of 2 or 4 mg/kg body weight in female rats from gestational to lactational (GD6-PD21) resulted to increased ROS, led to oxidative stress, and increased the apoptosis in the frontal cortex, hippocampus, and corpus striatum of developing rats on PD22, compared to controls. Enhanced levels of ROS were associated with decreased mitochondrial membrane potential and the activity of mitochondrial complexes, and hampered antioxidant levels. Further, neuronal apoptosis, as measured by changes in the expression of pro-apoptotic (Bax, Caspase-3), anti-apoptotic (Bcl2), and stress marker proteins (p-p38, pJNK) in arsenic-exposed rats, was discussed. The severities of changes were found to more persist in the corpus striatum than in other brain regions of arsenic-exposed rats even after the withdrawal of exposure on PD45 as compared to controls. Therefore, our results indicate that perinatal arsenic exposure leads to abrupt changes in ROS, oxidative stress, and mitochondrial functions and that apoptotic factor in different brain regions of rats might contribute to this arsenic-induced developmental neurotoxicity.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Chandravanshi LP,Gupta R,Shukla RKdoi
10.1007/s12011-018-1286-1subject
Has Abstractpub_date
2018-11-01 00:00:00pages
185-198issue
1eissn
0163-4984issn
1559-0720pii
10.1007/s12011-018-1286-1journal_volume
186pub_type
杂志文章abstract：:To examine whether an accumulation of Ca in the tissues was accompanied by an increase of Mg, the authors investigated the relationships between Ca and Mg contents in the common iliac arteries, aortic valves, xiphoid processes, costal cartilages, posterior longitudinal ligaments, trigeminal nerves, and ribs by inducti...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:102:1-3:083
更新日期：2004-01-01 00:00:00
abstract：:Instrumental epithermal neutron activation analysis was used in determining the halide concentration of camel serum. The halides determined were sodium, chloride, bromide, and iodide. Serum was examined when the camels had free access to drinking water, following 10 d of water restriction and 2 h following rapid rehyd...
journal_title：Biological trace element research
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doi：10.1007/BF02796697
更新日期：1987-04-01 00:00:00
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journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
doi：10.1007/s12011-017-0995-1
更新日期：2017-11-01 00:00:00
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journal_title：Biological trace element research
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doi：10.1007/s12011-018-1560-2
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doi：10.1007/s12011-015-0557-3
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02785356
更新日期：1980-09-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9715-7
更新日期：2013-08-01 00:00:00
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doi：10.1007/s12011-020-02534-9
更新日期：2021-01-06 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章,已发布勘误
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更新日期：2018-05-01 00:00:00
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journal_title：Biological trace element research
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doi：10.1007/BF02783193
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02916650
更新日期：1989-11-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02790111
更新日期：1995-01-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0498-x
更新日期：2016-05-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0048-y
更新日期：2014-08-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0282-y
更新日期：2015-09-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9011-3
更新日期：2011-12-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01740-4
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0100-y
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journal_title：Biological trace element research
pub_type： 杂志文章
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更新日期：2003-12-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917309
更新日期：1994-10-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
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更新日期：2001-03-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-8075-6
更新日期：2008-06-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1040-0
更新日期：2018-02-01 00:00:00
abstract：UNLABELLED:Limited data are available indicating the effects of chromium administration on endocrine profiles, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS). This study was done to assess the effects of chromium administration on endocrine profiles, biomarkers of inf...
journal_title：Biological trace element research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12011-015-0570-6
更新日期：2016-07-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917469
更新日期：1997-09-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8363-4
更新日期：2009-12-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01664-z
更新日期：2019-12-01 00:00:00
abstract：:In the present study, we investigated the effects of Se-enriched Agaricus blazei Murill (Se-AbM) on liver injury in mice induced by acute alcohol administration. Mice received ethanol (5 g/kg body weight (BW)) by gavage every 12 h for a total of 3 doses. Se-AbM was administrated before ethanol administration. Subseque...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0022-8
更新日期：2014-07-01 00:00:00
abstract：:The study was undertaken to investigate the influence of alpha-tocopherol on zinc, copper, iron, calcium, magnesium, and potassium concentrations in serum of rats with bleomycin-induced pulmonary fibrosis. Fourteen Wistar albino rats were randomly divided into two groups of seven animals each. The first group was trea...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:114:1:175
更新日期：2006-01-01 00:00:00
