Abstract:
:Quercetin, a plant-derived flavonoid, is frequently used as an antioxidant for efficient anti-oxidative capacity. However, whether quercetin has protective effects on goat sperm and preimplantation embryos against Cd2+-induced oxidative injury is still unclear. So, we researched the influence of quercetin on goat sperm and zygotes respectively under the oxidative stress induced by Cd2+. In our study, quercetin decreased the malonaldehyde (MDA) and reactive oxygen species (ROS) levels caused by Cd2+ in goat sperm (p < 0.05), which facilitated sperm characteristics including motility, survival rates, membrane integrity, and mitochondria activity during storage in vitro and subsequent embryo development (p < 0.05). Moreover, in goat zygotes, quercetin decreased peroxidation products including ROS, MDA, and carbonyl through preserving or maintaining mitochondrial function, gene expression, and anti-oxidative products such as glutathione peroxidase, superoxide dismutase, and catalase, which ameliorated subsequent embryo development and embryo quality (p < 0.05). Taken together, these results suggest that quercetin protects both goat sperm and preimplantation embryos from Cd2+-induced oxidative stress.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Mao T,Han C,Wei B,Zhao L,Zhang Q,Deng R,Liu J,Luo Y,Zhang Ydoi
10.1007/s12011-018-1255-8subject
Has Abstractpub_date
2018-10-01 00:00:00pages
344-355issue
2eissn
0163-4984issn
1559-0720pii
10.1007/s12011-018-1255-8journal_volume
185pub_type
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