Abstract:
:Glutathione peroxidase (GPx) is the prototypical eukaryotic selenoprotein, with the rare amino acid selenocysteine (Sec) at the enzyme active site, encoded by the UGA codon in RNA. A DNA virus, Molluscum contagiosum, has now been shown to encode a functional selenium-dependent GPx enzyme. Using modifications of conventional sequence database searching techniques to locate potential viral GPx modules, combined with structurally guided comparative sequence analysis, we provide compelling evidence that Se-dependent GPx modules are encoded in a number of RNA viruses, including potentially serious human pathogens like HIV-1 and hepatitis C virus, coxsackievirus B3, HIV-2, and measles virus. Analysis of the sequences of multiple viral isolates reveals conservation of the putative GPx-related features, at least within viral subtypes or genotypes, supporting the hypothesis that these are functional GPx modules.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Zhang W,Ramanathan CS,Nadimpalli RG,Bhat AA,Cox AG,Taylor EWdoi
10.1007/BF02783852subject
Has Abstractpub_date
1999-11-01 00:00:00pages
97-116issue
2eissn
0163-4984issn
1559-0720journal_volume
70pub_type
杂志文章abstract::Aluminum (Al) has various adverse effects on health of humans and animals. The aim of present study was to demonstrate that Lactobacillus plantarum CCFM639 can alleviate the adverse effects on liver and kidney of mice caused by chronic Al exposure. Animals were assigned into control, CCFM639 only, Al only, Al plus CCF...
journal_title:Biological trace element research
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journal_title:Biological trace element research
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journal_title:Biological trace element research
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8823-x
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abstract::Elemental concentrations in head hair and blood (whole-blood, erythrocytes and plasma) of 28 Nigerian subjects were determined using instrumental neutron activation analysis (INAA) and proton-induced X-ray emission (PIXE) techniques. Correlations found between different elements in hair and blood are reported. Hair le...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/BF02917347
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abstract::The solubility of both free and low molecular weight ligand complexed calcium, magnesium, and zinc in skimmed human and bovine milks over intestinal luminal pH ranges (approximately 3-7) was measured using ultrafiltration techniques. Some of the experimental difficulties associated with the separation of labile metal ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02925450
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abstract::The aim of this study was to investigate the effects of the Toxoplasma gondii infection on the total content of the essential elements Zn and Mg levels. Plasma zinc and magnesium concentrations were measured in 158 patients whose anti-T gondii IgG antibodies were positive. Scores were obtained for the patients and the...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:74:1:55
更新日期:2000-04-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1555-z
更新日期:2019-08-01 00:00:00
abstract::In the current study, 48 male rats were classified into four groups (12 rats/group): 1-control group received 1 ml distilled water, 2-origanum oil group treated daily with oral dose of origanum oil (5 mg/kg) for 30 and 60 days, 3-mercuric chloride group treated daily with oral dose of mercuric chloride (4 mg/kg) for 3...
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更新日期:2018-03-01 00:00:00
abstract::Zinc has been reported to enhance the response to interferon (IFN) or PEG-IFN plus ribavirin therapy, improve liver function, and ameliorate hematologic side effects in patients with chronic hepatitis C. However, the role of zinc supplementation during IFN therapy in chronic hepatitis B infection (CHB) remains unclear...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-8971-7
更新日期:2011-12-01 00:00:00
abstract::Normal and uremic adult male rats were given a daily ip injection of 20 mg Al (Al chloride)/kg for 14 d. The results indicate that Al induces a significant decrease in food ingestion, weight gain, and total protein concentration in the plasma. Compared with control animals, very high increases in Al levels were found ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785319
更新日期:1996-07-01 00:00:00
abstract::This study examined the effects of dietary (2.0 ppm for 8 wk) and in vitro (1 x 10(-7)M) supplementation with selenium (Se, as sodium selenite) on the activity of spleen natural killer (NK) cells and plastic-adherent lymphokine-activated killer (A-LAK) cells from C57B1/6J male mice. Dietary supplementation with Se res...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02789164
更新日期:1996-06-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1517-5
更新日期:2019-07-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02342-1
更新日期:2020-08-18 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:81:1:29
更新日期:2001-07-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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更新日期:2013-09-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0106-5
更新日期:2014-12-01 00:00:00
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更新日期:2012-02-01 00:00:00
abstract::Numerous observations suggest a possible connection between the levels of Mg, Zn, Fe, and Zn and the incidence of depressive symptoms. Depression is two to three times more common in women than in men. The menopausal period is extremely conducive to depressive disorders. The aim of this study was to assess the severit...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-016-0798-9
更新日期:2017-03-01 00:00:00
abstract::Zinc uptake regulator (Zur) is a negative transcriptional regulator of bacteria that belongs to the FUR superfamily of proteins and regulates zinc (Zn) homeostasis under extreme Zn conditions. The Zur protein of Bacillus anthracis (BaZur) was though characterized previously, but the residues of this transcriptional re...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02427-x
更新日期:2020-10-14 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0207-1
更新日期:2015-03-01 00:00:00
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abstract::To obtain real-time dynamic changes of non-protein-bound copper in the blood, we have developed an online microdialysis sampling system coupled with a flow-injection graphite furnace-atomic absorption spectrometer (FI-GFAAS). The analytical performances of the online system such as linearity, limit of detection, preci...
journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:2006-07-01 00:00:00
abstract::Plasma and erythrocyte lipid peroxidation levels of 20 patients with histopathologically confirmed testis cancer and 20 healthy control individuals were studied between November 1995 and June 1997. The group with testis cancer had a mean age of 24.8+/-8.2 yr and the control group's mean age was 28.3+/-6.9 yr. Stage di...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
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更新日期:2000-02-01 00:00:00
abstract::Previous studies showed the attenuation of both morphine-dependence and morphine-place preference by zinc. Conditioned place preference and aversion are experimental models frequently used to test the reward-stimulating, respectively the aversive effects induced by different stimuli or substances. Addictive substances...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-0995-1
更新日期:2017-11-01 00:00:00