Abstract:
:The synthesis, characterization, anti-hyperglycemic activity, oxidative DNA damage capacity, and acute toxicity of chromium(III) malate complex [Cr2(LMA)3] were described. [Cr2(LMA)3] was synthesized in a single-step reaction by chelating chromium(III) with L-malic acid in aqueous solution. Based on elemental analysis, thermodynamic analysis, and spectroscopy studies, the molecular formula of [Cr2(LMA)3] was inferred as Cr2(C4H4O5)3·5H2O. Daily treatment with 2.85-17.10 mg/kg body mass of [Cr2(LMA)3] in alloxan-induced diabetic rats for 2 weeks indicated that low-molecular-weight organic chromium complex [Cr2(LMA)3] had better bioavailability and more beneficial influences on the improvement of controlling blood glucose, serum lipid, and liver glycogen levels compared with CrCl3·6H2O. [Cr2(LMA)3] did not cause oxidative DNA damage under physiologically relevant conditions. Acute toxicity studies revealed no-measurable toxicity of the [Cr2(LMA)3]. Collectively, these results suggest that [Cr2(LMA)3] may represent a novel, proper chromium supplement with potential therapeutic value to control blood glucose and serum lipid in diabetes.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Wu XY,Li F,Xu WD,Zhao JL,Zhao T,Liang LH,Yang LQdoi
10.1007/s12011-010-8916-6subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1031-43issue
2eissn
0163-4984issn
1559-0720journal_volume
143pub_type
杂志文章abstract::Iron bioavailability seems to be regulated by vitamin A (VA) but the molecular events involved in this mechanism are not well understood. It is also known that retinoids mediate most of their function via interaction with retinoid receptors, which act as ligand-activated transcription factors controlling the expressio...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9397-6
更新日期:2012-10-01 00:00:00
abstract::The purpose of this 42-day study was to examine the effect of dietary vanadium on the ileac T cells and contents of cytokines including interleukin-2 (IL-2), interleukin-6 (IL-6), and interferon-gamma (IFN-γ) in broilers by flow cytometry and enzyme-linked immunosorbent assay. A total of 420 one-day-old avian broilers...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9274-8
更新日期:2012-06-01 00:00:00
abstract::The selenium concentrations were determined in liver, kidney, skeletal muscle, heart, brain, prostate, testis, bile, lung, and spleen of German traffic accident victims. In addition, the nitrogen and phosphorus contents were determined in the same organs and tissues. On a per-weight unit basis, the highest selenium co...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02990125
更新日期:1988-01-01 00:00:00
abstract::The abnormal metabolism of metal ions plays an important role in health and disease conditions; hence, the studies about them have received much interest. The objective of this study was to evaluate the association between trace and toxic elements zinc (Zn), cadmium (Cd), selenium (Se), and mercury (Hg) in biological ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0048-y
更新日期:2014-08-01 00:00:00
abstract::The lipid and fatty acid composition of the blue mussels Mytilus edulis L. gills and digestive glands was evaluated after 24 and 72 h of cadmium (Cd) and copper (Cu) exposure. Mussels were exposed to different cadmium (10, 100, and 500 μg/L) and copper (5, 50, and 250 μg/L) concentrations. Similar stress response of p...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9727-3
更新日期:2013-08-01 00:00:00
abstract::Manganese (Mn) is essential for several species and daily requirements are commonly met by an adequate diet. Mn overload may cause motor and psychiatric disturbances and may arise from an impaired or not fully developed excretion system, transporter malfunction and/or exposure to excessive levels of Mn. Therefore, dec...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1531-7
更新日期:2019-03-01 00:00:00
abstract::The present study was undertaken to evaluate the in vitro availability of chemically varying forms of selenium (Se), supplemented in cow's milk. Two inorganic (selenite and selenate) and two organic (seleno-methionine [Se-Met] and seleno-cystine [Se-Cys]) Se sources were evaluated. The in vitro availability was estima...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02910666
更新日期:1997-07-01 00:00:00
abstract::This study deals with synthesis of chromium nanoparticles (CrNPs) from potassium dichromate using the aqueous extract of Allium sativum. They were characterized through UV-VIS light, FE-SEM, EDX, XRD, and FT-IR, which revealed uniform, mono-dispersive, and highly stable CrNPs of 31-64-nm size. The Artemia nauplii was ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1407-x
更新日期:2019-02-01 00:00:00
abstract::Antioxidants can play a significant role in chronic inflammatory process. The aim of this study was to evaluate the content of selenium (Se), zinc (Zn), copper (Cu), and total antioxidant status (TAS) of patients with chronic tonsillitis (CT). The study group consisted of 84 patients with CT from 18 to 62 years old an...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/s12011-016-0634-2
更新日期:2016-09-01 00:00:00
abstract::Contents of Cu and Zn of into-pulmonary blood (IPB), out-pulmonary blood (OPB), Lung tissue, and supernatant and macrophages of Lung Lavage were determined in superior mesenteric artery occlusion (SMAO) shock of rabbits. Zn of pulmonary tissue was 11.42 +/- 0.60 and 14.52 +/- 1.78 (micrograms/g wet wt) in SMAO shock a...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF03032684
更新日期:1991-06-01 00:00:00
abstract::Arsenic poisoning in aquatic ecosystem is a global concern that obstructs the productivity of agricultural lands (paddy fields) by targeting the growth of cyanobacteria. The cyanobacteria also tolerate and accumulate elevated concentration of arsenic (As) inside the cell and excrete out from cells in less toxic forms ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02289-3
更新日期:2020-08-06 00:00:00
abstract::Two trials were conducted in a 2 × 2 + 1 factorial arrangement based on a completely randomized design to evaluate the effects of different sources of selenium (Se) on performance, blood metabolites, and nutrient digestibility in male lambs on a barley-based diet. The first trial lasted for 70 days and consisted of 30...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9698-4
更新日期:2013-07-01 00:00:00
abstract::In the present study, adult Wistar albino male rats were exposed to formaldehyde at different periods (subacute and subchronic) and concentrations (5.0 and 10.0 ppm) in order to figure out the changes in the concentration of Zn, Cu and Fe. It was observed that the formaldehyde inhalation caused gradual decline of body...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8686-1
更新日期:2011-05-01 00:00:00
abstract::The aim of this study was to evaluate and compare the oxidative profiles of three thyroid disorders: Graves' disease (GD), Hashimoto thyroiditis (HT), and papillary thyroid cancer (PTC). Malondialdehyde levels (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) activities were examined ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8625-1
更新日期:2010-12-01 00:00:00
abstract::This comparative study of the intestinal absorption of four toxic metals (aluminum, manganese, nickel, and lead) carried out in rats using the in situ intestinal perfusion technique was able to measure the partition of each metal between the intestine (intestinal retention), the blood circulation, and target tissues a...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:99:1-3:157
更新日期:2004-07-01 00:00:00
abstract::In vitro distribution of aluminium between plasma and erythrocytes has been studied in the presence of variable amounts of sodium L-glutamate. With a red blood cell suspension in isotonic sodium chloride, aluminium remains confined in erythrocytes even when the sodium L-glutamate concentration increases in the medium....
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02990262
更新日期:1990-04-01 00:00:00
abstract::Lithium is an integral drug used in the management of acute mania, unipolar and bipolar depression, and prophylaxis of bipolar disorders. Thyroid abnormalities have been associated with treatment with lithium. Zinc is an essential trace element that plays a role in several biological activities. Therefore, the present...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02356-9
更新日期:2020-08-26 00:00:00
abstract::The objective of the study was to evaluate the maximum tolerance limit of amino acid copper complex (Cu-Lys-Glu) for laying hens by measuring their laying performance, hematological and serum biochemical parameters, organ index, and histopathology. A total of 450 18-week-old Beijing White layers were randomly allocate...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02406-2
更新日期:2020-10-12 00:00:00
abstract::The binding of Cu(II), Zn(II), Ni(II), and Cd(II) to protein components in serum, placenta, kidney, and urine was investigated at physiological pH, using radioisotopes as tracers. All the four metals were bound to albumin and other macromolecules in serum. However, small amounts were also bound to low molecular weight...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917246
更新日期:1989-07-01 00:00:00
abstract::The aim of this study was to establish the possible effects of the sampling protocol (between-breast, within-feed, and diurnal differences) and the mother's personal factors (age, parity, iron supplementation, smoking habits, and lactation period) on the copper, iron, and zinc contents in human milk. One hundred thirt...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1385/BTER:76:3:217
更新日期:2000-09-01 00:00:00
abstract::Pituitary dwarfism (hGHD) is known to be associated with trace element deficiency, which causes improper functioning of the involved endocrine system. Previously, we reported on the head hair concentrations of zinc, copper, manganese, and iron from a total of 418 normal subjects (154 male and 264 female). In this repo...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:85:2:127
更新日期:2002-02-01 00:00:00
abstract::Plasma zinc (Zn) concentrations were measured in 4376 indigent women (86% African-American), at at mean (+/- SD) gestational age of 15 (+/- 7.8) wk to determine the relationship between various maternal characteristics and plasma Zn levels during pregnancy. Mean Plasma An levels were lower in African-American women th...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784174
更新日期:1996-10-01 00:00:00
abstract::Zinc (Zn) is an essential nutrient that is required in humans and animals for many physiological functions, including immune and antioxidant function, growth, and reproduction. The present study was performed to investigate the effects of three Zn levels, including Zn adequate (35.94 mg/kg, as a control), Zn deficienc...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:107:2:153
更新日期:2005-11-01 00:00:00
abstract::Supplementation with selenium is common for dairy cows, but the importance of selenium source is not clear. This study aimed to compare nano-selenium (Nano-Se) and sodium selenite supplements for dairy cows on lactation performance, milk Se levels and selenoprotein (Sel) gene expression. Twelve multiparous Holstein co...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02139-2
更新日期:2021-01-01 00:00:00
abstract::The influence of several commercial albumin preparations on the ferroxidase activity of ceruloplasmin (ferroxidase I, ferrous: O2 oxidoreductase EC 1.16.3.1) at pH 6.0 was determined using ferric-transferrin formation. The ability of several albumin preparations to inhibit the ferroxidase activity of ceruloplasmin dif...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02916628
更新日期:1983-04-01 00:00:00
abstract::A working analytical procedure for selenium determinations by INAA, using gamma spectrometry with a germanium well-type detector, is presented. The spectral line at 400.7 keV is employed, enhanced with the effect of energy summing in true coincidence of cascade photons. The main advantage of the method is high efficie...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917304
更新日期:1994-10-01 00:00:00
abstract::Human ocular tissues from 50 donor eyes were elementally and morphologically analyzed in order to correlate the elemental content and distribution of Ca, Ba, Cr, Cu, Zn, and Se with ocular morphology, sex, race, irideal pigmentation, age, time of death, birth weight, presence and severity of diabetes, and other pathol...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02796667
更新日期:1987-04-01 00:00:00
abstract::Selenium was added to the feed of White Leghorn type chickens 1 day prior to challenge with either Escherichia coli or sheep erythrocyte antigen. The incidence of death or lesions was reduced from 86% to 21% at the optimal dose of selenium (0.4 mg/kg resulting in feed concentration of 0.45 mg/kg). After the chickens w...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917469
更新日期:1997-09-01 00:00:00
abstract::Gut Zn homeostatic responses to low, replete, and excess dietary Zn (10, 150, and 400 mg Zn/kg, respectively) were compared in mice with (MT+/+) and without (MT-/-) metallothionein (MT) expression. MT concentrations decreased progressively from stomach (12.9 nmol Cd bound/g) to colon (4.6 nmol Cd bound/g). Small intes...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02778942
更新日期:1998-09-01 00:00:00
abstract::Variations in trace element concentration in the head and facial hair of five individuals with ever-increasing amounts of white hair were examined. Hair was collected from the scalp, cheeks, and chin from one donor on a regular basis since 1984. Samples were separated into white and pigmented fractions, and analyzed a...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02992728
更新日期:1990-07-01 00:00:00