Abstract:
:Lithium is an integral drug used in the management of acute mania, unipolar and bipolar depression, and prophylaxis of bipolar disorders. Thyroid abnormalities have been associated with treatment with lithium. Zinc is an essential trace element that plays a role in several biological activities. Therefore, the present study was aimed at investigating the potential role of zinc in the thyroid gland following lithium administration to explore the role of zinc under such conditions. To achieve this goal, male Wistar rats (150-195 g) were divided into four groups: Group 1 animals were fed standard pellet feed and tap water ad lib; Group 2 rats were fed lithium in the form of lithium carbonate through diet at a concentration of 1.1 g/kg body weight; Group 3 animals received zinc treatment in the form of zinc sulfate (ZnSO4·7H2O) at a dose level of 227 mg/L mixed with drinking water of the animals; and Group 4 animals were given lithium and zinc in a similar manner as was given to the animals belonging to groups 2 and 4 respectively. The role of zinc on thyroid functions in lithium-treated rats was studied after 2, 4, and 8 weeks of different treatments. Zinc has been observed to have the capability to nearly normalize the altered 2-h uptake of 131I, biological and effective half-lives of 131I, and circulating T4 levels that were altered after lithium treatment. The present study concludes that zinc may be an effective agent in normalizing the adverse effects caused by lithium on thyroid functions.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Pathak R,Pathak Adoi
10.1007/s12011-020-02356-9subject
Has Abstractpub_date
2020-08-26 00:00:00eissn
0163-4984issn
1559-0720pii
10.1007/s12011-020-02356-9pub_type
杂志文章abstract::The abnormal metabolism of metal ions plays an important role in health and disease conditions; hence, the studies about them have received much interest. The objective of this study was to evaluate the association between trace and toxic elements zinc (Zn), cadmium (Cd), selenium (Se), and mercury (Hg) in biological ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0048-y
更新日期:2014-08-01 00:00:00
abstract::For this study, we investigate more deeply the effect calcium (Ca) develops on the mechanism underlying fluoride-triggered osteocyte apoptosis. We detected the morphology of osteocytes by HE staining, mitochondrial microstructure by using the transmission electron microscope, and the biochemical indexes related to bon...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02305-6
更新日期:2020-07-25 00:00:00
abstract::Despite the name, rare earth elements are relatively abundant in soil. Therefore, these elements might interact with biosphere during the history of life. In this study, we have examined the effect of rare earth ions on the growth of bacteria, fungi and soil nematode. All rare earth ions, except radioactive promethium...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-016-0727-y
更新日期:2016-12-01 00:00:00
abstract::This experiment was conducted to evaluate the effects of zinc (ZnSO4.H2O) and vitamin A (retinol) supplementation on performance, carcass characteristics, and serum concentrations of glucose, cholesterol, total protein, and malondialdehyde (MDA) as an indicator of lipid peroxidation in broiler chickens (Ross) reared a...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1385/BTER:94:3:225
更新日期:2003-09-01 00:00:00
abstract::To elucidate compositional changes of peripheral nerves with aging, the authors investigated age-related changes of elements and their relationships in the optic, trigeminal, vagus, median, radial, ulnar, femoral, sciatic, tibial, and common peroneal nerves by inductively coupled plasma-atomic emission spectrometry. T...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:98:3:229
更新日期:2004-06-01 00:00:00
abstract::Selenium deficiency is the major cause of exudative diathesis in chicks. Subcutaneous hemorrhage is one of the typical symptoms of the disease. However, the reason for the occurrence of blood exudation remains unknown. In the present study, the vascular smooth muscle cells (VSMCs) were isolated from 17-day-old broiler...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-016-0823-z
更新日期:2017-04-01 00:00:00
abstract::The characteristics of aluminum and chromium binding to apo-transferrin (apo-tf) have been investigated and compared. Both metal ions were taken up by human transferrin forming complexes with the maximum absorbances at 405 nm for chromium-transferrin (cr-tf) and 240 nm for aluminum-transferrin (Al-tf). In the presence...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784585
更新日期:1992-01-01 00:00:00
abstract::The serum copper and zinc levels were determined by atomic absorption spectrometry in 135 Hodgkin's disease (HD) patients and in 100 healthy controls. These values were used to explore the application value of the serum copper/zinc ratio in the histologic classification and prognosis in this illness. The resuls show t...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1385/bter:83:2:133
更新日期:2001-11-01 00:00:00
abstract::The structure and bioactivity of Ginkgo biloba leaves polyprenol (GBP) are similar to that of dolichol which widely exists in human and mammalian organs. GBP possesses potential pharmacological activities against cancer. This study involved oil-in-water type nanoemulsion (NE) loading GBP was prepared by dissolving pol...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1184-y
更新日期:2018-07-01 00:00:00
abstract::The study was conducted to evaluate the effects of chromium-loaded chitosan nanoparticles (Cr-CNP) on glucose transporter 4 (GLUT4), relevant messenger RNA (mRNA), and proteins involved in phosphatidylinositol 3-kinase (PI3K), Akt2-kinase, and AMP-activated protein kinase (AMPK) of skeletal muscles in finishing pigs. ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-016-0890-1
更新日期:2017-07-01 00:00:00
abstract::Quin2, a fluorescent calcium probe, has a low affinity for calcium in comparison to its affinities for transition metal ions. Chelation of ferric ion with quin2 strongly enhanced the formation of oxidizing species in the presence of bolus H2O2 as detected with four assays, electron spin resonance with the spin-trap DM...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02790098
更新日期:1995-01-01 00:00:00
abstract::The effects of environmental lead on the immune system of young children were assessed by determining the peripheral blood lymphocytes CD3+, CD4+, CD8+, B(CD19+) counts, and natural killer (CD16+CD56+) cells in 35 preschool children whose mean blood lead level was 140.6 microg/L. The results were compared to an age- a...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:105:1-3:019
更新日期:2005-07-01 00:00:00
abstract::Recent publications in Japan suggest that Cd in river beds and locally harvested rice tend to be higher in seven prefectures in the north-eastern part on the coast of the Sea of Japan (the high-Cd zone). The present study was initiated to investigate the current level of exposure to Cd and possible health effects amon...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8646-9
更新日期:2011-02-01 00:00:00
abstract::In this study, eight kinds of nickel (Ni) compounds were orally administered to Wistar male rats and the distribution of each compound was investigated 24 h after the administration. The Ni compounds used in this experiment were nickel metal [Ni-M], nickel oxide (green) [NiO(G)], nickel oxide (black) [NiO(B)], nickel ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02789001
更新日期:1995-07-01 00:00:00
abstract::Selenium exerts many, if not most, of its physiological functions as a selenocysteine moiety in proteins. Selenoproteins are involved in many biochemical processes including regulation of cellular redox state, calcium homeostasis, protein biosynthesis, and degradation. A neurodevelopmental syndrome called progressive ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9920-z
更新日期:2014-05-01 00:00:00
abstract::In the present world, X-rays have been regarded as one of the most efficient tools in medicine, industry and research. On the contrary, extensive human exposure to these rays is responsible for causing detrimental effects on physiological system. The aim of the present study was to investigate the role of zinc (Zn), i...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-0976-4
更新日期:2017-10-01 00:00:00
abstract::Nonenzymatic glycation of long-lived proteins has been implicated in several complications related to age and diabetes. Dicarbonyl compounds such as methylglyoxal (MGO) have been identified as the predominant source for the formation of advanced glycation end-products (AGEs) in various tissues. We investigated the eff...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8915-7
更新日期:2011-11-01 00:00:00
abstract::The objective of the study was to evaluate the maximum tolerance limit of amino acid copper complex (Cu-Lys-Glu) for laying hens by measuring their laying performance, hematological and serum biochemical parameters, organ index, and histopathology. A total of 450 18-week-old Beijing White layers were randomly allocate...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02406-2
更新日期:2020-10-12 00:00:00
abstract::To elucidate compositional changes of the pubic symphysis (PS) by aging, elements of pubic symphysis (PSs) removed from 26 cadavers were determined by inductively coupled plasma atomic-emission spectrometry. It was found that the relative contents (RCs) of calcium and phosphorus in women's PSs were about three- and fi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783243
更新日期:1997-01-01 00:00:00
abstract::Patients on total parenteral nutrition without Cr supplementation develop symptoms similar to those of diabetes. Zn has been implicated in diabetes because of its antioxidant properties and interaction with insulin. To study the effect of these metal ions on insulin signaling proteins, cultured mouse skeletal muscle c...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:101:1:19
更新日期:2004-10-01 00:00:00
abstract::A 10-year-old Gir bullock was presented with four contiguous hard nodular submucosal masses attached to the right rostral mandible. Overgrown masses were resected surgically and submitted for microstructural, elemental, and molecular spectroscopic analyses. An osteoma was diagnosed histopathologically. Elemental analy...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-021-02604-6
更新日期:2021-01-26 00:00:00
abstract::In this study, a solid-phase extraction method combined with atomic absorption spectrometry for extraction, preconcentration, and determination of iron (Fe(3+)), copper (Cu(2+)), and lead (Pb(2+)) ions at trace levels in water samples has been reported. The influences of effective parameters such as flow rate, pH, elu...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9171-1
更新日期:2012-02-01 00:00:00
abstract::The key role of osteoblasts in skeletal fluorosis makes the exploration of the possible mechanisms of the fluoride-induced oxidative stress of osteoblasts of great importance. In this article, the in vitro effects of fluoride on the oxidative stress of osteoblasts are presented. To study the inhibitory effect of baica...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02685921
更新日期:2007-04-01 00:00:00
abstract::Few studies have evaluated the biomarker changes of fluoride exposure. In order to explore early and sensitive indicators, animal experiment was designed. Ninety-six healthy SD rats (48 males and 48 females) weighing approximately 60 g were randomly divided into six groups of 16 animals each by gender average. Control...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0034-4
更新日期:2014-07-01 00:00:00
abstract::Nickel (Ni) has not been elucidated as an essential mineral in dairy animals, though in plants and lower organisms, its role in activation of urease enzyme is well known. This study was conducted to evaluate the effect of Ni supplementation on intake, growth performance, urease activity, antioxidant and immune status,...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1524-6
更新日期:2019-07-01 00:00:00
abstract::The exposure of toxic elements may directly or indirectly associate with different pathogenesis of heart diseases. In the present study, the association of arsenic (As), cadmium (Cd), cobalt (Co), lead (Pb), and nickel (Ni) in biological samples (whole blood and urine) and mortality from myocardial infarction (MI) pat...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8713-2
更新日期:2011-06-01 00:00:00
abstract::The zinc content in the hair of 654 children living in various rural and industrial areas in southern Poland was assayed by means of the atomic absorption spectrometry, following the dry digestion procedure. The hair of girls exhibited statistically significant higher level of Zn than the boys' hair, although in the s...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02790111
更新日期:1995-01-01 00:00:00
abstract::Women with gestational diabetes mellitus (GDM) may have lower serum selenium levels than healthy controls, which may be associated with preterm birth. We explored the association of serum selenium levels in early pregnancy with the risk of GDM and preterm birth among Chinese women. We included 398 women with a singlet...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02191-y
更新日期:2021-02-01 00:00:00
abstract::Differences in mineral nutrient composition of soils have been considered to affect health and population characteristics of free-ranging animals, particularly herbivores. Contents of Ca, Mg, and K in hair of female fawn white-tailed deer (Odocoileus virginianus) were measured for eight consecutive years to determine ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783968
更新日期:1998-06-01 00:00:00
abstract::Obesity, a chronic inflammatory state, is associated with altered zinc metabolism. ZnT and Zip transporters are involved in the regulation of zinc metabolism. This study examined the relationships among obesity, zinc transporter gene expression, and inflammatory markers in young Korean women. The messenger RNA (mRNA) ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9902-1
更新日期:2014-04-01 00:00:00