Abstract:
:The study was conducted to evaluate the effects of chromium-loaded chitosan nanoparticles (Cr-CNP) on glucose transporter 4 (GLUT4), relevant messenger RNA (mRNA), and proteins involved in phosphatidylinositol 3-kinase (PI3K), Akt2-kinase, and AMP-activated protein kinase (AMPK) of skeletal muscles in finishing pigs. A total of 120 crossbred barrows (BW 65.00 ± 1.26 kg) were randomly allotted to four dietary treatments, with three pens per treatment and 10 pigs per pen. Pigs were fed the basal diet supplemented with 0, 100, 200, or 400 μg/kg of Cr from Cr-CNP for 35 days. After the feeding trials, 24 pigs were slaughtered to collect longissimus muscle samples for analysis. Cr-CNP supplementation increased GLUT4 messenger RNA (mRNA) (quadratically, P < 0.01) and total and plasma membrane GLUT4 protein contents (linearly and quadratically, P < 0.001) in skeletal muscles. Glycogen synthase kinase 3β (GSK-3β) mRNA was decreased linearly (P < 0.001) and quadratically (P < 0.001). Supplemental Cr-CNP increased insulin receptor (InsR) mRNA quadratically (P < 0.01), Akt2 total protein level linearly (P < 0.01) and quadratically (P < 0.001), and PI3K total protein was increased significantly (P < 0.05) in 200 μg/kg treatment group. The mRNA of AMPK subunit gamma-3 (PRKAG3) and protein of AMPKα1 was significantly increased (P < 0.001) with the addition of Cr-CNP. The results indicate that dietary supplementation of Cr-CNP may promote glucose uptake by leading to recruitment of GLUT4 to the plasma membrane in skeletal muscles, and these actions may be associated with the insulin signal transduction and AMPK.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Liu L,Wang B,He Y,Tao W,Liu Z,Wang Mdoi
10.1007/s12011-016-0890-1subject
Has Abstractpub_date
2017-07-01 00:00:00pages
36-43issue
1eissn
0163-4984issn
1559-0720pii
10.1007/s12011-016-0890-1journal_volume
178pub_type
杂志文章abstract::The aim of this study was to evaluate the impact of three different chromium forms--chromic chloride (CrCl3), chromium picolinate (CrPic), and a newly synthesized complex of chromium chelated with small peptides (CrSP)--on protein metabolism in vitro. In cultured skeletal muscle cells, CrSP was able to increase the ba...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-009-8579-3
更新日期:2010-11-01 00:00:00
abstract::A cohort study on platers in Tokyo was carried out using the records of the Tokyo Health Insurance Society of Plating Industry. The type of work and chromium-exposure history of each member of this society was investigated by a questionnaire sent to the manager of each factory. The recovery rate of the questionnaire w...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783841
更新日期:1979-03-01 00:00:00
abstract::Obesity, a chronic inflammatory state, is associated with altered zinc metabolism. ZnT and Zip transporters are involved in the regulation of zinc metabolism. This study examined the relationships among obesity, zinc transporter gene expression, and inflammatory markers in young Korean women. The messenger RNA (mRNA) ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9902-1
更新日期:2014-04-01 00:00:00
abstract::Although lead is known to induce arterial hypertension and vascular damage, it is not clear if after cessation of lead treatment, the increase of blood pressure is sustained and the vascular function is different from untreated rats. Therefore, we aimed to evaluate the systolic blood pressure during and following lead...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0497-y
更新日期:2016-04-01 00:00:00
abstract::Chronic copper exposure impaired spermatogenesis in adult male mice. The aim of this study was to determine whether chronic copper exposure can induce apoptosis of testicular cell and hypospermatogenesis via disturbing testosterone synthesis in adult male mice. In the present study, sixty CD-1 male mice were randomly ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01852-x
更新日期:2020-06-01 00:00:00
abstract::The study aimed at determination of the mineral composition of slimming herbal teas and estimation of the coverage of their total intake with infusions in women's daily diet. The content of Na+, K+, Ca+2, Mg+2, Zn+2, Cu+2, Fe+2, and Mn+2 was determined in infusions and mineralisates obtained from the slimming herbal t...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-016-0790-4
更新日期:2017-02-01 00:00:00
abstract::It has been demonstrated that zinc exerts its beneficial influence on skin fibroblasts. Propolis, a complex mixture of plant-derived and bees' products, was reported to stimulate cicatrization processes in skin and prevent infections. The aim of this study was to find out how zinc and propolis influence human skin fib...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0019-3
更新日期:2014-07-01 00:00:00
abstract::Since waterborne minerals appear in ionic form and are readily absorbed by the gastrointestinal tract, drinking water could be a crucial source of mineral intake. However, no comprehensive research has yet determined how trace elements in drinking water relate to body composition. We aimed to assess the relationship b...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/s12011-016-0779-z
更新日期:2017-02-01 00:00:00
abstract::Leukocytes incubated with Cu(II) showed a decrease in both glutathione reductase activity and reduced glutathione content. The glucose 6-phosphate dehydrogenase activity under the same conditions was not affected. Serum albumin added to mixtures prevented the loss of enzyme activity, whileD-penicillamine andL-histidin...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783258
更新日期:1982-06-01 00:00:00
abstract::Wild barley (Hordeum spontaneum), the progenitor of cultivated barley, is an important genetic resource for cereal improvement. Selenium (Se) is an essential trace mineral for humans and animals with antioxidant, anticancer, antiarthropathy, and antiviral effects. In the current study, the grain Se concentration (GSeC...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8770-6
更新日期:2011-09-01 00:00:00
abstract::Three hundred and sixty healthy Ross × Ross 1-day-old broilers were used to study the effects of zinc glycine chelate (Zn-Gly) on oxidative stress, contents of trace elements, and intestinal morphology. All broilers were randomly assigned to six treatment groups, which replicates three times. Diets were as follows: (1...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8824-9
更新日期:2011-09-01 00:00:00
abstract::Glutathione peroxidase (GPx) is the prototypical eukaryotic selenoprotein, with the rare amino acid selenocysteine (Sec) at the enzyme active site, encoded by the UGA codon in RNA. A DNA virus, Molluscum contagiosum, has now been shown to encode a functional selenium-dependent GPx enzyme. Using modifications of conven...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783852
更新日期:1999-11-01 00:00:00
abstract::The present study was designed to investigate the effect of mercuric chloride administration on copper, zinc, and iron concentrations in the liver, kidney, lung, heart, spleen, and muscle of rats. The results showed that after dose and time exposure to mercuric chloride, the concentration of mercury in the six tissues...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02910676
更新日期:1997-07-01 00:00:00
abstract::The nuclear microscope is now gaining popularity in the field of life sciences. In particular, the combination of proton-induced X-ray emission to measure the elemental concentrations of inorganic elements, Rutherford backscattering spectrometry to characterize the organic matrix, and scanning transmission ion microsc...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/BF02784192
更新日期:1999-01-01 00:00:00
abstract::Over the last decade, there has been an increased concern about the health risks from exposure to arsenic at low doses, because of their neurotoxic effects on the developing brain. The exact mechanism underlying arsenic-induced neurotoxicity during sensitive periods of brain development remains unclear, although enhan...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1286-1
更新日期:2018-11-01 00:00:00
abstract::The toxicity of boron has been understood for many years. However, limited data currently exist concerning the nutritional essentiality of B in chordates. Results from an ongoing research program evaluating the nutritional essentiality of B in the South African clawed frog, Xenopus laevis, found that X. laevis fed a l...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1385/BTER:90:1-3:117
更新日期:2002-01-01 00:00:00
abstract::Infant complementary foods are readily available in the UK markets and nowadays, weaning mothers prefer feeding their babies with these products due to modern lifestyles. However, there is a dearth of research with respect to the health risk assessment of trace essential and potentially toxic elements in these product...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02285-7
更新日期:2020-07-16 00:00:00
abstract::No specific treatment for COVID-19 infection is available up till now, and there is a great urge for effective treatment to reduce morbidity and mortality during this pandemic. We aimed to evaluate the effect of combining chloroquine/hydroxychloroquine (CQ/HCQ) and zinc in the treatment of COVID-19 patients. This was ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02512-1
更新日期:2020-11-27 00:00:00
abstract::Tibetan sheep have been observed with mineral deficiencies and marginal deficiencies in Qinghai-Tibetan Plateau. Adequate amounts of essential minerals are critical to maximize the productivity and health of livestock. The objectives of this study were to evaluate the effects of 6 months of mineral block supplementati...
journal_title:Biological trace element research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12011-015-0593-z
更新日期:2016-08-01 00:00:00
abstract::Numerous observations suggest a possible connection between the levels of Mg, Zn, Fe, and Zn and the incidence of depressive symptoms. Depression is two to three times more common in women than in men. The menopausal period is extremely conducive to depressive disorders. The aim of this study was to assess the severit...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-016-0798-9
更新日期:2017-03-01 00:00:00
abstract::Long-term copper application in vineyards and copper mining activities cause heavy metal pollution sites. Such sites need remediation to protect soil and water quality. Bioremediation of contaminated areas through bioleaching can help to remove copper ions from the contaminated soils. Thus, the aim of this work was to...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9213-8
更新日期:2012-04-01 00:00:00
abstract::Previous studies on the endodontic broken stainless steel instruments have mainly focused on retrieval of specimens. However, the systemic consequences of the retained separated instruments need an investigation. The current study aimed to evaluate the correlation between broken stainless steel instruments inside the ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9959-x
更新日期:2014-06-01 00:00:00
abstract::Differences in mineral nutrient composition of soils have been considered to affect health and population characteristics of free-ranging animals, particularly herbivores. Contents of Ca, Mg, and K in hair of female fawn white-tailed deer (Odocoileus virginianus) were measured for eight consecutive years to determine ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783968
更新日期:1998-06-01 00:00:00
abstract::Lithium is an integral drug used in the management of acute mania, unipolar and bipolar depression, and prophylaxis of bipolar disorders. Thyroid abnormalities have been associated with treatment with lithium. Zinc is an essential trace element that plays a role in several biological activities. Therefore, the present...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02356-9
更新日期:2020-08-26 00:00:00
abstract::The intervention effect of fucoxanthin, which is reportedly a powerful antioxidant, on cadmium-induced thyroid damage in mice was evaluated. Animals (N = 120) were divided into control group (given pure water, N = 20) and CdCl2-exposed group (given CdCl2 orally at a dose of 30 mg/kg body weight (bw)/day for 30 days, N...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02291-9
更新日期:2020-07-21 00:00:00
abstract::In this study, paraoxonase 1 (PON1; EC 3.1.8.1) was purified from bull semen, and some characteristics of the enzyme were investigated. In vitro inhibition effect of some heavy metals, including Cu(2+), Mn(2+), Cd(2+), Zn(2+), Ni(2+), and Pb(2+), on the activity of the purified enzyme was also investigated. The purifi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9916-8
更新日期:2014-04-01 00:00:00
abstract::The present research evaluated differential effects of sodium selenite and nano-Se on growth performance, tissue Se distribution, and glutathione peroxidase (GSH-Px) activity of avian broiler. Broilers were randomly segregated into 12 groups so that three replicates were available for each of the three treatments (T-1...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8264-y
更新日期:2009-05-01 00:00:00
abstract::Metallothionein (MT) is a low-mol-wt protein. The essential trace elements copper and zinc and the potentially toxic elements, such as cadmium, can induce the synthesis of and bind to MT. The major functions of MT are related to metal metabolism. This paper reported and evaluated a new method for determination of hepa...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783177
更新日期:1993-02-01 00:00:00
abstract::In vitro tests simulating the elements release from inhaled urban particulate matter (PM) with artificial lung fluids (Gamble's and Hatch's solutions) and simulated gastric and pancreatic solutions were applied for an estimation of hazardous element (As, Cd, Cr, Hg, Mn, Ni, Pb and Zn) bio-accessibility in this materia...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0101-x
更新日期:2014-11-01 00:00:00
abstract::Retraction to: Biol Trace Elem Res 144(1–3):1120–1132, DOI 10.1007/s12011-011-9149-z. Article has been retracted due to duplicate publication. ...
journal_title:Biological trace element research
pub_type: 撤回出版物
doi:10.1007/s12011-012-9550-2
更新日期:2013-01-01 00:00:00