Abstract:
:The aim of this study was to evaluate and compare the oxidative profiles of three thyroid disorders: Graves' disease (GD), Hashimoto thyroiditis (HT), and papillary thyroid cancer (PTC). Malondialdehyde levels (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) activities were examined in the plasma of 52 patients (29 untreated HT, 16 untreated GD, and 7 PTC who underwent surgical therapy). Results were compared with those of 30 healthy controls and among the three groups of patients. The GD, HT, and PTC patients exhibited increased plasma MDA levels and SOD activities compared with the controls (p < 0.05, p < 0.05, and p < 0.001, respectively). CAT activities significantly increased only for the PTC and HT patients (p < 0.001 and p < 0.05, respectively), whereas GPx activities significantly decreased only in the GD and PTC (p < 0.05 and p < 0.01, respectively). The comparison among the three groups of patients has shown increased MDA level and SOD activity for the PTC patients as compared to the GD patients (p < 0.01 and p < 0.001, respectively). Compared with HT, PTC patients exhibited significant higher MDA level, SOD, and CAT activities and a significant lower GPx activity (p < 0.01, p < 0.001, p < 0.05, and p < 0.05, respectively). No significant discrepancies were noted between the GD and HT patients. Our results have clearly shown an oxidative profile that is highly disturbed for the PTC patients as compared to those of autoimmune disorders. Future studies are needed to determine whether or not the oxidative stress has a prognostic value in this pathology.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Lassoued S,Mseddi M,Mnif F,Abid M,Guermazi F,Masmoudi H,El Feki A,Attia Hdoi
10.1007/s12011-010-8625-1subject
Has Abstractpub_date
2010-12-01 00:00:00pages
107-15issue
1-3eissn
0163-4984issn
1559-0720journal_volume
138pub_type
杂志文章abstract::An in vitro system employing collagen isolated from the sheep tendons to induce mineralization and demineralization reactions was used not only to study the effect of various concentrations of fluoride on the collagen-induced mineralization and demineralization reactions but also to compare their action with the inhib...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02340-3
更新日期:2020-08-27 00:00:00
abstract::The influence of several commercial albumin preparations on the ferroxidase activity of ceruloplasmin (ferroxidase I, ferrous: O2 oxidoreductase EC 1.16.3.1) at pH 6.0 was determined using ferric-transferrin formation. The ability of several albumin preparations to inhibit the ferroxidase activity of ceruloplasmin dif...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02916628
更新日期:1983-04-01 00:00:00
abstract::This study was designed to measure the effect of iron supplementation on antioxidant status in iron-deficient anemia, including the time for hemoglobin normalization and at the time of filling of iron body stores. The extent of plasma lipid peroxidation was evaluated by measuring the levels of malondialdehyde and glut...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:96:1-3:117
更新日期:2003-01-01 00:00:00
abstract::In this study, paraoxonase 1 (PON1; EC 3.1.8.1) was purified from bull semen, and some characteristics of the enzyme were investigated. In vitro inhibition effect of some heavy metals, including Cu(2+), Mn(2+), Cd(2+), Zn(2+), Ni(2+), and Pb(2+), on the activity of the purified enzyme was also investigated. The purifi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9916-8
更新日期:2014-04-01 00:00:00
abstract::Control of elemental impurities (EIs) in pharmaceutical herbal products is currently important but not a very popular topic in modern toxicological analysis. The occurrence and concentration of EIs in the pharmaceutical herbal products should be controlled and meet the standards of directive International Conference o...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-1643-8
更新日期:2019-10-01 00:00:00
abstract::The origins of the usage of different substances in beauty, skin, body, hair, and nails care products can be found in ancient times. To achieve better quality and enhance their effects, some additives such as preservatives, stabilizers, mineral pigments, dye, and shine were added to these products. Some of these subst...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0477-2
更新日期:2016-04-01 00:00:00
abstract::Although cisplatin (cisPt) is one of the most often used cytotoxic drugs in the treatment of cancer, its clinical application is associated with nephrotoxicity and a cumulative anemia. In this study, we evaluated posible protective effects of selenium (Se) on hematological and oxidative stress parameters in rats, acut...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8788-9
更新日期:2011-09-01 00:00:00
abstract::The present study was undertaken to evaluate the in vitro availability of chemically varying forms of selenium (Se), supplemented in cow's milk. Two inorganic (selenite and selenate) and two organic (seleno-methionine [Se-Met] and seleno-cystine [Se-Cys]) Se sources were evaluated. The in vitro availability was estima...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02910666
更新日期:1997-07-01 00:00:00
abstract::Women with preeclampsia have been shown to have elevated blood levels of the metabolite homocysteine, and alterations in blood levels of zinc and copper have also been reported. This study measured plasma levels of zinc, copper, and homocysteine in women with preeclampsia and in women with healthy, normotensive pregna...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:104:2:097
更新日期:2005-05-01 00:00:00
abstract::Since chromium(VI) is unreactive toward DNA under physiological conditions in vitro, the ability of carcinogenic chromium(VI) compounds to damage DNA depends on the presence of cellular redox components that reduce chromium(VI) to reactive species capable of interacting with DNA. We have examined the role of glutathio...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/BF02917282
更新日期:1989-07-01 00:00:00
abstract::Magnesium (Mg) concentrations in diets have been associated with performance and eggshell quality of laying hens, but the results have been inconclusive. In this experiment, the effects of increasing concentrations of dietary Mg on productive performance and eggshell quality of aged laying hens were evaluated. A total...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9537-z
更新日期:2013-01-01 00:00:00
abstract::Free oxygen radicals and insufficient antioxidant enzymes have been implicated in the pathogenesis of hypercholesterolemia (HC). Trace elements function as cofactors in antioxidant enzymes. Antioxidant system and trace elements were investigated in many different studies including HC, but these subjects have not been ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:98:2:119
更新日期:2004-05-01 00:00:00
abstract::Instrumental neutron activation (INAA) with k0 standardization has been used to determine the concentration levels of a variety of major and trace elements (Al, As, Br, Cd, Cl, Co, Cr, Cs, Cu, Fe, Hg, K, La, Mg, Mn, Mo, Na, Rb, Sc, Se, and Zn) in rice grains (raw and parboiled) and in rice flour collected from local m...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:103:1:083
更新日期:2005-01-01 00:00:00
abstract::The distribution, potential ecological hazards, and homologous relativity of heavy metals in the water-level fluctuating zone (WLFZ) of the Yangtze River within the Wanzhou Section (YRWS) were investigated. The heavy metal content (Cd, Cu, Cr, and Ni) of the surface soil was analysed via atomic absorption spectroscopy...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9179-6
更新日期:2012-02-01 00:00:00
abstract::The experiment was conducted to study the effects of different selenium (Se) sources on productive performance, serum and milk Se concentrations, and antioxidant status of sows. A total of 12 sows (Landrace×Yorkshire) with same pregnancy were randomly divided into two groups; each group was replicated six times. These...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8803-1
更新日期:2011-09-01 00:00:00
abstract::A simple, quick procedure has been developed for preparation of human lenses for total chromium (Cr) analysis by electrothermal atomic absorption spectrometry (EAAS). This procedure involves wet ashing in a mini-autoclave with HNO3 and H2SO4. Recovery was 101.6%. This procedure is simple to carry out, does not generat...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784598
更新日期:1992-01-01 00:00:00
abstract::Strontium stimulates cartilage matrix formation in vitro. However, the mechanisms governing these effects have not yet been extensively reported. In this study, chondrocytes were isolated from rat articular cartilage by enzymatic digestion and cultured for 24-72 h with 1-5 mM strontium. We investigated the effects of ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9640-9
更新日期:2013-06-01 00:00:00
abstract::The selenium levels and the glutathione peroxidase activity GSH-PX of whole blood and of erythrocytes, respectively, were determined in 139 normal Danes and related to sex and smoking habits. No differences were found in relation to sex apart from a higher GSH-PX activity of females when assayed with tertiary butyl hy...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/BF02990131
更新日期:1988-01-01 00:00:00
abstract::Bulk fabrication of ordered hollow structural particles (HSPs) with large surface area and high biocompatibility simultaneously is critical for the practical application of HSPs in biosensing and drug delivery. In this article, we describe a smart approach for batch synthesis of calcium carbonate nanotubes (CCNTs) bas...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9325-9
更新日期:2012-06-01 00:00:00
abstract::Rare earth elements (REEs) have been widely used to increase accumulation of biomass and secondary metabolites in medicinal plants in China. However, very few studies have investigated how REEs mediate secondary metabolism synthesis in medicinal plants. Lanthanum (La), an important REE, is known to improve the accumul...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9379-8
更新日期:2012-09-01 00:00:00
abstract::Mannheimia haemolytica is the main bacterial pathogen isolated in bovine respiratory disease (BRD), a common disease affecting calves before weaning. Previous research has shown that experimental infection with bovine herpesvirus 1, a respiratory virus, decreases plasma zinc (Zn) levels. However, changes in plasma Zn ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02145-4
更新日期:2021-01-01 00:00:00
abstract::Epimedium polysaccharide (EPS) and isatis root polysaccharide (IRPS) were extracted, purified, and selenizingly modified by nitric acid-sodium selenite method to obtain nine selenizing EPSs (sEPSs), sEPS1-sEPS9 and nine selenizing IRPSs (sIRPSs), sIRPS1-sIRPS9, respectively. Their effects on chicken peripheral lymphoc...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0511-4
更新日期:2016-05-01 00:00:00
abstract::Glutathione peroxidase (GPx) is the prototypical eukaryotic selenoprotein, with the rare amino acid selenocysteine (Sec) at the enzyme active site, encoded by the UGA codon in RNA. A DNA virus, Molluscum contagiosum, has now been shown to encode a functional selenium-dependent GPx enzyme. Using modifications of conven...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783852
更新日期:1999-11-01 00:00:00
abstract::Diabetic osteoporosis (DOP) is a complication of diabetes, with the characteristics of bone mineral density (BMD) reduction and bone structure destruction. Zinc was reported has a benefit effect on postmenopausal osteoporosise, it was also has hypoglycemic effect, whether zinc was beneficial on diabetes-induced osteop...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01810-7
更新日期:2020-04-01 00:00:00
abstract::The distribution and chemical species of iodine in various subcellular fractions of human liver were studied by using epithermal neutron activation analysis combined with chemical and biochemical separation techniques, such as gradient centrifugation and gel chromatography. It was found that the total iodine content o...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783916
更新日期:1999-07-01 00:00:00
abstract::Plasma chromium concentrations have been determined for 150 patients. These were subjected to coronary artery cineangiography and thereby divided into three groups: group CAD (those with coronary artery disease), group HD (those with heart disease, but no CAD) and group N (those with no CAD and no HD). Weighted, avera...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02989260
更新日期:1984-10-01 00:00:00
abstract::Consumption of edible plants satisfies a significant part of human body needs in macro- and micronutrients while biologically active substances contain strong antioxidant properties and reduce the risk of a number of diseases. Balanced nutrition and design of personalized diets and treatment rely on the data on the co...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02345-y
更新日期:2020-08-19 00:00:00
abstract::For this study, we investigate more deeply the effect calcium (Ca) develops on the mechanism underlying fluoride-triggered osteocyte apoptosis. We detected the morphology of osteocytes by HE staining, mitochondrial microstructure by using the transmission electron microscope, and the biochemical indexes related to bon...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02305-6
更新日期:2020-07-25 00:00:00
abstract::The incorporation of(3)H-thymidine into DNA in the brains of the 17-day and 20-day old rat fetuses was significantly reduced by maternal zinc restriction during pregnancy. The activity of the enzyme thymidine kinase (EC 2.7.1.21) was similarly reduced in the zine-deprived fetal brains on days 14 and 20 of gestation, b...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02789032
更新日期:1980-03-01 00:00:00
abstract::The effect of parenteral zinc on tissue metallothionein (MT) was studied in normal and streptozotocin-induced diabetic rats. The accumulation of Zn-MT in liver and pancreas of normal and diabetic rats following the administration (ip) of various amounts of zinc was not different. Renal Zn-MT was higher in the diabetic...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02795531
更新日期:1986-12-01 00:00:00