Abstract:
:Bulk fabrication of ordered hollow structural particles (HSPs) with large surface area and high biocompatibility simultaneously is critical for the practical application of HSPs in biosensing and drug delivery. In this article, we describe a smart approach for batch synthesis of calcium carbonate nanotubes (CCNTs) based on supported liquid membrane (SLM) with large surface area, excellent structural stability, prominent biocompatibility, and acid degradability. The products were characterized by transmission electron micrograph, X-ray diffraction, Fourier transform infrared spectra, UV-vis spectroscopy, zeta potential, and particle size distribution. The results showed that the tube-like structure facilitated podophyllotoxin (PPT) diffusion into the cavity of hollow structure, and the drug loading and encapsulation efficiency of CCNTs for PPT are as high as 38.5 and 64.4 wt.%, respectively. In vitro drug release study showed that PPT was released from the CCNTs in a pH-controlled and time-dependent manner. The treatment of HEK 293T and SGC 7901 cells demonstrated that PPT-loaded CCNTs were less toxic to normal cells and more effective in antitumor potency compared with free drugs. In addition, PPT-loaded CCNTs also enhanced the apoptotic process on tumor cells compared with the free drugs. This study not only provides a new kind of biocompatible and pH-sensitive nanomaterial as the feasible drug container and carrier but more importantly establishes a facile approach to synthesize novel hollow structural particles on a large scale based on SLM technology.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Tang J,Sun DM,Qian WY,Zhu RR,Sun XY,Wang WR,Li K,Wang SLdoi
10.1007/s12011-012-9325-9subject
Has Abstractpub_date
2012-06-01 00:00:00pages
408-17issue
1-3eissn
0163-4984issn
1559-0720journal_volume
147pub_type
杂志文章abstract::Infant complementary foods are readily available in the UK markets and nowadays, weaning mothers prefer feeding their babies with these products due to modern lifestyles. However, there is a dearth of research with respect to the health risk assessment of trace essential and potentially toxic elements in these product...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02285-7
更新日期:2020-07-16 00:00:00
abstract::The concentrations of 17 elements in the nail and hair of 117 subjects from a nonindustrialized environment were determined by instrumental neutron activation analysis (INAA). A new method of statistical treatment that allows for more meaningful use of detection limit values was used to process the concentration data....
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02795450
更新日期:1988-09-01 00:00:00
abstract::The objective of this study was to investigate the iron source absorption in the small intestine of broiler. In situ ligated intestinal loops of 70 birds were poured into one of seven solutions, including inorganic iron (FeSO4, Fe2(SO4)3), organic Fe glycine chelate (Fe-Gly(II), Fe-Gly(III)), the mixtures (FeSO4 with ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0179-1
更新日期:2015-02-01 00:00:00
abstract::Many studies have shown that zinc deficiency could decrease the response to insulin. In genetically diabetic animals, a low zinc status has been observed contrary to induced diabetic animals. The zinc status of human patients depends on the type of diabetes and the age. Zinc supplementation seems to have beneficial ef...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/BF02784615
更新日期:1992-01-01 00:00:00
abstract::Attempts were made to promote germination of natural aged rice seeds by treating them with lanthanum nitrate. In tests to measure the germination rate, germination index, and vigor index of natural aged rice seeds were found to be significantly increased by lanthanum. It is treating aged rice seed with lanthanum nitra...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/bter:75:1-3:205
更新日期:2000-07-01 00:00:00
abstract::The selenium levels and the glutathione peroxidase activity GSH-PX of whole blood and of erythrocytes, respectively, were determined in 139 normal Danes and related to sex and smoking habits. No differences were found in relation to sex apart from a higher GSH-PX activity of females when assayed with tertiary butyl hy...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/BF02990131
更新日期:1988-01-01 00:00:00
abstract::Serum copper and zinc estimations in humans were made to find their diagnostic and prognostic value in cases of myocardial infarction. Following infarction, there was an increase in serum copper levels from the first 24 h up to the 7th day, with gradual decline that did not reach the normal value up to the 14th day. T...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02990200
更新日期:1991-12-01 00:00:00
abstract::The variance of testing was compared between the College of American Pathologists clinical survey and that of a recent review about hair mineral testing. The review suggested that the accuracy of hair mineral testing was unreliable. In general, there was a greater range of variance in the College of American Pathologi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:87:1-3:001
更新日期:2002-07-01 00:00:00
abstract::To elucidate age-related changes of mineral contents in human veins, the relative contents (RCs) of elements in the human internal jugular veins, superior and inferior venae cavae, and femoral veins from 27 subjects ranging from 40 to 98 yr old were analyzed by inductively coupled plasma atomic emission spectrometry. ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02820017
更新日期:1998-04-01 00:00:00
abstract::The objective of this study was to assess the contamination levels of arsenic (As), lead (Pb), chromium (Cr), and cadmium (Cd) in raw milk and the subsequent potential health risk to local consumers close to leather-processing plants in China. The As and Pb concentrations in milk from contaminated areas were 0.43 ± 0....
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02470-8
更新日期:2020-11-12 00:00:00
abstract::The kidney has been regarded as a critical organ of toxicity induced by acute exposure to hexavalent chromium [Cr(VI)] compounds. Reactive intermediates and free radicals generated during reduction process might be responsible for Cr(VI) toxicity. In this study, the effects of pretreatment or posttreatment of taurine ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:102:1-3:209
更新日期:2004-01-01 00:00:00
abstract::Recently, several studies on the effects of a compound named "chromium malate," with the proposed formula "Cr2malate3·xH2O" where x = 3.5 or 5, on the health of healthy and diabetic rats have appeared. However, the compound is poorly characterized, and knowing the identity of this material could be important in the in...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1046-7
更新日期:2018-02-01 00:00:00
abstract::Garlic (Allium sativum) is known to reduce lead toxicity in some species of animals. The objective of this study was to evaluate the efficacy of allicin, one of the most active components of garlic, in the treatment of subacute lead intoxication in sheep. Nine female sheep weighing 25-29 kg orally received a daily dos...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8185-9
更新日期:2008-01-01 00:00:00
abstract::Urine is a clinical specimen often used in medical diagnostics for monitoring of elements concentrations and kidneys function. We determined the contents of magnesium (Mg), calcium (Ca), zinc (Zn), copper (Cu), iron (Fe), lead (Pb), and cadmium (Cd) in 74 samples of 24-h urine (from 46 women and 28 men). The measureme...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8745-7
更新日期:2011-07-01 00:00:00
abstract::Numerous experiments in vitro and in vivo have shown that an appropriate increase intake of silicon can facilitate the synthesis of collagen and its stabilization and promote the differentiation and mineralization of osteoblasts. In this study, we examined whether ortho-silicic acid restrains the differentiation of os...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02286-6
更新日期:2020-07-16 00:00:00
abstract::Although adriamycin (ADR) exhibits high anti-tumor efficacy in vitro, its clinical use in cancer chemotherapy is limited due to its high renal toxicity. This study investigated the mechanism of ADR nephropathy and the protective effect of selenium on ADR-induced kidney damage by analyzing of the relationship between s...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9273-9
更新日期:2012-06-01 00:00:00
abstract::Studies of effects of diazepam on liver parenchyma are very scanty. In this study, adult albino rats were treated with diazepam in two different doses (0.25 mg and 0.30 mg/kg body wt) daily for 30 and 60 d. Through light microscopy and electron microscopy, prenecrotic and necrotic changes were noted in the high-dose g...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785292
更新日期:1997-06-01 00:00:00
abstract::Cadmium (Cd) is an environmental toxicant and an inflammation-related xenobiotic. Selenium (Se) is a well-known nutritional trace element and a potent chemopreventive agent. The present study aimed to investigate the effect of Se on the cytotoxicity of Cd in bird immunocytes in vitro. Chicken splenic lymphocytes expos...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0354-z
更新日期:2015-11-01 00:00:00
abstract::Head hair concentrations of zinc, copper, manganese, alid iron from a total of 418 subjects (154 male and 264 female) aged between 6 mo and 20 yr were measured mainly with flameless atomic absorption spectrophotometry. Only zinc analysis of a part of the female samples (n = 140) were analyzed with inductively coupled ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:77:1:43
更新日期:2000-10-01 00:00:00
abstract::Copper oxide nanoparticles (CuONPs) are widely used in several products and their release into the environment can cause toxicity to major food crops. In this study, toxic responses as a result of CuONPs exposure were studied in soybean (Glycine max L.) seedlings. The plants were grown in 1/2 strength Murashige and Sk...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0106-5
更新日期:2014-12-01 00:00:00
abstract::The purpose of this research was to investigate whether copper (Cu) exposure could induce apoptosis via endoplasmic reticulum stress (ERS) in skeletal muscle of broilers. A total of 240 one-day-old chickens were randomly divided into four groups by free access; the diets are as follows: control diet (Cu 11 mg/kg, cont...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02076-0
更新日期:2020-12-01 00:00:00
abstract::The relationship between selenium (Se) deficiency-induced cardiac malfunction and endoplasmic reticulum (ER) stress is poorly understood. In the present study, 18 weaning Sprague Dawley rats were randomly fed with three different Se diets, and myocardial glutathione peroxidase (GPx) activity was measured by an enzyme ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9834-1
更新日期:2013-12-01 00:00:00
abstract::The movement of copper and zinc from the fertilized egg into the developing embryo and the subsequent association of the two metals with metallothionein-like proteins (MT) of chick liver was investigated. Hepatic levels of MT in 1-d-old chicks, estimated from specifically bound(115m)Cd, were increased eightfold over e...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02988942
更新日期:1983-12-01 00:00:00
abstract::Iron deficiency anemia (IDA) due to malnutrition and/or blood loss is a common condition, especially in women of reproductive age. Intense exercise can induce anemia via an inflammatory response, but whether intense exercise affects the efficacy of iron supplementation to treat IDA is unclear. Here, we show in a mouse...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02402-6
更新日期:2020-10-06 00:00:00
abstract::Zinc deficiency, which is common among Iranian populations, is believed to play a crucial role in the onset and progression of mood disorders such as depression in different stages of life. We have therefore investigated the relationship between serum/dietary zinc status and depression scores among adolescent girls li...
journal_title:Biological trace element research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12011-018-1301-6
更新日期:2018-11-01 00:00:00
abstract::Selenoprotein T (SelT) is associated with the regulation of calcium homeostasis and neuroendocrine secretion. SelT can also change cell adhesion and is involved in redox regulation and cell fixation. However, the structure and function of chicken SelT and its response to selenium (Se) remains unclear. In the present s...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0049-x
更新日期:2014-08-01 00:00:00
abstract::This report explains the employing of a combination test of traditional cell culture with a quantitative real-time PCR for assessment of the antiviral effect of zinc sulfate (ZnSO4) on herpes simplex virus (HSV)-infected Vero cells. Our evidence showed that the treatment with 0.3 mM ZnSO4 strongly inhibited the replic...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01728-0
更新日期:2020-02-01 00:00:00
abstract::Atomic absorption spectrometry was used in a quantitative study of zinc, magnesium, and manganese on 71 postmortal human aortas. Samples were obtained from accident victims 35-65 years of age. Fibrous plaques had higher levels of all three elements when compared to normal aortic tissue. The difference was significant ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02916613
更新日期:1989-12-01 00:00:00
abstract::Scleroderma, sclerosis of the skin, is a severe autoimmune disease refractant to all kind of treatments. To study the in vivo effects of a combination of three oligoelements selenium (Se), zinc (Zn), and manganese (Mn) plus Lachesis muta venom (O-LM) on the bleomycin (BLM)-induced scleroderma mouse experimental model....
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9876-4
更新日期:2014-02-01 00:00:00
abstract::Colon cancer in men and breast cancer in women are regarded as major health burdens, accounting for majority of cancer diagnoses globally. Doxorubicin (DOX) resistance in breast and colon cancers represents the main reason of unsuccessful therapy. The rationale of this study is to explore whether selenium nanoparticle...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01730-6
更新日期:2020-02-01 00:00:00