Abstract：
:Cadmium (Cd) is an environmental toxicant and an inflammation-related xenobiotic. Selenium (Se) is a well-known nutritional trace element and a potent chemopreventive agent. The present study aimed to investigate the effect of Se on the cytotoxicity of Cd in bird immunocytes in vitro. Chicken splenic lymphocytes exposed to CdCl2 (10(-6) mol/L), Na2SeO3 (10(-7) mol/L), or a mixture of the two (10(-7) mol/L Na2SeO3 and 10(-6) mol/L CdCI2) were incubated for 12, 24, 36, 48, or 60 h. Cd significantly increased (P < 0.05 or P < 0.01) the messenger RNA (mRNA) expression levels of nuclear factor kappaB (NF-κB), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF-α), and prostaglandin E2 (PGE2), and similar results were observed in the protein expression levels of NF-κB and COX-2. In addition, the nitric oxide (NO) content and the inducible iNOS activity were increased in the Cd-treated group compared to the control group. Furthermore, the protective effects of Se against Cd toxicity in chicken splenic lymphocytes were illustrated by the increase in select cytokines (NF-κB, iNOS, COX-2, TNF-α, and PGE2), NO content and iNOS activity. The biochemical parameters exhibited sensitivity to Se and Cd, suggesting that they may act as potential biomarkers for assessing the effects of Se and Cd risk on chicken splenic lymphocytes.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Liu S,Xu F,Fu J,Li Sdoi
10.1007/s12011-015-0354-zsubject
Has Abstractpub_date
2015-11-01 00:00:00pages
252-60issue
1eissn
0163-4984issn
1559-0720pii
10.1007/s12011-015-0354-zjournal_volume
168pub_type
杂志文章abstract：:The present study was undertaken to evaluate methylmercury-induced alterations in hepatic enzymes and oxidative stress markers in liver tissue of rainbow trout (Oncorhynchus mykiss) by using a perfusion method, and to explore possible protective effect of vitamin C against these alterations. Forty-eight fish were divi...
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pub_type： 杂志文章,随机对照试验
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journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/BF02917347
更新日期：1994-10-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Biological trace element research
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