Abstract:
:The effects of dietary sodium selenite and vitamin E on the microvascular permeability of rat organs such as heart, brain, kidney, liver and eye were investigated by using the Evans blue leakage method. Combined deficiency of selenium and vitamin E caused an increase in the permeability of the heart and eye with respect to their controls while it had no considerable effect on the permeability of other organs. On the other hand, toxic levels of selenium (4.2 mg/kg) in diet decreased the permeabilities in kidney, liver, and eye whereas this parameter of brain increased in the same animal group. These results suggested that low or high sodium selenite and vitamin E contents in diet could alter the microvascular permeability of different organs in different manners. It might be important to give reasonable explanations for the pathophysiology of some diseases that are characterized with organ damage and/or disfunction originated from selenium deficiency or toxicity.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Demirel-Yilmaz E,Dinçer D,Yilmaz G,Turan Bdoi
10.1007/BF02783332subject
Has Abstractpub_date
1998-07-01 00:00:00pages
161-8issue
1-3eissn
0163-4984issn
1559-0720journal_volume
64pub_type
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