The effect of selenium and vitamin E on microvascular permeability of rat organs.

Abstract:

:The effects of dietary sodium selenite and vitamin E on the microvascular permeability of rat organs such as heart, brain, kidney, liver and eye were investigated by using the Evans blue leakage method. Combined deficiency of selenium and vitamin E caused an increase in the permeability of the heart and eye with respect to their controls while it had no considerable effect on the permeability of other organs. On the other hand, toxic levels of selenium (4.2 mg/kg) in diet decreased the permeabilities in kidney, liver, and eye whereas this parameter of brain increased in the same animal group. These results suggested that low or high sodium selenite and vitamin E contents in diet could alter the microvascular permeability of different organs in different manners. It might be important to give reasonable explanations for the pathophysiology of some diseases that are characterized with organ damage and/or disfunction originated from selenium deficiency or toxicity.

journal_name

Biol Trace Elem Res

authors

Demirel-Yilmaz E,Dinçer D,Yilmaz G,Turan B

doi

10.1007/BF02783332

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

161-8

issue

1-3

eissn

0163-4984

issn

1559-0720

journal_volume

64

pub_type

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