Effect of Fluoride on Small Intestine Morphology and Serum Cytokine Contents in Rats.

Abstract:

:This study aimed to determine the effect of excessive fluoride (F) on the morphological characteristics of the small intestine and the contents of serum cytokines in rats. A total of 48 3-week-old healthy female Sprague-Dawley rats were randomly divided into four groups (n = 12). The control group was given deionized distilled water, while the F treatment groups were treated with water containing 25, 50, and 100 mg F-/L. After 70 days of treatment, the duodenum, the jejunum, and the ileum were collected to measure the developmental parameters and the distribution of intestinal glycoproteins, goblet cells, and mast cells through Pannoramic Viewer, Periodic Acid-Schiff (PAS) staining, Alcian blue and periodic acid-Schiff (AB-PAS) staining, and toluidine blue staining, respectively. The contents of cytokines, namely, interleukin (IL)-1β, IL-2, IL-6, and tumor necrosis factor (TNF)-α, in serum were detected via enzyme-linked immunosorbent assay (ELISA). Results showed that the villus height, crypt depth, villus height to crypt depth ratio, goblet cells, glycoproteins, and mast cells of the small intestine significantly decreased (P < 0.05 or P < 0.01) in the F treatment group. The contents of IL-1β, IL-2, IL-6, and TNF-α were significantly lower in the F treatment group than in the control group (P < 0.05 or P < 0.01). In summary, excessive F intake impaired intestinal development and immune function by decreasing the developmental parameters and the distribution of immune cells, glycoproteins, and cytokines.

journal_name

Biol Trace Elem Res

authors

Wang HW,Liu J,Zhao WP,Zhang ZH,Li SQ,Li SH,Zhu SQ,Zhou BH

doi

10.1007/s12011-018-1503-y

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

511-518

issue

2

eissn

0163-4984

issn

1559-0720

pii

10.1007/s12011-018-1503-y

journal_volume

189

pub_type

杂志文章
  • Risk Assessment of Metal(Loid)s Exposed to Infants via Consumption of Weaning Foods from Different Supermarkets in Sheffield, UK.

    abstract::Infant complementary foods are readily available in the UK markets and nowadays, weaning mothers prefer feeding their babies with these products due to modern lifestyles. However, there is a dearth of research with respect to the health risk assessment of trace essential and potentially toxic elements in these product...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02285-7

    authors: Ajala LO,Obasi NA,Okafor MC,Onwukeme VI

    更新日期:2020-07-16 00:00:00

  • Functionalized Core-Shell Yttrium Oxide Nanoparticles as Antioxidants Agents in Heat Stressed Rats.

    abstract::Herein, we assess the antioxidant potential of core-shell yttrium oxide nanoparticles functionalized with ethylene glycol methacrylate phosphate (EGMP). The antioxidant properties of these nanoparticles were investigated in heat stressed models of 21 rats (heat stressed group, group B). Different samples of blood, ser...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02036-8

    authors: Kassem S,Mohamed M,Sayour H,Canfarotta F,Piletsky S,Soliman MAM

    更新日期:2020-11-01 00:00:00

  • Differential effects of sodium selenite and nano-Se on growth performance, tissue se distribution, and glutathione peroxidase activity of avian broiler.

    abstract::The present research evaluated differential effects of sodium selenite and nano-Se on growth performance, tissue Se distribution, and glutathione peroxidase (GSH-Px) activity of avian broiler. Broilers were randomly segregated into 12 groups so that three replicates were available for each of the three treatments (T-1...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-008-8264-y

    authors: Wang Y

    更新日期:2009-05-01 00:00:00

  • The electrostatic interactions between nano-TiO(2) and trypsin inhibit the enzyme activity and change the secondary structure of trypsin.

    abstract::In this work, the interaction between nano-TiO(2) and trypsin was investigated, and the mechanisms of the interaction were explored by the methods of UV-vis detection, circular dichroism (CD), and fluorescence. The results clearly demonstrated that nano-TiO(2) had an inhibitory effect on the enzyme activity. The activ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-010-8823-x

    authors: Wang WR,Zhu RR,Xiao R,Liu H,Wang SL

    更新日期:2011-09-01 00:00:00

  • Changes in trace element concentrations in hair of growing children.

    abstract::Head hair concentrations of zinc, copper, manganese, alid iron from a total of 418 subjects (154 male and 264 female) aged between 6 mo and 20 yr were measured mainly with flameless atomic absorption spectrophotometry. Only zinc analysis of a part of the female samples (n = 140) were analyzed with inductively coupled ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:77:1:43

    authors: Sakai T,Wariishi M,Nishiyama K

    更新日期:2000-10-01 00:00:00

  • Impact of boron deficiency on Xenopus laevis: a summary of biological effects and potential biochemical roles.

    abstract::The toxicity of boron has been understood for many years. However, limited data currently exist concerning the nutritional essentiality of B in chordates. Results from an ongoing research program evaluating the nutritional essentiality of B in the South African clawed frog, Xenopus laevis, found that X. laevis fed a l...

    journal_title:Biological trace element research

    pub_type: 杂志文章,评审

    doi:10.1385/BTER:90:1-3:117

    authors: Fort DJ,Rogers RL,McLaughlin DW,Sellers CM,Schlekat CL

    更新日期:2002-01-01 00:00:00

  • Influence of fluoride on rat kidney antioxidant system: effects of methionine and vitamin E.

    abstract::The aim of the study has been to determine and compare the influence upon the kidney antioxidative system, exercised by administration of vitamin E, and vitamin E in combination with methionine, under conditions of oxidative stress induced by sodium fluoride. The experiment was carried out on Wistar FL rats (adult mal...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-007-8030-6

    authors: Błaszczyk I,Grucka-Mamczar E,Kasperczyk S,Birkner E

    更新日期:2008-01-01 00:00:00

  • Analytical Assessment of Bio- and Toxic Elements Distribution in Pu-erh and Fruit Teas in View of Chemometric Approach.

    abstract::This study concerns application of flame atomic absorption spectrometry (FAAS) in assessment of macro- and microelement and toxic metal levels (Mg, Ca, K, Na, Mn, Cu, Fe, Zn, Cr, Ni, Co, Cd and Pb) in dark (Pu-erh) and fruit tea leaves and their infusions. Phosphorus was also determined in the form of phosphomolybdate...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-016-0669-4

    authors: Brzezicha-Cirocka J,Grembecka M,Szefer P

    更新日期:2016-11-01 00:00:00

  • Selenite metabolism in rat and human blood.

    abstract::The binding of selenite, the form of selenium used in the treatment of Keshan disease, to plasma proteins and the role of erythrocytes in this process have been studied. The experiments were carried out by incubating 75Se as selenite with plasma and whole blood in vitro (human and rat) and in vivo (rat) and subsequent...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02990129

    authors: Mas A,Jiang JY,Sarkar B

    更新日期:1988-01-01 00:00:00

  • Protective role of selenium on pepper exposed to cadmium stress during reproductive stage.

    abstract::The aim of the present study was to examine the effects of exogenous selenium (Se) supplementation on the tolerance of pepper (Capsicum annuum L.) cv. Suryamukhi Cluster plants to cadmium (Cd) phytotoxicity at the reproductive stage. The pepper plants were supplied with Cd (0, 0.25 or 0.50 mM) and Se (0, 3 or 7 μM), i...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-014-0028-2

    authors: Mozafariyan M,Shekari L,Hawrylak-Nowak B,Kamelmanesh MM

    更新日期:2014-07-01 00:00:00

  • Natural variation in grain selenium concentration of wild barley, Hordeum spontaneum, populations from Israel.

    abstract::Wild barley (Hordeum spontaneum), the progenitor of cultivated barley, is an important genetic resource for cereal improvement. Selenium (Se) is an essential trace mineral for humans and animals with antioxidant, anticancer, antiarthropathy, and antiviral effects. In the current study, the grain Se concentration (GSeC...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-010-8770-6

    authors: Yan J,Wang F,Qin H,Chen G,Eviatar N,Fahima T,Cheng J

    更新日期:2011-09-01 00:00:00

  • Selenite or selenomethionine interaction with methylmercury on uptake and toxicity showing a weak selenite protection: studies on cultured K-562 cells.

    abstract::Selenium and methylmercuric chloride (MMC) interactions regarding cellular uptake and selenium protection on MMC toxicity have been studied. Human K-562 cells were pretreated or simultaneously treated with either selenite (5 or 50 microM) or selenomethionine (10 or 50 microM) together with (3.5 or 5 microM) MMC. Cells...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:80:3:251

    authors: Frisk P,Yaqob A,Nilsson K,Lindh U

    更新日期:2001-06-01 00:00:00

  • Normal Serum Fluoride Concentration in Dromedary Camel (Camelus dromedarius).

    abstract::Fluoride (F) concentration in blood serum of healthy dromedary camel population was measured, and its relationship with age and sex was determined. In male animals, the level varied from 0.017 to 0.296 ppm, with mean (± S.E.) value of 0.163 ± 0.013 ppm. In females, the level varied from 0.036 to 0.372 ppm with mean va...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02534-9

    authors: Ranjan A,Nabi J,Ranjan R

    更新日期:2021-01-06 00:00:00

  • Zinc Absorption from Fortified Milk Powder in Adolescent Girls.

    abstract::Zinc (Zn) is essential for development, growth, and reproduction. The Mexican government subsidizes micronutrient-fortified milk for risk groups, with positive effect on the targeted groups' plasma Zn level, inferring a good absorption is achieved although it has not being measured. The aim of this study was to determ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-015-0356-x

    authors: Méndez RO,Hambidge M,Baker M,Salgado SA,Ruiz J,García HS,Calderón de la Barca AM

    更新日期:2015-11-01 00:00:00

  • The effect of a moderate zinc deficiency and dietary fat source on the activity and expression of the Δ(3)Δ (2)-enoyl-CoA isomerase in the liver of growing rats.

    abstract::Auxiliary enzymes participate in β-oxidation of unsaturated fatty acids. The objective of the study was to investigate the impact of a moderate zinc deficiency and a high intake of polyunsaturated fat on Δ(3)Δ(2)-enoyl-CoA isomerase (ECI) in the liver and other tissues. Five groups of eight weanling rats each were fed...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-014-9940-8

    authors: Justus J,Weigand E

    更新日期:2014-06-01 00:00:00

  • Effect of iron supplementation on oxidative stress and antioxidant status in iron-deficiency anemia.

    abstract::This study was designed to measure the effect of iron supplementation on antioxidant status in iron-deficient anemia, including the time for hemoglobin normalization and at the time of filling of iron body stores. The extent of plasma lipid peroxidation was evaluated by measuring the levels of malondialdehyde and glut...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:96:1-3:117

    authors: Kurtoglu E,Ugur A,Baltaci AK,Undar L

    更新日期:2003-01-01 00:00:00

  • Effect of peroxovanadate compound on phenylalanine hydroxylase gene expression.

    abstract::Vanadium, a trace element in human cells and regarded as an essential nutrient, plays an active role in all tissues. It is known that peroxovanadate-nicotinic acid (POV), a complex compound of vanadium, can decrease hyperglycemia; however, its biochemical mechanism remains unclear. The object of the present study is t...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:74:3:237

    authors: Wang YL,Yu B

    更新日期:2000-06-01 00:00:00

  • Correction to: Mercury Exposure: Protein Biomarkers of Mercury Exposure in Jaraqui Fish from the Amazon Region.

    abstract::In the affiliation section, Luiz Fabricio Zara's affiliation "Pontifical Catholic University of Goiás (PUC), Goiânia, GO, Brazil" was incorrect. The correct affiliation is College of Planaltina, UnB - University of Brasília, Distrito Federal, Brazil. ...

    journal_title:Biological trace element research

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s12011-017-1195-8

    authors: Vieira JCS,Braga CP,de Oliveira G,do Carmo Federici Padilha C,de Moraes PM,Zara LF,de Lima Leite A,Buzalaf MAR,de Magalhães Padilha P

    更新日期:2018-05-01 00:00:00

  • Iron: a Strong Element in the Pathogenesis of Chronic Hyperglycaemia After Acute Pancreatitis.

    abstract::Evidence shows an association between markers of iron metabolism and glucose metabolism in type 2 diabetes mellitus. Acute pancreatitis is the largest contributor to diabetes of the exocrine pancreas. However, the pathogenesis of new-onset pre-diabetes or diabetes after pancreatitis remains unclear. This study aimed t...

    journal_title:Biological trace element research

    pub_type: 临床试验,杂志文章

    doi:10.1007/s12011-017-1131-y

    authors: Chand SK,Singh RG,Pendharkar SA,Petrov MS

    更新日期:2018-05-01 00:00:00

  • Zinc deficiency decreases the activity of calmodulin regulated cyclic nucleotide phosphodiesterases in vivo in selected rat tissues.

    abstract::The effect of zinc deficiency on calmodulin function was investigated by assessing the in vivo activity of two calmodulin regulated enzymes, adenosine 3',5'-monophosphate (c-AMP) and guanosine 3',5'-monophosphate (c-GMP) phosphodiesterase (PDE) in several rat tissues. Enzymatic activities in brain, heart, and testis o...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02797137

    authors: Law JS,McBride SA,Graham S,Nelson NR,Slotnick BM,Henkin RI

    更新日期:1988-08-01 00:00:00

  • Effect of Chromium Supplementation on Performance, Carcass Characteristics, Blood Biochemistry, and Immune Response of Unstressed Broiler Chickens: a Dose-Response Meta-Analysis.

    abstract::Studies investigating the effects of Chromium (Cr) supplementation on unstressed broiler chickens have reported an inconsistent association between Cr supplementation and broiler chickens' responses. We conducted a dose-response meta-analysis of previous studies to assess the dose-response associations between Cr supp...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-021-02589-2

    authors: Piray AH,Foroutanifar S

    更新日期:2021-01-17 00:00:00

  • Biological monitoring, by in vivo XRF measurements, of occupational exposure to lead, cadmium, and mercury.

    abstract::In vivo X-ray fluorescence (XRF) techniques were used for biological monitoring of lead, cadmium, and mercury. Lead accumulates in bone, the level of which may thus be used for monitoring of exposure. However, there was no close association between lead levels in bone and exposure time, partly because of differences i...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02796636

    authors: Skerfving S,Christoffersson JO,Schütz A,Welinder H,Spång G,Ahlgren L,Mattsson S

    更新日期:1987-08-01 00:00:00

  • Identification of citrate as the albumin-bound inhibitor of the ferroxidase activity of ceruloplasmin.

    abstract::The influence of several commercial albumin preparations on the ferroxidase activity of ceruloplasmin (ferroxidase I, ferrous: O2 oxidoreductase EC 1.16.3.1) at pH 6.0 was determined using ferric-transferrin formation. The ability of several albumin preparations to inhibit the ferroxidase activity of ceruloplasmin dif...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02916628

    authors: Witwicki J,Chidambaram MV,Frieden E

    更新日期:1983-04-01 00:00:00

  • Luteolin reduces zinc-induced tau phosphorylation at Ser262/356 in an ROS-dependent manner in SH-SY5Y cells.

    abstract::In brain, excess zinc alters the metabolism of amyloid precursor protein, leading to β-amyloid protein deposition, one of the hallmarks of Alzheimer's disease (AD) pathology. Recently, it has been reported that zinc accelerates in vitro tau fibrillization, another hallmark of AD. In the current study, we examined the ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-012-9411-z

    authors: Zhou F,Chen S,Xiong J,Li Y,Qu L

    更新日期:2012-11-01 00:00:00

  • Validity of hair mineral testing.

    abstract::The variance of testing was compared between the College of American Pathologists clinical survey and that of a recent review about hair mineral testing. The review suggested that the accuracy of hair mineral testing was unreliable. In general, there was a greater range of variance in the College of American Pathologi...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:87:1-3:001

    authors: Shamberger RJ

    更新日期:2002-07-01 00:00:00

  • Effect of different selenium sources on productive performance, serum and milk Se concentrations, and antioxidant status of sows.

    abstract::The experiment was conducted to study the effects of different selenium (Se) sources on productive performance, serum and milk Se concentrations, and antioxidant status of sows. A total of 12 sows (Landrace×Yorkshire) with same pregnancy were randomly divided into two groups; each group was replicated six times. These...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-010-8803-1

    authors: Hu H,Wang M,Zhan X,Li X,Zhao R

    更新日期:2011-09-01 00:00:00

  • Protective effect of selenomethionine on aflatoxin B1-induced oxidative stress in MDCK cells.

    abstract::AFB1 is a mycotoxin which exerts their cytotoxicity through increasing oxidative damage in target organ. Kidney is one of target organs vulnerable to damage caused by AFB1. In this study, Madin-Darby canine kidney (MDCK) cells were used to evaluate the AFB1-induced cell damage by the MTT assay. The results revealed th...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-014-9887-9

    authors: Parveen F,Nizamani ZA,Gan F,Chen X,Shi X,Kumbhar S,Zeb A,Huang K

    更新日期:2014-03-01 00:00:00

  • A comparative study in Alzheimer's and normal brains of trace element distribution using PIXE and INA analyses and glucose metabolism by positron emission tomography.

    abstract::The onset of Alzheimer's disease has been shown to affect trace element concentrations in the brain when compared to "normal" subjects in ex vivo samples. The techniques used to determine trace element concentrations were proton-induced X-ray emission and instrumental neutron activation analysis. With these methods, s...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02784242

    authors: Cutts DA,Maguire RP,Stedman JD,Leenders KL,Spyrou NM

    更新日期:1999-01-01 00:00:00

  • Heavy metal contamination in the water-level fluctuating zone of the Yangtze River within Wanzhou Section, China.

    abstract::The distribution, potential ecological hazards, and homologous relativity of heavy metals in the water-level fluctuating zone (WLFZ) of the Yangtze River within the Wanzhou Section (YRWS) were investigated. The heavy metal content (Cd, Cu, Cr, and Ni) of the surface soil was analysed via atomic absorption spectroscopy...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-011-9179-6

    authors: Lin J,Fu C,Zhang X,Xie K,Yu Z

    更新日期:2012-02-01 00:00:00

  • Nutrients Other than Selenium Are Important for Promoting Children's Health in Kashin-Beck Disease Areas.

    abstract::Overall nutritional status has been proved associated with people's health. The overall nutritional status of children in Kashin-Beck disease (KBD) areas has been overlooked for decades. Therefore, it is worth investigating in the current generation to gather evidence and make suggestions for improvement. A cross-sect...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-017-1154-4

    authors: Ning Y,Wang X,Guo X,Zhang P,Qu P,Zhang F,Wang S,Lei Y,Lammi M

    更新日期:2018-06-01 00:00:00