The IgM and IgG antibody responses in iron-deficient and iron-loaded mice.

Abstract:

:The humoral immune response was evaluated in male CD-1 mice fed the iron deficient (7 ppm Fe), iron sufficient (120 ppm Fe), and high-iron diets (3000 or 5000 ppm Fe) for 54 d. The IgM and IgG antibody responses against sheep erythrocytes (SRBC) determined by hemolytic plaque assay were suppressed by 65.4 and 51.2%, respectively, in the iron deficient mice. Subclinical iron deficiency was manifested by a marked reduction in hepatic iron concentration without any changes in hematocrit or body weight gain. In contrast, consumption of high-iron diets caused a marked accumulation of iron in the liver and a twofold reduction in the IgM antibody response without alteration in the IgG response. The suppression of the IgG antibody response in the iron deficient mice, however, did not result in a compensatory increase in delayed type hypersensitivity response.

journal_name

Biol Trace Elem Res

authors

Omara FO,Blakley BR

doi

10.1007/BF02790075

subject

Has Abstract

pub_date

1994-10-01 00:00:00

pages

155-61

issue

1-2

eissn

0163-4984

issn

1559-0720

journal_volume

46

pub_type

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