Abstract:
:Continuation of prolonged treatment against arsenicosis with conventional chelating therapy is a global challenge. The present study was intended to evaluate the defensive effect of arjunolic acid against arsenic-induced oxidative stress and female reproductive dysfunction. Wistar strain adult female rats were given sodium arsenite (10 mg/kg body weight) in combination with arjunolic acid (10 mg/kg body weight) orally for two estrous cycles. Electrozymographic analysis explored that arjunolic acid co-treatment counteracted As3+-induced ROS production in uterine tissue by stimulating the activities of endogenous enzymatic antioxidants. Arjunolic acid was able to enhance the protection against mutagenic uterine DNA breakage, necrosis, and ovarian-uterine tissue damages in arsenicated rats by improving the ovarian steroidogenesis. The mechanisms might be coupled with the augmentation of antioxidant defense system, partly through the elimination of arsenic with the involvement of S-adenosyl methionine pool where circulating levels of vitamin B12, folic acid, and homocysteine play critical roles as evidenced from our present investigation.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Maity M,Perveen H,Dash M,Jana S,Khatun S,Dey A,Mandal AK,Chattopadhyay Sdoi
10.1007/s12011-017-1077-0subject
Has Abstractpub_date
2018-03-01 00:00:00pages
78-90issue
1eissn
0163-4984issn
1559-0720pii
10.1007/s12011-017-1077-0journal_volume
182pub_type
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