Effects of lanthanum chloride administration in prenatal stage on one-trial passive avoidance learning in chicks.

Abstract:

:Lanthanum cations (La 3+) are well known for their inhibitory actions on calcium channels. Prenatal lanthanum exposure may affect the development of embryo and alter the capacity for learning and memory in adults, and the one-trial passive avoidance learning paradigm with day-old chicks is an excellent model to study several mechanisms of memory formation. In the present study, we examined the effects of prenatal lanthanum chloride exposure on memory consolidation using one-trial passive avoidance learning task in day-old chicks. The data suggest that chicks injected with lanthanum chloride (2 mg/kg) daily from E9 to E16 had significantly impaired long-term memory at 120 min after training (p < 0.05) but not the chicks injected with lanthanum chloride (0.1 mg/kg) daily from E9 to E16.

journal_name

Biol Trace Elem Res

authors

Che Y,Cui Y,Jiang X

doi

10.1007/s12011-008-8225-5

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

37-44

issue

1

eissn

0163-4984

issn

1559-0720

journal_volume

127

pub_type

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