Abstract：
:Decreased expression and increased phosphorylation of Forkhead box o1 (Foxo1) in ameloblasts were observed both in vivo and in vitro when treated by fluoride. The present study aims to investigate the possible relationship between Foxo1 and enamel matrix proteinases, matrix metalloproteinase 20 (MMP20), and kallikrein 4 (KLK4), in NaF-treated ameloblasts. Ameloblast-like cells (LS8 cells) were exposed to NaF at selected concentration (0/2 mM) for 24 h. Gene overexpression and silencing experiments were used to up- and down-regulate Foxo1 expression. The expression levels of Foxo1, MMP20, and KLK4 were detected by quantitative real-time PCR and western blot. Dual luciferase reporter assay was performed to evaluate the regulation of Foxo1 on the transcriptional activity of KLK4 promoter. The results showed that KLK4 expression was decreased in LS8 cells treated by NaF, while MMP20 expression was not changed. Foxo1 activation led to significantly up-regulation of KLK4 in LS8 cells under NaF condition. Knockout of Foxo1 markedly decreased klk4 expression in mRNA level, and intensified inhibition occurred in LS8 cells when combined with NaF treatment. However, the variation trend of MMP20 was not clear. Dual luciferase reporter assay showed that Foxo1 activation enhanced the transcriptional activity of KLK4 promoter. These findings suggest that the decrease of Foxo1 expression induced by high fluoride was a cause for low KLK4 expression.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Li J,Wang P,Gao J,Fei X,Liu Y,Ruan Jdoi
10.1007/s12011-018-1325-ysubject
Has Abstractpub_date
2018-12-01 00:00:00pages
498-504issue
2eissn
0163-4984issn
1559-0720pii
10.1007/s12011-018-1325-yjournal_volume
186pub_type
杂志文章abstract：:The present study was devoted to investigate the PTE concentrations including cadmium (Cd), chromium (Cr), copper(Cu), iron (Fe), mercury (Hg), manganese (Mn), nickel (Ni), lead (Pb), arsenic(As), and zinc (Zn) among six types of edible wild, 23 cultivated mushroom samples collected from Iran's market by the aid of an...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02130-x
更新日期：2021-01-01 00:00:00
abstract：:This report explains the employing of a combination test of traditional cell culture with a quantitative real-time PCR for assessment of the antiviral effect of zinc sulfate (ZnSO4) on herpes simplex virus (HSV)-infected Vero cells. Our evidence showed that the treatment with 0.3 mM ZnSO4 strongly inhibited the replic...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01728-0
更新日期：2020-02-01 00:00:00
abstract：:Consumption of edible plants satisfies a significant part of human body needs in macro- and micronutrients while biologically active substances contain strong antioxidant properties and reduce the risk of a number of diseases. Balanced nutrition and design of personalized diets and treatment rely on the data on the co...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02345-y
更新日期：2020-08-19 00:00:00
abstract：:In brain, excess zinc alters the metabolism of amyloid precursor protein, leading to β-amyloid protein deposition, one of the hallmarks of Alzheimer's disease (AD) pathology. Recently, it has been reported that zinc accelerates in vitro tau fibrillization, another hallmark of AD. In the current study, we examined the ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9411-z
更新日期：2012-11-01 00:00:00
abstract：:Although recent studies have shown that chromium (as the trivalent ion) is not an essential trace element, it has been demonstrated to generate beneficial effects at pharmacologically relevant doses on insulin sensitivity and cholesterol levels of rodent models of insulin insensitivity, including models of type 2 diab...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/s12011-015-0231-9
更新日期：2015-07-01 00:00:00
abstract：:It has become evident over the last two decades that there is an intimate relationship between the trace elements and cancer. Some trace elements have been shown to be carcinogens, others appear to provide protection against cancer. Profound changes in trace element concentrations and distribution occur in patients wi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783817
更新日期：1979-08-01 00:00:00
abstract：:The structure and bioactivity of Ginkgo biloba leaves polyprenol (GBP) are similar to that of dolichol which widely exists in human and mammalian organs. GBP possesses potential pharmacological activities against cancer. This study involved oil-in-water type nanoemulsion (NE) loading GBP was prepared by dissolving pol...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1184-y
更新日期：2018-07-01 00:00:00
abstract：:The current information about the effect of physical exercise on the body concentrations of several minerals is still limited, both in the acute (short-term) and adaptive (long-term) responses. So, this manuscript aims, on the one hand, to assess the possible differences on basal levels of cobalt (Co), copper (Cu), an...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-018-1500-1
更新日期：2019-06-01 00:00:00
abstract：:Comparison of the clastogenic effects of antimony and bismuth used as trioxides, when administered orally by gavaging to laboratory bred male mice, showed that the former was more strongly clastogenic than the latter. Three doses of each chemical (400, 666.67, and 1000 mg/kg body wt), corresponding to 1/50, 1/30, and ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783802
更新日期：1993-05-01 00:00:00
abstract：:This experiment was conducted to evaluate the effects of zinc (ZnSO4.H2O) and vitamin A (retinol) supplementation on performance, carcass characteristics, and serum concentrations of glucose, cholesterol, total protein, and malondialdehyde (MDA) as an indicator of lipid peroxidation in broiler chickens (Ross) reared a...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1385/BTER:94:3:225
更新日期：2003-09-01 00:00:00
abstract：:The current study aims to assess the concentration of cadmium (Cd) and lead (Pb) in five tissues of Cirrhinus mrigala, Labeo rohita, and Catla catla collected from fishponds of Jamshoro and Larkana, Sindh, Pakistan. Meanwhile, the levels of Cd and Pb in feeding materials, water, and sediments of fishponds of both area...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1628-z
更新日期：2019-10-01 00:00:00
abstract：:This study was focused on the analysis of arsenic (As) levels in scalp hair of children (age, <10 years) collected from two towns of Khairpur, Pakistan, to evaluate the effects of As-contaminated groundwater. For comparative purposes, scalp hair samples of children were also collected from that area having low levels ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8866-z
更新日期：2011-10-01 00:00:00
abstract：:Zinc has been reported to enhance the response to interferon (IFN) or PEG-IFN plus ribavirin therapy, improve liver function, and ameliorate hematologic side effects in patients with chronic hepatitis C. However, the role of zinc supplementation during IFN therapy in chronic hepatitis B infection (CHB) remains unclear...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-8971-7
更新日期：2011-12-01 00:00:00
abstract：:Selenoprotein K (SelK), a member of selenoprotein family, is identified as a single endoplasmic reticulum (ER) transmembrane protein. Although over-expression of SelK inhibits adherence and migration of human gastric cancer BGC-823 cells, the effects of SelK in human choriocarcinoma (CCA) are not well understood. In t...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1155-3
更新日期：2018-07-01 00:00:00
abstract：:Iron deficiency anemia (IDA) due to malnutrition and/or blood loss is a common condition, especially in women of reproductive age. Intense exercise can induce anemia via an inflammatory response, but whether intense exercise affects the efficacy of iron supplementation to treat IDA is unclear. Here, we show in a mouse...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02402-6
更新日期：2020-10-06 00:00:00
abstract：:A survey based on 838 samples of milk obtained from 537 dairies covering 70 of 95 districts in France was organized to assess iodine content of milk and its contribution to total intake. Iodine levels were significantly higher in winter than in summer. Very low iodine contents (less than 25 micrograms I/kg) were found...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784607
更新日期：1992-01-01 00:00:00
abstract：:Cactus (Opuntia ficus-indica) is a xerophyte plant that belongs to the Cactaceae family. The present study was designed to investigate the possible protective effects of cactus cladodes extract (CCE) on sodium dichromate-induced testis damage in adult male Wistar rats. For this purpose, CCE at a dose of 100 mg/kg was ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9969-8
更新日期：2014-06-01 00:00:00
abstract：:Fluoride and lead are two common pollutants in the environment. Previous investigations have found that high fluoride exposure can increase the lead burden. In this experiment, in order to study on the molecular mechanisms of central neural system injury induced by the above two elements, differently expressed protein...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0117-2
更新日期：2014-12-01 00:00:00
abstract：:The objective of the study was analysis of hair trace elements content in children with goiter living in Aktubinsk region. Children with goiter and age- and sex-adjusted controls were involved in the current study. Hair trace elements content was assessed using inductively coupled plasma mass spectrometry. Thyroid vol...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-016-0711-6
更新日期：2016-12-01 00:00:00
abstract：:To examine whether an accumulation of Ca in the tissues was accompanied by an increase of Mg, the authors investigated the relationships between Ca and Mg contents in the common iliac arteries, aortic valves, xiphoid processes, costal cartilages, posterior longitudinal ligaments, trigeminal nerves, and ribs by inducti...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:102:1-3:083
更新日期：2004-01-01 00:00:00
abstract：:In order to study the metabolism of mercury (Hg), its affinity to metallothionein (MT), and its influence on levels of the essential metals copper and zinc in the brain tissue of rats exposed to elemental mercury (HgO) vapor was investigated. The major findings were: 1. After long-term exposure, about 40% of mercury w...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789402
更新日期：1993-04-01 00:00:00
abstract：:The aim of this study was to investigate the protective effect of luteolin on liver Ca, Mg, Zn, Cu, Fe, and Mn content in mice with carbon tetrachloride (CCl4)-induced hepatotoxicity. Additionally, liver metallothionein (MT) expression was studied. Luteolin was administered intraperitoneally (i.p.) as a single 5- or 5...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8181-0
更新日期：2008-01-01 00:00:00
abstract：:Multivariate statistical analysis has been applied to time series measurements of aerosol elemental composition from PIXE analysis of filter samples, and principal components have been resolved that represent distinct particle types in an external mixture in the atmosphere. In this study, it is argued that a combinati...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02992673
更新日期：1990-07-01 00:00:00
abstract：:Auditory brainstem electric response (ABR) and somatosensory evoked potential (SEP) of 21 subjects (41 ears) among villagers in a rare earth element (REE) area in Gan County, Jiangxi, China, were studied. No difference in ABR between the subjects from the REE area and the control group was noted. However, the conducti...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02803871
更新日期：1997-04-01 00:00:00
abstract：:Nickel is an important kind of metal and a necessary trace element in people's production and livelihood; it is also a well-confirmed human carcinogen. In the past few years, researchers did a large number of studies about the molecular mechanisms of nickel carcinogenesis, and they focused on activation of proto-oncog...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9619-6
更新日期：2013-05-01 00:00:00
abstract：:The effects of selenium were investigated on three human colon cancer cell lines: Caco 2, HRT 18, and HT 29. At low concentrations (10-100 nM), selenium stimulated cell growth in serum-free medium. Thus, selenium is an essential trace element for cell proliferation. At higher concentrations, selenium inhibited cell gr...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02919096
更新日期：1989-04-01 00:00:00
abstract：:The movement of copper and zinc from the fertilized egg into the developing embryo and the subsequent association of the two metals with metallothionein-like proteins (MT) of chick liver was investigated. Hepatic levels of MT in 1-d-old chicks, estimated from specifically bound(115m)Cd, were increased eightfold over e...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02988942
更新日期：1983-12-01 00:00:00
abstract：:Sea cucumbers are a potential source of natural organic vanadium that may improve insulin resistance. In this work, vanadium was accumulated rapidly in blood, body wall, and intestine by sea cucumber Apostichopus japonicus. Furthermore, water-soluble vanadium-containing proteins, the main form of the organic vanadium,...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0517-y
更新日期：2016-05-01 00:00:00
abstract：:Plasma chromium concentrations have been determined for 150 patients. These were subjected to coronary artery cineangiography and thereby divided into three groups: group CAD (those with coronary artery disease), group HD (those with heart disease, but no CAD) and group N (those with no CAD and no HD). Weighted, avera...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02989260
更新日期：1984-10-01 00:00:00
abstract：:The effect of parenteral zinc on tissue metallothionein (MT) was studied in normal and streptozotocin-induced diabetic rats. The accumulation of Zn-MT in liver and pancreas of normal and diabetic rats following the administration (ip) of various amounts of zinc was not different. Renal Zn-MT was higher in the diabetic...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02795531
更新日期：1986-12-01 00:00:00
