Abstract:
:The glutathione transferase (GST) activity of rat liver cytosolic preparations with ethacrynic acid (EA) and (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydro-benzo(a)pyrene (BPDE) as substrates, increased by 125 and 350%, respectively, in animals that had been treated with a single intravenous dose of Pb(NO3)2 (100 mumol/kg body wt) 48 h prior to sacrifice, whereas activity with 1-chloro-2,4-dinitrobenzene (CDNB) increased only about 60%. No induction of these activities was observed in cytosolic preparations from regenerating rat liver, whereas cytosols prepared from hepatocyte nodules showed increased activity with all three substrates (EA: 400%; BPDE: 790%; CDNB: 205%). These results suggest that Pb(NO3)2 is an inducer of GST 7-7, an isoenzyme that has been associated with hepatocarcinogenesis. Elucidation of the mechanism of GST 7-7 induction by lead may contribute to our understanding of the process of chemical carcinogenesis.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Dock Ldoi
10.1007/BF02917265subject
Has Abstractpub_date
1989-07-01 00:00:00pages
283-8eissn
0163-4984issn
1559-0720journal_volume
21pub_type
杂志文章abstract::This study was conducted to investigate the effect of zinc chitosan chelate (CS-Zn) on zinc transporter expression and content of tissue zinc in weaned piglets. A total of 90 weaned pigs (Duroc × Landrace × Yorkshire) were randomly allocated to treatment groups with supplementation of 100 mg/kg zinc as ZnSO4, 100 mg/k...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-016-0732-1
更新日期:2016-12-01 00:00:00
abstract::Selenium concentrations in the blood of 112 (56 females and 56 males) normal subjects, from different regions of the Punjab (Pakistan), have been determined using the technique of inductively coupled plasma-mass spectrometry. The whole blood selenium concentrations were found to be 452 ± 12 ppb (parts per billion or n...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8867-y
更新日期:2011-10-01 00:00:00
abstract::Hexavalent chromium, a well-known environmental toxicant, adversely affects female reproduction and results in abnormal implantation, fetal resorption, and reduction in litter size. Uterine myogenic activity is under control of number of receptors and ion channels, and it regulates fetal-implantation and feto-maternal...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02041-x
更新日期:2020-11-01 00:00:00
abstract::Zinc (mostly as free/labile Zn2+) is an essential structural constituent of many proteins, including enzymes in cellular signaling pathways via functioning as an important signaling molecule in mammalian cells. In cardiomyocytes at resting condition, intracellular labile Zn2+ concentration ([Zn2+]i) is in the nanomola...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/s12011-018-1464-1
更新日期:2019-03-01 00:00:00
abstract::Biotransformation of inorganic arsenic in mammals is catalyzed by three serial enzyme activities: arsenate reductase, arsenite methyltransferase, and monomethylarsonate methyltransferase. Our laboratory has purified and characterized these enzymes in order to understand the mechanisms and elucidate the variations of t...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/BF02783907
更新日期:1999-06-01 00:00:00
abstract::The combination of excess mycotoxin exposure and selenium deficiency has been widely considered as a cause of Kashin-Beck disease (KBD). The present study aimed to investigate the expression profiles of selenium-related genes in human chondrocytes after exposure to T-2 toxin and deoxynivalenol (DON) and to preliminari...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1560-2
更新日期:2019-08-01 00:00:00
abstract::Rare earth elements can promote photosynthesis, but their mechanisms are still poorly understood under magnesium deficiency. The present study was designed to determine the role of cerium in magnesium-deficient maize plants. Maize was cultivated in Hoagland's solution added with cerium with and without adequate quanti...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8769-z
更新日期:2011-09-01 00:00:00
abstract::Herein, we assess the antioxidant potential of core-shell yttrium oxide nanoparticles functionalized with ethylene glycol methacrylate phosphate (EGMP). The antioxidant properties of these nanoparticles were investigated in heat stressed models of 21 rats (heat stressed group, group B). Different samples of blood, ser...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02036-8
更新日期:2020-11-01 00:00:00
abstract::Plasma concentrations of a zinc carrier peptide, namely thymulin, were measured according to a bioassay in young donors, healthy elderly, and patients with senile dementia of Alzheimer's type (SDAT). Thymulin is a hormone released by thymic epithelial cells and its biological activity on cells of immune system is depe...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02790147
更新日期:1996-01-01 00:00:00
abstract::Aluminum (Al) absorption seems to be very low, but many factors can enhance it in animals and humans. In the present study, we investigated the acute effect of Na citrate on Al absorption by monitoring Al levels in blood and several tissues. For this purpose, 18 Wistar male rats were divided into 3 groups: control, Al...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02778873
更新日期:1998-08-01 00:00:00
abstract::Lead (Pb)-induced reproductive toxicity is a well-characterized adverse effect associated with this heavy metal. It has been found that Pb exposure is associated with altered spermatogenesis, increased testicular degeneration, and pathological sperm alterations. On the other hand, it has been reported that Pb-induced ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1358-2
更新日期:2019-01-01 00:00:00
abstract::The objective of the study was analysis of hair trace elements content in children with goiter living in Aktubinsk region. Children with goiter and age- and sex-adjusted controls were involved in the current study. Hair trace elements content was assessed using inductively coupled plasma mass spectrometry. Thyroid vol...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/s12011-016-0711-6
更新日期:2016-12-01 00:00:00
abstract::This paper reports the synthesis of a new bioactive complex, 8-hydroxyquinolinato-bis-(salicylato) yttrium (III) (HSAY), whose composition and structure were characterized by elemental analysis, IR spectra, thermogravimetric analysis, and X-ray diffraction. The power-time curves of the compounds HSAY, C(7)H(6)O(3), C(...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9297-1
更新日期:2012-06-01 00:00:00
abstract::Human ocular tissues from 50 donor eyes were elementally and morphologically analyzed in order to correlate the elemental content and distribution of Ca, Ba, Cr, Cu, Zn, and Se with ocular morphology, sex, race, irideal pigmentation, age, time of death, birth weight, presence and severity of diabetes, and other pathol...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02796667
更新日期:1987-04-01 00:00:00
abstract::We investigated the effects of zinc supplementation in case of moderate growth retardation in which GH treatment could not be used. Zamic (ZA, an association containing arginine, L-methionine, and zinc; from Aguettant pharmaceuticals) was compared with arginine aspartate (AA) (5 g) in a crossover randomized trial (6 m...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02789076
更新日期:1995-04-01 00:00:00
abstract::Three kinds of plant leaves, Chinese white aspen, arborvitae, and pine needles, have been sampled from the Yanshan Oil refinery complex, the Capital Iron and Steel Factory, and Badachu, a control area in Beijing, as biomonitors for air-pollution studies. Each sample was divided into two parts, washed, and unwashed. Th...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784212
更新日期:1999-01-01 00:00:00
abstract::Although adriamycin (ADR) exhibits high anti-tumor efficacy in vitro, its clinical use in cancer chemotherapy is limited due to its high renal toxicity. This study investigated the mechanism of ADR nephropathy and the protective effect of selenium on ADR-induced kidney damage by analyzing of the relationship between s...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9273-9
更新日期:2012-06-01 00:00:00
abstract::Zinc concentrations in the dorsal horn of spinal cord are important for wound healing, neurological function, and reproduction. However, the response of the spinal cord to alterations in dietary zinc is unknown in rats after spinal cord injury (SCI). The current study explored cellular zinc levels and zinc transporter...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9414-9
更新日期:2012-11-01 00:00:00
abstract::Experiments were conducted to determine whether the increased glutathione S-transferase (GSH-T) activity associated with selenium (Se) deficiency is necessarily related to losses in the activity of Se-dependent glutathione peroxidase (SeGSHpx) in chicks. Nutritional Se status was altered in two ways: by treatment with...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783792
更新日期:1993-05-01 00:00:00
abstract::Trientine((R)) is not an effective drug for the treatment of intractable hand dermatitis in nickel-sensitive patients. In a controlled, double-blind study this chelator, on oral administration, failed to stimulate nickel excretion. Early morning urine samples from two groups of nine patients were analyzed by atomic ab...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02795597
更新日期:1987-10-01 00:00:00
abstract::Arsenic (As) is a widespread environmental contaminant present around the world in both organic and inorganic forms. Oxidative stress is postulated as the main mechanism for As-induced toxicity. This study was planned to examine the protective effect of acetyl-L-carnitine (ALC) on As-induced oxidative damage in male r...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0436-y
更新日期:2016-05-01 00:00:00
abstract::A simple, eco-friendly, green routine co-precipitation method was experimented to synthesize iron nanoparticles (Fe-NPs) using the cell-free supernatant of actinobacteria. The biosynthesized nanoparticles were characterized by UV-Vis spectroscopy, X-ray diffractometer (XRD), energy-dispersive X-ray (EDX), scanning ele...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01777-5
更新日期:2020-03-01 00:00:00
abstract::Various studies indicate the role of manganese (Mn) in the virulence of pathogens. Salmonella is an intracellular pathogen which is able to multiply within the macrophages. The present study was therefore, designed to assess the effect of Mn supplementation on Salmonella-macrophage interactions particularly in referen...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-009-8406-x
更新日期:2010-01-01 00:00:00
abstract::Breast milk is considered the best source of nutrition for all infants. However, exposure of newborns to toxic metals is of special interest due to their potential harmful effects. Thus, the primary aims of this study were to determine the concentration of toxic heavy metals including lead, mercury, cadmium, and bariu...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1355-5
更新日期:2019-01-01 00:00:00
abstract::Normal and uremic adult male rats were given a daily ip injection of 20 mg Al (Al chloride)/kg for 14 d. The results indicate that Al induces a significant decrease in food ingestion, weight gain, and total protein concentration in the plasma. Compared with control animals, very high increases in Al levels were found ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785319
更新日期:1996-07-01 00:00:00
abstract::The levels of iron, zinc, and copper in the tissues of the pregnant rat, on d 12, 19, and 21 after impregnation have been determined and compared with controls. Iron levels decreased considerably in late pregnancy as a result of increased fetal requirements, thus diminishing iron stores in rat tissues, but maintaining...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917464
更新日期:1985-09-01 00:00:00
abstract::Microbeam X-ray spectrometry, energy-dispersive X-ray fluorescence analysis, and neutron activation analysis were evaluated for the detection of selenium contained in the selenoprotein glutathione peroxidase. The glutathione peroxidase had been previously separated using polyacrylamide gel electrophoresis. The use of ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917328
更新日期:1994-10-01 00:00:00
abstract::Given the conflicting results about the positive effects of magnesium and L-carnitine and as there is no report concerning concurrent supplementation of magnesium and L-carnitine on migraine prophylaxis, the effects of magnesium, L-carnitine, and concurrent magnesium-L-carnitine supplementation on migraine indicators ...
journal_title:Biological trace element research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12011-012-9487-5
更新日期:2012-12-01 00:00:00
abstract::Aflatoxin B1 (AFB1) is a mycotoxin that causes cytotoxicity through oxidative damage to its target organs. The liver is the first target of AFB1 damage. The aim of this study was to evaluate the protective effect of selenium on AFB1-induced hepatic mitochondrial damage in ducklings using molecular biological and histo...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0189-z
更新日期:2015-02-01 00:00:00
abstract::Divalent metal ions (Fe2+, Cu2+, Zn2+, Ni2+, and Mn2+) induced lipid oxidation in cooked, but not in raw fish. The extent of lipid oxidation, measured by the production of thiobarbituric acid reactive substances (TBRS), was increased with higher concentrations of iron, zinc, and nickel, but was decreased with increasi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783896
更新日期:1992-07-01 00:00:00