Abstract:
:Trientine((R)) is not an effective drug for the treatment of intractable hand dermatitis in nickel-sensitive patients. In a controlled, double-blind study this chelator, on oral administration, failed to stimulate nickel excretion. Early morning urine samples from two groups of nine patients were analyzed by atomic absorption spectrophotometry in a stabilized Temperature Platform Furnace equipped with Zeeman background correction. Group 1 patients received placebo for 6 wk, then a 4-wk rest before crossover. Group 2 received the drug in the first period. No difference in Ni levels between the placebo period and the drug period in either group was demonstrated, nor was there any significant improvement in the hand eczema.Copper was measured in the same urine samples using the same instrumentation, but with atomization off the wall. There was a considerable increase in copper excretion during the drug treatment period. Group 1 excreted a mean 538±378 (SD) μg/L, which represented a mean increase of 787±653 % (SD). Group 2 excreted a mean 960±410 (SD) μg/L; a mean difference of 630±398 % (SD). It was concluded that the use of Trientine((R)) in subjects of normal copper status should be carefully controlled and monitored.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
McMaster D,Burrows D,Eedy DJ,Love AHdoi
10.1007/BF02795597subject
Has Abstractpub_date
1987-10-01 00:00:00pages
65-77issue
1-2eissn
0163-4984issn
1559-0720journal_volume
14pub_type
杂志文章abstract::The use of phosphate fertilizers is essential in agriculture, because they supply farmland with nutrients for growing plants. However, heavy metals might be included as impurities in natural materials and minerals, so heavy metals can also be present in phosphate fertilizers or other chemical fertilizers. The aim of t...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9161-3
更新日期:2012-01-01 00:00:00
abstract::Electron energy loss spectroscopy (EELS) is a high spatial resolution electron microscopic technique with the potential to quantify elements at the subcellular level. The presence of each element is demonstrated by the electron energy loss edge at the energy characteristic of that element. The area of the edge may ind...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02916819
更新日期:1994-01-01 00:00:00
abstract::Plasma and liver selenium of Wistar rats were determined after 1, 3, and 6 mo supplementation with 0.5, 2, 6, or 15 ppm selenium as sodium selenite in drinking water. Plasma selenium was not different from control values at additional intake of 0.5 ppm but increased above usual levels at higher intakes. A highly signi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784050
更新日期:1993-08-01 00:00:00
abstract::Glutathione peroxidase (GPx) is the prototypical eukaryotic selenoprotein, with the rare amino acid selenocysteine (Sec) at the enzyme active site, encoded by the UGA codon in RNA. A DNA virus, Molluscum contagiosum, has now been shown to encode a functional selenium-dependent GPx enzyme. Using modifications of conven...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783852
更新日期:1999-11-01 00:00:00
abstract::The results obtained in this study demonstrated that experimentally induced alimentary muscular dystrophy (MD) in Cobb 500 broiler chickens resulted in increased plasma concentrations of malondialdehyde (MDA), deviations in activities of erythrocyte antioxidant enzymes Cu,Zn-SOD (decrease), and CAT (increase) as well ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8782-2
更新日期:2011-09-01 00:00:00
abstract::The effects of selenium were investigated on three human colon cancer cell lines: Caco 2, HRT 18, and HT 29. At low concentrations (10-100 nM), selenium stimulated cell growth in serum-free medium. Thus, selenium is an essential trace element for cell proliferation. At higher concentrations, selenium inhibited cell gr...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02919096
更新日期:1989-04-01 00:00:00
abstract::Microbeam X-ray spectrometry, energy-dispersive X-ray fluorescence analysis, and neutron activation analysis were evaluated for the detection of selenium contained in the selenoprotein glutathione peroxidase. The glutathione peroxidase had been previously separated using polyacrylamide gel electrophoresis. The use of ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917328
更新日期:1994-10-01 00:00:00
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journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/s12011-014-0177-3
更新日期:2015-02-01 00:00:00
abstract::Stomatogenesis in ciliates is a complex and carefully orchestrated event. The exo- mutant SB255 of Tetrahymena thermophila has defects in mucocyst formation and docking and can also have one or two mouths. Three common culture media (proteose peptone, Medium 357, and yeast extract) were analyzed for total C, N, and in...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785409
更新日期:1995-12-01 00:00:00
abstract::Aflatoxin B1 (AFB1) is a mycotoxin that causes cytotoxicity through oxidative damage to its target organs. The liver is the first target of AFB1 damage. The aim of this study was to evaluate the protective effect of selenium on AFB1-induced hepatic mitochondrial damage in ducklings using molecular biological and histo...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0189-z
更新日期:2015-02-01 00:00:00
abstract::Since chromium(VI) is unreactive toward DNA under physiological conditions in vitro, the ability of carcinogenic chromium(VI) compounds to damage DNA depends on the presence of cellular redox components that reduce chromium(VI) to reactive species capable of interacting with DNA. We have examined the role of glutathio...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/BF02917282
更新日期:1989-07-01 00:00:00
abstract::The Nord-Trøndelag Health Study (The HUNT Study) is a large health survey population study in the county of Trøndelag, Norway. The survey has been repeated four times in about 10-year intervals. In the HUNT3 survey (2006-2008), we collected 28,000 samples for trace element analysis. Blood samples from 758 healthy pers...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02376-5
更新日期:2020-09-08 00:00:00
abstract::Studies investigating the effects of Chromium (Cr) supplementation on unstressed broiler chickens have reported an inconsistent association between Cr supplementation and broiler chickens' responses. We conducted a dose-response meta-analysis of previous studies to assess the dose-response associations between Cr supp...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-021-02589-2
更新日期:2021-01-17 00:00:00
abstract::In vivo X-ray fluorescence (XRF) techniques were used for biological monitoring of lead, cadmium, and mercury. Lead accumulates in bone, the level of which may thus be used for monitoring of exposure. However, there was no close association between lead levels in bone and exposure time, partly because of differences i...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02796636
更新日期:1987-08-01 00:00:00
abstract::Several studies have investigated the relationship between serum and hair nickel (Ni) concentration and breast cancer, but the results were inconsistent. Thus, we conducted a systematic review and meta-analysis to evaluate the association between serum and hair nickel levels and breast cancer. Nine studies determining...
journal_title:Biological trace element research
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12011-017-0949-7
更新日期:2017-09-01 00:00:00
abstract::A rapid cyclic instrumental neutron activation analysis (CINAA) method has been used to determine the selenium content of 27 duplicate diet samples from each of the 27 districts surrounding Pinhel, Portugal. The accuracy and precision of the CINAA method have been evaluated by analyzing certified reference materials a...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02992719
更新日期:1990-07-01 00:00:00
abstract::Our previous report indicated that magnesium (Mg) deficiency increased molybdenum (Mo) concentration in the rat liver, suggesting the possibility that Mg deficiency affects Mo metabolism. Growing male rats were given a control diet or a Mg-deficient diet for 4 weeks. Urine and feces were collected during the second an...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9541-3
更新日期:2013-01-01 00:00:00
abstract::The toxic effect of Pb2+ has been studied in eukaryotic cells by using Tetrahymena as a target. The maximum power (P(m)) and the growth rate constant (k) were determined, which showed that values of P(m) and k were linked to the concentration (C) of Pb2+. The addition of Pb2+ caused a decrease of the maximum heat prod...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-0055-3
更新日期:2007-11-01 00:00:00
abstract::Plasma and erythrocyte lipid peroxidation levels of 20 patients with histopathologically confirmed testis cancer and 20 healthy control individuals were studied between November 1995 and June 1997. The group with testis cancer had a mean age of 24.8+/-8.2 yr and the control group's mean age was 28.3+/-6.9 yr. Stage di...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1385/BTER:73:2:181
更新日期:2000-02-01 00:00:00
abstract::There are several factors that affected calcium bioavailability, such as physiological and dietary factors. These dietary factors help to achieve an appropiate status of calcium for a correct bone mineralization. In this pathway, recently some compounds present in milk that seem improve calcium absorption such as lact...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:89:1:43
更新日期:2002-10-01 00:00:00
abstract::The aim of this study was to investigate the possible protective role of selenium and L-carnitine on oxidative stress induced by 2.45-GHz radiation in heart of rat. For this purpose, 30 male Wistar Albino rats were equally divided into five groups namely controls, sham controls, radiation-exposed rats, radiation-expos...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-8994-0
更新日期:2011-12-01 00:00:00
abstract:UNLABELLED:There is conflicting evidence regarding the relationship between magnesium deficiency and metabolic syndrome, and a systematic assessment of the literature has not been performed. Our objective was to clarify the association between magnesium levels and metabolic syndrome by performing a meta-analysis. Based...
journal_title:Biological trace element research
pub_type: 杂志文章,meta分析
doi:10.1007/s12011-015-0446-9
更新日期:2016-03-01 00:00:00
abstract::Inducing the differentiation of stem cells from human exfoliated deciduous teeth (SHEDs) proceeds with low efficiency, which greatly limits clinical applications. Divalent metal elements play an important role in osteoinductivity for bone remodeling because they can simulate bone formation and decrease bone resorption...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1256-7
更新日期:2018-10-01 00:00:00
abstract::Deficiency in the intake of trace elements, such as copper (Cu), iron (Fe), selenium (Se), and zinc (Zn), is very common in the general population of most developing countries. A preliminary study in India and Pakistan showing the plasma levels of Zn and Fe indicates that approx 50% of the subjects who participated ha...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02789092
更新日期:1998-03-01 00:00:00
abstract::Sea cucumbers are a potential source of natural organic vanadium that may improve insulin resistance. In this work, vanadium was accumulated rapidly in blood, body wall, and intestine by sea cucumber Apostichopus japonicus. Furthermore, water-soluble vanadium-containing proteins, the main form of the organic vanadium,...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0517-y
更新日期:2016-05-01 00:00:00
abstract::The phosphorus NMR profile of normal and vanadium-treated chick muscle was obtained in vivo. The data show that the differentiation of breast and thigh muscles in terms of pH, lipid related metabolites, and bioenergetic parameters can be readily followed. Although the vanadium-treated chicks showed substantial retarda...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02990427
更新日期:1991-11-01 00:00:00
abstract::The combination of excess mycotoxin exposure and selenium deficiency has been widely considered as a cause of Kashin-Beck disease (KBD). The present study aimed to investigate the expression profiles of selenium-related genes in human chondrocytes after exposure to T-2 toxin and deoxynivalenol (DON) and to preliminari...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1560-2
更新日期:2019-08-01 00:00:00
abstract::Elemental analysis of archaeological bones, particularly for elements such as fluorine, strontium, and zinc, has been carried out for many years, with the aim of determining their age or relating their composition to diet. Bone samples are commonly dry ashed before analysis to remove organic material and render them m...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02990417
更新日期:1990-06-01 00:00:00
abstract::The variance of testing was compared between the College of American Pathologists clinical survey and that of a recent review about hair mineral testing. The review suggested that the accuracy of hair mineral testing was unreliable. In general, there was a greater range of variance in the College of American Pathologi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:87:1-3:001
更新日期:2002-07-01 00:00:00
abstract::Recent studies have identified a new existence of a genetically programmed and regulated cell death characterized by necrotic cell death morphology, termed necroptosis. Lead (Pb) is a ubiquitously distributed environmental pollutant that is highly toxic to animals and human beings. However, no detailed report has been...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02094-y
更新日期:2020-12-01 00:00:00