Abstract：
:Plasma and liver selenium of Wistar rats were determined after 1, 3, and 6 mo supplementation with 0.5, 2, 6, or 15 ppm selenium as sodium selenite in drinking water. Plasma selenium was not different from control values at additional intake of 0.5 ppm but increased above usual levels at higher intakes. A highly significant correlation was observed between the total quantity of selenium ingested and plasma selenium after 1 mo treatment (r = 0.99, p < 0.01), but was less pronounced after 3 and 6 mo (0.94, p < 0.05, and 0.78, p < 0.05, respectively). The decrease in plasma selenium with time of treatment was more pronounced at higher intakes. There was also a highly significant correlation between total selenium intake and liver selenium concentration (r = 0.99, p < 0.01) after 1 mo of treatment, but this time liver selenium did not change with time, and the correlation remained highly significant throughout the investigation. Liver selenium therefore appears as a more sensitive and more representative measure of selenium intake than plasma selenium. Most supplements did not affect body weight and survival of animals, except when the diet was supplemented with 15 ppm for 6 mo; however, alterations in biochemical parameters concerning lipid status and hepatic function were observed at levels above 2.0 ppm.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Crespo AM,Neve J,Pinto REdoi
10.1007/BF02784050subject
Has Abstractpub_date
1993-08-01 00:00:00pages
139-47issue
2eissn
0163-4984issn
1559-0720journal_volume
38pub_type
杂志文章abstract：:Although recent studies have shown that chromium (as the trivalent ion) is not an essential trace element, it has been demonstrated to generate beneficial effects at pharmacologically relevant doses on insulin sensitivity and cholesterol levels of rodent models of insulin insensitivity, including models of type 2 diab...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/s12011-015-0231-9
更新日期：2015-07-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8714-1
更新日期：2011-06-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917273
更新日期：1989-07-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02305-6
更新日期：2020-07-25 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8866-z
更新日期：2011-10-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1320-3
更新日期：2018-12-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/bter:86:3:227
更新日期：2002-06-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9297-1
更新日期：2012-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s12011-018-1411-1
更新日期：2019-04-01 00:00:00
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journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
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更新日期：2000-09-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/s12011-017-1119-7
更新日期：2018-05-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9446-1
更新日期：2012-12-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917499
更新日期：1988-12-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9739-z
更新日期：2013-09-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1559-8
更新日期：2019-08-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0101-x
更新日期：2014-11-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9566-7
更新日期：2013-03-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0096-3
更新日期：2014-11-01 00:00:00
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journal_title：Biological trace element research
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doi：10.1007/s12011-014-0110-9
更新日期：2015-02-01 00:00:00
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journal_title：Biological trace element research
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更新日期：2000-07-01 00:00:00
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journal_title：Biological trace element research
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更新日期：1992-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF02796636
更新日期：1987-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
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更新日期：2001-07-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
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更新日期：1982-03-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
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更新日期：1990-07-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-11-27 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
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更新日期：2021-01-07 00:00:00
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pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
