Abstract：
:Although recent studies have shown that chromium (as the trivalent ion) is not an essential trace element, it has been demonstrated to generate beneficial effects at pharmacologically relevant doses on insulin sensitivity and cholesterol levels of rodent models of insulin insensitivity, including models of type 2 diabetes. The mode of action of Cr(III) at a molecular level is still an area of active debate; however, the movement of Cr(III) in the body, particularly in response to changes in insulin concentration, suggests that Cr(III) could act as a second messenger, amplifying insulin signaling. The evidence for the pharmacological mechanism of Cr(III)'s ability to increase insulin sensitivity by acting as a second messenger is reviewed, and proposals for testing this hypothesis are described.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Vincent JBdoi
10.1007/s12011-015-0231-9subject
Has Abstractpub_date
2015-07-01 00:00:00pages
7-12issue
1eissn
0163-4984issn
1559-0720journal_volume
166pub_type
杂志文章,评审abstract：:Selenoprotein K (SelK), a member of selenoprotein family, is identified as a single endoplasmic reticulum (ER) transmembrane protein. Although over-expression of SelK inhibits adherence and migration of human gastric cancer BGC-823 cells, the effects of SelK in human choriocarcinoma (CCA) are not well understood. In t...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1155-3
更新日期：2018-07-01 00:00:00
abstract：:The aim of this study was to evaluate the impact of three different chromium forms as chromic chloride (CrCl), chromium picolinate (CrPic), and a newly synthesized complex of chromium chelated with small peptides (CrSP) on glucose uptake and metabolism in vitro. In cultured skeletal muscle cells, chromium augmented in...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8357-2
更新日期：2009-11-01 00:00:00
abstract：:In the present study, 15 different commercial tea brands sold in Khyber Pakhtunkhwa were collected from the markets. The samples were analyzed for the concentrations of ten selected heavy metals. The metal concentration showed a random distribution in all samples. The mean concentration of Cd, Cu, Mn, Pb, Zn, and Fe w...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02059-1
更新日期：2020-11-01 00:00:00
abstract：:The aim of the current study was to assess relationships between multiple metals burden in human seminal plasma and semen quality parameters. Levels of five metals (lead, manganese, copper, arsenic, and selenium) in human seminal plasma were determined by inductively coupled plasma mass spectrometry (ICP-MS), and the ...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-012-9335-7
更新日期：2012-07-01 00:00:00
abstract：:Arsenic is one of the most important environmental pollutants especially in drinking water. The S100B protein is presented as a sensitive biomarker for assessment of the blood-brain barrier integrity previously. The objective of this study was to determine the impact of chronic arsenic exposure in drinking water and s...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1463-2
更新日期：2019-05-01 00:00:00
abstract：:The aim of this study was to analyze the effect of high dietary Fe on liver antioxidant status in mice fed a corn-oil-enriched diet. Male Balb/c mice were fed for 3 wk with a standard diet enriched with 5% by weight of corn oil with adequate Fe (FCO diet) or supplemented with 1% carbonyl Fe (FCOFe diet). The control g...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:113:2:177
更新日期：2006-11-01 00:00:00
abstract：:Microcalorimetry was employed to investigate the action of Li(I) to aquatic ecosystem from the point view of bioenergetics. Tetrahymena thermophila BF5 was chosen as the model organism. The power-time curves of T. thermophila BF5 growth metabolism in the absence and presence of Li(I) were obtained. The corresponding t...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-0040-x
更新日期：2007-10-01 00:00:00
abstract：:Recent studies have identified a new existence of a genetically programmed and regulated cell death characterized by necrotic cell death morphology, termed necroptosis. Lead (Pb) is a ubiquitously distributed environmental pollutant that is highly toxic to animals and human beings. However, no detailed report has been...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02094-y
更新日期：2020-12-01 00:00:00
abstract：:This paper aims to compare the Cd, Cu, and Pb concentration in the bone, gills, and muscle of the seven fish species sampled during normal and dry seasons. Cadmium, Cu, and Pb concentrations varied significantly depending on the type of the tissue and season. Bone samples of the Osteochilus hasseltii showed the highes...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8596-2
更新日期：2010-12-01 00:00:00
abstract：:Pituitary dwarfism (hGHD) is known to be associated with trace element deficiency, which causes improper functioning of the involved endocrine system. Previously, we reported on the head hair concentrations of zinc, copper, manganese, and iron from a total of 418 normal subjects (154 male and 264 female). In this repo...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:85:2:127
更新日期：2002-02-01 00:00:00
abstract：:Aluminum (Al) has various adverse effects on health of humans and animals. The aim of present study was to demonstrate that Lactobacillus plantarum CCFM639 can alleviate the adverse effects on liver and kidney of mice caused by chronic Al exposure. Animals were assigned into control, CCFM639 only, Al only, Al plus CCF...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0843-8
更新日期：2017-04-01 00:00:00
abstract：:Nowadays, 70 % of global monogastric feeds contains an exogenous phytase. Phytase supplementation has enabled a more efficient utilisation of phytate phosphorous (P) and reduction of P pollution. Trace minerals, such as iron (Fe), zinc (Zn), copper (Cu) and manganese (Mn) are essential for maintaining health and immun...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0161-y
更新日期：2015-02-01 00:00:00
abstract：:Since 1992, the International Atomic Energy Agency (IAEA) has been promoting studies of air pollution using a standard design of air sampler that provides separation on filters into two size fractions with cutoffs of 2.5 and 10 microns (approximately). These are the size ranges presently considered to have the most im...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784202
更新日期：1999-01-01 00:00:00
abstract：:Selenium (Se) is a trace element for human and animal health. Cadmium (Cd) is a known human carcinogen. The effects of Cd on the environment and humans are well known. Because chickens are at the top of the food chain, it is a good experimental animal model for assessing heavy metal toxicity and its potential threat t...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01858-5
更新日期：2020-06-01 00:00:00
abstract：:Although coenzyme Q10 (CoQ10) is a component of the oxidative phosphorylation process in mitochondria that converts the energy in carbohydrates and fatty acids into ATP to drive cellular machinery and synthesis, its effect in type I diabetes is not clear. We have studied the effect of 4 wk of treatment with CoQ10 (10 ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:109:1:025
更新日期：2006-01-01 00:00:00
abstract：:Oxidative stress is involved in the pathogenesis of congestive heart failure (CHF). Some trace elements serve as antioxidant defenses. The purpose of this study was to analyze the effect of atrial fibrillation (AF) on zinc (Zn) and copper (Cu) levels in patients with advanced CHF. In this prospective study, serum Zn a...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-8956-6
更新日期：2011-12-01 00:00:00
abstract：:Because nickel may have a biological function in a pathway in which vitamin B12 is important, an experiment was performed to determine the effects of nitrous oxide exposure in rats deprived of nickel. Exposure to nitrous oxide (N2O) causes inactivation of cobalamin and a subsequent decrease in the vitamin B12-dependen...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783980
更新日期：1993-07-01 00:00:00
abstract：:Nickel (Ni) has not been elucidated as an essential mineral in dairy animals, though in plants and lower organisms, its role in activation of urease enzyme is well known. This study was conducted to evaluate the effect of Ni supplementation on intake, growth performance, urease activity, antioxidant and immune status,...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1524-6
更新日期：2019-07-01 00:00:00
abstract：:The aim of this study was to assess the effect of sibutramine on mineral status and selected biochemical parameters in obese women. The study was conducted on 24 patients who received 15 mg daily doses of sibutramine for 12 weeks, and on 20 patients who received placebo. At the baseline, after the sixth and twelfth we...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9425-6
更新日期：2012-11-01 00:00:00
abstract：:Arsenite has been known for half a century to have a protective effect against selenium poisoning. Paradoxically, arsenite inhibits the conversion of inorganic selenium salts to methylated excretory products, although methylation has long been regarded as a detoxification mechanism for selenium. Moreover, there is evi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02919103
更新日期：1989-04-01 00:00:00
abstract：:Plasma and liver selenium of Wistar rats were determined after 1, 3, and 6 mo supplementation with 0.5, 2, 6, or 15 ppm selenium as sodium selenite in drinking water. Plasma selenium was not different from control values at additional intake of 0.5 ppm but increased above usual levels at higher intakes. A highly signi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784050
更新日期：1993-08-01 00:00:00
abstract：:The purpose of the present study was to measure the pattern of uptake of(75)Se into proteins in normal rat lenses and into the proteins of lenses with selenite-induced cataract. Ten-day-old suckling rats received a single injection of(75)Se with or without a cataractous dose of cold carrier sodium selenite. Four days ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917506
更新日期：1984-06-01 00:00:00
abstract：:Heavy metals toxicity is a prevalent health problem particularly in developing countries. Mercury and cadmium are toxic elements that have no physiologic functions in human body. They should not be present in the human body by any concentration. Copper, on the other hand, is one of the elements that are essential for ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0525-y
更新日期：2016-06-01 00:00:00
abstract：:Osteoblast L-type voltage-dependent calcium channels (VDCC) play important roles in maintaining intracellular homeostasis and influencing multiple cellular processes. In particular, they contribute to the activities and functions of osteoblasts (OBs). In order to study how L-type VDCC modulate calcium ion (Ca(2+)) hom...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0118-1
更新日期：2014-12-01 00:00:00
abstract：:The present study investigated the interactive effects of copper sources and a high level of phytase on growth performance, nutrient digestibility, tissue mineral concentrations, and plasma parameters in nursery pigs. Weaning piglets (N = 192; 6.06 ± 0.99 kg), blocked by body weight, were randomly allotted to 1 of 4 d...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-021-02580-x
更新日期：2021-01-11 00:00:00
abstract：:Glutathione peroxidase (GPx) is the prototypical eukaryotic selenoprotein, with the rare amino acid selenocysteine (Sec) at the enzyme active site, encoded by the UGA codon in RNA. A DNA virus, Molluscum contagiosum, has now been shown to encode a functional selenium-dependent GPx enzyme. Using modifications of conven...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783852
更新日期：1999-11-01 00:00:00
abstract：:The intervention effect of fucoxanthin, which is reportedly a powerful antioxidant, on cadmium-induced thyroid damage in mice was evaluated. Animals (N = 120) were divided into control group (given pure water, N = 20) and CdCl2-exposed group (given CdCl2 orally at a dose of 30 mg/kg body weight (bw)/day for 30 days, N...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02291-9
更新日期：2020-07-21 00:00:00
abstract：:This study evaluated the effects of supplemental dietary chromium (Cr) on the performance, carcass traits, and some serum parameters of broilers under a heat stress (23.9 to 37 °C cycling) condition. A total of 150 1-day-old broiler chicks (Cobb 500) according to a completely randomized design were assigned into five ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9663-2
更新日期：2013-06-01 00:00:00
abstract：:Chronic alcoholics frequently show associated malnutrition. Both ethanol and malnutrition exert profound changes on zinc and copper metabolism. In this study, we found higher hair zinc and copper values in 43 male alcoholics than in 39 controls. Hair copper was significantly related to the amount of ethanol consumed, ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/bter:85:3:269
更新日期：2002-03-01 00:00:00
abstract：:The degree of accumulation and distribution of Cd and Pb in the organs of young animals compared to the amount taken in with water or feed have not been thoroughly investigated yet. The experiment aimed to verify whether the source of toxic metals (feed, drinking water) administered to growing rats orally has an influ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0414-4
更新日期：2016-02-01 00:00:00
