Abstract：
:Although coenzyme Q10 (CoQ10) is a component of the oxidative phosphorylation process in mitochondria that converts the energy in carbohydrates and fatty acids into ATP to drive cellular machinery and synthesis, its effect in type I diabetes is not clear. We have studied the effect of 4 wk of treatment with CoQ10 (10 mg/kg, ip, daily) in streptozotocin (STZ)-induced (40 mg/kg, iv in adult rats) type I diabetes rat models. Treatment with CoQ10 produced a significant decrease in elevated levels of glucose, cholesterol, triglycerides, very-low-density lipoprotein, low-density lipoprotein, and atherogenic index and increased high-density lipoprotein cholesterol levels in diabetic rats. CoQ10 treatment significantly decreased the area under the curve over 120 min for glucose in diabetic rats, without affecting serum insulin levels and the area under the curve over 120 min for insulin in diabetic rats. CoQ10 treatment also reduced lipid peroxidation and increased antioxidant parameters like superoxide dismutase, catalase, and glutathione in the liver homogenates of diabetic rats. CoQ10 also lowered the elevated blood pressure in diabetic rats. In conclusion, CoQ10 treatment significantly improved deranged carbohydrate and lipid metabolism of experimental chemically induced diabetes in rats. The mechanism of its beneficial effect appears to be its antioxidant property.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Modi K,Santani DD,Goyal RK,Bhatt PAdoi
10.1385/BTER:109:1:025subject
Has Abstractpub_date
2006-01-01 00:00:00pages
25-34issue
1eissn
0163-4984issn
1559-0720pii
BTER:109:1:025journal_volume
109pub_type
杂志文章abstract：:Chronic alcoholics frequently show associated malnutrition. Both ethanol and malnutrition exert profound changes on zinc and copper metabolism. In this study, we found higher hair zinc and copper values in 43 male alcoholics than in 39 controls. Hair copper was significantly related to the amount of ethanol consumed, ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/bter:85:3:269
更新日期：2002-03-01 00:00:00
abstract：:Studies investigating the effects of Chromium (Cr) supplementation on unstressed broiler chickens have reported an inconsistent association between Cr supplementation and broiler chickens' responses. We conducted a dose-response meta-analysis of previous studies to assess the dose-response associations between Cr supp...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-021-02589-2
更新日期：2021-01-17 00:00:00
abstract：:This study evaluated the plasma levels of trace elements in children with chronic hepatitis B virus (HBV) infection and assessed whether they can be a factor that affects the response to interferon alpha (IFN-alpha) treatment. The study included 35 cases (ten girls, 25 boys) aged 3-13 years with chronic HBV infection ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8507-6
更新日期：2010-06-01 00:00:00
abstract：:Chromium picolinate is used in the poultry diet because of its antistress effects in addition to the fact that the requirement for it is increased during stress. This study was conducted to determine if the negative effects of high ambient temperature (34 degrees C) on egg production, egg quality, antioxidant status, ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:101:2:181
更新日期：2004-11-01 00:00:00
abstract：:In a controlled animal experiment the effects of dietary subacute Zn deficiency on growth, Zn concentration, and tissue 42-K distribution were studied. Growth retardation caused lower body weight because both skeletal and heart muscle showed a reduction in cell mass. Zn concentrations were reduced in most tissues, how...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789301
更新日期：1994-12-01 00:00:00
abstract：:This experiment was designed to assess the effect of chronic fenvalerate toxicity on tissue Cu concentration in goats and to explore the pathways responsible for it. A significant decrease in tissue Cu concentration of kidney, heart, and brain while an increase in the liver were recorded in fenvalerate intoxicated goa...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8629-x
更新日期：2010-12-01 00:00:00
abstract：:In vivo and in vitro studies were conducted to investigate the chemical forms by ion-exchange chromatography of selenium (Se) present in rat and ovine spermatozoa. After injection with 75Se-selenite, the form of 75Se in rat sperm was selenocysteine, but selenocysteine and selenomethionine (SeMet) were present in ovine...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/bter:76:2:161
更新日期：2000-08-01 00:00:00
abstract：:Addition of zinc lowers the toxicity level of cadmium in cultured CHO cells. Cell survival and protein synthesis were used to measure the cellular toxicity of cadmium.(109)Cd was used to measure cadmium uptake by the cells. The results suggest that these class IIB transition metals, zinc and cadmium, share a common tr...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02785356
更新日期：1980-09-01 00:00:00
abstract：:Garlic (Allium sativum) is known to reduce lead toxicity in some species of animals. The objective of this study was to evaluate the efficacy of allicin, one of the most active components of garlic, in the treatment of subacute lead intoxication in sheep. Nine female sheep weighing 25-29 kg orally received a daily dos...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8185-9
更新日期：2008-01-01 00:00:00
abstract：:Microbeam X-ray spectrometry, energy-dispersive X-ray fluorescence analysis, and neutron activation analysis were evaluated for the detection of selenium contained in the selenoprotein glutathione peroxidase. The glutathione peroxidase had been previously separated using polyacrylamide gel electrophoresis. The use of ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917328
更新日期：1994-10-01 00:00:00
abstract：:Zinc has been shown to increase bone mass and promote bone cell proliferation and differentiation. We, therefore, hypothesized that zinc might be cytoprotective for bone cells during oxidative stress. The cells were divided into H(2)O(2), zinc and zinc+H(2)O(2) groups. In the present study, zinc was found to inhibit H...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9387-8
更新日期：2012-09-01 00:00:00
abstract：:The objective of this study was to examine relations between basal metabolic rate (BMR) and cadmium (Cd) accumulation in the liver, kidneys, and duodenum in mice. The 5-month-old mice selected for high (H) and low (L) BMR were exposed for 8 weeks to 0, 10, and 100 μg Cd/mL of drinking water. The H-BMR mice showed sign...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9061-6
更新日期：2011-12-01 00:00:00
abstract：:Urine is a clinical specimen often used in medical diagnostics for monitoring of elements concentrations and kidneys function. We determined the contents of magnesium (Mg), calcium (Ca), zinc (Zn), copper (Cu), iron (Fe), lead (Pb), and cadmium (Cd) in 74 samples of 24-h urine (from 46 women and 28 men). The measureme...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8745-7
更新日期：2011-07-01 00:00:00
abstract：:Two organoselenium compounds: xylitol selenious ester (xylitol-Se) and sucrose selenious ester (sucrose-Se) were synthesized, and their molecular structures were characterized in this study. In MTT assay, xylitol-Se and sucrose-Se showed cytostatic effects on human hepatocellular carcinoma cells SMMC-7221 in a dose-de...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9715-7
更新日期：2013-08-01 00:00:00
abstract：:Both manganese and copper may affect bone synthesis. Bone content of both metals can be altered in alcoholics, although controversy exists regarding this matter. To analyse the relative and combined effects of ethanol and a low protein diet on bone copper and manganese, and their relationships with bone structure and ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9296-2
更新日期：2012-06-01 00:00:00
abstract：:The onset of Alzheimer's disease has been shown to affect trace element concentrations in the brain when compared to "normal" subjects in ex vivo samples. The techniques used to determine trace element concentrations were proton-induced X-ray emission and instrumental neutron activation analysis. With these methods, s...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784242
更新日期：1999-01-01 00:00:00
abstract：:Strontium (Sr) ralenate is a new agent used for the prevention and treatment of osteoporosis. As a bone-seeking element, 98% of Sr is deposited in the bone and teeth after oral ingestion. However, the effect of Sr treatment on bone microarchitecture and bone nanomechanical properties remains unclear. In this study, 18...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9158-y
更新日期：2012-01-01 00:00:00
abstract：:Cadmium (Cd) is a highly toxic heavy metal that can affect human and animal health. Selenium (Se) is an essential microelement that can protect various organs against toxic heavy metals. Although many studies have investigated the adverse effect of Cd in rats and several other animals, little is known regarding the me...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1186-9
更新日期：2018-07-01 00:00:00
abstract：:Bioenvironmental trace elements play a vital role in plant, animal, and man metabolism. This study aims to determine trace element concentration in different parts (pods, pericarp, seeds, cotyledon, and taste) of the warm climate plant pigeon pea (Cajanus cajan L. Millsp.). The pigeon pea pods were collected from the ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02256-y
更新日期：2020-06-20 00:00:00
abstract：:Cantharellus cibarius Fr. (chanterelle) and Boletus badius Pers. (bay bolete) harvested from natural sites in Poland were used to derive in vitro cultures. The optimal medium composition for cultures was developed. Concentrations of the chosen elements (Zn, Cu, Fe, Mg, Ni, and Cd) in mycelium samples were measured by ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9670-3
更新日期：2013-06-01 00:00:00
abstract：:The relaxation rates (1/T(1) and 1/T(2)) in cysts have already been analyzed in terms of materials such as albumin, cholesterol, manganese, iron, and copper. However, the relaxivities of these materials have not been determined yet. In this work, five sets containing the ions, albumin, and cholesterol were prepared by...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8170-3
更新日期：2008-12-01 00:00:00
abstract：:The objective of this paper is to investigate the correlation between serum macro-element and trace element contents and bone mineral density (BMD) as well as the occurrence of osteoporosis. After the epidemiological investigation of 290 postmenopausal women from ages 45 to 65 in the Xi'an urban area, their blood was ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8363-4
更新日期：2009-12-01 00:00:00
abstract：:The objective of this study was to investigate the effects of dietary supplemental chromium (Cr) on growth performance, carcass traits, and meat quality of broilers reared under heat stress. A total of 252 1-d-old Cobb 500 commercial female broilers were randomly allotted by body weight (BW) to one of six replicate ca...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0443-z
更新日期：2016-03-01 00:00:00
abstract：:Zinc, copper, and selenium statuses were reported to be linked to the development of chronic diseases, especially coronary heart disease (CHD). Metabolic syndrome, a known CHD risk factor, was found to be highly prevalent in Lebanon. Nevertheless, no data are available on the statuses of plasma zinc, copper, and selen...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8112-0
更新日期：2008-07-01 00:00:00
abstract：:Selenomethionine metabolism and the biochemical basis for its cytotoxicity were analyzed in cultured human and murine lymphoid cells. The metabolic pathways were also addressed, using purified mammalian enzymes and crude tissue extracts. Selenomethionine was found to be effectively metabolized to S-adenosylmethionine ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02990463
更新日期：1991-01-01 00:00:00
abstract：:The risk of premature ovarian failure (POF) increases in association with alteration in immunological parameters and oxidative stress (OS). Adequate intake of trace elements is required for antioxidant property and immune defense mechanism. The aim of this study was to explore the involvement of trace elements, OS, an...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1197-6
更新日期：2018-08-01 00:00:00
abstract：:Fluoride can induce neurotoxicity, but the mechanism is not clear. In this study, we explored the role of autophagy in F--induced neurotoxicity of Wistar rats. Eighty Wistar rats were randomly divided into four groups: the control group (distilled water containing less than 0.1 mg/L F-) and three NaF-treated groups (F...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01735-1
更新日期：2020-02-01 00:00:00
abstract：:In vitro tests simulating the elements release from inhaled urban particulate matter (PM) with artificial lung fluids (Gamble's and Hatch's solutions) and simulated gastric and pancreatic solutions were applied for an estimation of hazardous element (As, Cd, Cr, Hg, Mn, Ni, Pb and Zn) bio-accessibility in this materia...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0101-x
更新日期：2014-11-01 00:00:00
abstract：:Epimedium polysaccharide (EPS) and isatis root polysaccharide (IRPS) were extracted, purified, and selenizingly modified by nitric acid-sodium selenite method to obtain nine selenizing EPSs (sEPSs), sEPS1-sEPS9 and nine selenizing IRPSs (sIRPSs), sIRPS1-sIRPS9, respectively. Their effects on chicken peripheral lymphoc...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0511-4
更新日期：2016-05-01 00:00:00
abstract：:Iron and copper are essential microminerals that are intimately related. The present study was performed to determine the effect of iron-deficiency anemia (IDA) and treatment with iron on laboratory indicators of copper status. Hemoglobin, mean corpuscular volume erythrocyte Zn protoporphyrin, serum ferritin, serum co...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:112:3:213
更新日期：2006-09-01 00:00:00
