Abstract：
:Fluoride can induce neurotoxicity, but the mechanism is not clear. In this study, we explored the role of autophagy in F--induced neurotoxicity of Wistar rats. Eighty Wistar rats were randomly divided into four groups: the control group (distilled water containing less than 0.1 mg/L F-) and three NaF-treated groups (F- was respectively administered at 25, 50, and 100 mg/L orally via drinking water). The water maze experiment showed that NaF exposure impaired the learning capabilities of the rats. When compared with the control group, the mean escape latency of the rats in the 100 mg/L F- group was much longer (P < 0.05). Immunohistochemical analysis showed that NaF exposure induced autophagy, as shown by the significant increase of Beclin-1 expression in the hippocampal CA1 region and DG region. Transmission electron microscopy was used to observe the ultrastructural changes of hippocampal neurons. With the increase of F- concentration, the ultrastructural abnormalities of hippocampal neurons increased. These results indicate that fluoride can impair the learning ability of rats, which may be related to the induction of autophagy in rat hippocampal neurons.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Zhang C,Huo S,Fan Y,Gao Y,Yang Y,Sun Ddoi
10.1007/s12011-019-01735-1subject
Has Abstractpub_date
2020-02-01 00:00:00pages
502-507issue
2eissn
0163-4984issn
1559-0720pii
10.1007/s12011-019-01735-1journal_volume
193pub_type
杂志文章abstract：:Selenium deficiency is known to cause cardiovascular diseases. However, the role of Se deficiency in causing oxidative damage and inflammation injury to the aorta vessels of chickens is not well known. In the present study, 180 1-day-old chickens were randomly divided into two groups, a low-Se group (L group) and a co...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0676-5
更新日期：2016-10-01 00:00:00
abstract：:Negative potassium balance during hypokinesia (decreased number of kilometers taken/day) is not based on the potassium shortage in the diet, but on the impossibility of the body to retain potassium. To assess this hypothesis, we study the effect of potassium loading on athletes during prolonged hypokinesia (HK). Studi...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/BF02783845
更新日期：1999-10-01 00:00:00
abstract：:Human ocular tissues from 50 donor eyes were elementally and morphologically analyzed in order to correlate the elemental content and distribution of Ca, Ba, Cr, Cu, Zn, and Se with ocular morphology, sex, race, irideal pigmentation, age, time of death, birth weight, presence and severity of diabetes, and other pathol...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02796667
更新日期：1987-04-01 00:00:00
abstract：:The effect of manganese (Mn) supplementation on bone mineral density (BMD) and bone metabolism parameters was determined in ovariectomized Sprague-Dawley rats. Rats were divided into four groups (OVX, OVX+Mn, sham, sham+Mn) and fed with different intake levels of manganese (adequate 0.001% Mn, supplementation 0.01% Mn...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8119-6
更新日期：2008-07-01 00:00:00
abstract：:Selenium (Se) is an essential trace element for both humans and animals. Se deficiency leads to myocardial injury, reproductive disorder, increased exudation, inflammatory injury, and other diseases. The present study analyzed the relationships of Se deficiency, inflammation, and smooth muscle contraction in the small...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02245-1
更新日期：2020-06-15 00:00:00
abstract：:Information on cadmium (Cd) uptake and transport is essential to understand better the physiology of Cd tolerance in plants. In this study, Cd uptake, translocation, and tolerance were investigated in AHA1 (Arabidopsis plasma membrane H(+)-ATPase gene) overexpressed plants. Exposed to 10 µM CdCl(2), AHA1OX showed a hi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8657-6
更新日期：2011-02-01 00:00:00
abstract：:Synaptosomes are used as an ex vivo model in the investigation of neuronal transmission and neurodegenerative processes. In this study, we aimed to determine the protective effects of boric acid (BA) and curcumin, which have antioxidant and anti-inflammatory properties, on Aβ1-42 induced neurodegenerative damage. Syna...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02511-2
更新日期：2020-11-25 00:00:00
abstract：:Cadmium (Cd) exposure has been recognized to result in a wide variety of cellular responses, including oxidative stress and body weight loss. The aim of the present study was to examine the effect of lycopene supplementation on the antioxidant defense system, lipid peroxidation (LPO) level, nitric oxide (NO), tumor ne...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-0027-7
更新日期：2007-08-01 00:00:00
abstract：:In this study, hair levels of Cu and Zn were determined in healthy male and female individuals (n = 192) ages 3.6-14.5 yr and the correlations with Cu and Zn daily intakes were examined. Determinations of Cu and Zn concentrations were performed by way of atomic absorption spectrometry and X-ray fluorescence. Nutrition...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02950788
更新日期：1994-02-01 00:00:00
abstract：:The thermogenic curves of the metabolism of mitochondria isolated from the liver of chicken Star-Cross 288 and the effect of La3+ on it were studied by using an LKB-2277 BioActivity Monitor, ampoule method, at 37 degrees C. After isolation from the chicken liver tissue, mitochondria still have metabolic activity and c...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/bter:84:1-3:103
更新日期：2001-01-01 00:00:00
abstract：:This study investigated whether boron would enhance the ability of 17beta-estradiol (E2) or parathyroid hormone (PTH) to improve bone quality in ovariectomized OVX rats. Adult OVX rats were treated for 5 wk with vehicle, boron (5 ppm as boric acid), E2 (30 microg/kg/d, sc), PTH (60 microg/kg/d, sc), or a combination o...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/bter:82:1-3:109
更新日期：2001-07-01 00:00:00
abstract：:Selenium is a trace element that, although toxic in higher concentrations, is essential for human and animal health. In this study, we looked at microarray-based gene expression patterns from liver and gastrocnemius tissues in mice fed either a selenium-deficient diet or diets containing sodium selenite, selenomethion...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8894-8
更新日期：2011-11-01 00:00:00
abstract：:To examine whether there were differences between races in regard to age-related changes of elements and the relationships among elements in the arteries, the authors investigated both the renal arteries of Thai and Japanese. The Thai subjects consisted of 27 men and 11 women, ranging in age from 27 to 88 yr, whereas ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:106:3:219
更新日期：2005-09-01 00:00:00
abstract：:The objective of the study was to evaluate the maximum tolerance limit of amino acid copper complex (Cu-Lys-Glu) for laying hens by measuring their laying performance, hematological and serum biochemical parameters, organ index, and histopathology. A total of 450 18-week-old Beijing White layers were randomly allocate...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02406-2
更新日期：2020-10-12 00:00:00
abstract：:Vanadium, a trace element in human cells and regarded as an essential nutrient, plays an active role in all tissues. It is known that peroxovanadate-nicotinic acid (POV), a complex compound of vanadium, can decrease hyperglycemia; however, its biochemical mechanism remains unclear. The object of the present study is t...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:74:3:237
更新日期：2000-06-01 00:00:00
abstract：:The decline in fish population because of water contamination is problem. As a result of direct exposure in water, it has been readily accepted that the gills are the main site of water contamination and toxicity (e.g., metal ions). In the present study, we investigated metal ion contamination on the functional capaci...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:100:3:229
更新日期：2004-09-01 00:00:00
abstract：:We examined how the influence of smoking on blood and urinary cadmium (Cd) concentrations was modified by the level of environmental Cd. We measured blood and urinary Cd concentrations of 1134 men over 50 yr of age in three areas in Japan that were exposed to different levels of environmental Cd. Analysis of variance ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:110:2:107
更新日期：2006-05-01 00:00:00
abstract：:The arsenic (As) hazardous quotient was estimated based on concentration of As in drinking water and scalp hair of male subjects of two age groups (n=360) consuming As contaminated water at different levels and non-contaminated drinking water. The total As concentrations in drinking water of less-exposed (LE) and high...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8933-5
更新日期：2011-11-01 00:00:00
abstract：:Footrot (FR) is a common, contagious bacterial disease of sheep that results in lameness and significant economic losses for producers. We previously reported that sheep affected with FR have lower whole-blood (WB) selenium (Se) concentrations and that Se supplementation in conjunction with routine control practices a...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9716-6
更新日期：2013-07-01 00:00:00
abstract：:This study aimed to determine the relationship between the metabolic and endocrinological pathologies in polycystic ovary syndrome (PCOS) and the levels of arsenic, chromium, cadmium, lead, mercury, antimony, zinc, and copper to evaluate the relationship of these toxic metals with inflammatory/oxidative parameters. Th...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02220-w
更新日期：2020-11-01 00:00:00
abstract：:Chronic alcoholics frequently show associated malnutrition. Both ethanol and malnutrition exert profound changes on zinc and copper metabolism. In this study, we found higher hair zinc and copper values in 43 male alcoholics than in 39 controls. Hair copper was significantly related to the amount of ethanol consumed, ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/bter:85:3:269
更新日期：2002-03-01 00:00:00
abstract：:A survey based on 838 samples of milk obtained from 537 dairies covering 70 of 95 districts in France was organized to assess iodine content of milk and its contribution to total intake. Iodine levels were significantly higher in winter than in summer. Very low iodine contents (less than 25 micrograms I/kg) were found...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784607
更新日期：1992-01-01 00:00:00
abstract：:A series of experiments was conducted to study the effects of dietary and injected lead (as Pb acetate-3H2O) and of dietary Cd, Hg, and Se on fatty acid composition of serum lipids of chicks as measured by gas-liquid chromatography. The effect of dietary Pb on fatty acid composition of erythrocyte membranes was measur...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02989250
更新日期：1985-06-01 00:00:00
abstract：:Iron and copper are essential microminerals that are intimately related. The present study was performed to determine the effect of iron-deficiency anemia (IDA) and treatment with iron on laboratory indicators of copper status. Hemoglobin, mean corpuscular volume erythrocyte Zn protoporphyrin, serum ferritin, serum co...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:112:3:213
更新日期：2006-09-01 00:00:00
abstract：:CuO nanoparticles (CuO-NPs) serve several important functions in human life, particularly in the fields of medicine, engineering, and technology. These nanoparticles have been utilized as catalysts, semiconductors, sensors, gaseous and solid ceramic pigments, and magnet rotatable devices. Further use for CuO-NPs has b...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1170-4
更新日期：2018-08-01 00:00:00
abstract：:Oxidative stress is a main factor in the pathogenesis of severe acute pancreatitis (SAP). The ability of zinc (Zn) to retard oxidative processes has been recognized for many years. This study aims to examine the levels of free oxygen radicals and antioxidant enzyme in SAP rats and know the effect of Zn supplementation...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9971-1
更新日期：2014-06-01 00:00:00
abstract：:The metabolic thermograms and heat output of mitochondria isolated from carp liver have been determined by using an LKB bioactivity monitor. The thermogram can be divided into four parts: the lag phase, active recovery phase, stationary phase, and decline phase. The thermokinetic equation was established for the activ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783314
更新日期：1997-10-01 00:00:00
abstract：:The aim of this study was to trace zinc nanocrystals in the anterior pituitary of zinc-deficient Wistar rats by using autometallographic technique. Male Wistar rats (30-40 days of age, pre-pubertal period) of 40-50 g body weight were divided into the following: the ZC (zinc control) group-fed with 100 ppm zinc in diet...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0881-2
更新日期：2017-06-01 00:00:00
abstract：:The ratios of Rb to Cs contents were studied in five fish species from seven lakes located in the Patagonia Andean Range, Argentina in order to trace fish diet. The species studied were native velvet catfish (Diplomistes viedmensis) and creole perch (Percichthys trucha), and exotic brown trout (Salmo trutta), rainbow ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:111:1:97
更新日期：2006-07-01 00:00:00
abstract：:Plasma concentrations of a zinc carrier peptide, namely thymulin, were measured according to a bioassay in young donors, healthy elderly, and patients with senile dementia of Alzheimer's type (SDAT). Thymulin is a hormone released by thymic epithelial cells and its biological activity on cells of immune system is depe...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02790147
更新日期：1996-01-01 00:00:00
