Abstract：
:Vanadium, a trace element in human cells and regarded as an essential nutrient, plays an active role in all tissues. It is known that peroxovanadate-nicotinic acid (POV), a complex compound of vanadium, can decrease hyperglycemia; however, its biochemical mechanism remains unclear. The object of the present study is to explore the hypoglycemia mechanism of POV at gene molecular levels. Rats rendered diabetic with streptozotocin were treated with POV. Total RNA was isolated from rat liver, and phenylalanine hydroxylase (PAH) mRNA abundance was determined by reverse transcriptase-polymerase chain reaction. PAH activity, blood glucose, and lipid levels were measured. Significantly increased hepatic PAH activity and corresponding mRNA with concomitant hyperglycemia and hyperlipemia were found in diabetic rats. These levels returned to normal after POV treatment and accompanied by negative glucosuria, normoglycemia, and normolipemia. The results from the current study indicates one of the mechanisms of POV action is to inhibit PAH gene expression and PAH activity, thus decreasing gluconeogenesis and hyperglycemia. At the same time, POV is able to promote diabetic recovery by lowering hyperlipemia.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Wang YL,Yu Bdoi
10.1385/BTER:74:3:237subject
Has Abstractpub_date
2000-06-01 00:00:00pages
237-44issue
3eissn
0163-4984issn
1559-0720pii
BTER:74:3:237journal_volume
74pub_type
杂志文章abstract：:Consumption of edible plants satisfies a significant part of human body needs in macro- and micronutrients while biologically active substances contain strong antioxidant properties and reduce the risk of a number of diseases. Balanced nutrition and design of personalized diets and treatment rely on the data on the co...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02345-y
更新日期：2020-08-19 00:00:00
abstract：:Analyzing the concentrations of heavy metals in the sera of umbilical cord blood samples can provide useful information about prenatal exposure to environmental agents. An analytical method based on ICP-MS to simultaneously determine multiple elements in umbilical cord blood samples was developed for assessing the in ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0853-6
更新日期：2017-05-01 00:00:00
abstract：:Selenium concentrations in the blood of 112 (56 females and 56 males) normal subjects, from different regions of the Punjab (Pakistan), have been determined using the technique of inductively coupled plasma-mass spectrometry. The whole blood selenium concentrations were found to be 452 ± 12 ppb (parts per billion or n...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8867-y
更新日期：2011-10-01 00:00:00
abstract：:Hexavalent chromium (Cr(VI)) is present in the marine environment and is a known carcinogen and reproductive toxicant. Cr(VI) is the form of chromium that is well absorbed through the cell membrane. It is also the most prevalent form in seawater. We measured the total Cr levels in skin biopsies obtained from healthy f...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0311-x
更新日期：2015-07-01 00:00:00
abstract：:Serum copper and zinc estimations in humans were made to find their diagnostic and prognostic value in cases of myocardial infarction. Following infarction, there was an increase in serum copper levels from the first 24 h up to the 7th day, with gradual decline that did not reach the normal value up to the 14th day. T...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02990200
更新日期：1991-12-01 00:00:00
abstract：:Manganese (Mn) pollution is an important environmental problem because of the potential toxicity to human and animal health. However, the effects of Mn on energy metabolism and autophagy are not clear. Consequently, we examined the effects of excessive and chronic exposure to Mn on liver function, oxidative stress, re...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01960-8
更新日期：2020-09-01 00:00:00
abstract：:Our previous report indicated that magnesium (Mg) deficiency increased molybdenum (Mo) concentration in the rat liver, suggesting the possibility that Mg deficiency affects Mo metabolism. Growing male rats were given a control diet or a Mg-deficient diet for 4 weeks. Urine and feces were collected during the second an...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9541-3
更新日期：2013-01-01 00:00:00
abstract：:It is well known that rare earth elements (REEs) have come into extensive use in a number of fields. As a result, REEs are becoming closely related to human's daily life. However, until now, the distributions of REEs in the brain are not yet very clear. In this study, Sprague-Dawley male rats were intraperitoneally in...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:104:1:033
更新日期：2005-04-01 00:00:00
abstract：:In a controlled animal experiment the effects of dietary subacute Zn deficiency on growth, Zn concentration, and tissue 42-K distribution were studied. Growth retardation caused lower body weight because both skeletal and heart muscle showed a reduction in cell mass. Zn concentrations were reduced in most tissues, how...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789301
更新日期：1994-12-01 00:00:00
abstract：:A dietary requirement is defined as the lowest continuing intake of a nutrient that for a specified indicator of adequacy, will maintain a defined level of nutriture in an individual. An essential dietary component is one that the body cannot synthesize in sufficient quantities to maintain health. Recommended dietary ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783138
更新日期：1998-01-01 00:00:00
abstract：:Many studies have shown that zinc deficiency could decrease the response to insulin. In genetically diabetic animals, a low zinc status has been observed contrary to induced diabetic animals. The zinc status of human patients depends on the type of diabetes and the age. Zinc supplementation seems to have beneficial ef...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/BF02784615
更新日期：1992-01-01 00:00:00
abstract：:Several authors have already underlined chromium implication in glucose and lipids metabolism of humans. In this field, physiological chromium determination in serum could be helpful, but the discrepancies reported in numerous papers are confusing. Here we report some results obtained by Zeeman correction Graphite Fur...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784591
更新日期：1992-01-01 00:00:00
abstract：:The effects of dietary sodium selenite and vitamin E on the microvascular permeability of rat organs such as heart, brain, kidney, liver and eye were investigated by using the Evans blue leakage method. Combined deficiency of selenium and vitamin E caused an increase in the permeability of the heart and eye with respe...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783332
更新日期：1998-07-01 00:00:00
abstract：:The k0 standardization method was adapted for NAA with stable low-flux reactors where flux monitors are not needed. The modified k0 method offers the convenience of the use of libraries of sensitivity constants. It was compared to the relative method for 52 elements using a SLOWPOKE reactor and 6 counting geometries. ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784232
更新日期：1999-01-01 00:00:00
abstract：:This work is a first attempt to determine the speciation of Cr in human plasma. With the aid of in vitro and in vivo 51Cr-labeled experiments, it was possible to develop the necessary biochemical techniques for the separation of the plasma proteins. Further work will use real samples, taking care to avoid contaminatio...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02992700
更新日期：1990-07-01 00:00:00
abstract：:Cadmium (Cd) is an environmental toxicant and an inflammation-related xenobiotic. Selenium (Se) is a well-known nutritional trace element and a potent chemopreventive agent. The present study aimed to investigate the effect of Se on the cytotoxicity of Cd in bird immunocytes in vitro. Chicken splenic lymphocytes expos...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0354-z
更新日期：2015-11-01 00:00:00
abstract：:The present study was aimed at estimating the current (2012) dietary intake of arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb) by the population of Catalonia, Spain. The temporal trends with respect to previous surveys, performed in 2000, 2005, and 2008, were also determined. For that purpose, metal concentrat...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0138-x
更新日期：2014-12-01 00:00:00
abstract：:Pituitary dwarfism (hGHD) is known to be associated with trace element deficiency, which causes improper functioning of the involved endocrine system. Previously, we reported on the head hair concentrations of zinc, copper, manganese, and iron from a total of 418 normal subjects (154 male and 264 female). In this repo...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:85:2:127
更新日期：2002-02-01 00:00:00
abstract：:Previous studies on the endodontic broken stainless steel instruments have mainly focused on retrieval of specimens. However, the systemic consequences of the retained separated instruments need an investigation. The current study aimed to evaluate the correlation between broken stainless steel instruments inside the ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9959-x
更新日期：2014-06-01 00:00:00
abstract：:Copper oxide nanoparticles (CuONPs) are widely used in several products and their release into the environment can cause toxicity to major food crops. In this study, toxic responses as a result of CuONPs exposure were studied in soybean (Glycine max L.) seedlings. The plants were grown in 1/2 strength Murashige and Sk...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0106-5
更新日期：2014-12-01 00:00:00
abstract：:Zinc concentrations in the dorsal horn of spinal cord are important for wound healing, neurological function, and reproduction. However, the response of the spinal cord to alterations in dietary zinc is unknown in rats after spinal cord injury (SCI). The current study explored cellular zinc levels and zinc transporter...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9414-9
更新日期：2012-11-01 00:00:00
abstract：:The effect of ad libitum ingestion of selenium (Se) in drinking water (0.15 mg SeO2/L) for 3 wk on the brain weight, total brain protein, glutathione (GSH) level, catalase activity, and lipid peroxidation in the brain of protein-undernourished (PU) rats was investigated, in an attempt to determine whether antioxidants...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02685933
更新日期：2007-05-01 00:00:00
abstract：:In the present study, we investigated the effects of lycopene on the expression of organic anion transporters (OATs), organic cation transporters (OCTs), and multidrug resistance-associated proteins (MRPs) of cisplatin-induced nephrotoxicity in rats. Twenty-eight 8-week-old Wistar rats were divided into four groups: c...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9914-x
更新日期：2014-04-01 00:00:00
abstract：:Androgenetic alopecia (AGA) is the most common variant of male pattern baldness in which occurrence and development of multiple genetic, hormonal, and metabolic factors are involved. We aimed to estimate plasma element content (Mg, Ca, Zn, Cu, Se, Fe), vitamin status (B12, D, E, and folic acid) in patients with AGA us...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02468-2
更新日期：2020-11-05 00:00:00
abstract：:In this study, we evaluated the synergistic effects of genistein and zinc on bone metabolism, bone mineral density, and the femoral metaphyseal histomorphology in the ovariectomized rats. Sixty female Sprague-Dawley rats, aged 13 weeks, were divided into sham-operated group (SHAM), ovariectomized group (OVX), genistei...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1134-8
更新日期：2018-06-01 00:00:00
abstract：:Our previous studies showed that serum calcium level may have influence in the blood pressure to older male subjects, but the relationship between serum calcium level and blood lipids is unclear. The aim of this study was to evaluate the relationship between total serum calcium level and blood lipids. In our study, to...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9895-9
更新日期：2014-03-01 00:00:00
abstract：:The anticryptosporidial effect of sodium selenite (selenium) was evaluated in a bovine fallopian tube epithelial (BFrE) cell culture system and an immunosuppressed C57BL/6N adult mouse model. Parasite numbers in cell culture were significantly reduced (p<0.01) following treatment with selenium (Se) at concentrations o...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:90:1-3:261
更新日期：2002-01-01 00:00:00
abstract：:Accumulation of lanthanum oxide nanoparticles (La2O3NPs) in the femur bone of rats after 30 days of oral administration was explored. Also, the influence of La2O3NPs on macro and trace elements in the rats' femur bone was assessed. Inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma op...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01907-z
更新日期：2020-07-01 00:00:00
abstract：:The lipid and fatty acid composition of the blue mussels Mytilus edulis L. gills and digestive glands was evaluated after 24 and 72 h of cadmium (Cd) and copper (Cu) exposure. Mussels were exposed to different cadmium (10, 100, and 500 μg/L) and copper (5, 50, and 250 μg/L) concentrations. Similar stress response of p...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9727-3
更新日期：2013-08-01 00:00:00
abstract：:Concentration of heavy metals (lead (Pb), cadmium (Cd), chromium (Cr), and copper (Cu)) was determined in the liver, gills, kidneys, and muscles of eight edible fish species (Channa punctata, Cirrhinus reba, Labeo rohita, Heteropneustes fossilis, Mystus cavasius, Oreochromis niloticus, Puntius sophore, and Wallago att...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9011-3
更新日期：2011-12-01 00:00:00
