Abstract：
:The anticryptosporidial effect of sodium selenite (selenium) was evaluated in a bovine fallopian tube epithelial (BFrE) cell culture system and an immunosuppressed C57BL/6N adult mouse model. Parasite numbers in cell culture were significantly reduced (p<0.01) following treatment with selenium (Se) at concentrations of 6, 9, and 12 microM at 48 h postinoculation (PI) and at 1.5, 3, and 6 microM at 96 h PI. Parasite reduction was greater than 50% at 48 h PI when 9 and 12 microM Se was used, and at 96 h PI when 6 pM Se was used. Such Se-induced reduction of Cryptosporidium parvum infection was significantly (p<0.0001) blocked when using free-radical scavengers such as mannitol (20 mM). A combined solution of mannitol (20 mM) and reduced glutathione (0.5 mM) enhanced the blockage to almost 100%. Adult C57BL/6N mice were immunosuppressed with dexamethasone phosphate administered ad libitum (16 microg/mL) in drinking water and inoculated with 10(5) oocysts/ mouse. Significantly fewer (p<0.001) oocysts were shed in the feces of mice treated with Se administered ad libitum (12 microM) in drinking water than in untreated mice. The survival time of mice was also significantly increased (p<0.001) following Se treatment. Collectively, these results indicate that Se plays an important role in cryptosporidiosis, and oxidative stress caused by Se is probably a major mechanism in inhibition of C. parvum infection.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Huang K,Yang Sdoi
10.1385/BTER:90:1-3:261subject
Has Abstractpub_date
2002-01-01 00:00:00pages
261-72issue
1-3eissn
0163-4984issn
1559-0720pii
BTER-90-1-3-261journal_volume
90pub_type
杂志文章abstract：:Instrumental neutron activation (INAA) with k0 standardization has been used to determine the concentration levels of a variety of major and trace elements (Al, As, Br, Cd, Cl, Co, Cr, Cs, Cu, Fe, Hg, K, La, Mg, Mn, Mo, Na, Rb, Sc, Se, and Zn) in rice grains (raw and parboiled) and in rice flour collected from local m...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:103:1:083
更新日期：2005-01-01 00:00:00
abstract：:Although substantial progress has been achieved in inductovely coupled plasma (ICP) spectroscopy, placing it among the principal spectroscopic tools in analytical chemistry research and applications laboratories, some limitations exist especially for the analysis of ultratrace concentration levels in biological materi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02918324
更新日期：1984-02-01 00:00:00
abstract：:This experiment was designed to investigate the histological and lipid peroxidation effects of chronic fluorosis on testes tissues of first- and second-generation rats. Sixteen virgin female Wistar rats were mated with eight males (2:1) for approximately 12 h to obtain first-generation rats. Pregnant rats were divided...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-0036-6
更新日期：2007-09-01 00:00:00
abstract：:Reversed-phase liquid chromatography-inductively coupled plasma mass spectrometric hyphenation was used for iodine speciation in human serum. First investigations showed that iodine species nearly quantitatively were eluted in the void volume. The result indicated that protein-linked thyroid hormones were not interact...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:78:1-3:81
更新日期：2000-01-01 00:00:00
abstract：:This study was conducted to investigate the effects of zinc sources on gene expression of zinc-related transporters in intestinal porcine epithelial cells (IPEC-1). IPEC-1 cells were treated with zinc glycine chelate (Zn-Gly), zinc methionine (Zn-Met), and zinc sulfate (ZnSO4), respectively, for measurement of cell vi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0655-x
更新日期：2016-10-01 00:00:00
abstract：:Because nickel may have a biological function in a pathway in which vitamin B12 is important, an experiment was performed to determine the effects of nitrous oxide exposure in rats deprived of nickel. Exposure to nitrous oxide (N2O) causes inactivation of cobalamin and a subsequent decrease in the vitamin B12-dependen...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783980
更新日期：1993-07-01 00:00:00
abstract：:The consumption of vegetables grown on soils polluted by trace elements can cause a serious threat for animal and human health and disturb the functioning of the ecosystem. The aim of this work is to determine the concentrations of As, Cd, Co, Cr, Cu, Ni, Pb, Mn, and Zn in soils and different vegetables from market ga...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01849-6
更新日期：2020-05-01 00:00:00
abstract：:Concentration of heavy metals (lead (Pb), cadmium (Cd), chromium (Cr), and copper (Cu)) was determined in the liver, gills, kidneys, and muscles of eight edible fish species (Channa punctata, Cirrhinus reba, Labeo rohita, Heteropneustes fossilis, Mystus cavasius, Oreochromis niloticus, Puntius sophore, and Wallago att...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9011-3
更新日期：2011-12-01 00:00:00
abstract：:This paper aims to compare the Cd, Cu, and Pb concentration in the bone, gills, and muscle of the seven fish species sampled during normal and dry seasons. Cadmium, Cu, and Pb concentrations varied significantly depending on the type of the tissue and season. Bone samples of the Osteochilus hasseltii showed the highes...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8596-2
更新日期：2010-12-01 00:00:00
abstract：:Methylmercury (MeHg) is highly toxic, and its principal target tissue in human is the nervous system, which has made MeHg intoxication a public health concern for many decades. Portulaca oleraceae (purslane), a member of the Portulacaceae family, is widespread as a weed and has been ranked the eighth most common plant...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0546-6
更新日期：2016-07-01 00:00:00
abstract：:Sea cucumbers are a potential source of natural organic vanadium that may improve insulin resistance. In this work, vanadium was accumulated rapidly in blood, body wall, and intestine by sea cucumber Apostichopus japonicus. Furthermore, water-soluble vanadium-containing proteins, the main form of the organic vanadium,...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0517-y
更新日期：2016-05-01 00:00:00
abstract：:Manganese (Mn) is essential for several species and daily requirements are commonly met by an adequate diet. Mn overload may cause motor and psychiatric disturbances and may arise from an impaired or not fully developed excretion system, transporter malfunction and/or exposure to excessive levels of Mn. Therefore, dec...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1531-7
更新日期：2019-03-01 00:00:00
abstract：:Selenium and mercuric chloride (MC) interactions regarding cellular uptake and selenium protection on MC toxicity have been studied. Human K-562 cells were pretreated or simultaneously treated with either selenite (5 or 50 microM) or selenomethionine (10 or 50 microM) together with MC (35 or 50 microM). Both treatment...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:81:3:229
更新日期：2001-09-01 00:00:00
abstract：:Arsenic poisoning in aquatic ecosystem is a global concern that obstructs the productivity of agricultural lands (paddy fields) by targeting the growth of cyanobacteria. The cyanobacteria also tolerate and accumulate elevated concentration of arsenic (As) inside the cell and excrete out from cells in less toxic forms ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02289-3
更新日期：2020-08-06 00:00:00
abstract：:Fluoride and lead are two common pollutants in the environment. Previous investigations have found that high fluoride exposure can increase the lead burden. In this experiment, in order to study on the molecular mechanisms of central neural system injury induced by the above two elements, differently expressed protein...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0117-2
更新日期：2014-12-01 00:00:00
abstract：:Body stores of lead, cadmium, and mercury are determined by the levels in the circulation, and their levels in blood may be related to hemoglobin levels and their absorption by soft tissue and bone. We investigated the association of body fat percentage, hemoglobin levels, and nutrient intakes with the blood concentra...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9566-7
更新日期：2013-03-01 00:00:00
abstract：:Using the dimethylbenz(a)anthracene-induced mammary tumor model in rats, our studies indicated that there was a dose-response relationship between dietary selenium supplementation and the inhibition of mammary carcinogenesis. The degree of inhibition was proportional to the level of dietary selenium up to 5 ppm, at wh...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02987217
更新日期：1983-08-01 00:00:00
abstract：:Given the conflicting results about the positive effects of magnesium and L-carnitine and as there is no report concerning concurrent supplementation of magnesium and L-carnitine on migraine prophylaxis, the effects of magnesium, L-carnitine, and concurrent magnesium-L-carnitine supplementation on migraine indicators ...
journal_title：Biological trace element research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12011-012-9487-5
更新日期：2012-12-01 00:00:00
abstract：:Bioenvironmental trace elements play a vital role in plant, animal, and man metabolism. This study aims to determine trace element concentration in different parts (pods, pericarp, seeds, cotyledon, and taste) of the warm climate plant pigeon pea (Cajanus cajan L. Millsp.). The pigeon pea pods were collected from the ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02256-y
更新日期：2020-06-20 00:00:00
abstract：:This study aimed to investigate the effects of a combination of a dairy product fermented by lactobacilli (DFL) and galactooligosaccharides (GOS) on mineral balances in growing rats with hypochlorhydria induced by a proton pump inhibitor (PPI). Three-week-old male rats were assigned to receive one of six diets: a cont...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9681-0
更新日期：2013-06-01 00:00:00
abstract：:It was determined if the sensitivity in macular mutant mouse to copper-induced toxicity was affected by sex or age. The sensitivity in 6-8-d-old or 3-4-wk-old macular mutant mouse to copper-induced toxicity was not affected by sex. However, 8-9-wk-old mutant females were more sensitive to copper-induced toxicity than ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783183
更新日期：1993-11-01 00:00:00
abstract：:Cadmium (Cd) is a highly toxic heavy metal that can affect human and animal health. Selenium (Se) is an essential microelement that can protect various organs against toxic heavy metals. Although many studies have investigated the adverse effect of Cd in rats and several other animals, little is known regarding the me...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1186-9
更新日期：2018-07-01 00:00:00
abstract：:The effect of parenteral zinc on tissue metallothionein (MT) was studied in normal and streptozotocin-induced diabetic rats. The accumulation of Zn-MT in liver and pancreas of normal and diabetic rats following the administration (ip) of various amounts of zinc was not different. Renal Zn-MT was higher in the diabetic...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02795531
更新日期：1986-12-01 00:00:00
abstract：:Mitochondria from Trigonella foenum-graecum seedlings grown independently in the presence of either selenium (0.75 ppm) or mimosine (0.1 mM) exhibited respiration-stimulated energy-dependent uptake of Ca2+. Uptake studies were carried out independently at a series of Ca2+ concentrations at two different levels: (1) 1-...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:82:1-3:217
更新日期：2001-07-01 00:00:00
abstract：:Human ocular tissues from 50 donor eyes were elementally and morphologically analyzed in order to correlate the elemental content and distribution of Ca, Ba, Cr, Cu, Zn, and Se with ocular morphology, sex, race, irideal pigmentation, age, time of death, birth weight, presence and severity of diabetes, and other pathol...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02796667
更新日期：1987-04-01 00:00:00
abstract：:The objective of the study was analysis of hair trace elements content in children with goiter living in Aktubinsk region. Children with goiter and age- and sex-adjusted controls were involved in the current study. Hair trace elements content was assessed using inductively coupled plasma mass spectrometry. Thyroid vol...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-016-0711-6
更新日期：2016-12-01 00:00:00
abstract：:The effectiveness and success of antituberculosis therapy is mainly measured by its ability to identify the organism in the sputum. In certain cases, available tuberculosis tests are not satisfactory and do not provide enough information on the effectiveness of antituberculosis therapy. Copper (Cu), zinc (Zn), and sel...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1385/BTER:95:1:65
更新日期：2003-10-01 00:00:00
abstract：:The exposure of toxic elements may directly or indirectly associate with different pathogenesis of heart diseases. In the present study, the association of arsenic (As), cadmium (Cd), cobalt (Co), lead (Pb), and nickel (Ni) in biological samples (whole blood and urine) and mortality from myocardial infarction (MI) pat...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8713-2
更新日期：2011-06-01 00:00:00
abstract：:The purpose of the study was to determine the concentration of trace elements in serum samples of women who are chronic users of skin-whitening agents as well as the hepatic and renal effects of these agents on these women. The study was conducted among 23 skin-whitening users while 25 women served as the controls. Th...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-8962-8
更新日期：2011-12-01 00:00:00
abstract：:Bulk fabrication of ordered hollow structural particles (HSPs) with large surface area and high biocompatibility simultaneously is critical for the practical application of HSPs in biosensing and drug delivery. In this article, we describe a smart approach for batch synthesis of calcium carbonate nanotubes (CCNTs) bas...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9325-9
更新日期：2012-06-01 00:00:00
