Abstract：
:An increase in hepatic iron concentration might exacerbate liver injury. However, it is unknown whether hepatic iron overload may exacerbate acute liver injury from various toxins. Therefore, we evaluated how manipulations to increase hepatic iron concentration affected the extent of acute liver injury from thioacetamide. In this study, we used rats with either "normal" or increased hepatic iron concentration. Iron overload was induced by either providing excess iron in the diet or by injecting iron subcutaneously. Both routes of providing excess iron induced an increase in hepatic iron overload. Meanwhile, the subcutaneous route induced both hepatocellular and sinusoidal cell iron deposition; the oral route induced lesser degree of hepatic iron concentration and only hepatocellular iron overload. Thioacetamide administration to the rats with "normal" hepatic iron concentration induced hepatic cell necrosis and apoptosis associated with a remarkable increase in serum aminotransaminases and depletion of hepatic glutathione and other antioxidative indices. Thioacetamide administration to the iron-overloaded rats exacerbated the extent of liver injury only in the rats orally induced with iron overload. In the rats subcutaneously induced with iron overload, the extent of liver injury from thioacetamide was not different from that observed in the rats with "normal" iron overload. It was concluded that the outcome of thioacetamide-induced acute liver injury may depend on both the level of hepatic iron concentration and on the cellular distribution of iron. While isolated hepatocellular iron overload may exacerbate thioacetamide-induced acute liver injury, a combined hepatocellular and sinusoidal cell iron deposition, even at high hepatic iron concentration, had no such an effect.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Ackerman Z,Pappo O,Link G,Glazer M,Grozovski Mdoi
10.1007/s12011-014-0110-9subject
Has Abstractpub_date
2015-02-01 00:00:00pages
169-76issue
1-2eissn
0163-4984issn
1559-0720journal_volume
163pub_type
杂志文章abstract：:The aim of this study was to investigate the relationships between the bronchopneumonia and mean concentrations of those trace elements in bronchoalveolar lavage fluid (BALF). Twenty-nine dogs were included this study (17 healthy dogs and 12 dogs with respiratory disease). Each BALF sample had been obtained during bro...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8149-0
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journal_title：Biological trace element research
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更新日期：2015-12-01 00:00:00
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journal_title：Biological trace element research
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journal_title：Biological trace element research
pub_type： 杂志文章
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journal_title：Biological trace element research
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journal_title：Biological trace element research
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journal_title：Biological trace element research
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Biological trace element research
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pub_type： 临床试验,杂志文章
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journal_title：Biological trace element research
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journal_title：Biological trace element research
pub_type： 杂志文章
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journal_title：Biological trace element research
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更新日期：2017-01-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
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journal_title：Biological trace element research
pub_type： 杂志文章
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journal_title：Biological trace element research
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journal_title：Biological trace element research
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journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
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journal_title：Biological trace element research
pub_type： 杂志文章
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journal_title：Biological trace element research
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