Abstract:
:According to undiscovered toxicity and safety of magnesium oxide nanoparticles (MgO NPs) in isolated pancreatic islet cells, this study was designed to examine the effects of its various concentrations on a time-course basis on the oxidative stress, viability, and function of isolated islets of rat's pancreas. Pancreatic islets were isolated and exposed to different MgO NP (<100 nm) concentrations within three different time points. After that, oxidative stress biomarkers were investigated and the best exposure time was selected. Then, safety of MgO NPs was investigated by flow cytometry and fluorescent staining, and levels of insulin secretion and caspase activity were measured. The results illustrated a considerable decrease in oxidative stress markers such as reactive oxygen species (ROS) and lipid peroxidation (LPO) levels of pancreatic islets which were treated by MgO NPs for 24 h. Also, in that time of exposure, cell apoptosis investigation by flow cytometry and insulin test showed that MgO NPs, in a concentration of 100 μg/ml, decreased the rate of apoptotic cells via inhibiting caspase-9 activity and made a significant increase in the level of insulin secretion. Data of function and apoptosis biomarkers correlated with each other. It is concluded that the use of MgO NPs in concentration of as low as 100 μg/ml can induce antiapoptotic, antioxidative, and antidiabetic effects in rat pancreatic islets, which support its possible benefit in islet transplantation procedures.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Moeini-Nodeh S,Rahimifard M,Baeeri M,Abdollahi Mdoi
10.1007/s12011-016-0754-8subject
Has Abstractpub_date
2017-01-01 00:00:00pages
146-155issue
1eissn
0163-4984issn
1559-0720pii
10.1007/s12011-016-0754-8journal_volume
175pub_type
杂志文章abstract::The aim of this study was to investigate the possible protective role of selenium and L-carnitine on oxidative stress induced by 2.45-GHz radiation in heart of rat. For this purpose, 30 male Wistar Albino rats were equally divided into five groups namely controls, sham controls, radiation-exposed rats, radiation-expos...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-8994-0
更新日期:2011-12-01 00:00:00
abstract::Lung cancer is seriously threatening human health and exposure to trace metals is the most important aetiology for lung cancer. Selected essential/toxic metals (Ca, Mg, Na, K, Fe, Zn, Cu, Sr, Li, Co, Mn, Ni, Cr, Cd and Pb) are measured in the scalp hair and nails of lung cancer patients and controls by atomic absorpti...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9942-6
更新日期:2014-06-01 00:00:00
abstract::The concentrations of 17 elements in the nail and hair of 117 subjects from a nonindustrialized environment were determined by instrumental neutron activation analysis (INAA). A new method of statistical treatment that allows for more meaningful use of detection limit values was used to process the concentration data....
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02795450
更新日期:1988-09-01 00:00:00
abstract::An experiment was conducted in a 3 × 3 (Cu × Zn) factorial experiment based on a completely randomized design to evaluate the effects of dietary copper and zinc on apparent mineral retention and serum biochemical indicators in young male mink on a corn-fish meal based diet. Animals were fed basal diets supplemented wi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0220-4
更新日期:2015-05-01 00:00:00
abstract::The aim of this study was to evaluate the effect of a daily intake of fluid and salt supplementation (FSS) on the deficiency of electrolytes, which is characterized by higher rather than lower plasma concentration of electrolytes during prolonged hypokinesia (HK) (decreased number of km taken per day). Forty long dist...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783342
更新日期:1998-07-01 00:00:00
abstract::Nano-titanium dioxide is a kind of widely used nanomaterial that exhibits various adverse outcomes. However, the role of oxidative stress in this regard remains controversial. This study aimed to evaluate whether oxidative stress is one of the toxicity mechanisms induced by nano-titanium dioxide in rats and mice model...
journal_title:Biological trace element research
pub_type: 杂志文章,meta分析
doi:10.1007/s12011-019-01761-z
更新日期:2020-03-01 00:00:00
abstract::Diabetic retinopathy (DR) is a common microvascular disorder which occurs in type 2 diabetes mellitus (T2DM) patients due to chronic hyperglycemia. Previous studies reported that serum zinc (Zn) and vitamin A levels were associated with certain diabetic microvascular complications. However, the relationship between Zn...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01664-z
更新日期:2019-12-01 00:00:00
abstract::The original version of this article unfortunately contained a mistake. The name of "Ali Ghorbani Ranjbary" is now corrected in the author group of this article. The original article has been corrected. ...
journal_title:Biological trace element research
pub_type: 杂志文章,已发布勘误
doi:10.1007/s12011-019-01787-3
更新日期:2020-04-01 00:00:00
abstract::Chronic copper exposure impaired spermatogenesis in adult male mice. The aim of this study was to determine whether chronic copper exposure can induce apoptosis of testicular cell and hypospermatogenesis via disturbing testosterone synthesis in adult male mice. In the present study, sixty CD-1 male mice were randomly ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01852-x
更新日期:2020-06-01 00:00:00
abstract::Iron-deficiency anemia (IDA) is the most common nutritional deficiency in childhood throughout the world. Although it has been shown that IRA is associated with elevated plasma copper and depleted zinc levels in children, there are conflicting results on the effect of iron supplementation on the absorption of these el...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1385/BTER:94:1:79
更新日期:2003-07-01 00:00:00
abstract::Biominerals and metals of intertidal corals of two species (Heliofungia actiniformis, Quoy and Gaimard; Galaxea fascicularis, Linnaeus), collected from the Iriomote Island of Ryukyu, were examined with an inductively coupled plasma atomic emission spectrometer (ICP-AES). Twelve elements were detectable in the corallin...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784268
更新日期:1998-11-01 00:00:00
abstract::This study was conducted to investigate the effects of zinc sources on gene expression of zinc-related transporters in intestinal porcine epithelial cells (IPEC-1). IPEC-1 cells were treated with zinc glycine chelate (Zn-Gly), zinc methionine (Zn-Met), and zinc sulfate (ZnSO4), respectively, for measurement of cell vi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-016-0655-x
更新日期:2016-10-01 00:00:00
abstract::The movement of copper and zinc from the fertilized egg into the developing embryo and the subsequent association of the two metals with metallothionein-like proteins (MT) of chick liver was investigated. Hepatic levels of MT in 1-d-old chicks, estimated from specifically bound(115m)Cd, were increased eightfold over e...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02988942
更新日期:1983-12-01 00:00:00
abstract::In vivo X-ray fluorescence (XRF) techniques were used for biological monitoring of lead, cadmium, and mercury. Lead accumulates in bone, the level of which may thus be used for monitoring of exposure. However, there was no close association between lead levels in bone and exposure time, partly because of differences i...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02796636
更新日期:1987-08-01 00:00:00
abstract::High blood glucose concentration in diabetes induces free radical production and, thus, causes oxidative stress. Damage of cellular structures by free radicals play an important role in development of diabetic complications. In this study, we evaluated effects of sodium tungstate on enzymatic and nonenzymatic markers ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-009-8537-0
更新日期:2010-08-01 00:00:00
abstract::In order to understand the normal and pathological physiologies of the epidermal cells, the simultaneous determination of several elements in the different cellular strata is of crucial importance. In recent years the electron microprobe (EMP) has become an established technique in this field. Its high spatial resolut...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02796687
更新日期:1987-04-01 00:00:00
abstract::In 47 children with malignancy, zinc status, growth, and performance during standard treatment were compared with those in controls. At diagnosis, growth was retarded and hair zinc values were high, 2.4 +/- 0.7 mumol/g, as in chronic deficiency. During induction therapy, serum declined to 10.4 +/- 2.3 mumol/L and urin...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02991414
更新日期:1991-09-01 00:00:00
abstract::In vivo and in vitro studies were conducted to investigate the chemical forms by ion-exchange chromatography of selenium (Se) present in rat and ovine spermatozoa. After injection with 75Se-selenite, the form of 75Se in rat sperm was selenocysteine, but selenocysteine and selenomethionine (SeMet) were present in ovine...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/bter:76:2:161
更新日期:2000-08-01 00:00:00
abstract::The lipid and fatty acid composition of the blue mussels Mytilus edulis L. gills and digestive glands was evaluated after 24 and 72 h of cadmium (Cd) and copper (Cu) exposure. Mussels were exposed to different cadmium (10, 100, and 500 μg/L) and copper (5, 50, and 250 μg/L) concentrations. Similar stress response of p...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9727-3
更新日期:2013-08-01 00:00:00
abstract::The relaxation rates (1/T(1) and 1/T(2)) in cysts have already been analyzed in terms of materials such as albumin, cholesterol, manganese, iron, and copper. However, the relaxivities of these materials have not been determined yet. In this work, five sets containing the ions, albumin, and cholesterol were prepared by...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8170-3
更新日期:2008-12-01 00:00:00
abstract::Aluminum (Al) has various adverse effects on health of humans and animals. The aim of present study was to demonstrate that Lactobacillus plantarum CCFM639 can alleviate the adverse effects on liver and kidney of mice caused by chronic Al exposure. Animals were assigned into control, CCFM639 only, Al only, Al plus CCF...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-016-0843-8
更新日期:2017-04-01 00:00:00
abstract::To reveal the role of key elements present in the hair of breast cancer patients on cancer development, the levels of a number of elements in scalp hair samples of 82 people including healthy individuals, people suffering from benign breast disease, and breast cancer patients were measured by PIXE analysis. Pellets of...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9671-2
更新日期:2013-06-01 00:00:00
abstract::The risk of premature ovarian failure (POF) increases in association with alteration in immunological parameters and oxidative stress (OS). Adequate intake of trace elements is required for antioxidant property and immune defense mechanism. The aim of this study was to explore the involvement of trace elements, OS, an...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1197-6
更新日期:2018-08-01 00:00:00
abstract::To examine whether there were differences between races in regard to age-related changes of elements and the relationships among elements in the arteries, the authors investigated both the renal arteries of Thai and Japanese. The Thai subjects consisted of 27 men and 11 women, ranging in age from 27 to 88 yr, whereas ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:106:3:219
更新日期:2005-09-01 00:00:00
abstract::Plasma molybdenum concentrations were determined in children, ages two to 12 yr, with and without phenylketonuria (PKU). Mean plasma molybdenum concentrations did not differ significantly between the children with PKU (1.33 +/- 0.5 microgram/L) and without PKU (1.75 +/- 0.8 microgram/L). Plasma molybdenum concentratio...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785307
更新日期:1993-09-01 00:00:00
abstract:CONTEXT:Complementary alternative medicine therapies based on the use of cesium chloride preparations for the treatment of cancer and radiation poisoning, have generated therapeutic interest; but oral or intravenous administration of cesium chloride (CsCl) to cancer patients as an alternative mode of cancer therapy hav...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:94:2:97
更新日期:2003-08-01 00:00:00
abstract::To examine whether an accumulation of Ca in the tissues was accompanied by an increase of Mg, the authors investigated the relationships between Ca and Mg contents in the common iliac arteries, aortic valves, xiphoid processes, costal cartilages, posterior longitudinal ligaments, trigeminal nerves, and ribs by inducti...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:102:1-3:083
更新日期:2004-01-01 00:00:00
abstract::Iron deficiency anemia (IDA) due to malnutrition and/or blood loss is a common condition, especially in women of reproductive age. Intense exercise can induce anemia via an inflammatory response, but whether intense exercise affects the efficacy of iron supplementation to treat IDA is unclear. Here, we show in a mouse...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02402-6
更新日期:2020-10-06 00:00:00
abstract::Serum iron levels have been shown to decline both with fever and with strenuous exercise, leading to the supposition that the decrease might be the result of a rise in core body temperature. To evaluate this hypothesis, the serum iron response to an exercise-induced 1.5 degrees C rise in core body temperature was meas...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:108:1-3:061
更新日期:2005-01-01 00:00:00
abstract::The current study investigated the role of selenium (Se) nanoparticles on the growth performance, hemato-biochemical indices, antioxidative, and immune-related genes of European seabass (Dicentrarchus labrax). Therefore, fish with initial weight of 20.53 ± 0.10 g/fish were fed diets with 0, 0.25, 0.5, and 1 mg Se nano...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02431-1
更新日期:2020-10-15 00:00:00