Abstract：
:Evidence linking copper and zinc to hypertension are limited and conflicting. Data from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 were used. Zinc and copper intake from diet and supplements was assessed with 24-h dietary recall. Hypertension was defined as systolic blood pressure (SBP) ≥ 140 mmHg/diastolic blood pressure (DBP) ≥ 90 mmHg/treatment with hypertensive medications. In a sensitivity analysis, according to the 2017 American College of Cardiology and American Heart Association guideline, hypertension was also defined as SBP ≥ 130 mmHg/DBP ≥ 80 mmHg/treatment with hypertensive medications. A total of 17,811 adults (8430 men and 9381 women) were included. After adjustment for age, gender, body mass index (BMI), race, educational level, smoking status, family income, and total daily energy intake, the OR of hypertension for highest vs. lowest quartile intake of copper, zinc, and copper/zinc ratio was 1.11 (0.90-1.37), 1.11 (0.90-1.35), and 0.95 (0.81-1.11), respectively. In stratified analysis by BMI (< 25 kg/m2, 25-30 kg/m2, > 30 kg/m2), no significant association was found between hypertension and intakes of copper, zinc, and copper/zinc ratio (highest vs. lowest quartile) in multivariate analysis. In multivariate analysis, the OR of hypertension for highest vs. lowest quartile levels of serum copper, zinc, and copper/zinc ratio was 1.11 (0.61-2.04), 1.43 (0.84-2.44), and 0.68 (0.34-1.33), respectively. Similar results were found in the sensitivity analysis. Zinc and copper might be not independently associated with hypertension in US adults.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Yao J,Hu P,Zhang Ddoi
10.1007/s12011-018-1320-3subject
Has Abstractpub_date
2018-12-01 00:00:00pages
346-353issue
2eissn
0163-4984issn
1559-0720pii
10.1007/s12011-018-1320-3journal_volume
186pub_type
杂志文章abstract：:Three hundred and sixty healthy Ross × Ross 1-day-old broilers were used to study the effects of zinc glycine chelate (Zn-Gly) on oxidative stress, contents of trace elements, and intestinal morphology. All broilers were randomly assigned to six treatment groups, which replicates three times. Diets were as follows: (1...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8824-9
更新日期：2011-09-01 00:00:00
abstract：:Responses of photosystem I and II activities of Microcystis aeruginosa to various concentrations of Cu(2+) were simultaneously examined using a Dual-PAM-100 fluorometer. Cell growth and contents of chlorophyll a were significantly inhibited by Cu(2+). Photosystem II activity [Y(II)] and electron transport [rETRmax(II)...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0039-z
更新日期：2014-08-01 00:00:00
abstract：:As Cr(III) compounds have been shown to increase insulin sensitivity and decrease plasma cholesterol and triglycerides in rodent models of diabetes and insulin resistance and as colorectal cancer risk has been associated with insulin resistance and diabetes, the effects of the Cr(III) compound Cr3 ([Cr3O(O2CCH2CH3)6(H...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0346-z
更新日期：2015-11-01 00:00:00
abstract：:The present study investigated whether boron would enhance the action of 17beta-estradiol (E2) or parathyroid hormone (PTH) on bone mineral balance in ovariectomized (OVX) rats. Forty-three days after OVX, the rats were treated for 5 wk with vehicle, boron (5 ppm as boric acid), E2 (30 microg/kg/d, sc), PTH (60 microg...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:81:1:29
更新日期：2001-07-01 00:00:00
abstract：:The influence of injection periods of 3-(1H-pyrrol-2-yl)-1H-indazole regarding vitamins A, E, C, selenium (Se), malondialdehyde (MDA) levels, and glutathione peroxidase (GSH-Px) activity in rats has been investigated. The substance was given by subcutaneous injection at 20 mg/kg every other day for a total of 15 injec...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8517-4
更新日期：2010-07-01 00:00:00
abstract：:CuO nanoparticles (CuO-NPs) serve several important functions in human life, particularly in the fields of medicine, engineering, and technology. These nanoparticles have been utilized as catalysts, semiconductors, sensors, gaseous and solid ceramic pigments, and magnet rotatable devices. Further use for CuO-NPs has b...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1170-4
更新日期：2018-08-01 00:00:00
abstract：:Some studies have found that nano-sized titanium dioxide (nano-TiO2) has adverse effects on the male reproductive system. Blood-testis barrier (BTB), as one of the tightest blood-tissue restriction, is crucial to the male reproductive system. However, the potential effects on BTB and signaling pathway changes in testi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02404-4
更新日期：2020-09-29 00:00:00
abstract：:Although cisplatin (cisPt) is one of the most often used cytotoxic drugs in the treatment of cancer, its clinical application is associated with nephrotoxicity and a cumulative anemia. In this study, we evaluated posible protective effects of selenium (Se) on hematological and oxidative stress parameters in rats, acut...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8788-9
更新日期：2011-09-01 00:00:00
abstract：:The protective effects of caffeic acid on angiotensin-converting enzyme (ACE) and purinergic enzyme activities, as well as gluconeogenesis was investigated in iron-induced cardiotoxicity. Cardiotoxicity was induced in heart tissues harvested from healthy male SD rats by 0.1 mM FeSO4. Treatment was carried out by co-in...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02227-3
更新日期：2021-03-01 00:00:00
abstract：:Both selenium and green tea have been reported to exhibit antigenotoxic and cancer chemopreventive properties. We compared the antimutagenic activities of regular green tea and selenium-enriched green tea obtained from Hubei Province, China, toward the heterocyclic amine, 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) i...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:86:2:177
更新日期：2002-05-01 00:00:00
abstract：:Significant disorders of liver metabolic pathways enzymes after high-cholesterol diet could give information on liver steatosis development. This process could probably also be inhibited by some compounds, as examined in rabbits. Forty-two male rabbits were served a high-cholesterol diet (2 g%) (0.67 g/kg b.m./24 h) w...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-0070-4
更新日期：2007-01-01 00:00:00
abstract：CONTEXT:Complementary alternative medicine therapies based on the use of cesium chloride preparations for the treatment of cancer and radiation poisoning, have generated therapeutic interest; but oral or intravenous administration of cesium chloride (CsCl) to cancer patients as an alternative mode of cancer therapy hav...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:94:2:97
更新日期：2003-08-01 00:00:00
abstract：:The objective was to evaluate metal ion accumulation in hair of patients undergoing orthodontic treatment with fixed appliances in time. The patients (N = 47) participated in a questionnaire survey. Hair sampling was performed at the beginning and in the 4th, 8th, and 12th month of the treatment. The content of metals...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-014-0152-z
更新日期：2015-02-01 00:00:00
abstract：:Modifications in the enzyme activity of lysozyme, a protein implied in the defence barrier of the organism, can be a good biomarker of alterations in the immune system as a result of exposure to toxic metal, such as lead. The aim of this work was to evaluate the effect of a 200 ppm dose of lead on lysozyme activity in...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9446-1
更新日期：2012-12-01 00:00:00
abstract：:Serum iron levels have been shown to decline both with fever and with strenuous exercise, leading to the supposition that the decrease might be the result of a rise in core body temperature. To evaluate this hypothesis, the serum iron response to an exercise-induced 1.5 degrees C rise in core body temperature was meas...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:108:1-3:061
更新日期：2005-01-01 00:00:00
abstract：:The relationship between selenium (Se) deficiency-induced cardiac malfunction and endoplasmic reticulum (ER) stress is poorly understood. In the present study, 18 weaning Sprague Dawley rats were randomly fed with three different Se diets, and myocardial glutathione peroxidase (GPx) activity was measured by an enzyme ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9834-1
更新日期：2013-12-01 00:00:00
abstract：:The concentrations of 3,4-dihydroxybenzoic acid, caffeic acid, catechin, chlorogenic acid, epicatechin, gallic acid, p-coumaric acid, quercetin, rutin, ferulic acid, and the major metals in graviola (Annona muricata), atemoya (A. squamosa x A. cherimola), fruta do conde (A. squamosa), biribá (Rollinia mucosa), and the...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-02005-w
更新日期：2020-10-01 00:00:00
abstract：:Lipid peroxy radicals (ROO.) were detected by electron spin resonance (ESR) at low temperature after formation by addition of H2O2 into a suspension of mice lymphocytes. If lymphocytes were treated with selenomethionine (Se-Met) prior to addition of H2O2, ROO. formation was inhibited in a fashion that was dependent on...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783233
更新日期：1997-01-01 00:00:00
abstract：:The chronic exposure to Aluminum (Al) may compromise different liver functions, mainly during the hepatic regeneration. The aim of this study is to investigate the interactions between the chronic i.p. exposure to Al and hepatic regeneration (HR) on bile flow and organic anion transport in experimental animals. For th...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8234-4
更新日期：2009-02-01 00:00:00
abstract：:Trace element involvement in wounds left to heal by secondary intention needs clarification. We have previously reported faster healing of wounds following acute surgery compared with elective excision of pilonidal sinus disease. The effect of topical zinc on the closure of the excisional wounds was mediocre compared ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9658-z
更新日期：2013-06-01 00:00:00
abstract：:Decreased expression and increased phosphorylation of Forkhead box o1 (Foxo1) in ameloblasts were observed both in vivo and in vitro when treated by fluoride. The present study aims to investigate the possible relationship between Foxo1 and enamel matrix proteinases, matrix metalloproteinase 20 (MMP20), and kallikrein...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1325-y
更新日期：2018-12-01 00:00:00
abstract：:The toxicity of boron has been understood for many years. However, limited data currently exist concerning the nutritional essentiality of B in chordates. Results from an ongoing research program evaluating the nutritional essentiality of B in the South African clawed frog, Xenopus laevis, found that X. laevis fed a l...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1385/BTER:90:1-3:117
更新日期：2002-01-01 00:00:00
abstract：:Fluoride can induce neurotoxicity, but the mechanism is not clear. In this study, we explored the role of autophagy in F--induced neurotoxicity of Wistar rats. Eighty Wistar rats were randomly divided into four groups: the control group (distilled water containing less than 0.1 mg/L F-) and three NaF-treated groups (F...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01735-1
更新日期：2020-02-01 00:00:00
abstract：:This study aimed to determine the effect of excessive fluoride (F) on the morphological characteristics of the small intestine and the contents of serum cytokines in rats. A total of 48 3-week-old healthy female Sprague-Dawley rats were randomly divided into four groups (n = 12). The control group was given deionized ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1503-y
更新日期：2019-06-01 00:00:00
abstract：:There are several factors that affected calcium bioavailability, such as physiological and dietary factors. These dietary factors help to achieve an appropiate status of calcium for a correct bone mineralization. In this pathway, recently some compounds present in milk that seem improve calcium absorption such as lact...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:89:1:43
更新日期：2002-10-01 00:00:00
abstract：:The present study was undertaken to evaluate the in vitro availability of chemically varying forms of selenium (Se), supplemented in cow's milk. Two inorganic (selenite and selenate) and two organic (seleno-methionine [Se-Met] and seleno-cystine [Se-Cys]) Se sources were evaluated. The in vitro availability was estima...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02910666
更新日期：1997-07-01 00:00:00
abstract：:The aim of this research was to assess plasma magnesium (Mg) concentration, the frequencies of activated T CD4+ and T CD8+ lymphocytes and B lymphocytes in adolescents with hyperthyroidism due to Graves' disease (GD), and to assess changes in the above-mentioned parameters during methimazole (MMI) treatment. The frequ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9690-z
更新日期：2013-06-01 00:00:00
abstract：:Male Sprague-Dawley rats, weighing 175-200 g, six per group were fed AIN 93M diet (CON) or diets containing 500 mg Ca (LCa), 7 mg Zn (LZn), 2 mg Cu (LCu), 60 mg Zn (HZn), or 12 mg Cu (HCu) per kilogram of diet in the following combinations: control (CON), LCa+LZn (LC+Z), LCa+LZn+LCu (LC+Z+C), or HZn+HCu (HZ+C) without...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:108:1-3:169
更新日期：2005-01-01 00:00:00
abstract：:Aflatoxin B1 (AFB1) is the most toxic among the mycotoxins and causes detrimental health effects on the liver of human and animals. Selenium (Se) plays an important role in protection of various animal species against numerous notorious toxic agents. The present study is designed to explore the protective effects of S...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1623-4
更新日期：2019-10-01 00:00:00
abstract：:Selenium is an essential nutrient in diets; however, the effects of selenium on enzyme metabolic activation are not currently clear. Cytochromes P450 (CYP450) are major phase I metabolic enzymes involved in the biotransformation of xenobiotics and endogenous compounds to form electrophilic reactive metabolites. To inv...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01945-7
更新日期：2020-08-01 00:00:00
