Abstract:
:Trace element involvement in wounds left to heal by secondary intention needs clarification. We have previously reported faster healing of wounds following acute surgery compared with elective excision of pilonidal sinus disease. The effect of topical zinc on the closure of the excisional wounds was mediocre compared with placebo. In contrast, parenteral zinc, copper, and selenium combined appear effective for wound healing in humans. We have investigated zinc, copper, and selenium with respect to (a) impact of acute versus chronic pilonidal sinus and (b) regional concentrations within granulating wounds treated topically with placebo or zinc in 42 (33 males) pilonidal disease patients. Baseline serum and skin concentrations of copper correlated (r S = 0.351, p = 0.033, n = 37), but not of zinc or selenium. Patients with abscesses had elevated serum C-reactive protein (CRP) and copper levels (+29 %; p < 0.001) compared with the elective patients consistent with the strong correlation between serum copper and CRP (r S = 0.715, p < 0.0005, n = 41). Seven days after elective surgery, serum CRP and copper levels were elevated (p = 0.010) versus preoperative values. The copper concentration in wound edges was higher than in periwound skin (p < 0.0005) and wound base (p = 0.010). Selenium levels were increased in wound edge compared to wound base (p = 0.003). Topical zinc oxide treatment doubled (p < 0.050) zinc concentrations in the three tissue localizations without concomitant significant changes of copper or selenium levels. In conclusion, copper and selenium are mobilized to injured sites possibly to enhance host defense and early wound healing mechanisms that are complementary to the necessity of zinc for matrix metalloproteinase activity.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Mirastschijski U,Martin A,Jorgensen LN,Sampson B,Ågren MSdoi
10.1007/s12011-013-9658-zsubject
Has Abstractpub_date
2013-06-01 00:00:00pages
76-83issue
1-3eissn
0163-4984issn
1559-0720journal_volume
153pub_type
杂志文章abstract::In the current study, 48 male rats were classified into four groups (12 rats/group): 1-control group received 1 ml distilled water, 2-origanum oil group treated daily with oral dose of origanum oil (5 mg/kg) for 30 and 60 days, 3-mercuric chloride group treated daily with oral dose of mercuric chloride (4 mg/kg) for 3...
journal_title:Biological trace element research
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journal_title:Biological trace element research
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abstract::Leukocytes incubated with Cu(II) showed a decrease in both glutathione reductase activity and reduced glutathione content. The glucose 6-phosphate dehydrogenase activity under the same conditions was not affected. Serum albumin added to mixtures prevented the loss of enzyme activity, whileD-penicillamine andL-histidin...
journal_title:Biological trace element research
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journal_title:Biological trace element research
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journal_title:Biological trace element research
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journal_title:Biological trace element research
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journal_title:Biological trace element research
pub_type: 杂志文章
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journal_title:Biological trace element research
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journal_title:Biological trace element research
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journal_title:Biological trace element research
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journal_title:Biological trace element research
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02916628
更新日期:1983-04-01 00:00:00
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journal_title:Biological trace element research
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journal_title:Biological trace element research
pub_type: 杂志文章
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journal_title:Biological trace element research
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doi:10.1007/s12011-012-9325-9
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784423
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journal_title:Biological trace element research
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doi:10.1007/BF02917464
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journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
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journal_title:Biological trace element research
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journal_title:Biological trace element research
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journal_title:Biological trace element research
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journal_title:Biological trace element research
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journal_title:Biological trace element research
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journal_title:Biological trace element research
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abstract::Two trials were conducted in a 2 × 2 + 1 factorial arrangement based on a completely randomized design to evaluate the effects of different sources of selenium (Se) on performance, blood metabolites, and nutrient digestibility in male lambs on a barley-based diet. The first trial lasted for 70 days and consisted of 30...
journal_title:Biological trace element research
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journal_title:Biological trace element research
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