Trivalent Chromium has no Effect on Delaying Azoxymethane-Induced Colorectal Cancer in FVB/NJ Mice.

Abstract:

:As Cr(III) compounds have been shown to increase insulin sensitivity and decrease plasma cholesterol and triglycerides in rodent models of diabetes and insulin resistance and as colorectal cancer risk has been associated with insulin resistance and diabetes, the effects of the Cr(III) compound Cr3 ([Cr3O(O2CCH2CH3)6(H2O)3](+)) were investigated in male and female FVB/NJ mice with azoxymethane-induced colorectal cancer. In contrast to a previous study on the effects of Cr3 on 1,2-dimethylhydrazine-induced colorectal cancer in Sprague Dawley rats, no effects of Cr3 at daily doses of 1 and 10 mg Cr/kg body mass were observed, leaving in question whether administration of Cr(III) compounds can delay or prevent the onset of colorectal cancer.

journal_name

Biol Trace Elem Res

authors

White PE,Deng G,Kuykendall MK,Tadros AM,Dyroff SL,Honan RE,Robertson PM,Vincent JB,Rasco JF

doi

10.1007/s12011-015-0346-z

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

221-6

issue

1

eissn

0163-4984

issn

1559-0720

pii

10.1007/s12011-015-0346-z

journal_volume

168

pub_type

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