Abstract:
:The effects of zinc chloride (ZnCl2), disodium zinc ethylenediamine tetraacetate (Zn-EDTA), and zinc gluconate (Zn-GLU) on the antioxidant enzyme activities and levels of interleukins (ILs) in psoriasis-induced mice were studied. One hundred twenty female mice were randomly divided into six groups with 20 mice in each group: the control, positive control (PC), methotrexate (MTX), ZnCl2, Zn-EDTA, and Zn-GLU groups. All animals except the control group were given diethylstilbestrol for three consecutive days. After successfully inducing psoriasis, the control and PC groups were given normal saline (i.g.) daily while the remaining groups were given MTX, ZnCl2, Zn-EDTA, and Zn-GLU, respectively. The results revealed that the zinc supplementation could significantly (p < 0.05) inhibit mitosis in the mouse vaginal epithelium as methotrexate did and the inhibiting efficacy had nothing to do with the zinc forms. After ZnCl2, Zn-EDTA, and Zn-GLU supplementation, the levels of liver superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities increased and the concentration of malondialdehyde (MDA) decreased significantly (p < 0.05) compared to the PC group. The levels of SOD, CAT activity, and MDA level between each zinc supplementation group and MTX group were insignificant (p > 0.05). The zinc treatments also caused a significant (p < 0.05) decrease in the raised IL-2 level of animal serum. The results obtained in the present work indicate the potential for zinc as a complementary pharmaceutical intervention for the treatment of topical psoriasis.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Yin LL,Zhang Y,Guo DM,An K,Yin MS,Cui Xdoi
10.1007/s12011-013-9799-0subject
Has Abstractpub_date
2013-12-01 00:00:00pages
411-5issue
3eissn
0163-4984issn
1559-0720journal_volume
155pub_type
杂志文章abstract::Two 42-d experiments were conducted with weanling male rats to study interactions between nickel and copper. In Experiment 1, a low-copper basal diet was supplemented with copper at 0 or 30 ppm and nickel at 0 or 30 ppm. Copper was added in Experiment 2 to a basal copper-deficient diet at a level of 0 or 15 ppm and ni...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02916540
更新日期:1985-04-01 00:00:00
abstract::The tissue distribution of 14 elements was simultaneously determined in rats 28 d after hypophysectomy (HPY), thyroparathyroidectomy (TPTY), adrenalectomy (ADY), and castration (CTN). The elements Na, K, Ca, Mg, Fe, S, P, Rb, Sr, Mn, Cu, and Zn were investigated in whole blood, plasma, brain, liver, kidney, heart, ske...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02797096
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abstract::Adaptive alterations in glutathione (GSH) metabolism were studied during oxidative stress induced by selenium (Se) deficiency in germinating seedlings of Trigonella foenum-graecum grown for 72 h and the response to supplementation individually of Se or mimosine was explored. Growth enhancement with improved mitochondr...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783830
更新日期:1999-12-01 00:00:00
abstract::Selenium is increasingly recognized as a versatile anticarcinogenic agent. Its protective functions cannot be solely attributed to the action of glutathione peroxidase. Instead, selenium appears to operate by several mechanisms, depending on dosage and chemical form of selenium and the nature of the carcinogenic stres...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/BF02783992
更新日期:1992-04-01 00:00:00
abstract::Tibetan sheep have been observed with mineral deficiencies and marginal deficiencies in Qinghai-Tibetan Plateau. Adequate amounts of essential minerals are critical to maximize the productivity and health of livestock. The objectives of this study were to evaluate the effects of 6 months of mineral block supplementati...
journal_title:Biological trace element research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12011-015-0593-z
更新日期:2016-08-01 00:00:00
abstract::Magnesium is the second most abundant intracellular cation and is a fundamental cofactor in a multitude of cellular enzymatic reactions. Magnesium deficiency causes diverse clinical features predominantly due to cardio- and neurotoxicity. We describe a case of severe hypomagnesaemia associated with intermittent downbe...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8757-3
更新日期:2011-08-01 00:00:00
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journal_title:Biological trace element research
pub_type: 历史文章,杂志文章,评审
doi:10.1007/s12011-018-1584-7
更新日期:2019-03-01 00:00:00
abstract::The degree of chromosome damage induced by three compounds of zinc (zinc chloride, zinc sulfate, zinc acetate) was compared in human leucocytes in vitro. Three concentrations of each salt, 3.0 x 10(-5)M, 3.0 x 10(-4)M, and 1.5 x 10(-3)M, were added to leukocyte cultures. The cells were harvested after 48 and 72 h and ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:78:1-3:113
更新日期:2000-01-01 00:00:00
abstract::Urine lead level is one of the most employed measures of lead exposure and risk. The urine samples used in this study were obtained from ten healthy male cyclists. Dispersive liquid-liquid microextraction combined with ultraviolet and visible spectrophotometry was utilized for preconcentration, extraction, and determi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-016-0844-7
更新日期:2017-04-01 00:00:00
abstract::The purpose of our study was to investigate the role of hypoxia-inducible factor-1α (HIF-1α) in arsenic-induced carcinogenesis. We included 39 articles for meta-analysis. The results showed that low-dose exposure to arsenic (≤ 10 μmol/L) could promote the expression of phosphatidylinositol 3-kinase (PI3K) and phosphor...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02087-x
更新日期:2020-12-01 00:00:00
abstract::Linolenic acid is an inhibitor of electron transport in chloroplasts of higher plants. It has obvious effects on the structure and function of chloroplasts. In the present paper, we investigated the nano-anatase relieving the inhibition of photoreduction activity and oxygen evolution caused by linolenic acid in spinac...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-8055-x
更新日期:2008-04-01 00:00:00
abstract::Cadmium (Cd) is a highly toxic heavy metal that can affect human and animal health. Selenium (Se) is an essential microelement that can protect various organs against toxic heavy metals. Although many studies have investigated the adverse effect of Cd in rats and several other animals, little is known regarding the me...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1186-9
更新日期:2018-07-01 00:00:00
abstract::Lead poisoning is a worldwide health problem, and its treatment is under investigation. The aim of this study was to access the efficacy of Coriandrum sativum (coriander) in reducing lead-induced changes in mice testis. Animal exposed to lead nitrate showed significant decrease in testicular SOD, CAT, GSH, total prote...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-009-8553-0
更新日期:2010-09-01 00:00:00
abstract::Osteoblast L-type voltage-dependent calcium channels (VDCC) play important roles in maintaining intracellular homeostasis and influencing multiple cellular processes. In particular, they contribute to the activities and functions of osteoblasts (OBs). In order to study how L-type VDCC modulate calcium ion (Ca(2+)) hom...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0118-1
更新日期:2014-12-01 00:00:00
abstract::Rare earth elements (REEs) have been widely used to increase accumulation of biomass and secondary metabolites in medicinal plants in China. However, very few studies have investigated how REEs mediate secondary metabolism synthesis in medicinal plants. Lanthanum (La), an important REE, is known to improve the accumul...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9379-8
更新日期:2012-09-01 00:00:00
abstract::Both selenium and green tea have been reported to exhibit antigenotoxic and cancer chemopreventive properties. We compared the antimutagenic activities of regular green tea and selenium-enriched green tea obtained from Hubei Province, China, toward the heterocyclic amine, 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) i...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:86:2:177
更新日期:2002-05-01 00:00:00
abstract::X-ray fluorescence experiments at the Photon Factory in Japan are described. An energy-dispersive X-ray fluorescence system was combined with various excitation modes, i.e., a continuum and a monochromatic excitation, which consist of a crystal monochromator or a wide band pass monochromator. These excitation modes pr...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02796677
更新日期:1987-04-01 00:00:00
abstract::Copper is an essential trace element with various biological functions. Excess copper, however, is extremely toxic, leading to many pathological conditions that are consistent with oxidative damage to membranes and molecules. Exposure to high levels of copper results in various changes in the tissues. In liver, hypert...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:96:1-3:209
更新日期:2003-01-01 00:00:00
abstract::No specific treatment for COVID-19 infection is available up till now, and there is a great urge for effective treatment to reduce morbidity and mortality during this pandemic. We aimed to evaluate the effect of combining chloroquine/hydroxychloroquine (CQ/HCQ) and zinc in the treatment of COVID-19 patients. This was ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02512-1
更新日期:2020-11-27 00:00:00
abstract::The growth of the protozoan Blepherisma is stimulated by Lanthanum (La) at concentrations as low as 0.32 ppm. In mice Yttrium (Y) and Ytterbium (Yb) are absorbed, accumulated, and metabolized. Both rare earth elements (RE) exhibit a high affinity for teeth and bones, accumulation occurs and metabolism is slow. In the ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02795448
更新日期:1988-09-01 00:00:00
abstract::In this study, the amount of reduced glutathione (GSH), oxidized glutathione (GSSG), and malondialdehyde (MDA) were determined by high performance liquid chromatography (HPLC), and selenium was determined by using the fluorescence spectrophotometer in eight different species of edible mushrooms. Brittlegill mushroom (...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-016-0715-2
更新日期:2016-12-01 00:00:00
abstract::In present study, the levels of some toxic elements in 19 different home-made cosmetic products (spray hair dye, henna, tattoo, eyeliner, eye mascara, smear, lip moisturizer, and lipstick) were analyzed by inductively coupled plasma mass spectrometric (ICP-MS) after microwave digestion. The ICP-MS results were verifie...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02357-8
更新日期:2020-09-05 00:00:00
abstract::A semiquantitative ICP-MS method suitable for evaluating metal content in plants exposed to high metal concentrations is described. The methodology which has been tested using different plant reference material is able, in only a few minutes, to obtain qualitative and quantitative information from the sample. Recoveri...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9140-8
更新日期:2011-12-01 00:00:00
abstract::To elucidate compositional changes of the pubic symphysis (PS) by aging, elements of pubic symphysis (PSs) removed from 26 cadavers were determined by inductively coupled plasma atomic-emission spectrometry. It was found that the relative contents (RCs) of calcium and phosphorus in women's PSs were about three- and fi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783243
更新日期:1997-01-01 00:00:00
abstract::The trace element selenium is an essential micronutrient for human health and its low levels in serum are implicated in the pathogenesis of several chronic diseases. Therefore, the determination of total selenium in serum may contribute to the assessment of the health and nutritional status of certain populations. The...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8252-2
更新日期:2009-04-01 00:00:00
abstract:UNLABELLED:Limited data are available indicating the effects of chromium administration on endocrine profiles, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS). This study was done to assess the effects of chromium administration on endocrine profiles, biomarkers of inf...
journal_title:Biological trace element research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12011-015-0570-6
更新日期:2016-07-01 00:00:00
abstract::Although cisplatin (cisPt) is one of the most often used cytotoxic drugs in the treatment of cancer, its clinical application is associated with nephrotoxicity and a cumulative anemia. In this study, we evaluated posible protective effects of selenium (Se) on hematological and oxidative stress parameters in rats, acut...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8788-9
更新日期:2011-09-01 00:00:00
abstract::Silicon (Si) is important for the growth and development of bone and connective tissues. Several studies have reported that Si supplementation improved bone mineral density (BMD) in female ovarectomized rats. However, few studies have investigated the effects of Si supplementation on bone status and bone metabolism in...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9936-4
更新日期:2014-05-01 00:00:00
abstract::Variations in trace element concentration in the head and facial hair of five individuals with ever-increasing amounts of white hair were examined. Hair was collected from the scalp, cheeks, and chin from one donor on a regular basis since 1984. Samples were separated into white and pigmented fractions, and analyzed a...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02992728
更新日期:1990-07-01 00:00:00
abstract::Chromium (Cr), manganese (Mn), copper (Cu), zinc (Zn), and iron (Fe) concentrations were quantified in serum (n = 112), milk (n = 112), liver (n = 70), and kidney samples (n = 67) of dairy cows from an iron-steel processing region (Payas-Iskenderun) and from an area free of industrial pollution (Antakya) in Hatay, loc...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:98:1:51
更新日期:2004-04-01 00:00:00