Abstract：
:Two 42-d experiments were conducted with weanling male rats to study interactions between nickel and copper. In Experiment 1, a low-copper basal diet was supplemented with copper at 0 or 30 ppm and nickel at 0 or 30 ppm. Copper was added in Experiment 2 to a basal copper-deficient diet at a level of 0 or 15 ppm and nickel was supplemented at 0, 15, or 225 ppm. Responses to dietary nickel were dependent upon copper nutriture and experimental duration. Nickel had little effect on growth during the first 21 d of either study when added at low levels (15 or 30 ppm) to copper-deficient diets. Nickel supplementation depressed gains between 21 and 42 d in rats fed copper-deficient, but not copper-adequate, diets. Hematocrits and hemoglobin concentrations were not significantly affected by dietary nickel at 21 d. Nickel supplementation decreased hematocrits and hemoglobin values in copper deficient rats at 42 d in Experiment 1, but not in Experiment 2. Absorption of copper apparently was not reduced by nickel, since tissue copper concentrations were generally not decreased by increasing dietary nickel. Nickel supplementation increased lung and heart copper concentrations in Experiment 2. Liver iron was not affected by nickel, but spleen iron concentrations were reduced by nickel supplementation in copper-deficient rats in Experiment 2. The present studies suggest that nickel acts antagonistically to copper in certain biological processes.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Spears JW,Hatfield EEdoi
10.1007/BF02916540subject
Has Abstractpub_date
1985-04-01 00:00:00pages
181-93issue
3eissn
0163-4984issn
1559-0720journal_volume
7pub_type
杂志文章abstract：:The present study was undertaken to investigate the utility of cystatin C (CysC) as an early biomarker of cadmium (Cd)-induced renal injury. The study was carried out on 50 adult male individuals divided into five groups of 10 individuals as follows: control, welders, smoker welders, diabetic welders, and smoker diabe...
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journal_title：Biological trace element research
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1998-07-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
