Gender-dependent effects of selenite on the perfused rat heart: a toxicological study.

Abstract:

:Gender differences are related to the manner in which the heart responds to chronic and acute stress conditions of physiological and pathological nature. Depending on dose, sodium selenite acts as an antioxidant proven to have beneficial effects in several pathological conditions G. Drasch, J. Schopfer, and G. N. Schrauzer, Selenium/cadmium ratios in human prostates: indicators of prostate cancer risk of smokers and nonsmokers, and relevance to the cancer protective effects of selenium, Biol. Trace Element Res. 103(2), 103-107 (2005); R. G. Kasseroller and G. N. Schrauzer, Treatment of secondary lymphedema of the arm with physical decongestive therapy and sodium selenite: a review, Am. J. Ther. 7(4), 273-279 (2000); G. N. Schrauzer, Anticarcinogenic effects of selenium, Cell. Mol. Life Sci. 57(13-14), 1864-1873 (2000); I. S. Palmer and O. E. Olson, Relative toxicities of selenite and selenate in the drinking water of rats, J. Nutr. 104(3), 306-314 (1974). To date, little is known about the gender-dependent direct effects of toxic doses of selenite on electrophysiology of the cardiovascular system H. A. Schroeder and M. Mitchener, Selenium and tellurium in rats: effect on growth, survival and tumors, J. Nutr. 101(11), 1531-1540 (1971); G. N. Schrauzer, The nutritional significance, metabolism and toxicology of selenomethionine, Adv. Food Nutr. Res. 47, 73-112 (2003). In the present study, the effects of in vitro toxic concentrations of sodium selenite ranging from 10-6 M to 10-3 M were tested on both male and female rat heart preparations. The toxic effects seen in an electrocardiogram and left ventricular pressure were dose and sex dependent at most of the tested concentrations. The present study clearly shows that at toxic doses, stress conditions are induced by selenite, resulting in genderdependent modifications of the heart function. This modification is more pronounced in the contraction cascade of female rats. Males, on the other hand, had been much more affected in excitation-related parameters.

journal_name

Biol Trace Elem Res

authors

Ayaz M,Dalkilic N,Bariskaner H,Tuncer S,Demirel I

doi

10.1007/BF02698014

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

301-10

issue

3

eissn

0163-4984

issn

1559-0720

pii

BTER:116:3:301

journal_volume

116

pub_type

杂志文章
  • Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.

    abstract::This study was performed to assess how 4 weeks of magnesium supplementation and exercise affect the free and total plasma testosterone levels of sportsmen practicing tae kwon do and sedentary controls at rest and after exhaustion. The testosterone levels were determined at four different periods: resting before supple...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-010-8676-3

    authors: Cinar V,Polat Y,Baltaci AK,Mogulkoc R

    更新日期:2011-04-01 00:00:00

  • Zinc Absorption from Fortified Milk Powder in Adolescent Girls.

    abstract::Zinc (Zn) is essential for development, growth, and reproduction. The Mexican government subsidizes micronutrient-fortified milk for risk groups, with positive effect on the targeted groups' plasma Zn level, inferring a good absorption is achieved although it has not being measured. The aim of this study was to determ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-015-0356-x

    authors: Méndez RO,Hambidge M,Baker M,Salgado SA,Ruiz J,García HS,Calderón de la Barca AM

    更新日期:2015-11-01 00:00:00

  • Hypertension and Salt-Restrictive Diet Promotes Low Urinary Iodine Concentration in High-Risk Pregnant Women: Results from a Cross-Sectional Study Conducted After Salt Iodination Reduction in Brazil.

    abstract::During pregnancy, the demand for daily iodine increases by 50-70% which occurs to reach around 250 μg/day. Limited information is available on the association of high-risk pregnancy (HRP) with urinary iodine concentration (UIC) and variables such as socioeconomic factors. To analyze iodine nutritional status and socio...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02028-8

    authors: Sant'Ana Leone de Souza L,de Oliveira Campos R,Dos Santos Alves V,Cerqueira TLO,da Silva TM,Teixeira LSG,Feitosa ACR,de Aragão Dantas Alves C,Ramos HE

    更新日期:2020-10-01 00:00:00

  • Inhibition of lipid peroxidation.

    abstract::Lipid peroxy radicals (ROO.) were detected by electron spin resonance (ESR) at low temperature after formation by addition of H2O2 into a suspension of mice lymphocytes. If lymphocytes were treated with selenomethionine (Se-Met) prior to addition of H2O2, ROO. formation was inhibited in a fashion that was dependent on...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02783233

    authors: Sun E,Xu H,Wen D,Zuo P,Zhou J,Wang J

    更新日期:1997-01-01 00:00:00

  • MR proton relaxivities of some ions, albumin, and cholesterol added to odontogenic jaw cysts.

    abstract::The relaxation rates (1/T(1) and 1/T(2)) in cysts have already been analyzed in terms of materials such as albumin, cholesterol, manganese, iron, and copper. However, the relaxivities of these materials have not been determined yet. In this work, five sets containing the ions, albumin, and cholesterol were prepared by...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-008-8170-3

    authors: Yilmaz UN,Guner R

    更新日期:2008-12-01 00:00:00

  • Effect of different selenium sources on productive performance, serum and milk Se concentrations, and antioxidant status of sows.

    abstract::The experiment was conducted to study the effects of different selenium (Se) sources on productive performance, serum and milk Se concentrations, and antioxidant status of sows. A total of 12 sows (Landrace×Yorkshire) with same pregnancy were randomly divided into two groups; each group was replicated six times. These...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-010-8803-1

    authors: Hu H,Wang M,Zhan X,Li X,Zhao R

    更新日期:2011-09-01 00:00:00

  • A new microcomputer-controlled neutron activation and analysis system. Description and applications for the analysis of bioenvironmental specimens.

    abstract::A microcomputer-controlled irradiation and measurement system and a microprocessor-controlled sample changer have been installed at the SLOWPOKE-2 Facility at the Royal Military College of Canada (RMC). These systems can provide the gamut of instrumental neutron activation analysis (INAA) techniques for the analyst. C...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02992658

    authors: Edward JB,Beeley PA,Bennett LG,Poland JS

    更新日期:1990-07-01 00:00:00

  • Use of selenite, selenide, and selenocysteine for the synthesis of formate dehydrogenase by a cysteine-requiring mutant ofEscherichia coli K-12.

    abstract::The forms of Se in the Se-dependent enzyme formate dehydrogenase is known to be selenocysteine, but the way this amino acid enters the polypeptide chain has not been established. Through the use of a cysteine-requiring mutant ofEscherichia coli K-12 that could also grow in the presence of glutathione, we were able to ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02795520

    authors: Karle JA,Shrift A

    更新日期:1986-12-01 00:00:00

  • Combined effect of high-fat diet and copper deficiency during gestation on fetal copper status in the rat.

    abstract::We have previously shown that a low-copper (Cu) diet produced alterations in placental Cu transport and fetal Cu stores. Because Cu deficiency has been associated with lipid deposition in rat dam liver, we hypothesized that a high fat intake, a prevalent dietary habit in many populations, may worsen fetal Cu status an...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02784069

    authors: Ebesh O,Barone A,Harper RG,Wapnir RA

    更新日期:1999-02-01 00:00:00

  • The Concentration and Probabilistic Health Risk of Potentially Toxic Elements (PTEs) in Edible Mushrooms (Wild and Cultivated) Samples Collected from Different Cities of Iran.

    abstract::The present study was devoted to investigate the PTE concentrations including cadmium (Cd), chromium (Cr), copper(Cu), iron (Fe), mercury (Hg), manganese (Mn), nickel (Ni), lead (Pb), arsenic(As), and zinc (Zn) among six types of edible wild, 23 cultivated mushroom samples collected from Iran's market by the aid of an...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02130-x

    authors: Karami H,Shariatifar N,Nazmara S,Moazzen M,Mahmoodi B,Mousavi Khaneghah A

    更新日期:2021-01-01 00:00:00

  • Levels of heavy metals and trace elements in umbilical cord blood and the risk of adverse pregnancy outcomes: a population-based study.

    abstract::To better understand the relationship between prenatal exposure to heavy metals and trace elements and the risk of adverse pregnancy outcomes, we investigated the status of heavy metals and trace elements level in a Chinese population by collecting umbilical cord blood. Umbilical cord blood heavy metals and trace elem...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-014-0057-x

    authors: Zheng G,Zhong H,Guo Z,Wu Z,Zhang H,Wang C,Zhou Y,Zuo Z

    更新日期:2014-09-01 00:00:00

  • Dose-Dependent Differential Effects of In Vivo Exposure of Cadmium on Myometrial Activity in Rats: Involvement of VDCC and Ca2+-Mimicking Pathways.

    abstract::Present study was undertaken to study the effect of 28-days exposure of female adult rats to cadmium (Cd) in drinking water @ 3, 10 and 30 parts per million (ppm) on myometrial responsiveness to different spasmogens and unravel the possible mechanism of alterations in myometrial activity. Cadmium and Ca2+ levels in bl...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-017-1040-0

    authors: Saroj VK,Nakade UP,Sharma A,Choudhury S,Hajare SW,Garg SK

    更新日期:2018-02-01 00:00:00

  • Effects of taurine on oxidative stress parameters and chromium levels altered by acute hexavalent chromium exposure in mice kidney tissue.

    abstract::The kidney has been regarded as a critical organ of toxicity induced by acute exposure to hexavalent chromium [Cr(VI)] compounds. Reactive intermediates and free radicals generated during reduction process might be responsible for Cr(VI) toxicity. In this study, the effects of pretreatment or posttreatment of taurine ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:102:1-3:209

    authors: Boşgelmez II,Güvendik G

    更新日期:2004-01-01 00:00:00

  • Effects of increasing supplementation of magnesium in diets on productive performance and eggshell quality of aged laying hens.

    abstract::Magnesium (Mg) concentrations in diets have been associated with performance and eggshell quality of laying hens, but the results have been inconclusive. In this experiment, the effects of increasing concentrations of dietary Mg on productive performance and eggshell quality of aged laying hens were evaluated. A total...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-012-9537-z

    authors: Kim CH,Paik IK,Kil DY

    更新日期:2013-01-01 00:00:00

  • Effectiveness of Zinc Supplementation on Lithium-Induced Alterations in Thyroid Functions.

    abstract::Lithium is an integral drug used in the management of acute mania, unipolar and bipolar depression, and prophylaxis of bipolar disorders. Thyroid abnormalities have been associated with treatment with lithium. Zinc is an essential trace element that plays a role in several biological activities. Therefore, the present...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02356-9

    authors: Pathak R,Pathak A

    更新日期:2020-08-26 00:00:00

  • Effect of exercise-induced hyperthermia on serum iron concentration.

    abstract::Serum iron levels have been shown to decline both with fever and with strenuous exercise, leading to the supposition that the decrease might be the result of a rise in core body temperature. To evaluate this hypothesis, the serum iron response to an exercise-induced 1.5 degrees C rise in core body temperature was meas...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:108:1-3:061

    authors: Buono MJ,Barrack MT,Bouton-Sander F,Bradley P,Cottonaro KA

    更新日期:2005-01-01 00:00:00

  • Effect of magnesium sulfate administration on subendocardial and subepicardial perfusion.

    abstract::The objective of this study was to determine the effect of systemic MgSO4 infusion on subendocardial and subepicardial perfusion. Seventeen spontaneously breathing piglets were examined. Myocardial perfusion was measured using radiolabeled microspheres at baseline, 30 and 60 min after either MgSO4 (80 mg/kg) or saline...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02784442

    authors: Fantidis P,Stiris TA,Blanco D,Jarabo RM,Del Cerro MJ,Ruiz MA

    更新日期:1997-12-01 00:00:00

  • Doublet cells in Tetrahymena as indicators of culture media composition.

    abstract::Stomatogenesis in ciliates is a complex and carefully orchestrated event. The exo- mutant SB255 of Tetrahymena thermophila has defects in mucocyst formation and docking and can also have one or two mouths. Three common culture media (proteose peptone, Medium 357, and yeast extract) were analyzed for total C, N, and in...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02785409

    authors: Christopher GK,Sundermann CA

    更新日期:1995-12-01 00:00:00

  • Determination of arsenic in scalp hair of children and its correlation with drinking water in exposed areas of Sindh Pakistan.

    abstract::This study was focused on the analysis of arsenic (As) levels in scalp hair of children (age, <10 years) collected from two towns of Khairpur, Pakistan, to evaluate the effects of As-contaminated groundwater. For comparative purposes, scalp hair samples of children were also collected from that area having low levels ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-010-8866-z

    authors: Kazi TG,Baig JA,Shah AQ,Arain MB,Jamali MK,Kandhro GA,Afridi HI,Kolachi NF,Khan S,Wadhwa SK,Shah F

    更新日期:2011-10-01 00:00:00

  • Heavy Metals Level, Health Risk Assessment Associated with Contamination of Black Tea; A Case Study from Khyber Pakhtunkhwa (KPK), Pakistan.

    abstract::In the present study, 15 different commercial tea brands sold in Khyber Pakhtunkhwa were collected from the markets. The samples were analyzed for the concentrations of ten selected heavy metals. The metal concentration showed a random distribution in all samples. The mean concentration of Cd, Cu, Mn, Pb, Zn, and Fe w...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02059-1

    authors: Idrees M,Jan FA,Hussain S,Salam A

    更新日期:2020-11-01 00:00:00

  • A Cross-sectional Study of Plasma Trace Elements and Vitamins Content in Androgenetic Alopecia in Men.

    abstract::Androgenetic alopecia (AGA) is the most common variant of male pattern baldness in which occurrence and development of multiple genetic, hormonal, and metabolic factors are involved. We aimed to estimate plasma element content (Mg, Ca, Zn, Cu, Se, Fe), vitamin status (B12, D, E, and folic acid) in patients with AGA us...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02468-2

    authors: Kondrakhina IN,Verbenko DA,Zatevalov AM,Gatiatulina ER,Nikonorov AA,Deryabin DG,Kubanov AA

    更新日期:2020-11-05 00:00:00

  • Subcellular distribution of selenium during uptake and its influence on mitochondrial oxidations in germinating Vigna radiata L.

    abstract::The metabolic significance of Se in plants is not well documented, though the presence of many selenoenzymes in bacteria and the essentiality of Se in higher animals is established. Since germination is an active process in plant growth and metabolism, the effect of Se was investigated in germinating Vigna radiata L, ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02789188

    authors: Easwari K,Lalitha K

    更新日期:1995-05-01 00:00:00

  • Metal determination by EDXRF in lichens. A contribution to pollutants monitoring.

    abstract::Samples of Evernia prunastri, collected in a mountainous zone, were exposed in urban and highly industrialized areas in order to monitor the atmospheric pollution. Amounts of Cr, Mn, Fe, Ni, Cu, Zn, and Pb were determined by EDXRF spectrometry in secondary target excitation mode and in the thin film approach. An incre...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02917318

    authors: Caniglia G,Calliari I,Celin L,Tollardo AM

    更新日期:1994-10-01 00:00:00

  • Use of stringent selection parameters for the identification of possible selenium-responsive marker genes in mouse liver and gastrocnemius.

    abstract::Selenium is a trace element that, although toxic in higher concentrations, is essential for human and animal health. In this study, we looked at microarray-based gene expression patterns from liver and gastrocnemius tissues in mice fed either a selenium-deficient diet or diets containing sodium selenite, selenomethion...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-010-8894-8

    authors: Mallonee DH,Crowdus CA,Barger JL,Dawson KA,Power RF

    更新日期:2011-11-01 00:00:00

  • Effects of low copper and high zinc intakes and related changes in Cu,Zn-superoxide dismutase activity on DMBA-induced mammary tumorigenesis.

    abstract::The effect of low copper and high zinc intakes on Cu,Zn-superoxide dismutase (Cu,Zn-SOD) activity and mammary tumorigenesis induced by 9,10-dimethyl-1,2-benzanthracene (DMBA) was investigated. Groups of 40 weanling female Sprague-Dawley rats were fed a modified AIN-76 diet containing the following (/kg diet): 1 mg Cu ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02990343

    authors: Fischer PW,Campbell JS,Giroux A

    更新日期:1991-07-01 00:00:00

  • An interaction between selenate and a sulfate transporter in the lactating rat mammary gland.

    abstract::The efficacy of selenate and other divalent anions to stimulate the efflux of radiolabeled sulfate from lactating rat mammary tissue slices has been examined. Both selenate and sulfate markedly increased the fractional release of sulfate via a system that is temperature-sensitive and sensitive to the anion-exchange in...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02917205

    authors: Shennan DB,McNeillie SA

    更新日期:1990-03-01 00:00:00

  • Effect of Chromium Supplementation on Performance, Carcass Characteristics, Blood Biochemistry, and Immune Response of Unstressed Broiler Chickens: a Dose-Response Meta-Analysis.

    abstract::Studies investigating the effects of Chromium (Cr) supplementation on unstressed broiler chickens have reported an inconsistent association between Cr supplementation and broiler chickens' responses. We conducted a dose-response meta-analysis of previous studies to assess the dose-response associations between Cr supp...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-021-02589-2

    authors: Piray AH,Foroutanifar S

    更新日期:2021-01-17 00:00:00

  • The interaction of the vanadyl (IV) cation with chondroitin sulfate A.

    abstract::The interaction of VO2+ with the muchopolysaccharide chondroitin sulfate A (CSA) has been investigated by electron absorption spectroscopy and infrared measurements in aqueous solutions at different pH-values and ligand to metal ratios up to 6:1. The generation of a VO(CSA)2 species could be demonstrated. Coordination...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02990487

    authors: Etcheverry SB,Williams PA,Baran EJ

    更新日期:1994-07-01 00:00:00

  • Magnesium, zinc, and manganese in atherosclerosis of the aorta.

    abstract::Atomic absorption spectrometry was used in a quantitative study of zinc, magnesium, and manganese on 71 postmortal human aortas. Samples were obtained from accident victims 35-65 years of age. Fibrous plaques had higher levels of all three elements when compared to normal aortic tissue. The difference was significant ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02916613

    authors: Mendis S

    更新日期:1989-12-01 00:00:00

  • Experimental Research Showing the Reduction of Naloxone-Place Aversion by Oral Zinc Administration in Rats.

    abstract::Previous studies showed the attenuation of both morphine-dependence and morphine-place preference by zinc. Conditioned place preference and aversion are experimental models frequently used to test the reward-stimulating, respectively the aversive effects induced by different stimuli or substances. Addictive substances...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-017-0995-1

    authors: Ciubotariu D,Lupușoru RV,Luca E,Mititelu-Tarțău L,Lupușoru CE

    更新日期:2017-11-01 00:00:00