Abstract:
:Lead poisoning is a worldwide health problem, and its treatment is under investigation. The aim of this study was to access the efficacy of Coriandrum sativum (coriander) in reducing lead-induced changes in mice testis. Animal exposed to lead nitrate showed significant decrease in testicular SOD, CAT, GSH, total protein, and tissue lead level. This was accompanied by simultaneous increase in the activities of LPO, AST, ALT, ACP, ALP, and cholesterol level. Serum testosterone level and sperm density were suppressed in lead-treated group compared with the control. These influences of lead were prevented by concurrent daily administration of C. sativum extracts to some extent. Treating albino mice with lead-induced various histological changes in the testis and treatment with coriander led to an improvement in the histological testis picture. The results thus led us to conclude that administration of C. sativum significantly protects against lead-induced oxidative stress. Further work need to be done to isolate and purify the active principle involved in the antioxidant activity of this plant.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Sharma V,Kansal L,Sharma Adoi
10.1007/s12011-009-8553-0subject
Has Abstractpub_date
2010-09-01 00:00:00pages
337-54issue
3eissn
0163-4984issn
1559-0720journal_volume
136pub_type
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journal_title:Biological trace element research
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pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章,随机对照试验
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journal_title:Biological trace element research
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journal_title:Biological trace element research
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更新日期:2013-06-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:2020-10-10 00:00:00
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journal_title:Biological trace element research
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更新日期:2010-09-01 00:00:00
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journal_title:Biological trace element research
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journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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journal_title:Biological trace element research
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