Abstract：
:This study has analyzed the role of several serum constituents, that have been proposed to effect the following reactionin situ: {fx1-1} {fx1-2} These reactions were monitored by measuring the rate of Fe(II) oxidation in the presence of apo-transferrin (reaction A) and Fe(III)-transferrin formation (reaction B) at 465 nm. Reactions A and B were found to be kinetically equivalent. The results show that, singly or in combination, bicarbonate, orthophosphate, citrate, apo-transferrin, and/or albumin have less than one-tenth of the ability to enhance the oxidation of Fe(II) compared to the serum enzyme, ceruloplasmin. It was also found that the rate of Fe(II) oxidation by serum Fe-ligands was influenced by the efficiency of oxygen utilization. Whereas ceruloplasmin produces a 4∶1 ratio of Fe(II) oxidized to oxygen utilized, the non-enzymic components yield a 2∶1 or 3.09∶1 ratio. These data support the role of ceruloplasmin as an antioxidant that prevents the formation of the intermediate active oxygen species O 2 (-) · and H2O 2 (·) through the Fe(II) auto-oxidation reaction.A hitherto unrecognized factor in the control of nonenzymic oxidation of Fe(II) was serum albumin. This protein, at >25 μM, was found to sharply dampen the rate of Fe(II) oxidation in the presence of a physiological concentration of bicarbonate, citrate, and transferrin Albumin did not appear to affect the ceruloplasmin catalyzed oxidation of Fe(II) at pH 7.0. The addition of ceruloplasmin effected up to a 44 × increase in the rate of Fe(II) oxidation and Fe(III)-transferrin formation even in the presence of 0.60 mM albumin.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Carver FJ,Farb DL,Frieden Edoi
10.1007/BF02789129subject
Has Abstractpub_date
1982-03-01 00:00:00pages
1-19issue
1eissn
0163-4984issn
1559-0720journal_volume
4pub_type
杂志文章abstract：:Several studies have investigated the relationship between serum and hair nickel (Ni) concentration and breast cancer, but the results were inconsistent. Thus, we conducted a systematic review and meta-analysis to evaluate the association between serum and hair nickel levels and breast cancer. Nine studies determining...
journal_title：Biological trace element research
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s12011-017-0949-7
更新日期：2017-09-01 00:00:00
abstract：:Nutritional profile of minerals and antioxidants in Indian spice extracts was evaluated in order to examine their efficacy in treating various diseases, disorders, and allergies in human health. Extracts of four medicinal plants such as Curcuma longa, Zingiber officinale, Piper nigrum, and Piper longum, regularly cons...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02228-2
更新日期：2021-03-01 00:00:00
abstract：:Lead (Pb)-induced reproductive toxicity is a well-characterized adverse effect associated with this heavy metal. It has been found that Pb exposure is associated with altered spermatogenesis, increased testicular degeneration, and pathological sperm alterations. On the other hand, it has been reported that Pb-induced ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1358-2
更新日期：2019-01-01 00:00:00
abstract：:Biotransformation of inorganic arsenic in mammals is catalyzed by three serial enzyme activities: arsenate reductase, arsenite methyltransferase, and monomethylarsonate methyltransferase. Our laboratory has purified and characterized these enzymes in order to understand the mechanisms and elucidate the variations of t...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/BF02783907
更新日期：1999-06-01 00:00:00
abstract：:The small intestine is one of the target organs of dietary selenium (Se) deficiency. Our objective was to investigate the effects of Se deficiency on small intestinal mucosa morphology and function in chickens. In the present study, 1-day (d)-old chickens were fed either a commercial diet with 0.15 mg/kg Se (control g...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-02017-6
更新日期：2020-10-01 00:00:00
abstract：:Selenium (Se) is an essential trace element for both humans and animals. Se deficiency leads to myocardial injury, reproductive disorder, increased exudation, inflammatory injury, and other diseases. The present study analyzed the relationships of Se deficiency, inflammation, and smooth muscle contraction in the small...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02245-1
更新日期：2020-06-15 00:00:00
abstract：:Selenoprotein K (SelK), a member of selenoprotein family, is identified as a single endoplasmic reticulum (ER) transmembrane protein. Although over-expression of SelK inhibits adherence and migration of human gastric cancer BGC-823 cells, the effects of SelK in human choriocarcinoma (CCA) are not well understood. In t...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1155-3
更新日期：2018-07-01 00:00:00
abstract：:Fluoride (F) concentration in blood serum of healthy dromedary camel population was measured, and its relationship with age and sex was determined. In male animals, the level varied from 0.017 to 0.296 ppm, with mean (± S.E.) value of 0.163 ± 0.013 ppm. In females, the level varied from 0.036 to 0.372 ppm with mean va...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02534-9
更新日期：2021-01-06 00:00:00
abstract：:Auxiliary enzymes participate in β-oxidation of unsaturated fatty acids. The objective of the study was to investigate the impact of a moderate zinc deficiency and a high intake of polyunsaturated fat on Δ(3)Δ(2)-enoyl-CoA isomerase (ECI) in the liver and other tissues. Five groups of eight weanling rats each were fed...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9940-8
更新日期：2014-06-01 00:00:00
abstract：:Calcium, magnesium, and zinc balances were determined in eleven young adult college females (mean age, 24.9±2.35) during a 39-d metabolic study when the subjects were fed an adequate calorie and protein diet based on habitually consumed foods. Analysis showed that the dietary contribution of calcium, magnesium, and zi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917454
更新日期：1985-11-01 00:00:00
abstract：:Multielemental detection using Instrumental Neutron Activation Analysis (INAA) and Proton-Induced X-Ray Emission (PIXE) of drinkable water of Florence (Italy) is described. The concentrations of 52 elements were measured. No chemical treatment was performed on the samples, before or after irradiation. On the basis of ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02992691
更新日期：1990-07-01 00:00:00
abstract：:Inducing the differentiation of stem cells from human exfoliated deciduous teeth (SHEDs) proceeds with low efficiency, which greatly limits clinical applications. Divalent metal elements play an important role in osteoinductivity for bone remodeling because they can simulate bone formation and decrease bone resorption...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1256-7
更新日期：2018-10-01 00:00:00
abstract：:Using the dimethylbenz(a)anthracene-induced mammary tumor model in rats, our studies indicated that there was a dose-response relationship between dietary selenium supplementation and the inhibition of mammary carcinogenesis. The degree of inhibition was proportional to the level of dietary selenium up to 5 ppm, at wh...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02987217
更新日期：1983-08-01 00:00:00
abstract：:The influence of hair color on the trace elemental status in horse's hair has been studied. A current analytical technique such as particle-induced X-ray emission (PIXE) used in this study has provided reliable, rapid, easy, and relatively inexpensive diagnostic methods. Twenty-eight elements (Al, Br, Ca, Cl, Co, Cu, ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:103:2:169
更新日期：2005-02-01 00:00:00
abstract：:Tissue distribution of Fe, Mn, Cu, and Zn, the essential trace elements associated with oxidant and/or antioxidant processes, was examined in iodine- and/or selenium-deficient rats (ID, SeD, ISeD). Fe and Mn were the most affected minerals in all types of deficiency states. Mn levels decreased significantly in the liv...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:95:3:247
更新日期：2003-12-01 00:00:00
abstract：:As a nutritionally essential trace element, selenium (Se) is crucial for fish growth. However, the underlying mechanisms remain unclear. Fish somatic growth relies on the white muscle growth. This study aimed to explore the effects and underlying mechanisms of Se on fish white muscle growth using a juvenile rainbow tr...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02282-w
更新日期：2020-07-14 00:00:00
abstract：:It has been demonstrated that zinc exerts its beneficial influence on skin fibroblasts. Propolis, a complex mixture of plant-derived and bees' products, was reported to stimulate cicatrization processes in skin and prevent infections. The aim of this study was to find out how zinc and propolis influence human skin fib...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0019-3
更新日期：2014-07-01 00:00:00
abstract：:A simple, quick procedure has been developed for preparation of human lenses for total chromium (Cr) analysis by electrothermal atomic absorption spectrometry (EAAS). This procedure involves wet ashing in a mini-autoclave with HNO3 and H2SO4. Recovery was 101.6%. This procedure is simple to carry out, does not generat...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784598
更新日期：1992-01-01 00:00:00
abstract：:The effect of ad libitum ingestion of selenium (Se) in drinking water (0.15 mg SeO2/L) for 3 wk on the brain weight, total brain protein, glutathione (GSH) level, catalase activity, and lipid peroxidation in the brain of protein-undernourished (PU) rats was investigated, in an attempt to determine whether antioxidants...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02685933
更新日期：2007-05-01 00:00:00
abstract：:The aim of this study was to investigate the protective effect of luteolin on liver Ca, Mg, Zn, Cu, Fe, and Mn content in mice with carbon tetrachloride (CCl4)-induced hepatotoxicity. Additionally, liver metallothionein (MT) expression was studied. Luteolin was administered intraperitoneally (i.p.) as a single 5- or 5...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8181-0
更新日期：2008-01-01 00:00:00
abstract：:The levels of iron, zinc, and copper in the tissues of the pregnant rat, on d 12, 19, and 21 after impregnation have been determined and compared with controls. Iron levels decreased considerably in late pregnancy as a result of increased fetal requirements, thus diminishing iron stores in rat tissues, but maintaining...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917464
更新日期：1985-09-01 00:00:00
abstract：:Head hair concentrations of zinc, copper, manganese, alid iron from a total of 418 subjects (154 male and 264 female) aged between 6 mo and 20 yr were measured mainly with flameless atomic absorption spectrophotometry. Only zinc analysis of a part of the female samples (n = 140) were analyzed with inductively coupled ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:77:1:43
更新日期：2000-10-01 00:00:00
abstract：:The objective of this study was to investigate the effects of dietary supplemental chromium (Cr) on growth performance, carcass traits, and meat quality of broilers reared under heat stress. A total of 252 1-d-old Cobb 500 commercial female broilers were randomly allotted by body weight (BW) to one of six replicate ca...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0443-z
更新日期：2016-03-01 00:00:00
abstract：:Age-related changes in the concentrations of constituent elements in the brains of rats and mice 1 wk to 24 mo old were determined with inductively coupled plasma-mass spectrometry (ICP-MS) and inductively coupled plasma-atomic emission spectrometry (ICP-AES). Seventeen elements could be determined with reasonable acc...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:80:2:145
更新日期：2001-05-01 00:00:00
abstract：:Two trials were conducted in a 2 × 2 + 1 factorial arrangement based on a completely randomized design to evaluate the effects of different sources of selenium (Se) on performance, blood metabolites, and nutrient digestibility in male lambs on a barley-based diet. The first trial lasted for 70 days and consisted of 30...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9698-4
更新日期：2013-07-01 00:00:00
abstract：:Because nickel may have a biological function in a pathway in which vitamin B12 is important, an experiment was performed to determine the effects of nitrous oxide exposure in rats deprived of nickel. Exposure to nitrous oxide (N2O) causes inactivation of cobalamin and a subsequent decrease in the vitamin B12-dependen...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783980
更新日期：1993-07-01 00:00:00
abstract：:This study was designed to investigate the pro-inflammatory cytokines and their involvement in the cytotoxic potential of fluoride (F) in HeLa cells. HeLa cells were cultured with varying F concentrations (1-50 mg/L) for 48 h, and treatment effects were analyzed. The viability of HeLa cells was determined with a color...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0749-5
更新日期：2017-01-01 00:00:00
abstract：:Manganese (Mn) is an essential element for normal development and bodily functions in humans. In the present study, we examined whether Mn supplementation can alter the serum lipid parameters and liver function in Ca-deficient ovariectomized (OVX) rats. Sixty female Sprague-Dawley rats (6 weeks) were divided into five...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8714-1
更新日期：2011-06-01 00:00:00
abstract：:Metabolic alterations and inflammation are regarded as hallmarks of cancer. Glycolytic flux and intermediate accumulation lead to the production of building blocks and NADPH which is important in protecting the cell from oxidative damage. Inflammation causes the release of mediators responsible for regulating molecula...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02363-w
更新日期：2020-09-03 00:00:00
abstract：:Heavy metals are the most common form of aquatic pollutants and are of great health risk to consumers of contaminated sea food. This study investigated the level of heavy metals in three species of catfishes Chrysichthys nigrodigitatus (marine catfish), Clarias gariepinus (African catfish), and Schilbe mystus (silver ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1484-x
更新日期：2019-06-01 00:00:00
