Age-related changes in the concentrations of major and trace elements in the brain of rats and mice.

Abstract:

:Age-related changes in the concentrations of constituent elements in the brains of rats and mice 1 wk to 24 mo old were determined with inductively coupled plasma-mass spectrometry (ICP-MS) and inductively coupled plasma-atomic emission spectrometry (ICP-AES). Seventeen elements could be determined with reasonable accuracy and reproducibility. They were P, K, Na, Mg, Ca, Fe, Zn, Cu, Rb, Al, Mn, Sr, Mo, Co, Pb, Cs, and Cd in order of concentrations in the adult rat brains. In these elements, six major elements (P, K, Na, Fe, Mg, Ca) were determined with ICP-AES and the others with ICP-MS. The concentrations of each element and the pattern of age-related changes were similar between the rat and mouse brains. The elements of which concentrations decreased with aging were K and Rb. On the other hand, the concentrations of some metal elements, including Fe, Cu, Sr, and Co, appeared to increase with growth and aging. The concentrations of other elements were relatively constant throughout the age examined.

journal_name

Biol Trace Elem Res

authors

Takahashi S,Takahashi I,Sato H,Kubota Y,Yoshida S,Muramatsu Y

doi

10.1385/BTER:80:2:145

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

145-58

issue

2

eissn

0163-4984

issn

1559-0720

journal_volume

80

pub_type

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