Abstract:
:Age-related changes in the concentrations of constituent elements in the brains of rats and mice 1 wk to 24 mo old were determined with inductively coupled plasma-mass spectrometry (ICP-MS) and inductively coupled plasma-atomic emission spectrometry (ICP-AES). Seventeen elements could be determined with reasonable accuracy and reproducibility. They were P, K, Na, Mg, Ca, Fe, Zn, Cu, Rb, Al, Mn, Sr, Mo, Co, Pb, Cs, and Cd in order of concentrations in the adult rat brains. In these elements, six major elements (P, K, Na, Fe, Mg, Ca) were determined with ICP-AES and the others with ICP-MS. The concentrations of each element and the pattern of age-related changes were similar between the rat and mouse brains. The elements of which concentrations decreased with aging were K and Rb. On the other hand, the concentrations of some metal elements, including Fe, Cu, Sr, and Co, appeared to increase with growth and aging. The concentrations of other elements were relatively constant throughout the age examined.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Takahashi S,Takahashi I,Sato H,Kubota Y,Yoshida S,Muramatsu Ydoi
10.1385/BTER:80:2:145subject
Has Abstractpub_date
2001-05-01 00:00:00pages
145-58issue
2eissn
0163-4984issn
1559-0720journal_volume
80pub_type
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