Abstract:
:Water-borne arsenicosis is caused by the consumption of excess levels of inorganic arsenic from drinking water and is a worldwide public health issue. Arsenic exposure has recently attracted extensive attention due to its damage to the cardiovascular system. Vascular endothelial dysfunction (VED) is recognized as an important cause of cardiovascular diseases. Pigment epithelium-derived factor (PEDF) plays an important role in maintaining endothelial function, and our previous studies suggested that PEDF may have role in arsenic-induced damage. In the present study, we established subchronic arsenic exposure (3 months) rat model from drinking water at doses of 0, 2 mg/L, 10 mg/L, and 50 mg/L, respectively. The results showed that the endothelial cells of the aortic arch were obviously damaged, the apoptosis rate increased, the vWF and iNOS levels increased, and the NO and TNOS levels significantly decreased in the arsenic exposure groups. Regardless of serum or aortic arch endothelium, PEDF levels in the arsenic exposure groups decreased compared to the control group. The oxidative stress level and key proteins associated with apoptosis such as Fas, FasL, P53, and p-p38 were then detected to explore the detailed mechanisms. The results showed that the P53 and p-p38 levels significantly increased in the 10 mg/L and 50 mg/L groups compared to the control group. The MDA content in the arsenic exposure groups increased markedly, whereas the SOD activity decreased significantly with the increased arsenic dose. Taken together, our study is the first to find that PEDF plays a protective role in arsenic-induced endothelial dysfunction through anti-oxidation and anti-apoptosis, and p38 and P53 may be promising target proteins.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Guo X,Fu X,Liu X,Wang J,Li Z,Gao L,Li Y,Zhang Wdoi
10.1007/s12011-018-1559-8subject
Has Abstractpub_date
2019-08-01 00:00:00pages
405-413issue
2eissn
0163-4984issn
1559-0720pii
10.1007/s12011-018-1559-8journal_volume
190pub_type
杂志文章abstract::An increase in hepatic iron concentration might exacerbate liver injury. However, it is unknown whether hepatic iron overload may exacerbate acute liver injury from various toxins. Therefore, we evaluated how manipulations to increase hepatic iron concentration affected the extent of acute liver injury from thioacetam...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0110-9
更新日期:2015-02-01 00:00:00
abstract::To elucidate compositional changes of the mitral valve with aging, the authors investigated the relationships among element contents in the mitral valves. The subjects consisted of 10 men and 15 women, ranging in age from 65 to 102 yr. After the ordinary dissection, mitral valves, lower parts of the interventricular s...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:88:3:203
更新日期:2002-09-01 00:00:00
abstract::The purpose of this study was to evaluate the effects of cadmium-induced peroxidative damage to rat liver, heart, and spleen. Sprague-Dawley rats were injected subcutaneously with a single dose of 25, 125, 500, or 1250 microg Cd/kg and evaluated 6, 12, 24, or 72 h later. Liver, heart, and spleen were analyzed for lipi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:78:1-3:219
更新日期:2000-01-01 00:00:00
abstract::In 47 children with malignancy, zinc status, growth, and performance during standard treatment were compared with those in controls. At diagnosis, growth was retarded and hair zinc values were high, 2.4 +/- 0.7 mumol/g, as in chronic deficiency. During induction therapy, serum declined to 10.4 +/- 2.3 mumol/L and urin...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02991414
更新日期:1991-09-01 00:00:00
abstract::Mitochondrial membrane potential is reduced in copper-deficient rat hearts, but it is uncertain if this will lead to the onset of apoptosis. To determine if copper deficiency per se leads to apoptosis, C2C12 cells were made copper deficient by treatment with the copper chelator tetraethylenepentamine (TEPA). In TEPA-t...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:106:1:051
更新日期:2005-07-01 00:00:00
abstract::Recent publications in Japan suggest that Cd in river beds and locally harvested rice tend to be higher in seven prefectures in the north-eastern part on the coast of the Sea of Japan (the high-Cd zone). The present study was initiated to investigate the current level of exposure to Cd and possible health effects amon...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8646-9
更新日期:2011-02-01 00:00:00
abstract::Two 42-d experiments were conducted with weanling male rats to study interactions between nickel and copper. In Experiment 1, a low-copper basal diet was supplemented with copper at 0 or 30 ppm and nickel at 0 or 30 ppm. Copper was added in Experiment 2 to a basal copper-deficient diet at a level of 0 or 15 ppm and ni...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02916540
更新日期:1985-04-01 00:00:00
abstract::Gender differences are related to the manner in which the heart responds to chronic and acute stress conditions of physiological and pathological nature. Depending on dose, sodium selenite acts as an antioxidant proven to have beneficial effects in several pathological conditions G. Drasch, J. Schopfer, and G. N. Schr...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02698014
更新日期:2007-06-01 00:00:00
abstract::Few studies have evaluated the biomarker changes of fluoride exposure. In order to explore early and sensitive indicators, animal experiment was designed. Ninety-six healthy SD rats (48 males and 48 females) weighing approximately 60 g were randomly divided into six groups of 16 animals each by gender average. Control...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0034-4
更新日期:2014-07-01 00:00:00
abstract::Bulk fabrication of ordered hollow structural particles (HSPs) with large surface area and high biocompatibility simultaneously is critical for the practical application of HSPs in biosensing and drug delivery. In this article, we describe a smart approach for batch synthesis of calcium carbonate nanotubes (CCNTs) bas...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9325-9
更新日期:2012-06-01 00:00:00
abstract::The original version of this article unfortunately contained a mistake. The name of "Ali Ghorbani Ranjbary" is now corrected in the author group of this article. The original article has been corrected. ...
journal_title:Biological trace element research
pub_type: 杂志文章,已发布勘误
doi:10.1007/s12011-019-01787-3
更新日期:2020-04-01 00:00:00
abstract::Neonatal uptake of mercury (Hg) from milk was examined in a pregnant sheep model, where radioactive mercury (Hg203)/silver tooth fillings (amalgam) were newly placed. A crossover experimental design was used in which lactating ewes nursed foster lambs. In a parallel study, the relationship between dental history and b...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785388
更新日期:1997-02-01 00:00:00
abstract::Selenium concentrations in the blood of 112 (56 females and 56 males) normal subjects, from different regions of the Punjab (Pakistan), have been determined using the technique of inductively coupled plasma-mass spectrometry. The whole blood selenium concentrations were found to be 452 ± 12 ppb (parts per billion or n...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8867-y
更新日期:2011-10-01 00:00:00
abstract::In the present study, 15 different commercial tea brands sold in Khyber Pakhtunkhwa were collected from the markets. The samples were analyzed for the concentrations of ten selected heavy metals. The metal concentration showed a random distribution in all samples. The mean concentration of Cd, Cu, Mn, Pb, Zn, and Fe w...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02059-1
更新日期:2020-11-01 00:00:00
abstract::The distribution, potential ecological hazards, and homologous relativity of heavy metals in the water-level fluctuating zone (WLFZ) of the Yangtze River within the Wanzhou Section (YRWS) were investigated. The heavy metal content (Cd, Cu, Cr, and Ni) of the surface soil was analysed via atomic absorption spectroscopy...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9179-6
更新日期:2012-02-01 00:00:00
abstract::Twenty-seven infants with classical phenylketonuria were evaluated longitudinally for 6 mo while ingesting Phenex-1 Amino Acid Modified Medical Food With Iron as their primary protein source. Intake of selected nutrients and biochemical indices of trace and ultratrace mineral status and plasma retinol and alpha-tocoph...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/BF02784277
更新日期:1999-01-01 00:00:00
abstract::Significant disorders of liver metabolic pathways enzymes after high-cholesterol diet could give information on liver steatosis development. This process could probably also be inhibited by some compounds, as examined in rabbits. Forty-two male rabbits were served a high-cholesterol diet (2 g%) (0.67 g/kg b.m./24 h) w...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-0070-4
更新日期:2007-01-01 00:00:00
abstract::The effect of aging on the status of macrominerals and trace elements in tissues was studied using two strains (SAMP1 and SAMR1) of senescence accelerated mouse. Two-month-old, 6-mo-old, and 10-mo-old female SAMP1 and SAMR1 mice were fed a commercial diet. Iron, zinc, copper, calcium, magnesium, phosphorus, sulfur, so...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:80:1:53
更新日期:2001-04-01 00:00:00
abstract::Chromium picolinate is used in the poultry diet because of its antistress effects in addition to the fact that the requirement for it is increased during stress. This study was conducted to determine if the negative effects of high ambient temperature (34 degrees C) on egg production, egg quality, antioxidant status, ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:101:2:181
更新日期:2004-11-01 00:00:00
abstract::A 10-year-old Gir bullock was presented with four contiguous hard nodular submucosal masses attached to the right rostral mandible. Overgrown masses were resected surgically and submitted for microstructural, elemental, and molecular spectroscopic analyses. An osteoma was diagnosed histopathologically. Elemental analy...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-021-02604-6
更新日期:2021-01-26 00:00:00
abstract::Previous studies have shown that there is a controversial relationship between iron homeostasis and obesity. This study aims to explore the relationship of anemia and iron status with different body size phenotypes in adult Chinese population. Using information on iron status-related parameters and lifestyle data from...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1213-x
更新日期:2018-09-01 00:00:00
abstract::Body stores of lead, cadmium, and mercury are determined by the levels in the circulation, and their levels in blood may be related to hemoglobin levels and their absorption by soft tissue and bone. We investigated the association of body fat percentage, hemoglobin levels, and nutrient intakes with the blood concentra...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9566-7
更新日期:2013-03-01 00:00:00
abstract::In vitro tests simulating the elements release from inhaled urban particulate matter (PM) with artificial lung fluids (Gamble's and Hatch's solutions) and simulated gastric and pancreatic solutions were applied for an estimation of hazardous element (As, Cd, Cr, Hg, Mn, Ni, Pb and Zn) bio-accessibility in this materia...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0101-x
更新日期:2014-11-01 00:00:00
abstract::Concentration of heavy metals (lead (Pb), cadmium (Cd), chromium (Cr), and copper (Cu)) was determined in the liver, gills, kidneys, and muscles of eight edible fish species (Channa punctata, Cirrhinus reba, Labeo rohita, Heteropneustes fossilis, Mystus cavasius, Oreochromis niloticus, Puntius sophore, and Wallago att...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9011-3
更新日期:2011-12-01 00:00:00
abstract::Human serum butyrylcholinesterase (BChE) has been converted into a stable but less active desensitized form when heated at 45 degrees C for 24 h. The desensitized BChE follows Michaelis-Menten kinetics, whereas native enzyme exhibits slightly negative cooperativity with respect to butyrylthiocholine binding. In this s...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:93:1-3:55
更新日期:2003-07-01 00:00:00
abstract::Silicon (Si) is important for the growth and development of bone and connective tissues. Several studies have reported that Si supplementation improved bone mineral density (BMD) in female ovarectomized rats. However, few studies have investigated the effects of Si supplementation on bone status and bone metabolism in...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9936-4
更新日期:2014-05-01 00:00:00
abstract::Magnesium is the second most abundant intracellular cation and is a fundamental cofactor in a multitude of cellular enzymatic reactions. Magnesium deficiency causes diverse clinical features predominantly due to cardio- and neurotoxicity. We describe a case of severe hypomagnesaemia associated with intermittent downbe...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8757-3
更新日期:2011-08-01 00:00:00
abstract::Consumption of edible plants satisfies a significant part of human body needs in macro- and micronutrients while biologically active substances contain strong antioxidant properties and reduce the risk of a number of diseases. Balanced nutrition and design of personalized diets and treatment rely on the data on the co...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02345-y
更新日期:2020-08-19 00:00:00
abstract::Aluminum promotes osteoblast (OB) apoptosis. Apoptosis is induced by the disordered calcium homeostasis. Therefore, to investigate the relationship between Al-induced OB apoptosis and calcium homeostasis, calvarium OBs from neonatal rats (3-4 days) were cultured and exposed to 0.048-mg/mL Al(3+) or 0.048-mg/mL Al(3+) ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0417-1
更新日期:2016-02-01 00:00:00
abstract::The aim of the study was to determine the role of alcoholic drinks as a potential source of dietary fluoride by means of measuring fluoride levels in selected alcoholic drinks available on the Polish market that are also diverse in terms of the percentage content of ethanol. The study was conducted on 48 types of drin...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0519-9
更新日期:2016-06-01 00:00:00