Abstract：
:Zinc (mostly as free/labile Zn2+) is an essential structural constituent of many proteins, including enzymes in cellular signaling pathways via functioning as an important signaling molecule in mammalian cells. In cardiomyocytes at resting condition, intracellular labile Zn2+ concentration ([Zn2+]i) is in the nanomolar range, whereas it can increase dramatically under pathological conditions, including hyperglycemia, but the mechanisms that affect its subcellular redistribution is not clear. Therefore, overall, very little is known about the precise mechanisms controlling the intracellular distribution of labile Zn2+, particularly via Zn2+ transporters during cardiac function under both physiological and pathophysiological conditions. Literature data demonstrated that [Zn2+]i homeostasis in mammalian cells is primarily coordinated by Zn2+ transporters classified as ZnTs (SLC30A) and ZIPs (SLC39A). To identify the molecular mechanisms of diverse functions of labile Zn2+ in the heart, the recent studies focused on the discovery of subcellular localization of these Zn2+ transporters in parallel to the discovery of novel physiological functions of [Zn2+]i in cardiomyocytes. The present review summarizes the current understanding of the role of [Zn2+]i changes in cardiomyocytes under pathological conditions, and under high [Zn2+]i and how Zn2+ transporters are important for its subcellular redistribution. The emerging importance and the promise of some Zn2+ transporters for targeted cardiac therapy against pathological stimuli are also provided. Taken together, the review clearly outlines cellular control of cytosolic Zn2+ signaling by Zn2+ transporters, the role of Zn2+ transporters in heart function under hyperglycemia, the role of Zn2+ under increased oxidative stress and ER stress, and their roles in cancer are discussed.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Turan Bdoi
10.1007/s12011-018-1464-1subject
Has Abstractpub_date
2019-03-01 00:00:00pages
160-176issue
1eissn
0163-4984issn
1559-0720pii
10.1007/s12011-018-1464-1journal_volume
188pub_type
杂志文章,评审abstract：:This study was aimed to assess the protective effect of sodium selenite on the ileum mucosal immunologic injury induced by AFB1. One hundred eighty-one-day-old healthy male Avian broilers were divided into four groups of three replicates and 15 birds per replicate and fed with basal diet (control group), 0.3 mg/kg AFB...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0035-3
更新日期：2014-07-01 00:00:00
abstract：:This study was designed to investigate the pro-inflammatory cytokines and their involvement in the cytotoxic potential of fluoride (F) in HeLa cells. HeLa cells were cultured with varying F concentrations (1-50 mg/L) for 48 h, and treatment effects were analyzed. The viability of HeLa cells was determined with a color...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0749-5
更新日期：2017-01-01 00:00:00
abstract：:Assessing the ability of a selenium (Se) sample to induce cellular glutathione peroxidase (GPx) activity in Se-deficient animals is the most commonly used method to determine Se bioavailability. Our goal is to establish a Se-deficient cell culture model with differential incorporation of Se chemical forms into GPx, wh...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8097-8
更新日期：2008-07-01 00:00:00
abstract：:The toxic effect of Pb2+ has been studied in eukaryotic cells by using Tetrahymena as a target. The maximum power (P(m)) and the growth rate constant (k) were determined, which showed that values of P(m) and k were linked to the concentration (C) of Pb2+. The addition of Pb2+ caused a decrease of the maximum heat prod...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-0055-3
更新日期：2007-11-01 00:00:00
abstract：:The present study was conducted to investigate whether the combined treatment with Se and Zn offers more beneficial effects than that provided by either of them alone in reversing Cd-induced oxidative stress in the kidney of rat. For this purpose, 30 adult male Wistar albino rats, equally divided into control and four...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8324-y
更新日期：2009-08-01 00:00:00
abstract：:The distribution and chemical species of iodine in various subcellular fractions of human liver were studied by using epithermal neutron activation analysis combined with chemical and biochemical separation techniques, such as gradient centrifugation and gel chromatography. It was found that the total iodine content o...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783916
更新日期：1999-07-01 00:00:00
abstract：:Spinal fusion is among the most frequently applied spinal surgical procedures. The goal of the present study was to evaluate whether the local administration of boric acid (BA) improves spinal fusion in an experimental spinal fusion model in rats. Currently, there is no published data that evaluates the possible posit...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0274-y
更新日期：2015-09-01 00:00:00
abstract：:Tungstate is an oxyanion that has biological similarities to vanadate. In recent years, a number of studies have shown the antidiabetic effects of oral tungstate in animal models of diabetes. However, because of the tissue accumulation and potential toxicity derived from chronic administration of vanadium and tungsten...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1385/BTER:88:2:097
更新日期：2002-08-01 00:00:00
abstract：:The aim of this study was to investigate the effects of the Toxoplasma gondii infection on the total content of the essential elements Zn and Mg levels. Plasma zinc and magnesium concentrations were measured in 158 patients whose anti-T gondii IgG antibodies were positive. Scores were obtained for the patients and the...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1385/BTER:92:1:11
更新日期：2003-04-01 00:00:00
abstract：:Two organoselenium compounds: xylitol selenious ester (xylitol-Se) and sucrose selenious ester (sucrose-Se) were synthesized, and their molecular structures were characterized in this study. In MTT assay, xylitol-Se and sucrose-Se showed cytostatic effects on human hepatocellular carcinoma cells SMMC-7221 in a dose-de...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9715-7
更新日期：2013-08-01 00:00:00
abstract：:Lanthanum cations (La 3+) are well known for their inhibitory actions on calcium channels. Prenatal lanthanum exposure may affect the development of embryo and alter the capacity for learning and memory in adults, and the one-trial passive avoidance learning paradigm with day-old chicks is an excellent model to study ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8225-5
更新日期：2009-01-01 00:00:00
abstract：:Wild barley (Hordeum spontaneum), the progenitor of cultivated barley, is an important genetic resource for cereal improvement. Selenium (Se) is an essential trace mineral for humans and animals with antioxidant, anticancer, antiarthropathy, and antiviral effects. In the current study, the grain Se concentration (GSeC...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8770-6
更新日期：2011-09-01 00:00:00
abstract：:Tomato quality and its potential health benefits are directly related to its chemical composition. The characterization of nutritional properties of Solanum germplasm is essential to choose suitable donor parents for breeding programs. In this sense, wild species could be very useful for tomato fruit quality genetic i...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8738-6
更新日期：2011-06-01 00:00:00
abstract：:Divalent metal ions (Fe2+, Cu2+, Zn2+, Ni2+, and Mn2+) induced lipid oxidation in cooked, but not in raw fish. The extent of lipid oxidation, measured by the production of thiobarbituric acid reactive substances (TBRS), was increased with higher concentrations of iron, zinc, and nickel, but was decreased with increasi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783896
更新日期：1992-07-01 00:00:00
abstract：:In this article, we report the results of a case control study carried out on 290 Turkish pregnant women at 5-24 wk of gestation to determine their zinc, folic acid, and vitamin B12 levels in relation to their nutritional and socioeconomic status. The women were divided into two groups (n=145 each), depending on the s...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:109:2:105
更新日期：2006-02-01 00:00:00
abstract：:Biominerals and metals of intertidal corals of two species (Heliofungia actiniformis, Quoy and Gaimard; Galaxea fascicularis, Linnaeus), collected from the Iriomote Island of Ryukyu, were examined with an inductively coupled plasma atomic emission spectrometer (ICP-AES). Twelve elements were detectable in the corallin...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784268
更新日期：1998-11-01 00:00:00
abstract：:This study aimed to investigate the effects of a combination of a dairy product fermented by lactobacilli (DFL) and galactooligosaccharides (GOS) on mineral balances in growing rats with hypochlorhydria induced by a proton pump inhibitor (PPI). Three-week-old male rats were assigned to receive one of six diets: a cont...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9681-0
更新日期：2013-06-01 00:00:00
abstract：:This study concerns application of flame atomic absorption spectrometry (FAAS) in assessment of macro- and microelement and toxic metal levels (Mg, Ca, K, Na, Mn, Cu, Fe, Zn, Cr, Ni, Co, Cd and Pb) in dark (Pu-erh) and fruit tea leaves and their infusions. Phosphorus was also determined in the form of phosphomolybdate...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0669-4
更新日期：2016-11-01 00:00:00
abstract：:Methylmercury (MeHg) is highly toxic, and its principal target tissue in human is the nervous system, which has made MeHg intoxication a public health concern for many decades. Portulaca oleraceae (purslane), a member of the Portulacaceae family, is widespread as a weed and has been ranked the eighth most common plant...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0546-6
更新日期：2016-07-01 00:00:00
abstract：:Relative stability of mineral elements in tissues is necessary for health. High static magnetic fields (HiSMFs) have been widely used in biomedical research and industry. However, the bioeffect of HiSMFs on animals is still unclear. In this study, we investigated the effects of HiSMF exposure on the levels of Mg, Fe, ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02469-1
更新日期：2021-01-07 00:00:00
abstract：:Kashin-Beck disease (KBD) is an endemic, degenerative osteoarthropathy, and particularly seen in China. A deficiency of selenium and iodine is implicated as the main etiological factor for KBD. This meta-analysis aimed to evaluate the differences in the selenium and iodine levels between patients with KBD and healthy ...
journal_title：Biological trace element research
pub_type： 杂志文章,meta分析
doi：10.1007/s12011-015-0463-8
更新日期：2016-03-01 00:00:00
abstract：:Lead is a biohazardous metal that is commonly involved in human illness including renal injury. Although it is a non-redox reactive metal, lead-induced renal injury is largely based on oxidative stress. The current work aimed at exploring the possible protective effect of γ-glutamyl cysteine (γGC) against lead-induced...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0624-4
更新日期：2016-09-01 00:00:00
abstract：:Pituitary dwarfism (hGHD) is known to be associated with trace element deficiency, which causes improper functioning of the involved endocrine system. Previously, we reported on the head hair concentrations of zinc, copper, manganese, and iron from a total of 418 normal subjects (154 male and 264 female). In this repo...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:85:2:127
更新日期：2002-02-01 00:00:00
abstract：:Many studies have shown that zinc deficiency could decrease the response to insulin. In genetically diabetic animals, a low zinc status has been observed contrary to induced diabetic animals. The zinc status of human patients depends on the type of diabetes and the age. Zinc supplementation seems to have beneficial ef...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/BF02784615
更新日期：1992-01-01 00:00:00
abstract：:Three-month studies were performed on 18 adult rabbits of New Zealand breed divided into three groups, with six animals in each: a control group on standard diet, a cholesterol group receiving 500 mg of cholesterol/100 g of feed per rabbit per 24 h (CH group), and a cholesterol + fluorine group (CH + F group) receivin...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8129-4
更新日期：2008-08-01 00:00:00
abstract：:Nickel (Ni) has not been elucidated as an essential mineral in dairy animals, though in plants and lower organisms, its role in activation of urease enzyme is well known. This study was conducted to evaluate the effect of Ni supplementation on intake, growth performance, urease activity, antioxidant and immune status,...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1524-6
更新日期：2019-07-01 00:00:00
abstract：:This experiment was conducted to evaluate the effects of zinc (ZnSO4.H2O) and vitamin A (retinol) supplementation on performance, carcass characteristics, and serum concentrations of glucose, cholesterol, total protein, and malondialdehyde (MDA) as an indicator of lipid peroxidation in broiler chickens (Ross) reared a...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1385/BTER:94:3:225
更新日期：2003-09-01 00:00:00
abstract：:The purpose of this study was to assess insoluble salts containing gadolinium (Gd(3+)) for effects on human dermal fibroblasts. Responses to insoluble Gd(3+) salts were compared to responses seen with Gd(3+) solubilized with organic chelators, as in the Gd(3+)-based contrast agents (GBCAs) used for magnetic resonance ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9176-9
更新日期：2012-02-01 00:00:00
abstract：:Selenium is a trace element that has antioxidant and neuroprotective effects. The aim of this study is to investigate the effects of selenium in reducing ischemia-reperfusion injury of the gastrocnemius muscle. In this experimental study, 80 adult male Wistar rats weighing 250-300 g were divided into ten groups (N = 8...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0218-y
更新日期：2015-04-01 00:00:00
abstract：:This study is aimed at investigating the inhibitory effect of cadmium ion on glutathione reductase activity of rabbit brain and liver and the relationship of this effect with dietary selenium. For this purpose, one group of New Zealand rabbits were fed a selenium-deficient diet, another group was fed a selenium-rich d...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/bter:91:2:151
更新日期：2003-02-01 00:00:00
