Effects of sodium selenite on aflatoxin B1-induced decrease of ileal IgA+ cell numbers and immunoglobulin contents in broilers.

Abstract:

:This study was aimed to assess the protective effect of sodium selenite on the ileum mucosal immunologic injury induced by AFB1. One hundred eighty-one-day-old healthy male Avian broilers were divided into four groups of three replicates and 15 birds per replicate and fed with basal diet (control group), 0.3 mg/kg AFB1 (AFB1 group), 0.4 mg/kg Se (+Se group), and 0.3 mg/kg AFB1 + 0.4 mg/kg Se (AFB1 + Se group) respectively. The numbers of IgA(+) cells of ileum were determined by immunohistochemistry as well as the contents of sIgA, IgA, IgG, and IgM in the mucosa of ileum by ELISA. Compared with those in the control group, the numbers of IgA(+) cells as well as the sIgA, IgA, IgG, and IgM contents were decreased in the AFB1 group. However, compared with those in the AFB1 group, the numbers of IgA(+) cells as well as the sIgA, IgA, IgG, and IgM contents were increased in the AFB1 + Se group, and these data had no difference between AFB1 + Se group and control group. It was concluded that 0.3 mg/kg AFB1 could reduce the humoral immune function of the ileum mucosa, but 0.4 mg/kg supplemented dietary selenium could protect the mucosal humoral immune function from AFB1-induced impairment.

journal_name

Biol Trace Elem Res

authors

He Y,Fang J,Peng X,Cui H,Zuo Z,Deng J,Chen Z,Geng Y,Lai W,Shu G,Tang L

doi

10.1007/s12011-014-0035-3

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

49-55

issue

1

eissn

0163-4984

issn

1559-0720

journal_volume

160

pub_type

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