Abstract：
:Little is known about the influence of subchronic cadmium exposure on apoptosis in the immune organs of birds and the protective effects on apoptosis by selenium against cadmium. The aim of this study was to investigate the effect of subchronic cadmium exposure on nitric oxide and apoptosis in the immune organs of chicken and the protective roles of selenium against cadmium-induced apoptosis. Two hundred ten 30-day-old chickens were randomly assigned to three groups and were fed a basal diet, cadmium+selenium (as 150 mg of CdCl2 per kg of diet+10 mg of Na2SeO3 per kg of diet ) or cadmium (as 150 mg of CdCl2 per kg of diet) in basic diets for 15, 30, 45, and 60 days. Then, the production of nitric oxide, messenger RNA (mRNA level), and the activity of inducible nitric oxide synthase, ultrastructural changes, TUNEL assay, and flow cytometric analysis of apoptosis and Bcl-2 and p53 mRNA levels in the immune organs were examined. The results showed that cadmium exposure caused ultrastructural damage and increased production of nitric oxide, mRNA level, and activity of inducible nitric oxide synthase, the degree, and the number of apoptotic cells in a time-dependent manner. Cadmium exposure decreased Bcl-2 mRNA level and increased p53 mRNA level in a time-dependent manner. Selenium supplementation during dietary cadmium reduced the production of nitric oxide, the mRNA level, and activity of inducible nitric oxide synthase, ultrastructural damage, and apoptosis in the immune organs of chicken. It indicated that cadmium induced nitric oxide-mediated apoptosis of immune organs, and selenium played protective effects against cadmium-induced apoptosis in the immune organs of chickens.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Liu LL,Zhang JL,Zhang ZW,Yao HD,Sun G,Xu SWdoi
10.1007/s12011-014-0007-7subject
Has Abstractpub_date
2014-06-01 00:00:00pages
199-209issue
1-3eissn
0163-4984issn
1559-0720journal_volume
159pub_type
杂志文章abstract：:Addition of zinc lowers the toxicity level of cadmium in cultured CHO cells. Cell survival and protein synthesis were used to measure the cellular toxicity of cadmium.(109)Cd was used to measure cadmium uptake by the cells. The results suggest that these class IIB transition metals, zinc and cadmium, share a common tr...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02785356
更新日期：1980-09-01 00:00:00
abstract：:The aim of this study was to explore the effects of selenium addition on hepatic tissue ultrastructure and mitochondrial antioxidant capacity in copper-overloaded rats. Eighteen adult male Sprague-Dawley (SD) rats were randomly divided into three groups (n = 6 per group). Each group received 1 mL (intragastrically) of...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0293-8
更新日期：2015-09-01 00:00:00
abstract：:Osteoporosis is a bone disease that leads to an increased risk of fracture. Oxidative stress may play a major role in the development of osteoporosis in part by inhibiting osteoblastic differentiation of bone marrow stromal cells (MSCs). Some evidence suggested that antioxidant selenium could prevent osteoporosis, but...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9488-4
更新日期：2012-12-01 00:00:00
abstract：:The present study aimed to investigate the prevalence of thrombocytopenia and its association with serum magnesium in a nationally representative cohort. A total of 8478 participants aged 18 years and over were recruited in a cross-sectional survey. Thrombocytopenia was defined as platelet count less than 150 × 10(9)/...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0406-4
更新日期：2016-01-01 00:00:00
abstract：:There have been few investigations of trace elements in the urine and hair of populations exposed to high levels of arsenic (As) in drinking water. Therefore, concentrations of selected metals in urine and hair samples from a population in a study area where arsenism was endemic and a control area were determined. It ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1108-x
更新日期：2018-04-01 00:00:00
abstract：:Mannheimia haemolytica is the main bacterial pathogen isolated in bovine respiratory disease (BRD), a common disease affecting calves before weaning. Previous research has shown that experimental infection with bovine herpesvirus 1, a respiratory virus, decreases plasma zinc (Zn) levels. However, changes in plasma Zn ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02145-4
更新日期：2021-01-01 00:00:00
abstract：:Selenomethionine metabolism and the biochemical basis for its cytotoxicity were analyzed in cultured human and murine lymphoid cells. The metabolic pathways were also addressed, using purified mammalian enzymes and crude tissue extracts. Selenomethionine was found to be effectively metabolized to S-adenosylmethionine ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02990463
更新日期：1991-01-01 00:00:00
abstract：:Nickel is an important kind of metal and a necessary trace element in people's production and livelihood; it is also a well-confirmed human carcinogen. In the past few years, researchers did a large number of studies about the molecular mechanisms of nickel carcinogenesis, and they focused on activation of proto-oncog...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9619-6
更新日期：2013-05-01 00:00:00
abstract：:Long-term diabetes mellitus can induce osteopenia and osteoporosis, an increase in the incidence of low-stress fractures, and/or delayed fracture healing. Strontium ranelate (SrR) is a dual-action anti-osteoporotic agent whose use in individuals with diabetic osteopathy has not been adequately evaluated. In this study...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1322-1
更新日期：2018-12-01 00:00:00
abstract：:Interaction between toxic and essential elements is of particular interest, because the deficiency of essential element can dramatically increase the absorption rate of toxic metals inside the body. This study was conducted to evaluate the possible correlation of lead (Pb) with calcium (Ca), iron (Fe), and zinc (Zn) i...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1141-9
更新日期：2018-06-01 00:00:00
abstract：:Yerba mate (Ilex paraguariensis), a widely consumed beverage in South America, contains various biochemically active substances, among them are several minerals. This paper reports on the results of a survey of trace elements in the yerba mate infusions. Three different commercially available trademarks of I. paraguar...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9056-3
更新日期：2011-12-01 00:00:00
abstract：:The aim of this work was to explore the effects of a low- and high-zinc diet and vitamin Aon the distribution of fatty acids in chylomicrons. Mongolian Gerbils were fed a basal diet (for 3 wk) containing 8 or 38 mg zinc/kg of feed (low-zinc group [termed LZ group] and saturated zinc group [termed SZ group], respective...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:112:2:145
更新日期：2006-08-01 00:00:00
abstract：:Zinc (Zn) is an essential nutrient that is required in humans and animals for many physiological functions, including immune and antioxidant function, growth, and reproduction. The present study was performed to investigate the effects of three Zn levels, including Zn adequate (35.94 mg/kg, as a control), Zn deficienc...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:107:2:153
更新日期：2005-11-01 00:00:00
abstract：:Relative stability of mineral elements in tissues is necessary for health. High static magnetic fields (HiSMFs) have been widely used in biomedical research and industry. However, the bioeffect of HiSMFs on animals is still unclear. In this study, we investigated the effects of HiSMF exposure on the levels of Mg, Fe, ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02469-1
更新日期：2021-01-07 00:00:00
abstract：:Six important metal contents (i.e., zinc, barium, magnesium, calcium, copper, and selenium) in blood samples coupled with an ensemble classification algorithm have been used for the classification of normal people and cancer patients. A dataset containing 42 healthy samples and 32 cancer samples was used for experimen...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8864-1
更新日期：2011-10-01 00:00:00
abstract：:Present study investigates relationships between total and bioaccessibility of trace elements (Cd, Co, Cr, Cu, Mn, NI, Pb, V, and Zn) concentrations in sediment and their bioaccumulation in species in Shadegan wetland in southwest of Iran. Bioavailability factor (BAF) and translocation factor (TF) were calculated in p...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8795-x
更新日期：2011-09-01 00:00:00
abstract：:Microcalorimetry was employed to investigate the action of Li(I) to aquatic ecosystem from the point view of bioenergetics. Tetrahymena thermophila BF5 was chosen as the model organism. The power-time curves of T. thermophila BF5 growth metabolism in the absence and presence of Li(I) were obtained. The corresponding t...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-0040-x
更新日期：2007-10-01 00:00:00
abstract：:Studies of effects of diazepam on liver parenchyma are very scanty. In this study, adult albino rats were treated with diazepam in two different doses (0.25 mg and 0.30 mg/kg body wt) daily for 30 and 60 d. Through light microscopy and electron microscopy, prenecrotic and necrotic changes were noted in the high-dose g...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02785292
更新日期：1997-06-01 00:00:00
abstract：:In the present study, we investigated the effects of Se-enriched Agaricus blazei Murill (Se-AbM) on liver injury in mice induced by acute alcohol administration. Mice received ethanol (5 g/kg body weight (BW)) by gavage every 12 h for a total of 3 doses. Se-AbM was administrated before ethanol administration. Subseque...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0022-8
更新日期：2014-07-01 00:00:00
abstract：:The control of metallothionein (MT) synthesis was investigated in freshly prepared rat hepatocytes in experiments of short-term duration. Viability and metabolic function were maintained in incubations of 6-h duration. MT synthesis was measurable in hepatocytes from fed rats at Zn concentrations down to 1 microM. Zn a...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783778
更新日期：1993-01-01 00:00:00
abstract：:The AIN-93 reformulation of the AIN-76A rodent diet includes a change in selenium supplement from sodium selenite to sodium selenate to reduce dietary lipid peroxidation. A change to selenate as the standard form of Se in rat diets would render results from previous work using selenite less relevant for comparison wit...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:79:3:257
更新日期：2001-03-01 00:00:00
abstract：:Male Sprague-Dawley rats, weighing 175-200 g, six per group were fed AIN 93M diet (CON) or diets containing 500 mg Ca (LCa), 7 mg Zn (LZn), 2 mg Cu (LCu), 60 mg Zn (HZn), or 12 mg Cu (HCu) per kilogram of diet in the following combinations: control (CON), LCa+LZn (LC+Z), LCa+LZn+LCu (LC+Z+C), or HZn+HCu (HZ+C) without...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:108:1-3:169
更新日期：2005-01-01 00:00:00
abstract：:This meta-analysis was conducted aiming to summarize the results obtained from the previous studies so that the effect of opium on blood lead levels (BLLs) can be investigated. Scopus, Embase, PubMed, and Web of Science (ISI) were systematically searched up to June 2020. Heterogeneity of the included studies was evalu...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02504-1
更新日期：2020-11-26 00:00:00
abstract：:The aim of this study was to investigate the effects of the Toxoplasma gondii infection on the total content of the essential elements Zn and Mg levels. Plasma zinc and magnesium concentrations were measured in 158 patients whose anti-T gondii IgG antibodies were positive. Scores were obtained for the patients and the...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1385/BTER:92:1:11
更新日期：2003-04-01 00:00:00
abstract：:Several authors have already underlined chromium implication in glucose and lipids metabolism of humans. In this field, physiological chromium determination in serum could be helpful, but the discrepancies reported in numerous papers are confusing. Here we report some results obtained by Zeeman correction Graphite Fur...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784591
更新日期：1992-01-01 00:00:00
abstract：:In this study, a method of positive matrix factorization (PMF) combined support vector machines (SVMs) was adopted to identify possible sources and apportion contributions for trace element pollution in surface sediments from the Jinjiang River, Southeastern China. Utilizing diagnostics tools, four significant factors...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9576-5
更新日期：2013-03-01 00:00:00
abstract：:Neurodegeneration disorders are complex and multifaceted, leading to many chronic diseases, like Parkinson's disease (PD). Electrolytes imbalance has a significant role in the pathophysiology of neurological disorders, which might serve as a bio-indicator of these problems. In the present study, the disturbances of th...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02399-y
更新日期：2020-09-22 00:00:00
abstract：:Aluminum (Al) absorption seems to be very low, but many factors can enhance it in animals and humans. In the present study, we investigated the acute effect of Na citrate on Al absorption by monitoring Al levels in blood and several tissues. For this purpose, 18 Wistar male rats were divided into 3 groups: control, Al...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02778873
更新日期：1998-08-01 00:00:00
abstract：:Hyperlipidemia is one of the major risk factors for atherosclerosis and ischemic heart disease. Chromium (Cr) mineral is playing a crucial role in glucose and lipid homeostasis. The aim of this study was to evaluate the protective effects of combined chromium picolinate (CrPic) and atorvastatin treatment against hyper...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1010-6
更新日期：2017-12-01 00:00:00
abstract：:Variations in trace element concentration in the head and facial hair of five individuals with ever-increasing amounts of white hair were examined. Hair was collected from the scalp, cheeks, and chin from one donor on a regular basis since 1984. Samples were separated into white and pigmented fractions, and analyzed a...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02992728
更新日期：1990-07-01 00:00:00
