Multi-Scale Approach for the Evaluation of Bone Mineralization in Strontium Ranelate-Treated Diabetic Rats.

Abstract:

:Long-term diabetes mellitus can induce osteopenia and osteoporosis, an increase in the incidence of low-stress fractures, and/or delayed fracture healing. Strontium ranelate (SrR) is a dual-action anti-osteoporotic agent whose use in individuals with diabetic osteopathy has not been adequately evaluated. In this study, we studied the effects of an oral treatment with SrR and/or experimental diabetes on bone composition and biomechanics. Young male Wistar rats (half non-diabetic, half with streptozotocin/nicotinamide-induced diabetes) were either untreated or orally administered 625 mg/kg/day of SrR for 6 weeks. After sacrifice, femora from all animals were evaluated by a multi-scale approach (X-ray diffraction, Fourier transform infrared spectroscopy, inductively coupled plasma optical-emission spectrometry, static histomorphometry, pQCT, and mechanical testing) to determine chemical, crystalline, and biomechanical properties. Untreated diabetic animals (versus untreated non-diabetic) showed a decrease in femoral mineral carbonate content, in cortical thickness and BMC, in trabecular osteocyte density, in maximum load supported at rupture and at yield point, and in overall toughness at mid-shaft. Treatment of diabetic animals with SrR further affected several parameters of bone (some already impaired by diabetes): crystallinity index (indicating less mature apatite crystals); trabecular area, BMC, and vBMD; maximum load at yield point; and structural elastic rigidity. However, SrR was also able to prevent the diabetes-induced decreases in trabecular osteocyte density (completely) and in bone ultimate strength at rupture (partially). Our results indicate that SrR treatment can partially but significantly prevent some bone structural mechanical properties as previously affected by diabetes, but not others (which may even be worsened).

journal_name

Biol Trace Elem Res

authors

Álvarez-Lloret P,Fernández JM,Molinuevo MS,Lino AB,Ferretti JL,Capozza RF,Cortizo AM,McCarthy AD

doi

10.1007/s12011-018-1322-1

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

457-466

issue

2

eissn

0163-4984

issn

1559-0720

pii

10.1007/s12011-018-1322-1

journal_volume

186

pub_type

杂志文章
  • Cerium depresses endocardial endothelial cell-mediated proliferation of cardiac fibroblasts.

    abstract::Cerium has been implicated in the pathogenesis of cardiac disorders such as acute myocardial infarction and endomyocardial fibrosis (EMF). A geochemical hypothesis for the causation of EMF linked the cardiac lesions to magnesium deficiency consequent to malnutrition and increased cardiac levels of cerium derived from ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/bter:114:1:85

    authors: Kuruvilla L,Kartha CC

    更新日期:2006-01-01 00:00:00

  • Effects of Local Administration of Boric Acid on Posterolateral Spinal Fusion with Autogenous Bone Grafting in a Rodent Model.

    abstract::Spinal fusion is among the most frequently applied spinal surgical procedures. The goal of the present study was to evaluate whether the local administration of boric acid (BA) improves spinal fusion in an experimental spinal fusion model in rats. Currently, there is no published data that evaluates the possible posit...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-015-0274-y

    authors: Kömürcü E,Özyalvaçlı G,Kaymaz B,Gölge UH,Göksel F,Cevizci S,Adam G,Ozden R

    更新日期:2015-09-01 00:00:00

  • Effect of zinc supplementation on antioxidant activity in young wrestlers.

    abstract::This study aims to examine the effect of zinc supplementation on free-radical formation and antioxidant system in individuals who are actively engaged in wrestling as a sport. The study registered a total of 40 male subjects, of whom 20 were wrestlers and 20 were sedentary individuals. The subjects were equally alloca...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-009-8457-z

    authors: Kara E,Gunay M,Cicioglu I,Ozal M,Kilic M,Mogulkoc R,Baltaci AK

    更新日期:2010-04-01 00:00:00

  • Neuroprotective Effect of Portulaca oleraceae Ethanolic Extract Ameliorates Methylmercury Induced Cognitive Dysfunction and Oxidative Stress in Cerebellum and Cortex of Rat Brain.

    abstract::Methylmercury (MeHg) is highly toxic, and its principal target tissue in human is the nervous system, which has made MeHg intoxication a public health concern for many decades. Portulaca oleraceae (purslane), a member of the Portulacaceae family, is widespread as a weed and has been ranked the eighth most common plant...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-015-0546-6

    authors: Sumathi T,Christinal J

    更新日期:2016-07-01 00:00:00

  • Oxidative Stress Parameters, Trace Elements, and Lipid Profile in Iranian Patients with Gaucher Disease.

    abstract::Gaucher disease (GD) is most frequent disorder of glycolipid storage. The glucosylceramide accumulation might lead to oxidative stress and changes in lipid profile. Regarding the main role of trace elements in hematopoiesis and oxidative stress, this study was aimed to evaluate the zinc and copper levels, three oxidat...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-019-01709-3

    authors: Mozafari H,Khatami S,Kiani A,Rahimi Z,Vaisi-Raygani A,Afsharnaderi A,Alaei MR

    更新日期:2020-01-01 00:00:00

  • Lipid peroxidation in liver of mice administrated with nickel chloride: with special reference to trace elements and antioxidants.

    abstract::The relationship between Ni-induced hepatic lipid peroxidation (LPO) and the concentrations of Ni and trace elements was investigated in male ICR mice. The protective effects of antioxidants were also examined. Hepatic LPO and the concentrations of Ni, Fe, Cu, and Zn in the liver were enhanced after an ip injection of...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02784030

    authors: Chen CY,Huang YL,Lin TH

    更新日期:1998-02-01 00:00:00

  • Effect of Selenium from Selenium-Enriched Kale Sprout Versus Other Selenium Sources on Productivity and Selenium Concentrations in Egg and Tissue of Laying Hens.

    abstract::A 6-week trial was conducted to compare the effect of selenium (Se) from hydroponically produced Se-enriched kale sprout (HPSeKS), sodium selenite (SS), and Se-enriched yeast (SeY) in laying hens. A total of 144 40-week-old hens were randomly divided into four groups, according to a completely randomized design. Each ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-017-1069-0

    authors: Chantiratikul A,Chinrasri O,Chantiratikul P

    更新日期:2018-03-01 00:00:00

  • Monitoring metals in the population living in the vicinity of a hazardous waste incinerator: levels in hair of school children.

    abstract::Hair samples of 134 school children (12-14 yr old) living in three residential zones in the vicinity of a new hazardous waste incinerator (HWI) (Constanti, Tarragona County, Catalonia, Spain) were analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) for arsenic (As), beryllium (Be), cadmium (Cd), chromium...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:104:3:203

    authors: Nadal M,Bocio A,Schuhmacher M,Domingo JL

    更新日期:2005-06-01 00:00:00

  • Selenium and L-carnitine reduce oxidative stress in the heart of rat induced by 2.45-GHz radiation from wireless devices.

    abstract::The aim of this study was to investigate the possible protective role of selenium and L-carnitine on oxidative stress induced by 2.45-GHz radiation in heart of rat. For this purpose, 30 male Wistar Albino rats were equally divided into five groups namely controls, sham controls, radiation-exposed rats, radiation-expos...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-011-8994-0

    authors: Türker Y,Nazıroğlu M,Gümral N,Celik O,Saygın M,Cömlekçi S,Flores-Arce M

    更新日期:2011-12-01 00:00:00

  • A microcalorimetric study of the effect of La3+ on mitochondria isolated from Star-Cross 288 chicken liver tissue cells.

    abstract::The thermogenic curves of the metabolism of mitochondria isolated from the liver of chicken Star-Cross 288 and the effect of La3+ on it were studied by using an LKB-2277 BioActivity Monitor, ampoule method, at 37 degrees C. After isolation from the chicken liver tissue, mitochondria still have metabolic activity and c...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/bter:84:1-3:103

    authors: Yi L,Peng L,Fengjiao D,Zhong C,Cunxin W,Songsheng Q

    更新日期:2001-01-01 00:00:00

  • Comparative in situ study of the intestinal absorption of aluminum, manganese, nickel, and lead in rats.

    abstract::This comparative study of the intestinal absorption of four toxic metals (aluminum, manganese, nickel, and lead) carried out in rats using the in situ intestinal perfusion technique was able to measure the partition of each metal between the intestine (intestinal retention), the blood circulation, and target tissues a...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:99:1-3:157

    authors: Arnich N,Cunat L,Lanhers MC,Burnel D

    更新日期:2004-07-01 00:00:00

  • Oral treatment of pressure ulcers with polaprezinc (zinc L-carnosine complex): 8-week open-label trial.

    abstract::Polaprezinc (zinc L-carnosine complex) is a tablet commonly prescribed for gastric ulcers in Japan. Recently, we reported the effects of polaprezinc on pressure ulcer healing at 4-week follow-up. We aimed to further evaluate the efficacy and safety of polaprezinc in 8-week treatment for chronic pressure ulcers. Patien...

    journal_title:Biological trace element research

    pub_type: 临床试验,杂志文章

    doi:10.1007/s12011-014-9943-5

    authors: Sakae K,Yanagisawa H

    更新日期:2014-06-01 00:00:00

  • Serum zinc and copper in myocardial infarction with particular reference to prognosis.

    abstract::Serum copper and zinc estimations in humans were made to find their diagnostic and prognostic value in cases of myocardial infarction. Following infarction, there was an increase in serum copper levels from the first 24 h up to the 7th day, with gradual decline that did not reach the normal value up to the 14th day. T...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02990200

    authors: Jain VK,Mohan G

    更新日期:1991-12-01 00:00:00

  • The Determination of Toxic Metals in some Traditional Cosmetic Products and Health Risk Assessment.

    abstract::In present study, the levels of some toxic elements in 19 different home-made cosmetic products (spray hair dye, henna, tattoo, eyeliner, eye mascara, smear, lip moisturizer, and lipstick) were analyzed by inductively coupled plasma mass spectrometric (ICP-MS) after microwave digestion. The ICP-MS results were verifie...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02357-8

    authors: Kilic S,Kilic M,Soylak M

    更新日期:2020-09-05 00:00:00

  • Trace Elements in the Large Population-Based HUNT3 Survey.

    abstract::The Nord-Trøndelag Health Study (The HUNT Study) is a large health survey population study in the county of Trøndelag, Norway. The survey has been repeated four times in about 10-year intervals. In the HUNT3 survey (2006-2008), we collected 28,000 samples for trace element analysis. Blood samples from 758 healthy pers...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02376-5

    authors: Syversen T,Evje L,Wolf S,Flaten TP,Lierhagen S,Simic A

    更新日期:2020-09-08 00:00:00

  • Calcium Fructoborate Prevents Skin Cancer Development in Balb-c Mice: Next Part, Reverse Inflammation, and Metabolic Alteration.

    abstract::Metabolic alterations and inflammation are regarded as hallmarks of cancer. Glycolytic flux and intermediate accumulation lead to the production of building blocks and NADPH which is important in protecting the cell from oxidative damage. Inflammation causes the release of mediators responsible for regulating molecula...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02363-w

    authors: Kisacam MA,Kocamuftuoglu GO,Ozan IE,Yaman M,Ozan S

    更新日期:2020-09-03 00:00:00

  • Combined effect of high-fat diet and copper deficiency during gestation on fetal copper status in the rat.

    abstract::We have previously shown that a low-copper (Cu) diet produced alterations in placental Cu transport and fetal Cu stores. Because Cu deficiency has been associated with lipid deposition in rat dam liver, we hypothesized that a high fat intake, a prevalent dietary habit in many populations, may worsen fetal Cu status an...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02784069

    authors: Ebesh O,Barone A,Harper RG,Wapnir RA

    更新日期:1999-02-01 00:00:00

  • Cation shifts in human retina-choroid.

    abstract::Human ocular tissues from 50 donor eyes were elementally and morphologically analyzed in order to correlate the elemental content and distribution of Ca, Ba, Cr, Cu, Zn, and Se with ocular morphology, sex, race, irideal pigmentation, age, time of death, birth weight, presence and severity of diabetes, and other pathol...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02796667

    authors: Panessa-Warren BJ,Kraner HW,Jones KW,Kaplan C

    更新日期:1987-04-01 00:00:00

  • The effect of diabetes on the molecular localization of maternal and fetal zinc and copper metalloprotein in the rat.

    abstract::The molecular localization of maternal and fetal zinc and copper metalloproteins in diabetic and control rats was studied. Compared to controls, liver and kidneys of diabetic dams showed an increased concentration of zinc and copper that was associated with metallothionein. In contrast, fetuses of diabetic dams had lo...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02917490

    authors: Uriu-Hare JY,Stern JS,Keen CL

    更新日期:1988-12-01 00:00:00

  • Effects of low copper and high zinc intakes and related changes in Cu,Zn-superoxide dismutase activity on DMBA-induced mammary tumorigenesis.

    abstract::The effect of low copper and high zinc intakes on Cu,Zn-superoxide dismutase (Cu,Zn-SOD) activity and mammary tumorigenesis induced by 9,10-dimethyl-1,2-benzanthracene (DMBA) was investigated. Groups of 40 weanling female Sprague-Dawley rats were fed a modified AIN-76 diet containing the following (/kg diet): 1 mg Cu ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02990343

    authors: Fischer PW,Campbell JS,Giroux A

    更新日期:1991-07-01 00:00:00

  • Selenium supplementation alters gene expression profiles associated with innate immunity in whole-blood neutrophils of sheep.

    abstract::Footrot (FR) is a common, contagious bacterial disease of sheep that results in lameness and significant economic losses for producers. We previously reported that sheep affected with FR have lower whole-blood (WB) selenium (Se) concentrations and that Se supplementation in conjunction with routine control practices a...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-013-9716-6

    authors: Hugejiletu H,Bobe G,Vorachek WR,Gorman ME,Mosher WD,Pirelli GJ,Hall JA

    更新日期:2013-07-01 00:00:00

  • Influence of dietary supplementation with thiamine on lead intoxication in rats.

    abstract::The influence of dietary supplementation with thiamine on lead (Pb) contents in blood and tissues, blood δ-aminolevulinic acid dehydratase (δ-ALAD) activity, and urinary excretion of δ-aminolevulinic acid (δ-ALA) was evaluated in male Sprague-Dawley rats. Groups of randomly selected animals were given a thiamine-defic...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02795566

    authors: Flora SJ,Sharma RP

    更新日期:1986-08-01 00:00:00

  • Dietary subacute zinc deficiency and potassium metabolism.

    abstract::In a controlled animal experiment the effects of dietary subacute Zn deficiency on growth, Zn concentration, and tissue 42-K distribution were studied. Growth retardation caused lower body weight because both skeletal and heart muscle showed a reduction in cell mass. Zn concentrations were reduced in most tissues, how...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02789301

    authors: Wouwe JP,Veldhuizen M

    更新日期:1994-12-01 00:00:00

  • Magnesium, zinc, and manganese in atherosclerosis of the aorta.

    abstract::Atomic absorption spectrometry was used in a quantitative study of zinc, magnesium, and manganese on 71 postmortal human aortas. Samples were obtained from accident victims 35-65 years of age. Fibrous plaques had higher levels of all three elements when compared to normal aortic tissue. The difference was significant ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02916613

    authors: Mendis S

    更新日期:1989-12-01 00:00:00

  • Developmental effects of boric acid in rats related to maternal blood boron concentrations.

    abstract::Timed-mated Sprague-Dawley rats (60/group) were exposed to boric acid (BA) from gestational days (gd) 0 to 20. BA added to the diet (0, 0.025, 0.050, 0.075, 0.1, or 0.2%) yielded boron (B) intakes of <0.35 (control), 3, 6, 10, 13, or 25 mg B/kg body wt/d. Approximately one-half of the dams/group were terminated on gd ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02783148

    authors: Price CJ,Strong PL,Murray FJ,Goldberg MM

    更新日期:1998-01-01 00:00:00

  • Effects of Supplemental Chromium Source and Concentration on Growth Performance, Carcass Traits, and Meat Quality of Broilers Under Heat Stress Conditions.

    abstract::The objective of this study was to investigate the effects of dietary supplemental chromium (Cr) on growth performance, carcass traits, and meat quality of broilers reared under heat stress. A total of 252 1-d-old Cobb 500 commercial female broilers were randomly allotted by body weight (BW) to one of six replicate ca...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-015-0443-z

    authors: Huang Y,Yang J,Xiao F,Lloyd K,Lin X

    更新日期:2016-03-01 00:00:00

  • Effects of Long-Term Mineral Block Supplementation on Antioxidants, Immunity, and Health of Tibetan Sheep.

    abstract::Tibetan sheep have been observed with mineral deficiencies and marginal deficiencies in Qinghai-Tibetan Plateau. Adequate amounts of essential minerals are critical to maximize the productivity and health of livestock. The objectives of this study were to evaluate the effects of 6 months of mineral block supplementati...

    journal_title:Biological trace element research

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s12011-015-0593-z

    authors: Wang H,Liu Z,Huang M,Wang S,Cui D,Dong S,Li S,Qi Z,Liu Y

    更新日期:2016-08-01 00:00:00

  • The influence of scattering on the total efficiency for point sources in gamma-ray spectrometry.

    abstract::The contribution of gamma-ray scattering to the total efficiency for point-source geometries in a gamma spectrometer was measured. Scattering of gamma-rays on the shield and in the sample was considered. For a 25% efficiency detector in a small shield, about a 1% contribution to the total efficiency was measured, wher...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02917374

    authors: Korun M,Martincic R

    更新日期:1994-10-01 00:00:00

  • Serum Selenium Levels and Cervical Cancer: Systematic Review and Meta-Analysis.

    abstract::Several studies have investigated the relationship between serum Se concentration and cervical cancer, but the results were inconsistent. Thus, we conducted a systematic review and meta-analysis to evaluate the association between serum selenium levels and cervical cancer. Twelve studies investigating the association ...

    journal_title:Biological trace element research

    pub_type: 杂志文章,meta分析

    doi:10.1007/s12011-017-0982-6

    authors: He D,Wang Z,Huang C,Fang X,Chen D

    更新日期:2017-10-01 00:00:00

  • Serum Trace Elements and Electrolytes Are Associated with Fasting Plasma Glucose and HbA1c in Postmenopausal Women with Type 2 Diabetes Mellitus.

    abstract::The primary aim of the research was to assess the level of trace elements and electrolytes in serum of postmenopausal diabetic women. Sixty-four postmenopausal women with type 2 diabetes mellitus (DM2) and 64 age- and body mass index-matched controls were examined. Serum trace elements were assessed using inductively ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-016-0868-z

    authors: Skalnaya MG,Skalny AV,Yurasov VV,Demidov VA,Grabeklis AR,Radysh IV,Tinkov AA

    更新日期:2017-05-01 00:00:00